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The map label for this gene is nhaR [H]

Identifier: 34498677

GI number: 34498677

Start: 3504400

End: 3505302

Strand: Direct

Name: nhaR [H]

Synonym: CV_3222

Alternate gene names: 34498677

Gene position: 3504400-3505302 (Clockwise)

Preceding gene: 34498672

Following gene: 34498679

Centisome position: 73.76

GC content: 68.0

Gene sequence:

>903_bases
ATGAGCCGGCTCAACTACCACCATCTGCACTATTTCTGGGCGGTTGCCAGCGAGGGCCACCTGACGCGCGCGGCCGAGAG
GCTGCATGTCTCGCAATCGGCGCTGTCGGCGCAAATTCGCCAGCTGGAAGAGCAACTGGGCCAGCCGTTGTTCCTGCGCG
AAGGCCGCAAGCTGCAGCTGACCGAGCTGGGCGCGGTGGTGATGCGCTATGCCGAGGAGATTTTCGCGCTGGGCAACGAG
CTGTTGGCCACCGCCGCCTCCGGCCAAGGACGCGGCACCTTGCGCATAGGCAGCGTGGCCACGCTGTCGCGCAATTTCCA
GGAATGGTTTTTGCAGCCGGTGCTGAAAGAAGCCGATGTACGGCTGGTGCTGGAGTCCGGCAGCCTGGACGAGCTGCTGC
AGCGGCTCAAGGCGCACGAACTGGACGTGGTGCTGTCCAATCGCCCTGCCCTGGGCGACGACAAGCAATCCTGGCGCTGC
CGCACGCTGGCGCGCCAGCCGGTGGTGCTGGTGGGGCCGCCGCGGCCGGAGGGGCGGACCTTCCAGTTCGAGCGCGATCT
GCCGGCGCTGCCGCTGCTGGTGCCCAGCCGCAAGAGCGAGATCCGCCTGCGCTTCGACCTGCTGTGCGAGGAGCTGGCGC
TGCAGCCGGCCATCCGCGCCGAAGTGGACGATATGGCCATGCTGCGCCTGCTGGCGCGCGACGCCGGCTGCGTGGCGCTG
CTGCCGGCCATCGTGGTGCGCGACGAGCTAGGCAAGGGCTTGCTGCAACAATACTGCGTGGTGCCGCGCGTCGAGGAGAC
CTTCTACGCCATCACCGTGCAGCGGCAGTATCTGCCGCCGCTGCTGCAAGATCTGCTGCGCATGGCGGCAGACGATCAGG
CACGGAGCCTGGCCGCGCCCTGA

Upstream 100 bases:

>100_bases
GGCATGGAAGGCTCCGTTGTTTTCCTGCTCGAACTTTGCCTGAGCGAATATGTTCAGTAAAATAGATTAAATATTAGTTT
TCATTCTTTATTTTAGAACA

Downstream 100 bases:

>100_bases
TCCGCGGCTTCACGCGTCTCCGTCAGCGCGGCGCTGGCCAGCCGACATGCCGTCGAAACAGACCTCAAGCATATGCCTGA
CGATGTCTTCATCCGGGTAT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Na(+)/H(+) antiporter regulatory protein [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MSRLNYHHLHYFWAVASEGHLTRAAERLHVSQSALSAQIRQLEEQLGQPLFLREGRKLQLTELGAVVMRYAEEIFALGNE
LLATAASGQGRGTLRIGSVATLSRNFQEWFLQPVLKEADVRLVLESGSLDELLQRLKAHELDVVLSNRPALGDDKQSWRC
RTLARQPVVLVGPPRPEGRTFQFERDLPALPLLVPSRKSEIRLRFDLLCEELALQPAIRAEVDDMAMLRLLARDAGCVAL
LPAIVVRDELGKGLLQQYCVVPRVEETFYAITVQRQYLPPLLQDLLRMAADDQARSLAAP

Sequences:

>Translated_300_residues
MSRLNYHHLHYFWAVASEGHLTRAAERLHVSQSALSAQIRQLEEQLGQPLFLREGRKLQLTELGAVVMRYAEEIFALGNE
LLATAASGQGRGTLRIGSVATLSRNFQEWFLQPVLKEADVRLVLESGSLDELLQRLKAHELDVVLSNRPALGDDKQSWRC
RTLARQPVVLVGPPRPEGRTFQFERDLPALPLLVPSRKSEIRLRFDLLCEELALQPAIRAEVDDMAMLRLLARDAGCVAL
LPAIVVRDELGKGLLQQYCVVPRVEETFYAITVQRQYLPPLLQDLLRMAADDQARSLAAP
>Mature_299_residues
SRLNYHHLHYFWAVASEGHLTRAAERLHVSQSALSAQIRQLEEQLGQPLFLREGRKLQLTELGAVVMRYAEEIFALGNEL
LATAASGQGRGTLRIGSVATLSRNFQEWFLQPVLKEADVRLVLESGSLDELLQRLKAHELDVVLSNRPALGDDKQSWRCR
TLARQPVVLVGPPRPEGRTFQFERDLPALPLLVPSRKSEIRLRFDLLCEELALQPAIRAEVDDMAMLRLLARDAGCVALL
PAIVVRDELGKGLLQQYCVVPRVEETFYAITVQRQYLPPLLQDLLRMAADDQARSLAAP

Specific function: Plays a role in the positive regulation of nhaA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786202, Length=287, Percent_Identity=28.9198606271777, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI157672245, Length=295, Percent_Identity=30.8474576271186, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788297, Length=254, Percent_Identity=29.5275590551181, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI2367136, Length=163, Percent_Identity=34.9693251533742, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1790208, Length=258, Percent_Identity=28.6821705426357, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788887, Length=169, Percent_Identity=34.9112426035503, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787806, Length=95, Percent_Identity=36.8421052631579, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1790399, Length=147, Percent_Identity=32.6530612244898, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33755; Mature: 33623

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRLNYHHLHYFWAVASEGHLTRAAERLHVSQSALSAQIRQLEEQLGQPLFLREGRKLQL
CCCCCHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEH
TELGAVVMRYAEEIFALGNELLATAASGQGRGTLRIGSVATLSRNFQEWFLQPVLKEADV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCE
RLVLESGSLDELLQRLKAHELDVVLSNRPALGDDKQSWRCRTLARQPVVLVGPPRPEGRT
EEEEECCCHHHHHHHHHHHCEEEEECCCCCCCCCCHHHHHHHHCCCCEEEECCCCCCCCC
FQFERDLPALPLLVPSRKSEIRLRFDLLCEELALQPAIRAEVDDMAMLRLLARDAGCVAL
EEECCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHH
LPAIVVRDELGKGLLQQYCVVPRVEETFYAITVQRQYLPPLLQDLLRMAADDQARSLAAP
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHCCHHHHHHHHHHCCHHHHHCCCC
>Mature Secondary Structure 
SRLNYHHLHYFWAVASEGHLTRAAERLHVSQSALSAQIRQLEEQLGQPLFLREGRKLQL
CCCCHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEH
TELGAVVMRYAEEIFALGNELLATAASGQGRGTLRIGSVATLSRNFQEWFLQPVLKEADV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCE
RLVLESGSLDELLQRLKAHELDVVLSNRPALGDDKQSWRCRTLARQPVVLVGPPRPEGRT
EEEEECCCHHHHHHHHHHHCEEEEECCCCCCCCCCHHHHHHHHCCCCEEEECCCCCCCCC
FQFERDLPALPLLVPSRKSEIRLRFDLLCEELALQPAIRAEVDDMAMLRLLARDAGCVAL
EEECCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHH
LPAIVVRDELGKGLLQQYCVVPRVEETFYAITVQRQYLPPLLQDLLRMAADDQARSLAAP
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHCCHHHHHHHHHHCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2429258; 1630901; 9278503; 3413113; 1316901; 8168494 [H]