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The map label for this gene is dacC [H]

Identifier: 34498549

GI number: 34498549

Start: 3379508

End: 3380653

Strand: Direct

Name: dacC [H]

Synonym: CV_3094

Alternate gene names: 34498549

Gene position: 3379508-3380653 (Clockwise)

Preceding gene: 34498546

Following gene: 34498550

Centisome position: 71.13

GC content: 63.09

Gene sequence:

>1146_bases
ATGAAAAAACTCACCACTGCCCTGGTGGCCTCCGCGCTGGCGCTGCCTTCTCTTGGCTTTGCCAACACCGCATTCGTGCC
GCCGACGCCGGAAATCGCCGGCAAAGCCTATTACCTGCTCGACTACAACAGCCAGCAGGTGCTCGCCGCCCGCGATCCGG
ACGCCCGCATCGAACCGGCCTCGCTGACCAAGCTGATGACCGCCTACCTGACCTTCAAGGCGCTGAAGGAAAAACGGCTG
TCGCTGGAACAGACGCTGACCGTGTCGCAGCGCGGCTGGAAGACCGAAGGCTCGCGCATGTTCCTGGATCCCAAGGTTCC
GGCCAAGGTGGATGACCTGATCAAGGGCATGATCGTGCAATCCGGCAACGACGCCTGCGTGACGCTGGCCGAAGCCATCG
CCGGCAGCGAGGACGTGTTCGGCCAGCTGATGACCCAGCAAGCGCTGAAGCTGGGCATGAAGAACACCCAGTTCAAGAAC
GCCACCGGCTTGCCGCACGAGGGCCATTACACCACGGTGCACGACCTGGGCATCCTGGCCGCCGCGCTGATCCGCGACTA
CCCCGAGTTCTACCCGATCTACTCGATGAAGTCGTTCACCTACAACAACATCAAGCAGCCGAACCGCAATCTGCTGCTGT
ACCGCGACCCCAACGTCGACGGCATGAAGACCGGCTACACCGACAGCGCCGGCTACAATATGGTCACCTCCAGCCATCGC
GACGGCCGCCGCGTGATTTCCGTCGTCGTCGGCACCGCCAGCCCCGAAGCGCGCGCGGTGGAAAGCTCCAAGCTGCTGAA
CTACGGCTTGCAATTCTTCGACACGCCCAAACTTTATGCTGCGAACACCCGCGTATCCGACGTCTCCGTGTACAAGGGCA
GCGAGAAGATCGTGCCGGTCGGCTTCGGCAGCGACGTGTTTGCCACCGTGGCCAAGGGCCAGGCAGCCAAGCTGAAGGCC
GACATGACCACGATGCAGCCGCTGATCGCGCCGATCAAGGCCGGCCAGGTGGTGGGCAAGCTGACCGTGTCCCTGGACGG
CAAGCCGCTGCTGGAGCGTCCGGTGATCGCGCTGAAGGCCGTCGAGGAAGGCGGTTTCTTCAGCCGGCTGTGGGACAGCC
TGAAGCTGATGCTCGGGTGGAAGTAA

Upstream 100 bases:

>100_bases
TGCAATGTGTCGGACAGGCTTTTTCCGGCTGCGTAGCCAGCTCGAGTGTGTATAATCAACGGCTACTGTTTGTGACCCCT
AGCAAGCCCCCTTCCAGAAA

Downstream 100 bases:

>100_bases
GCCGGGGTATAATAGTATTTGTCAGTAGTACGCAGCGCCGCGGCCAGACCGCGGCCTGCCATTTTGTAATCGCGTTAGAG
TAGCCAGACATGTCCGACGA

Product: D-ala-D-ala-carboxypeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MKKLTTALVASALALPSLGFANTAFVPPTPEIAGKAYYLLDYNSQQVLAARDPDARIEPASLTKLMTAYLTFKALKEKRL
SLEQTLTVSQRGWKTEGSRMFLDPKVPAKVDDLIKGMIVQSGNDACVTLAEAIAGSEDVFGQLMTQQALKLGMKNTQFKN
ATGLPHEGHYTTVHDLGILAAALIRDYPEFYPIYSMKSFTYNNIKQPNRNLLLYRDPNVDGMKTGYTDSAGYNMVTSSHR
DGRRVISVVVGTASPEARAVESSKLLNYGLQFFDTPKLYAANTRVSDVSVYKGSEKIVPVGFGSDVFATVAKGQAAKLKA
DMTTMQPLIAPIKAGQVVGKLTVSLDGKPLLERPVIALKAVEEGGFFSRLWDSLKLMLGWK

Sequences:

>Translated_381_residues
MKKLTTALVASALALPSLGFANTAFVPPTPEIAGKAYYLLDYNSQQVLAARDPDARIEPASLTKLMTAYLTFKALKEKRL
SLEQTLTVSQRGWKTEGSRMFLDPKVPAKVDDLIKGMIVQSGNDACVTLAEAIAGSEDVFGQLMTQQALKLGMKNTQFKN
ATGLPHEGHYTTVHDLGILAAALIRDYPEFYPIYSMKSFTYNNIKQPNRNLLLYRDPNVDGMKTGYTDSAGYNMVTSSHR
DGRRVISVVVGTASPEARAVESSKLLNYGLQFFDTPKLYAANTRVSDVSVYKGSEKIVPVGFGSDVFATVAKGQAAKLKA
DMTTMQPLIAPIKAGQVVGKLTVSLDGKPLLERPVIALKAVEEGGFFSRLWDSLKLMLGWK
>Mature_381_residues
MKKLTTALVASALALPSLGFANTAFVPPTPEIAGKAYYLLDYNSQQVLAARDPDARIEPASLTKLMTAYLTFKALKEKRL
SLEQTLTVSQRGWKTEGSRMFLDPKVPAKVDDLIKGMIVQSGNDACVTLAEAIAGSEDVFGQLMTQQALKLGMKNTQFKN
ATGLPHEGHYTTVHDLGILAAALIRDYPEFYPIYSMKSFTYNNIKQPNRNLLLYRDPNVDGMKTGYTDSAGYNMVTSSHR
DGRRVISVVVGTASPEARAVESSKLLNYGLQFFDTPKLYAANTRVSDVSVYKGSEKIVPVGFGSDVFATVAKGQAAKLKA
DMTTMQPLIAPIKAGQVVGKLTVSLDGKPLLERPVIALKAVEEGGFFSRLWDSLKLMLGWK

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=365, Percent_Identity=43.8356164383562, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI1786851, Length=384, Percent_Identity=39.5833333333333, Blast_Score=282, Evalue=3e-77,
Organism=Escherichia coli, GI87082022, Length=377, Percent_Identity=37.6657824933687, Blast_Score=247, Evalue=9e-67,
Organism=Escherichia coli, GI87082054, Length=246, Percent_Identity=31.3008130081301, Blast_Score=79, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 41559; Mature: 41559

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLTTALVASALALPSLGFANTAFVPPTPEIAGKAYYLLDYNSQQVLAARDPDARIEPA
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCHH
SLTKLMTAYLTFKALKEKRLSLEQTLTVSQRGWKTEGSRMFLDPKVPAKVDDLIKGMIVQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHEEE
SGNDACVTLAEAIAGSEDVFGQLMTQQALKLGMKNTQFKNATGLPHEGHYTTVHDLGILA
CCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEHHHHHHHHH
AALIRDYPEFYPIYSMKSFTYNNIKQPNRNLLLYRDPNVDGMKTGYTDSAGYNMVTSSHR
HHHHHHCHHHCEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEECCCC
DGRRVISVVVGTASPEARAVESSKLLNYGLQFFDTPKLYAANTRVSDVSVYKGSEKIVPV
CCCEEEEEEEECCCCHHHHHHHHHHHHHCHHHCCCCCEEEECCCCCEEEEECCCCEEEEE
GFGSDVFATVAKGQAAKLKADMTTMQPLIAPIKAGQVVGKLTVSLDGKPLLERPVIALKA
ECCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHCCEEEEEE
VEEGGFFSRLWDSLKLMLGWK
ECCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKLTTALVASALALPSLGFANTAFVPPTPEIAGKAYYLLDYNSQQVLAARDPDARIEPA
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCHH
SLTKLMTAYLTFKALKEKRLSLEQTLTVSQRGWKTEGSRMFLDPKVPAKVDDLIKGMIVQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHEEE
SGNDACVTLAEAIAGSEDVFGQLMTQQALKLGMKNTQFKNATGLPHEGHYTTVHDLGILA
CCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEHHHHHHHHH
AALIRDYPEFYPIYSMKSFTYNNIKQPNRNLLLYRDPNVDGMKTGYTDSAGYNMVTSSHR
HHHHHHCHHHCEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEECCCC
DGRRVISVVVGTASPEARAVESSKLLNYGLQFFDTPKLYAANTRVSDVSVYKGSEKIVPV
CCCEEEEEEEECCCCHHHHHHHHHHHHHCHHHCCCCCEEEECCCCCEEEEECCCCEEEEE
GFGSDVFATVAKGQAAKLKADMTTMQPLIAPIKAGQVVGKLTVSLDGKPLLERPVIALKA
ECCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHCCEEEEEE
VEEGGFFSRLWDSLKLMLGWK
ECCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389 [H]