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The map label for this gene is pdhR [H]

Identifier: 34498492

GI number: 34498492

Start: 3315446

End: 3316216

Strand: Direct

Name: pdhR [H]

Synonym: CV_3037

Alternate gene names: 34498492

Gene position: 3315446-3316216 (Clockwise)

Preceding gene: 34498491

Following gene: 34498503

Centisome position: 69.78

GC content: 67.96

Gene sequence:

>771_bases
ATGGCCTACCCCAAAGTCACCCTGCCCAAGCTGTCCGACATGATCGTGCAGCAACTGGAAAAACGCATACTGGACGGCGT
GCTCAAGCCGGGCGATCGCCTGCCGCCGGAACGGCAGCTCGCCGAGGAGTTCGGCGTATCGCGGCCTTCGCTGCGGGAAG
CCATCCAGCAACTGACGTCGCGCGGCCTGCTGTCCAGCCGCCAGGGCGGCGGCACCTGGGTGACCGACAGGCTGGAGACG
GCGTTTTCCGATCCCTGGGAAAAATTGCTGAACCAGCACGAAGAATTGCATGGCGACCTGCTGGAATTCCGCCGCGTGCT
GGAGGGCACAGTGGCGCGCTGCGCCGCCAGCCGGGCGACCCCGGCCGACCTGGAACGGATGCAACGCTGCGTGGACCGGC
TGCAGCAAGCCTATCGCGGCGGCGAACTGGCCGAACAGGCGCAGGCCGACGTGGAGTTTCACCAAGCGGTGGCCGAGGCT
TCGCACAACGTGCTGTTCGCCCACCTGTCCGGCAGCCTGCTGGCGATGCTGCAGCGGCATGTGAAGGACAATATCGCCAA
TCTGTTCGCCGTCGGCGAGGTCGCGGAGGCGCTGCGCGAGCAGCACCTGGCCATCTGGCAGGCGATACGCGGCCGCCAGC
CGGACGCCGCGCAGCAGGCGGCGGAGCGGCATATCGACTTCGTCGCCGACACGCTGCAAAACCAGATGCTGCTGGCCGAG
CGCGACGCGCGCGCGCGCCTGCGGCTGGAACAGGAAAGCGCCGGGCGCTGA

Upstream 100 bases:

>100_bases
TTTCACGACGTTGCTGACGCAGTGAATCAGGAAAATCGGCATTTATCGGCATTGCTATGTGCTATGCTCGTTCATCCGGT
CAGACCAATTTTCCCATCAC

Downstream 100 bases:

>100_bases
AACAAAAAAAACCGCGCCATCTTCGACGATGACGCGGTTTTTGCACCGACGGATGAATCGTTCCGGCGATCAGCCCTGGC
GGCCGATCAGCCAGTCGACA

Product: pyruvate dehydrogenase complex repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MAYPKVTLPKLSDMIVQQLEKRILDGVLKPGDRLPPERQLAEEFGVSRPSLREAIQQLTSRGLLSSRQGGGTWVTDRLET
AFSDPWEKLLNQHEELHGDLLEFRRVLEGTVARCAASRATPADLERMQRCVDRLQQAYRGGELAEQAQADVEFHQAVAEA
SHNVLFAHLSGSLLAMLQRHVKDNIANLFAVGEVAEALREQHLAIWQAIRGRQPDAAQQAAERHIDFVADTLQNQMLLAE
RDARARLRLEQESAGR

Sequences:

>Translated_256_residues
MAYPKVTLPKLSDMIVQQLEKRILDGVLKPGDRLPPERQLAEEFGVSRPSLREAIQQLTSRGLLSSRQGGGTWVTDRLET
AFSDPWEKLLNQHEELHGDLLEFRRVLEGTVARCAASRATPADLERMQRCVDRLQQAYRGGELAEQAQADVEFHQAVAEA
SHNVLFAHLSGSLLAMLQRHVKDNIANLFAVGEVAEALREQHLAIWQAIRGRQPDAAQQAAERHIDFVADTLQNQMLLAE
RDARARLRLEQESAGR
>Mature_255_residues
AYPKVTLPKLSDMIVQQLEKRILDGVLKPGDRLPPERQLAEEFGVSRPSLREAIQQLTSRGLLSSRQGGGTWVTDRLETA
FSDPWEKLLNQHEELHGDLLEFRRVLEGTVARCAASRATPADLERMQRCVDRLQQAYRGGELAEQAQADVEFHQAVAEAS
HNVLFAHLSGSLLAMLQRHVKDNIANLFAVGEVAEALREQHLAIWQAIRGRQPDAAQQAAERHIDFVADTLQNQMLLAER
DARARLRLEQESAGR

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=232, Percent_Identity=44.8275862068966, Blast_Score=192, Evalue=1e-50,
Organism=Escherichia coli, GI1790032, Length=233, Percent_Identity=37.7682403433476, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1789353, Length=227, Percent_Identity=33.0396475770925, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI48994955, Length=220, Percent_Identity=31.8181818181818, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1790780, Length=203, Percent_Identity=29.064039408867, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789621, Length=229, Percent_Identity=29.6943231441048, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI87082208, Length=175, Percent_Identity=30.2857142857143, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI48994961, Length=161, Percent_Identity=30.4347826086957, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786950, Length=96, Percent_Identity=40.625, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 28749; Mature: 28618

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AYPKVTLPKLSDMIVQQLEKRILDGVLKPGDRLPPERQLAEEFGVSRPSLREAIQQLTS
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
RGLLSSRQGGGTWVTDRLETAFSDPWEKLLNQHEELHGDLLEFRRVLEGTVARCAASRAT
HHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PADLERMQRCVDRLQQAYRGGELAEQAQADVEFHQAVAEASHNVLFAHLSGSLLAMLQRH
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHH
VKDNIANLFAVGEVAEALREQHLAIWQAIRGRQPDAAQQAAERHIDFVADTLQNQMLLAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RDARARLRLEQESAGR
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]