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The map label for this gene is gntR [H]

Identifier: 34498411

GI number: 34498411

Start: 3236081

End: 3237100

Strand: Direct

Name: gntR [H]

Synonym: CV_2956

Alternate gene names: 34498411

Gene position: 3236081-3237100 (Clockwise)

Preceding gene: 34498409

Following gene: 34498412

Centisome position: 68.11

GC content: 70.49

Gene sequence:

>1020_bases
ATGTCCAGAAAACCGCGCGTCCGCTCCGGCAGCGGCGTCACCATGCACGACGTGGCCAAGGCGGCCGGCGTCAGCGCCAT
CACCGTGTCCCGGGTGCTGAACCAACCCCAGCAGGTGTCCGAGCAGCTGCGCGAAAAAGTGATGCAAGCCGTGGACGCGC
TGGCCTACGTGCCCAGCCGCTCCGCCAGCACGCTGGCCTCGGCCAAGTCGCGGACGGTGCTGGTGCTGATCCCCTCGCTG
GCCAACACCGTGTTCCTGGAAACGCTGACCGGCATCGAAACGGTGCTGGACGCCGCCGGCTACCAGATGCTGATCGGCAA
CAGCCATTACGACGCAGGCCAGGAGCTGCAGTTGCTGCGCGCCTATCTGCAGCACCGGCCGGATGGCGTCCTGATCACCG
GCCTCAGCCACGCGGAGCCGTTCGAACGCATCCTGAGCCAGCACGCGCTGCCGGTGGTCTACATGATGGACCTGGCCGAC
GACGGCCGCTGCTGCGTGGGGTTTTCGCAGGAGGATGCCGGCGCCGCCATCACCCGCCACCTGCTGTCGCGCGGCAAGCG
CCGCATCGGCTTTCTCGGCGCGCAGCTGGACGAGCGGGTGATGAAGCGCCTGGACGGCTACCGCGCGGCGCTGGACGCGG
CCGACTGCCGCGACGCCGGGCTGGAATGGCTGGACCCGCAGCCGTCCAGCATGCAGATGGGCGCGGACATGCTGGACCGC
GCGCTGGCGGAGCGGCCGGACTGCGACGCGCTGTTCTGCTGCAACGACGACCTGGCGATCGGCGCGCTGGCGCGCAGCCA
GCAGCTGGGCATCGCCGTGCCGGAGCGGCTGGCCATCGCCGGCTTCAACGACCTGCAGCCCGCCGCATGGTGCACCCCGC
CCCTGACCACGGTGGCCACGCCGCGGCGCGACATCGGCGTCCACGCCGCCAAAGCGCTGTTGCAGCTGATAGATGGCGAG
GAGCCGGCGTCCCGCCGCGCCGATCTGGGCTTCCGGCTGATGTTGCGCCGCAGCAGCTGA

Upstream 100 bases:

>100_bases
CGGGAAAAATCACGACCTTACAAGCAGACGTCATCGCGCGGCAAGCGATTGCCCCGCGATATAATGACAAGTGTATTGCC
AATCCATTTCAGAGAAGCAC

Downstream 100 bases:

>100_bases
AAGCCGGCGCCGAAGCCGCTTTGGCCATCATTGCAAGATTGTTGCGATACCACTACAGCATGGTCCGGACAATCGATGAA
ACTTGATCCAACTGCTTGTT

Product: transcriptional regulator GntR

Products: NA

Alternate protein names: Gluconate utilization system GNT-I transcriptional repressor [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MSRKPRVRSGSGVTMHDVAKAAGVSAITVSRVLNQPQQVSEQLREKVMQAVDALAYVPSRSASTLASAKSRTVLVLIPSL
ANTVFLETLTGIETVLDAAGYQMLIGNSHYDAGQELQLLRAYLQHRPDGVLITGLSHAEPFERILSQHALPVVYMMDLAD
DGRCCVGFSQEDAGAAITRHLLSRGKRRIGFLGAQLDERVMKRLDGYRAALDAADCRDAGLEWLDPQPSSMQMGADMLDR
ALAERPDCDALFCCNDDLAIGALARSQQLGIAVPERLAIAGFNDLQPAAWCTPPLTTVATPRRDIGVHAAKALLQLIDGE
EPASRRADLGFRLMLRRSS

Sequences:

>Translated_339_residues
MSRKPRVRSGSGVTMHDVAKAAGVSAITVSRVLNQPQQVSEQLREKVMQAVDALAYVPSRSASTLASAKSRTVLVLIPSL
ANTVFLETLTGIETVLDAAGYQMLIGNSHYDAGQELQLLRAYLQHRPDGVLITGLSHAEPFERILSQHALPVVYMMDLAD
DGRCCVGFSQEDAGAAITRHLLSRGKRRIGFLGAQLDERVMKRLDGYRAALDAADCRDAGLEWLDPQPSSMQMGADMLDR
ALAERPDCDALFCCNDDLAIGALARSQQLGIAVPERLAIAGFNDLQPAAWCTPPLTTVATPRRDIGVHAAKALLQLIDGE
EPASRRADLGFRLMLRRSS
>Mature_338_residues
SRKPRVRSGSGVTMHDVAKAAGVSAITVSRVLNQPQQVSEQLREKVMQAVDALAYVPSRSASTLASAKSRTVLVLIPSLA
NTVFLETLTGIETVLDAAGYQMLIGNSHYDAGQELQLLRAYLQHRPDGVLITGLSHAEPFERILSQHALPVVYMMDLADD
GRCCVGFSQEDAGAAITRHLLSRGKRRIGFLGAQLDERVMKRLDGYRAALDAADCRDAGLEWLDPQPSSMQMGADMLDRA
LAERPDCDALFCCNDDLAIGALARSQQLGIAVPERLAIAGFNDLQPAAWCTPPLTTVATPRRDIGVHAAKALLQLIDGEE
PASRRADLGFRLMLRRSS

Specific function: Negative regulator for the gluconate utilization system GNT-I, the gntUKR operon [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI48994940, Length=326, Percent_Identity=39.2638036809816, Blast_Score=215, Evalue=3e-57,
Organism=Escherichia coli, GI1790715, Length=324, Percent_Identity=33.3333333333333, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI1790369, Length=341, Percent_Identity=31.3782991202346, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1787948, Length=340, Percent_Identity=30, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1790194, Length=333, Percent_Identity=30.6306306306306, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1788474, Length=297, Percent_Identity=31.3131313131313, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1787906, Length=342, Percent_Identity=28.9473684210526, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789068, Length=316, Percent_Identity=28.7974683544304, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1787580, Length=335, Percent_Identity=25.9701492537313, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1789202, Length=296, Percent_Identity=28.7162162162162, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786540, Length=315, Percent_Identity=27.6190476190476, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1786268, Length=314, Percent_Identity=27.0700636942675, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790689, Length=318, Percent_Identity=26.4150943396226, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1789456, Length=310, Percent_Identity=24.5161290322581, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36728; Mature: 36596

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKPRVRSGSGVTMHDVAKAAGVSAITVSRVLNQPQQVSEQLREKVMQAVDALAYVPSR
CCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCC
SASTLASAKSRTVLVLIPSLANTVFLETLTGIETVLDAAGYQMLIGNSHYDAGQELQLLR
CHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHH
AYLQHRPDGVLITGLSHAEPFERILSQHALPVVYMMDLADDGRCCVGFSQEDAGAAITRH
HHHHHCCCCEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCCHHHHHHHH
LLSRGKRRIGFLGAQLDERVMKRLDGYRAALDAADCRDAGLEWLDPQPSSMQMGADMLDR
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
ALAERPDCDALFCCNDDLAIGALARSQQLGIAVPERLAIAGFNDLQPAAWCTPPLTTVAT
HHHCCCCCCEEEEECCCCCHHHHHHCCCCCCCCCCHHEECCCCCCCCCCCCCCCCCCCCC
PRRDIGVHAAKALLQLIDGEEPASRRADLGFRLMLRRSS
CCHHHHHHHHHHHHHHHCCCCCCHHHHCCCEEEEEECCC
>Mature Secondary Structure 
SRKPRVRSGSGVTMHDVAKAAGVSAITVSRVLNQPQQVSEQLREKVMQAVDALAYVPSR
CCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCC
SASTLASAKSRTVLVLIPSLANTVFLETLTGIETVLDAAGYQMLIGNSHYDAGQELQLLR
CHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHH
AYLQHRPDGVLITGLSHAEPFERILSQHALPVVYMMDLADDGRCCVGFSQEDAGAAITRH
HHHHHCCCCEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCCHHHHHHHH
LLSRGKRRIGFLGAQLDERVMKRLDGYRAALDAADCRDAGLEWLDPQPSSMQMGADMLDR
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
ALAERPDCDALFCCNDDLAIGALARSQQLGIAVPERLAIAGFNDLQPAAWCTPPLTTVAT
HHHCCCCCCEEEEECCCCCHHHHHHCCCCCCCCCCHHEECCCCCCCCCCCCCCCCCCCCC
PRRDIGVHAAKALLQLIDGEEPASRRADLGFRLMLRRSS
CCHHHHHHHHHHHHHHHCCCCCCHHHHCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]