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The map label for this gene is oxyR [H]

Identifier: 34498021

GI number: 34498021

Start: 2767378

End: 2768229

Strand: Direct

Name: oxyR [H]

Synonym: CV_2566

Alternate gene names: 34498021

Gene position: 2767378-2768229 (Clockwise)

Preceding gene: 34498017

Following gene: 34498024

Centisome position: 58.25

GC content: 70.07

Gene sequence:

>852_bases
ATGGATATTCGCCAACTAAAGGCATTTGTCGCCGTTTTCGAGGAGCGCAGCATCACGCTGGCGGCGCAGCGGCTGTTCGT
CACCCAGCCAACGCTGTCCGTCACCATACGCCAGTTGGAAGATGAGCTGGGCGTCAGCCTGTTCGAACGGCAGCCCCGCG
GAGTCGATGTCAGCGAAAACGCCCGCCTGCTCTACCCGCAGGCGCGCCGGATGCTGGCTCAGGCACAGGCCTTGGCCGGC
ATGTTCCGCCAGCGGCGCGATTGCCTGCCGCTATGCCTGGGCGTGGACGGCGATGTGAGCCGCAGCCACCTGGAAGCCTT
GCTGGCGCGCGCGGCGCGGGCCGAACCGGCGATATTGCTGGAAACGCGGGAAGGATGCTGCGGCGACGCGCGGCTGGCGG
CCGAGGACGGCCGCTGCGAGGACGAGCTGTTTCTGCCCTTGTGGGAGGAAAATTTCGTGTTGGCCGTGCCGGCCGGCCAC
CGGCTGGCGGCGCGCGATCAGGTGGATATGGCGCTGCTGGACGAGCCGGACTGGATCGTCTGCCCGGACCATCCCAGCCA
CCAGCGGCTGCTGGATCTGCACGGCGCCGCGGCGCCGGCGCTGGCGACGGCCGCGCGGGCCGGCAGCCTGAGGCTGGCCG
CCCACATGGCGGCCGCGGGGCTCGGCGTCGCGCTGCTGCCCGCCTCGCTGGCGAACGACCATCCTGGCCTGGAGGCCATC
CCGCTGTCCGGTGCGACGCCCTACCGCCGCGTCGGCTTGTGCCATGCGCCCCAGGCGCTGGAACTGCCGGCCTTGCAGGC
CTTGAAAACGGCGTTGGAAGATTACAGCGGCAGCGGCGCGGATAGCCCGTAG

Upstream 100 bases:

>100_bases
TCCATAAGATTTATCGATACGAAACAGATGCCATGCAGTATATTTACCGCCATGCCGACTGAAAAATGATAAAAATCTCT
GCCTGAAATAGATTATTTTT

Downstream 100 bases:

>100_bases
TTGTAGACCAGCATGGAGGCGGTGAACAGCATCACGAAGCCGATCACGCAGTCCAGCACCCGCCAGCTCGCAGGCTTGGT
GAACAGCGGCGCCAGCTTGC

Product: peroxide-inducible genes activator

Products: NA

Alternate protein names: Morphology and auto-aggregation control protein [H]

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MDIRQLKAFVAVFEERSITLAAQRLFVTQPTLSVTIRQLEDELGVSLFERQPRGVDVSENARLLYPQARRMLAQAQALAG
MFRQRRDCLPLCLGVDGDVSRSHLEALLARAARAEPAILLETREGCCGDARLAAEDGRCEDELFLPLWEENFVLAVPAGH
RLAARDQVDMALLDEPDWIVCPDHPSHQRLLDLHGAAAPALATAARAGSLRLAAHMAAAGLGVALLPASLANDHPGLEAI
PLSGATPYRRVGLCHAPQALELPALQALKTALEDYSGSGADSP

Sequences:

>Translated_283_residues
MDIRQLKAFVAVFEERSITLAAQRLFVTQPTLSVTIRQLEDELGVSLFERQPRGVDVSENARLLYPQARRMLAQAQALAG
MFRQRRDCLPLCLGVDGDVSRSHLEALLARAARAEPAILLETREGCCGDARLAAEDGRCEDELFLPLWEENFVLAVPAGH
RLAARDQVDMALLDEPDWIVCPDHPSHQRLLDLHGAAAPALATAARAGSLRLAAHMAAAGLGVALLPASLANDHPGLEAI
PLSGATPYRRVGLCHAPQALELPALQALKTALEDYSGSGADSP
>Mature_283_residues
MDIRQLKAFVAVFEERSITLAAQRLFVTQPTLSVTIRQLEDELGVSLFERQPRGVDVSENARLLYPQARRMLAQAQALAG
MFRQRRDCLPLCLGVDGDVSRSHLEALLARAARAEPAILLETREGCCGDARLAAEDGRCEDELFLPLWEENFVLAVPAGH
RLAARDQVDMALLDEPDWIVCPDHPSHQRLLDLHGAAAPALATAARAGSLRLAAHMAAAGLGVALLPASLANDHPGLEAI
PLSGATPYRRVGLCHAPQALELPALQALKTALEDYSGSGADSP

Specific function: Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstre

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=274, Percent_Identity=31.3868613138686, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI2367136, Length=267, Percent_Identity=28.8389513108614, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1788481, Length=245, Percent_Identity=26.530612244898, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI157672245, Length=261, Percent_Identity=29.1187739463602, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1787601, Length=127, Percent_Identity=31.496062992126, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 30465; Mature: 30465

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRQLKAFVAVFEERSITLAAQRLFVTQPTLSVTIRQLEDELGVSLFERQPRGVDVSEN
CCHHHHHHHHHHHHCCCCEEEEHHHHEECCHHHHHHHHHHHHHCHHHHHCCCCCCCCCCC
ARLLYPQARRMLAQAQALAGMFRQRRDCLPLCLGVDGDVSRSHLEALLARAARAEPAILL
CEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCEEEE
ETREGCCGDARLAAEDGRCEDELFLPLWEENFVLAVPAGHRLAARDQVDMALLDEPDWIV
ECCCCCCCCCEEECCCCCCCCCEEEEEECCCEEEEECCCCCCCCCCCCCEEEECCCCEEE
CPDHPSHQRLLDLHGAAAPALATAARAGSLRLAAHMAAAGLGVALLPASLANDHPGLEAI
CCCCCCHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEE
PLSGATPYRRVGLCHAPQALELPALQALKTALEDYSGSGADSP
ECCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MDIRQLKAFVAVFEERSITLAAQRLFVTQPTLSVTIRQLEDELGVSLFERQPRGVDVSEN
CCHHHHHHHHHHHHCCCCEEEEHHHHEECCHHHHHHHHHHHHHCHHHHHCCCCCCCCCCC
ARLLYPQARRMLAQAQALAGMFRQRRDCLPLCLGVDGDVSRSHLEALLARAARAEPAILL
CEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCEEEE
ETREGCCGDARLAAEDGRCEDELFLPLWEENFVLAVPAGHRLAARDQVDMALLDEPDWIV
ECCCCCCCCCEEECCCCCCCCCEEEEEECCCEEEEECCCCCCCCCCCCCEEEECCCCEEE
CPDHPSHQRLLDLHGAAAPALATAARAGSLRLAAHMAAAGLGVALLPASLANDHPGLEAI
CCCCCCHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEE
PLSGATPYRRVGLCHAPQALELPALQALKTALEDYSGSGADSP
ECCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]