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The map label for this gene is hemH

Identifier: 34497935

GI number: 34497935

Start: 2670294

End: 2671388

Strand: Direct

Name: hemH

Synonym: CV_2480

Alternate gene names: 34497935

Gene position: 2670294-2671388 (Clockwise)

Preceding gene: 34497934

Following gene: 34497936

Centisome position: 56.2

GC content: 61.55

Gene sequence:

>1095_bases
ATGGCCATGCCCCGCTATCTGACTGAACCGGCGTTCCGCCATGATTACGCGCCCAAAACCGGCGTGCTGCTGATCAACCT
GGGCACGCCGGACGCGCCCACCGCGCAAGCGCTGCGTCCCTACCTCAAGCAATTTTTGTCCGACCCGCGCGTGATCGAGA
TTCCGCGCCTGCCCTGGTGGCTGATTCTCAACGGCATCATCCTGAACACCCGCCCCAAGCAGTCGGCCAAGAAATACGCC
AGCATCTGGACCAAGGAAGGTTCGCCGTTGCTGCTACATACCCGCAGCCAGGCCAAGCTGCTGAAAGGCCAGTTGGGCGA
GATGGGACTGCACAATCTGGCCGTCGACTACGCGATGCGTTACGGCAACCCATCGATCGAGAGCGTGATCGGCAAGATGC
GCGAGCAAGGCGTGGAAAGACTGCTGCTGCTGCCGCTGTATCCGCAATACGCCGCCTCCTCCAGCGCCACCGCGCTGGAC
GAAGCCTTCCGCGTGCTGAGCCGGCTGCGCAACATGCCGGAAGTCCGCACGGTGAGGCATTTTCACGATGATCCGGGCTA
CATCGCCGCGCTGGCCGCTCAAATCCGCAAGCATTGGCAATACGGCCAGCGGCCGGACAAGCTGGTGATGAGCTTCCACG
GCGTGCCGCGCTTCACCCGCGACAAAGGCGATCCCTACCATTGCGAATGCCAGAAGACAGGACGGCTGCTGGCGGAAGCG
CTGCAGCTGCGGCCGGATCAATACGTCATCAGTTTCCAGAGCCGCTTCGGCCGCACCGAATGGCTAAAACCGTATACCAG
CGAAGTGCTGGAAGCGCTGGGCAAGGCGAAAACCGCCAGGGTGGATGTCGTCTGCCCCGGTTTTGTCGGCGATTGCCTGG
AAACGCTGGAAGAAATCGCGATGGAGGGCAAGGAAACCTTCCTGAGCCACGGCGGTGGCGAATTCCGCTACATCCCCTGT
CTGAACGAAGACCCGCAATGGATATCCTCTCTCGCGGGAATAGTCCGGAACAATCTGGCCGGATGGACTGAAATTCGGGC
AGAAGATAGCCAGCAAAGAGCGGCCCTCGCCCATGACATGGGGGCATCCGCCTGA

Upstream 100 bases:

>100_bases
ATCCTCGATGGAAAGCAACGGCAACCGCACCGTGCTGGCCCCCGCCCGCGACGATTGACCTTCGGGGGCGCTTTTGCGCC
CCGCTACCCACTTCTTAAGG

Downstream 100 bases:

>100_bases
CATCAATGCCGGGCGCGGCATGTCGGCGCGCAACGCACAAAGCATTGAAAATCAAACGGATAAGCTAAAATGACGGGCGT
ATGACCAAATGGCCATACGC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MAMPRYLTEPAFRHDYAPKTGVLLINLGTPDAPTAQALRPYLKQFLSDPRVIEIPRLPWWLILNGIILNTRPKQSAKKYA
SIWTKEGSPLLLHTRSQAKLLKGQLGEMGLHNLAVDYAMRYGNPSIESVIGKMREQGVERLLLLPLYPQYAASSSATALD
EAFRVLSRLRNMPEVRTVRHFHDDPGYIAALAAQIRKHWQYGQRPDKLVMSFHGVPRFTRDKGDPYHCECQKTGRLLAEA
LQLRPDQYVISFQSRFGRTEWLKPYTSEVLEALGKAKTARVDVVCPGFVGDCLETLEEIAMEGKETFLSHGGGEFRYIPC
LNEDPQWISSLAGIVRNNLAGWTEIRAEDSQQRAALAHDMGASA

Sequences:

>Translated_364_residues
MAMPRYLTEPAFRHDYAPKTGVLLINLGTPDAPTAQALRPYLKQFLSDPRVIEIPRLPWWLILNGIILNTRPKQSAKKYA
SIWTKEGSPLLLHTRSQAKLLKGQLGEMGLHNLAVDYAMRYGNPSIESVIGKMREQGVERLLLLPLYPQYAASSSATALD
EAFRVLSRLRNMPEVRTVRHFHDDPGYIAALAAQIRKHWQYGQRPDKLVMSFHGVPRFTRDKGDPYHCECQKTGRLLAEA
LQLRPDQYVISFQSRFGRTEWLKPYTSEVLEALGKAKTARVDVVCPGFVGDCLETLEEIAMEGKETFLSHGGGEFRYIPC
LNEDPQWISSLAGIVRNNLAGWTEIRAEDSQQRAALAHDMGASA
>Mature_363_residues
AMPRYLTEPAFRHDYAPKTGVLLINLGTPDAPTAQALRPYLKQFLSDPRVIEIPRLPWWLILNGIILNTRPKQSAKKYAS
IWTKEGSPLLLHTRSQAKLLKGQLGEMGLHNLAVDYAMRYGNPSIESVIGKMREQGVERLLLLPLYPQYAASSSATALDE
AFRVLSRLRNMPEVRTVRHFHDDPGYIAALAAQIRKHWQYGQRPDKLVMSFHGVPRFTRDKGDPYHCECQKTGRLLAEAL
QLRPDQYVISFQSRFGRTEWLKPYTSEVLEALGKAKTARVDVVCPGFVGDCLETLEEIAMEGKETFLSHGGGEFRYIPCL
NEDPQWISSLAGIVRNNLAGWTEIRAEDSQQRAALAHDMGASA

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=331, Percent_Identity=26.2839879154079, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI60499025, Length=331, Percent_Identity=26.2839879154079, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1786681, Length=317, Percent_Identity=45.7413249211356, Blast_Score=290, Evalue=7e-80,
Organism=Saccharomyces cerevisiae, GI6324750, Length=332, Percent_Identity=25.6024096385542, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17864156, Length=339, Percent_Identity=27.4336283185841, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24651774, Length=271, Percent_Identity=27.6752767527675, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_CHRVO (Q7NV65)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_902150.1
- ProteinModelPortal:   Q7NV65
- SMR:   Q7NV65
- GeneID:   2547518
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_2480
- NMPDR:   fig|243365.1.peg.2480
- HOGENOM:   HBG697135
- OMA:   TIEEIGM
- PhylomeDB:   Q7NV65
- ProtClustDB:   PRK00035
- BioCyc:   CVIO243365:CV_2480-MONOMER
- BRENDA:   4.99.1.1
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 41028; Mature: 40896

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMPRYLTEPAFRHDYAPKTGVLLINLGTPDAPTAQALRPYLKQFLSDPRVIEIPRLPWW
CCCCCCCCCCHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHH
LILNGIILNTRPKQSAKKYASIWTKEGSPLLLHTRSQAKLLKGQLGEMGLHNLAVDYAMR
HHHCCEEECCCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCHHHHHHHHHHHH
YGNPSIESVIGKMREQGVERLLLLPLYPQYAASSSATALDEAFRVLSRLRNMPEVRTVRH
CCCCCHHHHHHHHHHHHHHHEEHHCCCHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
FHDDPGYIAALAAQIRKHWQYGQRPDKLVMSFHGVPRFTRDKGDPYHCECQKTGRLLAEA
HCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCEECHHHHHHHHHHH
LQLRPDQYVISFQSRFGRTEWLKPYTSEVLEALGKAKTARVDVVCPGFVGDCLETLEEIA
HHCCCCHHEEEEHHHCCCCHHCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHH
MEGKETFLSHGGGEFRYIPCLNEDPQWISSLAGIVRNNLAGWTEIRAEDSQQRAALAHDM
HHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHC
GASA
CCCC
>Mature Secondary Structure 
AMPRYLTEPAFRHDYAPKTGVLLINLGTPDAPTAQALRPYLKQFLSDPRVIEIPRLPWW
CCCCCCCCCHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHH
LILNGIILNTRPKQSAKKYASIWTKEGSPLLLHTRSQAKLLKGQLGEMGLHNLAVDYAMR
HHHCCEEECCCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCHHHHHHHHHHHH
YGNPSIESVIGKMREQGVERLLLLPLYPQYAASSSATALDEAFRVLSRLRNMPEVRTVRH
CCCCCHHHHHHHHHHHHHHHEEHHCCCHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
FHDDPGYIAALAAQIRKHWQYGQRPDKLVMSFHGVPRFTRDKGDPYHCECQKTGRLLAEA
HCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCEECHHHHHHHHHHH
LQLRPDQYVISFQSRFGRTEWLKPYTSEVLEALGKAKTARVDVVCPGFVGDCLETLEEIA
HHCCCCHHEEEEHHHCCCCHHCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHH
MEGKETFLSHGGGEFRYIPCLNEDPQWISSLAGIVRNNLAGWTEIRAEDSQQRAALAHDM
HHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHC
GASA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782