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The map label for this gene is arpR [H]

Identifier: 34497911

GI number: 34497911

Start: 2642345

End: 2642956

Strand: Direct

Name: arpR [H]

Synonym: CV_2456

Alternate gene names: 34497911

Gene position: 2642345-2642956 (Clockwise)

Preceding gene: 34497907

Following gene: 34497917

Centisome position: 55.62

GC content: 66.67

Gene sequence:

>612_bases
ATGGCTCGCAAAACCAAGGAAGACTCGCAAAAAACCCGGGACGCGATACTGGATGGCGCGGAACGGGTGTTTTTGGACAA
GGGCATCGCCAACGCCACCATGGCCGAGATCGCCGACGCGGCGCAGGTATCGCGCGGCGCGGTGTACGGTCATTACGACA
ACAAGCTGGAAGTGTGCCAGGCGATGATAGACCGCGCCTTCGCGCTGGACGCGCTGCGCTTCCCCGCCCCCTGCGCATCC
GCTTGCGACACGCTGCTGGCGGCCGGAACTTACTACCTGGCGCAATTCCTGGAGCCCGGCTCGCCGCAACGGGTGTACCA
GATCCTGTACCAGAAGTGCGAGCAGACAGAGGAAAACCGCAGCGTGCTGCGGCGCCGCGAGCTGGCGGACCGCCTGACCA
TGCATTACGCGCGGCGACAACTGCGGCGGGCCATCGCCCAGCAGGAACTGCCCGACCGGCTGGACGTGGGCCTGGCCGCC
GACTACCTGGTCTGTCTGTTCCTGGGCCTGTACGAGCTGCTGGAGGCCAGCCCGGACGCGCTGCCGCGCTGCGAGCGCAT
TCTGCGCGGTGCGCTGCAAGGCTTGCCGCACGCGGCCAGCATCATGCGTTGA

Upstream 100 bases:

>100_bases
GCAAAGAGCGATGGGAAAGACCATTCTAGCATTTAATTAATCATGCATGATTGATTAAATGTTGGCAGAATGTGACCAAC
CATGACAAGAAAGCAGGCAG

Downstream 100 bases:

>100_bases
CGACCGCTATTCGACATGGCGGCGGAAGCGCCATAGCGCCAGGCTCAGCGTGATGGCGGCGATCAGCCACAGCGGCAGCA
GCCACGGCCAGGCGTCGACG

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: Antibiotic efflux pump ArpABC operon regulator [H]

Number of amino acids: Translated: 203; Mature: 202

Protein sequence:

>203_residues
MARKTKEDSQKTRDAILDGAERVFLDKGIANATMAEIADAAQVSRGAVYGHYDNKLEVCQAMIDRAFALDALRFPAPCAS
ACDTLLAAGTYYLAQFLEPGSPQRVYQILYQKCEQTEENRSVLRRRELADRLTMHYARRQLRRAIAQQELPDRLDVGLAA
DYLVCLFLGLYELLEASPDALPRCERILRGALQGLPHAASIMR

Sequences:

>Translated_203_residues
MARKTKEDSQKTRDAILDGAERVFLDKGIANATMAEIADAAQVSRGAVYGHYDNKLEVCQAMIDRAFALDALRFPAPCAS
ACDTLLAAGTYYLAQFLEPGSPQRVYQILYQKCEQTEENRSVLRRRELADRLTMHYARRQLRRAIAQQELPDRLDVGLAA
DYLVCLFLGLYELLEASPDALPRCERILRGALQGLPHAASIMR
>Mature_202_residues
ARKTKEDSQKTRDAILDGAERVFLDKGIANATMAEIADAAQVSRGAVYGHYDNKLEVCQAMIDRAFALDALRFPAPCASA
CDTLLAAGTYYLAQFLEPGSPQRVYQILYQKCEQTEENRSVLRRRELADRLTMHYARRQLRRAIAQQELPDRLDVGLAAD
YLVCLFLGLYELLEASPDALPRCERILRGALQGLPHAASIMR

Specific function: Probable regulatory protein for the antibiotic efflux pump arpABC operon. May function as a repressor [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786669, Length=121, Percent_Identity=32.2314049586777, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789664, Length=125, Percent_Identity=32, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR013572
- InterPro:   IPR001647 [H]

Pfam domain/function: PF08361 TetR_C_2; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 22749; Mature: 22618

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKTKEDSQKTRDAILDGAERVFLDKGIANATMAEIADAAQVSRGAVYGHYDNKLEVCQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
AMIDRAFALDALRFPAPCASACDTLLAAGTYYLAQFLEPGSPQRVYQILYQKCEQTEENR
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHH
SVLRRRELADRLTMHYARRQLRRAIAQQELPDRLDVGLAADYLVCLFLGLYELLEASPDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LPRCERILRGALQGLPHAASIMR
CHHHHHHHHHHHHCCCHHHHHCC
>Mature Secondary Structure 
ARKTKEDSQKTRDAILDGAERVFLDKGIANATMAEIADAAQVSRGAVYGHYDNKLEVCQ
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
AMIDRAFALDALRFPAPCASACDTLLAAGTYYLAQFLEPGSPQRVYQILYQKCEQTEENR
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHH
SVLRRRELADRLTMHYARRQLRRAIAQQELPDRLDVGLAADYLVCLFLGLYELLEASPDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LPRCERILRGALQGLPHAASIMR
CHHHHHHHHHHHHCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11160799 [H]