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The map label for this gene is tyrB1 [H]

Identifier: 34497837

GI number: 34497837

Start: 2564268

End: 2565476

Strand: Direct

Name: tyrB1 [H]

Synonym: CV_2382

Alternate gene names: 34497837

Gene position: 2564268-2565476 (Clockwise)

Preceding gene: 34497835

Following gene: 34497838

Centisome position: 53.97

GC content: 65.84

Gene sequence:

>1209_bases
ATGACCTCTTCGATCTTCGCCGGCGTGGAGCTGGCGCCGCGCGACCCCATCCTCGGACTCAATGAGGCGTTCAACGCCGA
TACCCGCAGCACCAAGGTCAATCTTGGCGTGGGCGTGTATTCCGACGACAACGGCAAGATTCCACTGCTGGCCGCGGTGC
AGGCGGCCGAGAAAGCTCGCCTCGAAGCATTGCCGGCGCGCGGCTACCAGCCGATCGAAGGCCCCGCCGCTTACGATGTC
GCCGTGCAGAAGCTGCTGTTCGGCGAGAGCAGCGAACTGCTGGCCGCCGGCCGCGTGGTGACCGCCCAGGCGCTGGGCGG
CACCGGCGCGCTGAAGATCGGCGCGGACTTCCTGAAACGCCTGAATCCGGCCGCCAAGGTGTACATCAGCGACCCGTCCT
GGGAAAACCACCGCGCGCTGTTCGAGTCCGCCGGCTTTGCCGTGGAAAACTACCCGTATTATCACGCAGCCAGCCGCGGC
GTGGATTTCGCCGCGATGAAGGCGCATTTGTCCTCGCTGGATGCGGGCTCCATCATCGTGCTGCATGCCTGCTGCCACAA
TCCCACCGGCGCCGACCTGTCCGCCGCGCAATGGGAAGAAGTGGTGTCGATCTGCCGCGAGCGCAGCCTGGTGCCCTTCC
TGGACATGGCCTACCAGGGCTTCGCCGACGGCATCGACGCCGATGCGCTGGCGGTGCGCCTGTTCGCCGCCTCGAATCTG
CAGTTCTTCGTCGCCAGCTCCTTCTCCAAGAGCTTCTCGCTGTACGGAGAGCGTGTCGGCGCGCTGTCCATCATCACGGC
AGCCAAGGACGAGTCGGTCCGCGTCTTGTCCCAGCTGAAGCGCGTGATCCGCACCAACTACTCCAATCCGCCCATCCATG
GCGCGGCCATCGTCGCCGCCGTGCTGTCCAGCCCGGCGCTGCGCGCGCAATGGGAGGAAGAGCTGGCGGGCATGCGCGAT
CGCATTCGCGACATGCGATTGGCCTTGCTGGAGGCGATCAAGGCGCAAGGCGTGGCCGTCGACTTTTCCTTCATCACGGC
CCAGCGCGGCATGTTCTCCTACACCGGCCTGAGCGCCGCCCAGGTGGACCGCCTGCGCGAGGAGTTCGGCATTTACGCGG
TATCCACTGGCCGCATCTGCCTGGCGGCCCTGAACAGCAAGAACGTAGGCTATGTGGCCTCCGCCATCGCCAAGGTGGTT
CAGGCCTGA

Upstream 100 bases:

>100_bases
TTCGACAGCGAACAACCTTCCTTCGGAAGGCAACAAGCAGCATCGGATTTTTTTGATCGGCCTCTTGGCCGGTGCATTCG
TAAAGCTAATGGAGCCTGGT

Downstream 100 bases:

>100_bases
CGGGATCCGGCACTCATGAGCAAGAGCCCTGGTATGACCAGGGCTTTTTTTTATAATGATAAAAAATCATACCATGACCC
TCGTCAAATGAAGCATTCAA

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: AspAT; Transaminase A [H]

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MTSSIFAGVELAPRDPILGLNEAFNADTRSTKVNLGVGVYSDDNGKIPLLAAVQAAEKARLEALPARGYQPIEGPAAYDV
AVQKLLFGESSELLAAGRVVTAQALGGTGALKIGADFLKRLNPAAKVYISDPSWENHRALFESAGFAVENYPYYHAASRG
VDFAAMKAHLSSLDAGSIIVLHACCHNPTGADLSAAQWEEVVSICRERSLVPFLDMAYQGFADGIDADALAVRLFAASNL
QFFVASSFSKSFSLYGERVGALSIITAAKDESVRVLSQLKRVIRTNYSNPPIHGAAIVAAVLSSPALRAQWEEELAGMRD
RIRDMRLALLEAIKAQGVAVDFSFITAQRGMFSYTGLSAAQVDRLREEFGIYAVSTGRICLAALNSKNVGYVASAIAKVV
QA

Sequences:

>Translated_402_residues
MTSSIFAGVELAPRDPILGLNEAFNADTRSTKVNLGVGVYSDDNGKIPLLAAVQAAEKARLEALPARGYQPIEGPAAYDV
AVQKLLFGESSELLAAGRVVTAQALGGTGALKIGADFLKRLNPAAKVYISDPSWENHRALFESAGFAVENYPYYHAASRG
VDFAAMKAHLSSLDAGSIIVLHACCHNPTGADLSAAQWEEVVSICRERSLVPFLDMAYQGFADGIDADALAVRLFAASNL
QFFVASSFSKSFSLYGERVGALSIITAAKDESVRVLSQLKRVIRTNYSNPPIHGAAIVAAVLSSPALRAQWEEELAGMRD
RIRDMRLALLEAIKAQGVAVDFSFITAQRGMFSYTGLSAAQVDRLREEFGIYAVSTGRICLAALNSKNVGYVASAIAKVV
QA
>Mature_401_residues
TSSIFAGVELAPRDPILGLNEAFNADTRSTKVNLGVGVYSDDNGKIPLLAAVQAAEKARLEALPARGYQPIEGPAAYDVA
VQKLLFGESSELLAAGRVVTAQALGGTGALKIGADFLKRLNPAAKVYISDPSWENHRALFESAGFAVENYPYYHAASRGV
DFAAMKAHLSSLDAGSIIVLHACCHNPTGADLSAAQWEEVVSICRERSLVPFLDMAYQGFADGIDADALAVRLFAASNLQ
FFVASSFSKSFSLYGERVGALSIITAAKDESVRVLSQLKRVIRTNYSNPPIHGAAIVAAVLSSPALRAQWEEELAGMRDR
IRDMRLALLEAIKAQGVAVDFSFITAQRGMFSYTGLSAAQVDRLREEFGIYAVSTGRICLAALNSKNVGYVASAIAKVVQ
A

Specific function: Biosynthesis of Phe, Tyr, Asp and Leu. [C]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=398, Percent_Identity=45.7286432160804, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI4504067, Length=409, Percent_Identity=42.7872860635697, Blast_Score=314, Evalue=7e-86,
Organism=Homo sapiens, GI117414139, Length=404, Percent_Identity=26.4851485148515, Blast_Score=169, Evalue=4e-42,
Organism=Escherichia coli, GI1790488, Length=398, Percent_Identity=52.2613065326633, Blast_Score=408, Evalue=1e-115,
Organism=Escherichia coli, GI1787159, Length=396, Percent_Identity=46.2121212121212, Blast_Score=389, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI71981858, Length=397, Percent_Identity=42.8211586901763, Blast_Score=361, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI25147133, Length=399, Percent_Identity=42.1052631578947, Blast_Score=337, Evalue=6e-93,
Organism=Caenorhabditis elegans, GI17569539, Length=402, Percent_Identity=38.5572139303483, Blast_Score=289, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17569537, Length=406, Percent_Identity=32.2660098522167, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17550384, Length=270, Percent_Identity=37.4074074074074, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI25147136, Length=213, Percent_Identity=39.906103286385, Blast_Score=173, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6323055, Length=410, Percent_Identity=39.7560975609756, Blast_Score=311, Evalue=1e-85,
Organism=Saccharomyces cerevisiae, GI6322743, Length=435, Percent_Identity=35.4022988505747, Blast_Score=245, Evalue=8e-66,
Organism=Drosophila melanogaster, GI24580972, Length=402, Percent_Identity=44.0298507462687, Blast_Score=342, Evalue=3e-94,
Organism=Drosophila melanogaster, GI24580970, Length=402, Percent_Identity=44.0298507462687, Blast_Score=342, Evalue=4e-94,
Organism=Drosophila melanogaster, GI19920542, Length=394, Percent_Identity=44.1624365482233, Blast_Score=335, Evalue=3e-92,
Organism=Drosophila melanogaster, GI24654046, Length=402, Percent_Identity=40.2985074626866, Blast_Score=298, Evalue=5e-81,
Organism=Drosophila melanogaster, GI19922362, Length=400, Percent_Identity=40.25, Blast_Score=297, Evalue=9e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.1 [H]

Molecular weight: Translated: 42884; Mature: 42753

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSIFAGVELAPRDPILGLNEAFNADTRSTKVNLGVGVYSDDNGKIPLLAAVQAAEKAR
CCCCEECCCEECCCCCCCCCHHHCCCCCCCEEEEEEEEEEECCCCCEEHHHHHHHHHHHH
LEALPARGYQPIEGPAAYDVAVQKLLFGESSELLAAGRVVTAQALGGTGALKIGADFLKR
HHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHCCCEEEEECCCCCCEEHHHHHHHHH
LNPAAKVYISDPSWENHRALFESAGFAVENYPYYHAASRGVDFAAMKAHLSSLDAGSIIV
CCCCCEEEECCCCCCHHHHHHHHCCCEEECCCCEEHHCCCCCHHHHHHHHHCCCCCCEEE
LHACCHNPTGADLSAAQWEEVVSICRERSLVPFLDMAYQGFADGIDADALAVRLFAASNL
EEEECCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
QFFVASSFSKSFSLYGERVGALSIITAAKDESVRVLSQLKRVIRTNYSNPPIHGAAIVAA
EEEEEHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
VLSSPALRAQWEEELAGMRDRIRDMRLALLEAIKAQGVAVDFSFITAQRGMFSYTGLSAA
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHCCCCCEECCCCHH
QVDRLREEFGIYAVSTGRICLAALNSKNVGYVASAIAKVVQA
HHHHHHHHHCEEEEECCCEEEEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TSSIFAGVELAPRDPILGLNEAFNADTRSTKVNLGVGVYSDDNGKIPLLAAVQAAEKAR
CCCEECCCEECCCCCCCCCHHHCCCCCCCEEEEEEEEEEECCCCCEEHHHHHHHHHHHH
LEALPARGYQPIEGPAAYDVAVQKLLFGESSELLAAGRVVTAQALGGTGALKIGADFLKR
HHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHCCCEEEEECCCCCCEEHHHHHHHHH
LNPAAKVYISDPSWENHRALFESAGFAVENYPYYHAASRGVDFAAMKAHLSSLDAGSIIV
CCCCCEEEECCCCCCHHHHHHHHCCCEEECCCCEEHHCCCCCHHHHHHHHHCCCCCCEEE
LHACCHNPTGADLSAAQWEEVVSICRERSLVPFLDMAYQGFADGIDADALAVRLFAASNL
EEEECCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
QFFVASSFSKSFSLYGERVGALSIITAAKDESVRVLSQLKRVIRTNYSNPPIHGAAIVAA
EEEEEHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
VLSSPALRAQWEEELAGMRDRIRDMRLALLEAIKAQGVAVDFSFITAQRGMFSYTGLSAA
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHCCCCCEECCCCHH
QVDRLREEFGIYAVSTGRICLAALNSKNVGYVASAIAKVVQA
HHHHHHHHHCEEEEECCCEEEEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043; 8808952 [H]