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The map label for this gene is argE [H]

Identifier: 34497834

GI number: 34497834

Start: 2561022

End: 2562185

Strand: Direct

Name: argE [H]

Synonym: CV_2379

Alternate gene names: 34497834

Gene position: 2561022-2562185 (Clockwise)

Preceding gene: 34497831

Following gene: 34497835

Centisome position: 53.9

GC content: 62.11

Gene sequence:

>1164_bases
ATGGATACCACACTCGCCGACTTGCTGGCCGAACTGATCGGCTTCGATACCACCAGCCGGAATTCCAATCTGCAACTGAT
AGAATGGGTAAGGCGTTATCTTGCCGGCCACGGGTTGGCAAGCCGGCTCACCCATAGCGACGACGGCAGCAAGGCTAATC
TGTTCTGCCGCATCGGCGGAGATGATTTGCCATTGATTGTCCTGTCCGGCCATAGCGACGTGGTGCCGGTGGATGGGCAG
GACTGGTCCTATCCGCCATTCCAGCTGACGGATGGCGGCGATGGGCGCCTGTATGGGCGCGGCAGCGCCGACATGAAAGG
CTTCATTGCCTGCGTGCTGGCGAGAGTGCCGGATTTCGTGGCGCTGGCGAAGGCCGGCCAGCTGAGGCAGGGCATAGGCA
TTGCGCTTTCCTACGATGAGGAAGTGGGCTGCCTGGGCGTCGGCAGGCTCATCGACGATTTGGTCGCCCAGGGCGTGACG
GTGGCTGGGTGCCTGATAGGGGAGCCGACTTCGATGCGGCCGGTGGTGGCGCATAAAGGCATCGCGCATTACCGTTGCCG
GGTCAGGGGCCGTGCGGCGCATTCTTCCCTGACGCCTTACGGGGTCAATGCCATCGAGTATGCGGCAAGACTGATCACCC
ATATCCGCAAGCTGGCCGACGCCGAGGCGTCGTTCGGCCACCGCCAGCCTTTGTATGACGTTCCTTTCACCACGATGCAG
ACTGGCGTGATCCGCGGCGGCGTAGCCTGCAATATCGTGCCGGCCGACTGCGAATTCATGTTCGAGTGCCGCTGGCTGCC
GGGAGACGATCCGCAGCGGCTGGTCTCGTCGGTGGCCGACTACGCGGCGAGCCTGCTGCTGGAAATGCGGGCGGTGGCGG
AGGAGGCTGATATCGAGATCGAGCGCGTGGTATACAGCCCGGCATTCGAAGCCGAGCCGGATTCGGATATCAGCCGCTAC
GTTCATGGATTGTGCGCTTGCGCCGGGCGGGGCGTCGCCTACACTACCGAGGCGGGGTTGTTCAGCGAGGCAGGCATGCC
GTGCGTGGTGCTGGGGCCGGGATCGATAGAGCAGGCTCACCGGCCGGACGAGTTCATAGAAATCGCCCAGCTGAATGCAT
GCCATGATTGGCTTGGGCTATTGACTAACAACTTAATCAAATAA

Upstream 100 bases:

>100_bases
GGCGGAAGGAGTCGTCGGCGGGGAGAGTGGCTATTGATTGCGCGCATCATGCGGTGCAGACTCGGCAGTCAAGCCACCTA
ATATATACACGCCAAGCGCC

Downstream 100 bases:

>100_bases
CTGTCAGAAATGCTTTGCATCCATAAGCGATAGGCTGCAAAATTCTGCCCCTTGGAAACGAAGGACTATTGAGCCCGCCG
GTGACTTCCGCGCGGGTTCA

Product: acetylornithine deacetylase

Products: NA

Alternate protein names: AO; Acetylornithinase; N-acetylornithinase; NAO [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MDTTLADLLAELIGFDTTSRNSNLQLIEWVRRYLAGHGLASRLTHSDDGSKANLFCRIGGDDLPLIVLSGHSDVVPVDGQ
DWSYPPFQLTDGGDGRLYGRGSADMKGFIACVLARVPDFVALAKAGQLRQGIGIALSYDEEVGCLGVGRLIDDLVAQGVT
VAGCLIGEPTSMRPVVAHKGIAHYRCRVRGRAAHSSLTPYGVNAIEYAARLITHIRKLADAEASFGHRQPLYDVPFTTMQ
TGVIRGGVACNIVPADCEFMFECRWLPGDDPQRLVSSVADYAASLLLEMRAVAEEADIEIERVVYSPAFEAEPDSDISRY
VHGLCACAGRGVAYTTEAGLFSEAGMPCVVLGPGSIEQAHRPDEFIEIAQLNACHDWLGLLTNNLIK

Sequences:

>Translated_387_residues
MDTTLADLLAELIGFDTTSRNSNLQLIEWVRRYLAGHGLASRLTHSDDGSKANLFCRIGGDDLPLIVLSGHSDVVPVDGQ
DWSYPPFQLTDGGDGRLYGRGSADMKGFIACVLARVPDFVALAKAGQLRQGIGIALSYDEEVGCLGVGRLIDDLVAQGVT
VAGCLIGEPTSMRPVVAHKGIAHYRCRVRGRAAHSSLTPYGVNAIEYAARLITHIRKLADAEASFGHRQPLYDVPFTTMQ
TGVIRGGVACNIVPADCEFMFECRWLPGDDPQRLVSSVADYAASLLLEMRAVAEEADIEIERVVYSPAFEAEPDSDISRY
VHGLCACAGRGVAYTTEAGLFSEAGMPCVVLGPGSIEQAHRPDEFIEIAQLNACHDWLGLLTNNLIK
>Mature_387_residues
MDTTLADLLAELIGFDTTSRNSNLQLIEWVRRYLAGHGLASRLTHSDDGSKANLFCRIGGDDLPLIVLSGHSDVVPVDGQ
DWSYPPFQLTDGGDGRLYGRGSADMKGFIACVLARVPDFVALAKAGQLRQGIGIALSYDEEVGCLGVGRLIDDLVAQGVT
VAGCLIGEPTSMRPVVAHKGIAHYRCRVRGRAAHSSLTPYGVNAIEYAARLITHIRKLADAEASFGHRQPLYDVPFTTMQ
TGVIRGGVACNIVPADCEFMFECRWLPGDDPQRLVSSVADYAASLLLEMRAVAEEADIEIERVVYSPAFEAEPDSDISRY
VHGLCACAGRGVAYTTEAGLFSEAGMPCVVLGPGSIEQAHRPDEFIEIAQLNACHDWLGLLTNNLIK

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. ArgE subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790395, Length=320, Percent_Identity=36.875, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1788816, Length=209, Percent_Identity=28.2296650717703, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17551016, Length=330, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24649202, Length=212, Percent_Identity=30.188679245283, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24649204, Length=212, Percent_Identity=30.188679245283, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010169
- InterPro:   IPR001261
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.16 [H]

Molecular weight: Translated: 41720; Mature: 41720

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTTLADLLAELIGFDTTSRNSNLQLIEWVRRYLAGHGLASRLTHSDDGSKANLFCRIGG
CCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEEEEECC
DDLPLIVLSGHSDVVPVDGQDWSYPPFQLTDGGDGRLYGRGSADMKGFIACVLARVPDFV
CCCCEEEECCCCCEEECCCCCCCCCCEEECCCCCCEEEECCCCCHHHHHHHHHHHCCHHH
ALAKAGQLRQGIGIALSYDEEVGCLGVGRLIDDLVAQGVTVAGCLIGEPTSMRPVVAHKG
HHHHHCHHHCCCCEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHCC
IAHYRCRVRGRAAHSSLTPYGVNAIEYAARLITHIRKLADAEASFGHRQPLYDVPFTTMQ
CHHEEEEECCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
TGVIRGGVACNIVPADCEFMFECRWLPGDDPQRLVSSVADYAASLLLEMRAVAEEADIEI
HHHEECCEEEEEEECCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
ERVVYSPAFEAEPDSDISRYVHGLCACAGRGVAYTTEAGLFSEAGMPCVVLGPGSIEQAH
EEEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHCCCCCEEEECCCCCCCCC
RPDEFIEIAQLNACHDWLGLLTNNLIK
CCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDTTLADLLAELIGFDTTSRNSNLQLIEWVRRYLAGHGLASRLTHSDDGSKANLFCRIGG
CCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEEEEECC
DDLPLIVLSGHSDVVPVDGQDWSYPPFQLTDGGDGRLYGRGSADMKGFIACVLARVPDFV
CCCCEEEECCCCCEEECCCCCCCCCCEEECCCCCCEEEECCCCCHHHHHHHHHHHCCHHH
ALAKAGQLRQGIGIALSYDEEVGCLGVGRLIDDLVAQGVTVAGCLIGEPTSMRPVVAHKG
HHHHHCHHHCCCCEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHCC
IAHYRCRVRGRAAHSSLTPYGVNAIEYAARLITHIRKLADAEASFGHRQPLYDVPFTTMQ
CHHEEEEECCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
TGVIRGGVACNIVPADCEFMFECRWLPGDDPQRLVSSVADYAASLLLEMRAVAEEADIEI
HHHEECCEEEEEEECCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
ERVVYSPAFEAEPDSDISRYVHGLCACAGRGVAYTTEAGLFSEAGMPCVVLGPGSIEQAH
EEEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHCCCCCEEEECCCCCCCCC
RPDEFIEIAQLNACHDWLGLLTNNLIK
CCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9829957 [H]