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The map label for this gene is manA [H]

Identifier: 34497767

GI number: 34497767

Start: 2505302

End: 2506492

Strand: Direct

Name: manA [H]

Synonym: CV_2312

Alternate gene names: 34497767

Gene position: 2505302-2506492 (Clockwise)

Preceding gene: 34497766

Following gene: 34497768

Centisome position: 52.73

GC content: 69.86

Gene sequence:

>1191_bases
ATGAGCGCCTTTCCCTTGCATGGCCTGGCCCAGCACTACGCCTGGGGCGGCCGCCGCTTCATTCCCGGCATGCTGGGCCT
GGACAATGCCGAGCAGCAACGTTTCGCCGAGTGGTGGCTAGGCGCGCACGAGGACGCGCCGTCGGTGATCGAGACGCCGC
TGGGGCCGCAGCCGCTGCATTACGCGATCGCCCATCAGGCGCCGGCTTTTTTGGGCGAGGCGCTGATCCGCCGCCACGGA
CGACGCCTGCCCTTCCTGCTGAAGGTGCTGGACGTGGACGCGCCGCTGTCCATCCAGGCGCATCCTGACGAAGCGCAGGC
GCGGGCGGGCTTCGCGCGCGAAAACGCCGTCGGCCTGGCCATCGACGATGCCCGGCGCAACTATAGGGACCCGTATCCCA
AGCCGGAAATGATGGTGGCGCTGTCGCCGTTCTGGCTATTGCACGGCATGAGGCCGGACGCGCAGATCGACGCGCTGCTG
GCGCGGCAGCCGGCGTGGACGCCGTTGCGGGAAGGGCTGGCGCGTGAAGGCGGCGCGGCGCTGTATCGCCGCCTGTTGCG
GCTGCCGCAGGCGGAGATCGCGGCGTTGCTGCGTCCGCTATGGAGAAGGCTGGAGACCGGAGACGATGCCGGTCCGGACG
ATCCCGACCATTGGACGCGGCGGCTGGCCGGCAGCCGGGCCGAGGACAGGGGGATATTCGGCTGCTATCTGCTCAACCTG
GTGGGACTGCGGCCGGGAGAGGCCATCTTCCAGCCGGCGCGGCTGCCGCATGCCTATCTGCATGGCCGCAATATCGAGCT
GATGGCCAACTCCGACAATGTGCTGCGCGCCGGCCTCACCGACAAGCCGGTGGACGTGGAGGCCTTGCTGGGGGTGATGG
ACGGCGAACCAGTCCGCCCCGAAACCATGGCCGCGCCGGACGGCTGCGGGCTAAGACCGTATCCGCGCTGCGGCGGCGAT
TATTTCGCGCTGGACCAGCTGCTGCTGGGAGAAGGCGAAAGCGAGTCCTGGCGCAGCGCCGGGCCGGAGGTGCTGCTGGT
GGTGGATGGCAGCCTGAGGCTGCGCCACCCCGGCGGCGAGCTAGCGCTGGAACAGGGACAAAGCGCCTTGCTGCAGCCCG
GCCTGGCGTGCGAGGCGCAAGCCGGCCGGCTGGCGCTGGCCTACCGCGCCTTTTGCCCGATGGCCGGCTGA

Upstream 100 bases:

>100_bases
CCAGGCTGGTGATGCACGAGGACTTCCGCCAGGCGTTGCGCGCCGAGCGCGATCCCGAGCGCTTGCTGGCGCTGCTGCGG
GACAGGCTGGAGGGCGCGGC

Downstream 100 bases:

>100_bases
TGCTAAGGTGGCGGATAGTCCAGATTGAGACGGATAGAAAGACATGACGCCGCTCCCGTCCTTCCGCCTGAGCTGGCCGT
CCGCGCTCCAGCGGCTGTGC

Product: mannose-6-phosphate isomerase

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MSAFPLHGLAQHYAWGGRRFIPGMLGLDNAEQQRFAEWWLGAHEDAPSVIETPLGPQPLHYAIAHQAPAFLGEALIRRHG
RRLPFLLKVLDVDAPLSIQAHPDEAQARAGFARENAVGLAIDDARRNYRDPYPKPEMMVALSPFWLLHGMRPDAQIDALL
ARQPAWTPLREGLAREGGAALYRRLLRLPQAEIAALLRPLWRRLETGDDAGPDDPDHWTRRLAGSRAEDRGIFGCYLLNL
VGLRPGEAIFQPARLPHAYLHGRNIELMANSDNVLRAGLTDKPVDVEALLGVMDGEPVRPETMAAPDGCGLRPYPRCGGD
YFALDQLLLGEGESESWRSAGPEVLLVVDGSLRLRHPGGELALEQGQSALLQPGLACEAQAGRLALAYRAFCPMAG

Sequences:

>Translated_396_residues
MSAFPLHGLAQHYAWGGRRFIPGMLGLDNAEQQRFAEWWLGAHEDAPSVIETPLGPQPLHYAIAHQAPAFLGEALIRRHG
RRLPFLLKVLDVDAPLSIQAHPDEAQARAGFARENAVGLAIDDARRNYRDPYPKPEMMVALSPFWLLHGMRPDAQIDALL
ARQPAWTPLREGLAREGGAALYRRLLRLPQAEIAALLRPLWRRLETGDDAGPDDPDHWTRRLAGSRAEDRGIFGCYLLNL
VGLRPGEAIFQPARLPHAYLHGRNIELMANSDNVLRAGLTDKPVDVEALLGVMDGEPVRPETMAAPDGCGLRPYPRCGGD
YFALDQLLLGEGESESWRSAGPEVLLVVDGSLRLRHPGGELALEQGQSALLQPGLACEAQAGRLALAYRAFCPMAG
>Mature_395_residues
SAFPLHGLAQHYAWGGRRFIPGMLGLDNAEQQRFAEWWLGAHEDAPSVIETPLGPQPLHYAIAHQAPAFLGEALIRRHGR
RLPFLLKVLDVDAPLSIQAHPDEAQARAGFARENAVGLAIDDARRNYRDPYPKPEMMVALSPFWLLHGMRPDAQIDALLA
RQPAWTPLREGLAREGGAALYRRLLRLPQAEIAALLRPLWRRLETGDDAGPDDPDHWTRRLAGSRAEDRGIFGCYLLNLV
GLRPGEAIFQPARLPHAYLHGRNIELMANSDNVLRAGLTDKPVDVEALLGVMDGEPVRPETMAAPDGCGLRPYPRCGGDY
FALDQLLLGEGESESWRSAGPEVLLVVDGSLRLRHPGGELALEQGQSALLQPGLACEAQAGRLALAYRAFCPMAG

Specific function: Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide [H]

COG id: COG1482

COG function: function code G; Phosphomannose isomerase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family [H]

Homologues:

Organism=Homo sapiens, GI4505235, Length=323, Percent_Identity=33.4365325077399, Blast_Score=145, Evalue=4e-35,
Organism=Escherichia coli, GI1787899, Length=373, Percent_Identity=36.9973190348526, Blast_Score=195, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI71997620, Length=422, Percent_Identity=29.3838862559242, Blast_Score=135, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6320839, Length=403, Percent_Identity=29.7766749379653, Blast_Score=133, Evalue=5e-32,
Organism=Drosophila melanogaster, GI21356061, Length=302, Percent_Identity=29.4701986754967, Blast_Score=119, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR001250
- InterPro:   IPR016305
- InterPro:   IPR018050
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01238 PMI_typeI [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 43442; Mature: 43311

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAFPLHGLAQHYAWGGRRFIPGMLGLDNAEQQRFAEWWLGAHEDAPSVIETPLGPQPLH
CCCCCCHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHCCCCCCCCHHHHCCCCCCCHH
YAIAHQAPAFLGEALIRRHGRRLPFLLKVLDVDAPLSIQAHPDEAQARAGFARENAVGLA
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEECCCHHHHHHCCCCCCCEEEE
IDDARRNYRDPYPKPEMMVALSPFWLLHGMRPDAQIDALLARQPAWTPLREGLAREGGAA
EHHHHHHCCCCCCCCCEEEEECHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHCCCCHH
LYRRLLRLPQAEIAALLRPLWRRLETGDDAGPDDPDHWTRRLAGSRAEDRGIFGCYLLNL
HHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHH
VGLRPGEAIFQPARLPHAYLHGRNIELMANSDNVLRAGLTDKPVDVEALLGVMDGEPVRP
HCCCCCHHHHCCCCCCHHHHCCCCEEEEECCCCEEECCCCCCCCCHHHHHHHCCCCCCCC
ETMAAPDGCGLRPYPRCGGDYFALDQLLLGEGESESWRSAGPEVLLVVDGSLRLRHPGGE
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHCCCCCEEEEECCCEEEECCCCH
LALEQGQSALLQPGLACEAQAGRLALAYRAFCPMAG
HHHHCCCHHHHCCCCCCCCCCCCEEEHHHHHCCCCC
>Mature Secondary Structure 
SAFPLHGLAQHYAWGGRRFIPGMLGLDNAEQQRFAEWWLGAHEDAPSVIETPLGPQPLH
CCCCCHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHCCCCCCCCHHHHCCCCCCCHH
YAIAHQAPAFLGEALIRRHGRRLPFLLKVLDVDAPLSIQAHPDEAQARAGFARENAVGLA
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEECCCHHHHHHCCCCCCCEEEE
IDDARRNYRDPYPKPEMMVALSPFWLLHGMRPDAQIDALLARQPAWTPLREGLAREGGAA
EHHHHHHCCCCCCCCCEEEEECHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHCCCCHH
LYRRLLRLPQAEIAALLRPLWRRLETGDDAGPDDPDHWTRRLAGSRAEDRGIFGCYLLNL
HHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHH
VGLRPGEAIFQPARLPHAYLHGRNIELMANSDNVLRAGLTDKPVDVEALLGVMDGEPVRP
HCCCCCHHHHCCCCCCHHHHCCCCEEEEECCCCEEECCCCCCCCCHHHHHHHCCCCCCCC
ETMAAPDGCGLRPYPRCGGDYFALDQLLLGEGESESWRSAGPEVLLVVDGSLRLRHPGGE
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHCCCCCEEEEECCCEEEECCCCH
LALEQGQSALLQPGLACEAQAGRLALAYRAFCPMAG
HHHHCCCHHHHCCCCCCCCCCCCEEEHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1879695; 11677609 [H]