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The map label for this gene is dxr

Identifier: 34497657

GI number: 34497657

Start: 2372142

End: 2373326

Strand: Direct

Name: dxr

Synonym: CV_2202

Alternate gene names: 34497657

Gene position: 2372142-2373326 (Clockwise)

Preceding gene: 34497656

Following gene: 34497658

Centisome position: 49.93

GC content: 68.19

Gene sequence:

>1185_bases
ATGACCAAACCTCAGGGTATTGCCGTACTGGGGGCTACTGGCAGCGTGGGCTGCAACACGCTGGATGTGGTCGCCCGCCA
TCCGGAGCGCTACCGCGTCGTGGCGTTGACCGCCCATCGCCAGCTCGACAAGCTGTTCGAGCAGGCCCGCCGTTTTTGTC
CCGATTACCTGGTGGTGGCCGATGCCGACGCGGCGGCGCGATTGCGCGCCCGCCTGGCGGAGGCGGGCCTTCGGTCCGAG
GTGCTGCACGGCGCGGACGCGTTGGTCCAGGTGGCCGCGTTGCCCGAGGTGGACGCGGTCATGGCCTCCATCGTCGGCGC
GGCCGGACTGCCGTCGGCGCTGGCCGCGGCTCGAGCCGGCAAGCGCATCCTGCTGGCCAACAAAGAGTCGCTGGTGGTGG
CGGGCCGCCTGTTCATGGACGCGGTGCGCGCCAGCGGTTCTGCGCTGTTGCCGGTGGACAGCGAGCACAGCGCCATTTTC
CAGTCGCTGCCTGCCGATTACGCAGGCAATCCGGACGGCGCCGGCGTTCGCAAGATCATTCTCACCGCCTCGGGCGGGCC
GTTCCGCAATCGCCCCGCCGCGGATCTCGCCCATGTCACGCCGGATGAGGCCTGCCGCCACCCGAACTGGAGCATGGGAC
GCAAAATCTCGGTCGATTCCGCCACCTTGATGAACAAGGGCCTGGAGGTGATCGAGGCGCGCTGGCTGTTCAATGTGCCG
CCAAGCCGCATCGAGGTGGCAGTGCATCCGCAAAGCGTGATCCATTCGATGGTCCAGTACCGCGATGGCTCGGTGATGGC
GCAACTCGGTTCGCCGGACATGCGCACCCCCATCGCCTGCGCGCTGGCCTGGCCGGAGCGCATAGACGCCGGCGTCGAGC
CCATGGATTTCTTCTCCTTGTCCGATCTCACGTTTGAAAAGCCCGATCTCGAACGCTTCCCTTGTCTGCAGCTGGCCTTC
GACGCGCTGGAGATGGGCGGCGACGCCCCGGCGGTGCTCAACGCCGCCAACGAGGTGGCGGTCGCGGCCTTCCTGGCTGG
GCGCTTGCGCTTCGTCGACATTCCGCGCGTGGTGGCCGCCTCGCTGAGCGGCGTATCCTGCGCCGCCAGCGACAGCCTTG
AGGGTTTGCTGGCTCGGGACGAAGAGGCGCGGCGCTTCGCCGAGGGCGGGGTGGCTGCATGCTGA

Upstream 100 bases:

>100_bases
CATGGCGGCGTGTATGACCGAATCGACAGCCTGATCGCCGTATTGGCGGTCAGCAACGCCCTGCGCGCGCTGGGCGGCAT
GTAATTCTGGAAACATAGCA

Downstream 100 bases:

>100_bases
CGCTGCTGGCGTTCCTGGTGGCCATCGGCCTGCTGGTGACCTTTCACGAATTGGGCCACTACTGGGTGGCCAAGCTGTGC
GGCGTGAAAGTGCAGCGCTT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MTKPQGIAVLGATGSVGCNTLDVVARHPERYRVVALTAHRQLDKLFEQARRFCPDYLVVADADAAARLRARLAEAGLRSE
VLHGADALVQVAALPEVDAVMASIVGAAGLPSALAAARAGKRILLANKESLVVAGRLFMDAVRASGSALLPVDSEHSAIF
QSLPADYAGNPDGAGVRKIILTASGGPFRNRPAADLAHVTPDEACRHPNWSMGRKISVDSATLMNKGLEVIEARWLFNVP
PSRIEVAVHPQSVIHSMVQYRDGSVMAQLGSPDMRTPIACALAWPERIDAGVEPMDFFSLSDLTFEKPDLERFPCLQLAF
DALEMGGDAPAVLNAANEVAVAAFLAGRLRFVDIPRVVAASLSGVSCAASDSLEGLLARDEEARRFAEGGVAAC

Sequences:

>Translated_394_residues
MTKPQGIAVLGATGSVGCNTLDVVARHPERYRVVALTAHRQLDKLFEQARRFCPDYLVVADADAAARLRARLAEAGLRSE
VLHGADALVQVAALPEVDAVMASIVGAAGLPSALAAARAGKRILLANKESLVVAGRLFMDAVRASGSALLPVDSEHSAIF
QSLPADYAGNPDGAGVRKIILTASGGPFRNRPAADLAHVTPDEACRHPNWSMGRKISVDSATLMNKGLEVIEARWLFNVP
PSRIEVAVHPQSVIHSMVQYRDGSVMAQLGSPDMRTPIACALAWPERIDAGVEPMDFFSLSDLTFEKPDLERFPCLQLAF
DALEMGGDAPAVLNAANEVAVAAFLAGRLRFVDIPRVVAASLSGVSCAASDSLEGLLARDEEARRFAEGGVAAC
>Mature_393_residues
TKPQGIAVLGATGSVGCNTLDVVARHPERYRVVALTAHRQLDKLFEQARRFCPDYLVVADADAAARLRARLAEAGLRSEV
LHGADALVQVAALPEVDAVMASIVGAAGLPSALAAARAGKRILLANKESLVVAGRLFMDAVRASGSALLPVDSEHSAIFQ
SLPADYAGNPDGAGVRKIILTASGGPFRNRPAADLAHVTPDEACRHPNWSMGRKISVDSATLMNKGLEVIEARWLFNVPP
SRIEVAVHPQSVIHSMVQYRDGSVMAQLGSPDMRTPIACALAWPERIDAGVEPMDFFSLSDLTFEKPDLERFPCLQLAFD
ALEMGGDAPAVLNAANEVAVAAFLAGRLRFVDIPRVVAASLSGVSCAASDSLEGLLARDEEARRFAEGGVAAC

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=392, Percent_Identity=57.3979591836735, Blast_Score=433, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_CHRVO (Q7NVY8)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_901872.1
- ProteinModelPortal:   Q7NVY8
- SMR:   Q7NVY8
- GeneID:   2549212
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_2202
- NMPDR:   fig|243365.1.peg.2202
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- PhylomeDB:   Q7NVY8
- ProtClustDB:   PRK05447
- BioCyc:   CVIO243365:CV_2202-MONOMER
- BRENDA:   1.1.1.267
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 41674; Mature: 41543

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: BINDING 128-128 BINDING 155-155 BINDING 184-184 BINDING 207-207 BINDING 229-229

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKPQGIAVLGATGSVGCNTLDVVARHPERYRVVALTAHRQLDKLFEQARRFCPDYLVVA
CCCCCCEEEEECCCCCCCCHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCEEEEE
DADAAARLRARLAEAGLRSEVLHGADALVQVAALPEVDAVMASIVGAAGLPSALAAARAG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHCC
KRILLANKESLVVAGRLFMDAVRASGSALLPVDSEHSAIFQSLPADYAGNPDGAGVRKII
CEEEEECCCCEEEHHHHHHHHHHCCCCEEECCCCCHHHHHHHCCCCCCCCCCCCCEEEEE
LTASGGPFRNRPAADLAHVTPDEACRHPNWSMGRKISVDSATLMNKGLEVIEARWLFNVP
EEECCCCCCCCCCHHHHCCCCHHHHCCCCCCCCCEEECCHHHHHHHCHHHHHHHEEECCC
PSRIEVAVHPQSVIHSMVQYRDGSVMAQLGSPDMRTPIACALAWPERIDAGVEPMDFFSL
CCCEEEEECHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEECHHHHCCCCCCCHHEEC
SDLTFEKPDLERFPCLQLAFDALEMGGDAPAVLNAANEVAVAAFLAGRLRFVDIPRVVAA
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEECHHHHHH
SLSGVSCAASDSLEGLLARDEEARRFAEGGVAAC
HCCCCEECCCCCHHHHHHCCHHHHHHHCCCCCCC
>Mature Secondary Structure 
TKPQGIAVLGATGSVGCNTLDVVARHPERYRVVALTAHRQLDKLFEQARRFCPDYLVVA
CCCCCEEEEECCCCCCCCHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCEEEEE
DADAAARLRARLAEAGLRSEVLHGADALVQVAALPEVDAVMASIVGAAGLPSALAAARAG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHCC
KRILLANKESLVVAGRLFMDAVRASGSALLPVDSEHSAIFQSLPADYAGNPDGAGVRKII
CEEEEECCCCEEEHHHHHHHHHHCCCCEEECCCCCHHHHHHHCCCCCCCCCCCCCEEEEE
LTASGGPFRNRPAADLAHVTPDEACRHPNWSMGRKISVDSATLMNKGLEVIEARWLFNVP
EEECCCCCCCCCCHHHHCCCCHHHHCCCCCCCCCEEECCHHHHHHHCHHHHHHHEEECCC
PSRIEVAVHPQSVIHSMVQYRDGSVMAQLGSPDMRTPIACALAWPERIDAGVEPMDFFSL
CCCEEEEECHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEECHHHHCCCCCCCHHEEC
SDLTFEKPDLERFPCLQLAFDALEMGGDAPAVLNAANEVAVAAFLAGRLRFVDIPRVVAA
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEECHHHHHH
SLSGVSCAASDSLEGLLARDEEARRFAEGGVAAC
HCCCCEECCCCCHHHHHHCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782