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The map label for this gene is uppS

Identifier: 34497655

GI number: 34497655

Start: 2370559

End: 2371314

Strand: Direct

Name: uppS

Synonym: CV_2200

Alternate gene names: 34497655

Gene position: 2370559-2371314 (Clockwise)

Preceding gene: 34497654

Following gene: 34497656

Centisome position: 49.9

GC content: 64.55

Gene sequence:

>756_bases
TTGTTTTCCGGTTCTTCGAATGCAGTGCCGGAGGGGCGCGAGCCGCCCCGGCATATCGCCATCATCATGGATGGCAACGG
CCGCTGGGCCAAGAAACGCTTCCTGCCGCGCGTAGCCGGCCACAAGCGCGGACTGGACGCGGTGCGCGAGGTGGTGAAGG
CCTGCAAGGAAATGGGCGTCGGCTATCTGACGCTGTTCGCCTTCTCCACCGAAAACTGGCGGCGTCCGCAGGAGGAAGTG
TCCTTTCTGATGGACCTGTTCCTGCGCGCGCTCGAGCATGAGGTGGCCAAGCTTCACAACAACAATATCCGCCTGAAGGT
GCTGGGTTCGCGCGAGCGTTTCAGCGCGGAGTTGTCCGAGCGCATAGACCGCGCCGAGGCCAAGACCGCCGGCAACGACG
GGCTGGTGCTGACCATCGCCGCCGACTACGGCGGCCGCTGGGATATCGTGCACGCGGTGAATCGGCTGATCGCCGAAGGC
CGGTCCGAGATCACCGAGGAGATGGTCACCGATCGCCTGGGCATGGCATGGGCGCCGGAGCCGGACCTGTTCATCCGCAC
CGGCGGCGAGCAGCGCATCAGCAATTTCCTGCTGTGGCAGCTGGCGTATTCCGAGCTGTATTTCACCGACCTGCTGTGGC
CCGATTTCGACCGAGCGGCGCTGCAGGAGGCGATCCACTCCTACTGGCAGCGTGAGCGCCGCTTTGGCCGCACCAGCGAG
CAATTGCCCGAACACCTGCGTCGAGACAAGCTCTGA

Upstream 100 bases:

>100_bases
CCAGGACGAAATCCAGAAGCTGACCGACAAGTACACCGCCGAAATCGACAAGATGCTGGCCACCAAAGAAGCCGACCTGT
TGGCGGTATAAGGGGCGATC

Downstream 100 bases:

>100_bases
TCTCATGCTGATAACGCGAATTCTGACCGCGCTCGTATTGCTGCCGCTGATGCTGGCGGCGCTTTTCCTGTTTCCCGCCG
CGGCCTGGGCGGGGTTTTCC

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MFSGSSNAVPEGREPPRHIAIIMDGNGRWAKKRFLPRVAGHKRGLDAVREVVKACKEMGVGYLTLFAFSTENWRRPQEEV
SFLMDLFLRALEHEVAKLHNNNIRLKVLGSRERFSAELSERIDRAEAKTAGNDGLVLTIAADYGGRWDIVHAVNRLIAEG
RSEITEEMVTDRLGMAWAPEPDLFIRTGGEQRISNFLLWQLAYSELYFTDLLWPDFDRAALQEAIHSYWQRERRFGRTSE
QLPEHLRRDKL

Sequences:

>Translated_251_residues
MFSGSSNAVPEGREPPRHIAIIMDGNGRWAKKRFLPRVAGHKRGLDAVREVVKACKEMGVGYLTLFAFSTENWRRPQEEV
SFLMDLFLRALEHEVAKLHNNNIRLKVLGSRERFSAELSERIDRAEAKTAGNDGLVLTIAADYGGRWDIVHAVNRLIAEG
RSEITEEMVTDRLGMAWAPEPDLFIRTGGEQRISNFLLWQLAYSELYFTDLLWPDFDRAALQEAIHSYWQRERRFGRTSE
QLPEHLRRDKL
>Mature_251_residues
MFSGSSNAVPEGREPPRHIAIIMDGNGRWAKKRFLPRVAGHKRGLDAVREVVKACKEMGVGYLTLFAFSTENWRRPQEEV
SFLMDLFLRALEHEVAKLHNNNIRLKVLGSRERFSAELSERIDRAEAKTAGNDGLVLTIAADYGGRWDIVHAVNRLIAEG
RSEITEEMVTDRLGMAWAPEPDLFIRTGGEQRISNFLLWQLAYSELYFTDLLWPDFDRAALQEAIHSYWQRERRFGRTSE
QLPEHLRRDKL

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580742, Length=251, Percent_Identity=36.2549800796813, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI45580738, Length=246, Percent_Identity=34.9593495934959, Blast_Score=143, Evalue=1e-34,
Organism=Escherichia coli, GI1786371, Length=228, Percent_Identity=54.8245614035088, Blast_Score=249, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI71993029, Length=224, Percent_Identity=35.7142857142857, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323748, Length=259, Percent_Identity=31.6602316602317, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319474, Length=208, Percent_Identity=34.1346153846154, Blast_Score=119, Evalue=6e-28,
Organism=Drosophila melanogaster, GI18857969, Length=227, Percent_Identity=37.0044052863436, Blast_Score=150, Evalue=8e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_CHRVO (Q7NVZ0)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_901870.1
- ProteinModelPortal:   Q7NVZ0
- SMR:   Q7NVZ0
- GeneID:   2549213
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_2200
- NMPDR:   fig|243365.1.peg.2200
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- PhylomeDB:   Q7NVZ0
- BioCyc:   CVIO243365:CV_2200-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 28951; Mature: 28951

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 24-24

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSGSSNAVPEGREPPRHIAIIMDGNGRWAKKRFLPRVAGHKRGLDAVREVVKACKEMGV
CCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
GYLTLFAFSTENWRRPQEEVSFLMDLFLRALEHEVAKLHNNNIRLKVLGSRERFSAELSE
CEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHH
RIDRAEAKTAGNDGLVLTIAADYGGRWDIVHAVNRLIAEGRSEITEEMVTDRLGMAWAPE
HHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCC
PDLFIRTGGEQRISNFLLWQLAYSELYFTDLLWPDFDRAALQEAIHSYWQRERRFGRTSE
CCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHH
QLPEHLRRDKL
HHHHHHHHCCC
>Mature Secondary Structure
MFSGSSNAVPEGREPPRHIAIIMDGNGRWAKKRFLPRVAGHKRGLDAVREVVKACKEMGV
CCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
GYLTLFAFSTENWRRPQEEVSFLMDLFLRALEHEVAKLHNNNIRLKVLGSRERFSAELSE
CEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHH
RIDRAEAKTAGNDGLVLTIAADYGGRWDIVHAVNRLIAEGRSEITEEMVTDRLGMAWAPE
HHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCC
PDLFIRTGGEQRISNFLLWQLAYSELYFTDLLWPDFDRAALQEAIHSYWQRERRFGRTSE
CCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHH
QLPEHLRRDKL
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782