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The map label for this gene is era

Identifier: 34497522

GI number: 34497522

Start: 2254488

End: 2255378

Strand: Direct

Name: era

Synonym: CV_2067

Alternate gene names: 34497522

Gene position: 2254488-2255378 (Clockwise)

Preceding gene: 34497521

Following gene: 34497523

Centisome position: 47.45

GC content: 62.4

Gene sequence:

>891_bases
ATGACCGATACCCCATTCCACTGCGGCTTCGTCGCCATCGTCGGCCGTCCCAACGTGGGCAAGTCCACGCTGATGAACCA
CCTGATCGGCCAGAAGATCAGCATCACGTCCAAGAAGTCGCAGACCACGCGCCATCGCGTCACCGGCATCCATACCGAGG
ACGCGGCGCAGTTCGTCTTTGTCGACACGCCCGGCTTCCAGACCTATCACAAGGGCGCGCTGAACGAGGCGCTGAACAAG
AGCGTCAAGGATTCCCTGGGCAGCGTGGACTGCGTGCTGTTCCTGCTGGAGGCGATGCGCTTCACCGCCGCCGACCGCGA
GGTGATGGCGCTGCTGCCGAAGAAGACCCCGGTGATCCTGGTGGTGAACAAGCTGGACAAGGCCAAGGACAAGCTGACCC
TGCAGGCTTTCATCGATGAGGTGACCGCCGAATTCGAGTTCGCCGGCGTGGAAGTGGTCAGCGCCAAGCACGGCCAGCGG
CTGGCCGAGCTCTTGGACCAGGTGCGTCCGCATCTGCCGGAGTCGATGCCCCTGTATCCGGAGGACATGATCACCGACAA
GAACGAGCGCTTCCTGGCCGCCGAGATCGTCCGCGAGAAGCTGTTCCGCTACCTGGGCGAAGAGCTGCCGTACGAGATGA
ACGTGGAAGTGGAAATGTTCGAGATGGACGGCGCGCTGCGCCGCATCCACATCGCGGTGCTGGTGGACAAGGAGCACCAG
AAGCCCATCGTGATCGGCAGGGGCGGAGAGAAGCTGAAGAAGATCTCCACCGAGGCGCGCCTGGACATGGAAAAGCTGTT
CGACGGCAAGGTATTCCTGCAGGTGTGGGTGAAGGTCAAATCCGGCTGGGCCGACGACGTCCGCTTCCTGCGCGAGTTTG
GTCTGGACTGA

Upstream 100 bases:

>100_bases
CCACCGGCGACGGCGGCAGCCGCCGCGCCGCCGAACAGCAGGCCGCCGAAGCGGCGCTGACCCTGCTGGAACAGAAACTC
GCAGCAAGCAAGAAAAGATC

Downstream 100 bases:

>100_bases
TGACAGTATTGGACAGGCCGCCGGCGCAGGCTTGCTGGGCGGCGAACCTTGCCGGCGACGGCGCGGCGGCGGAACTGTCG
CGCTGCGCGCTGAGGCTGGC

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MTDTPFHCGFVAIVGRPNVGKSTLMNHLIGQKISITSKKSQTTRHRVTGIHTEDAAQFVFVDTPGFQTYHKGALNEALNK
SVKDSLGSVDCVLFLLEAMRFTAADREVMALLPKKTPVILVVNKLDKAKDKLTLQAFIDEVTAEFEFAGVEVVSAKHGQR
LAELLDQVRPHLPESMPLYPEDMITDKNERFLAAEIVREKLFRYLGEELPYEMNVEVEMFEMDGALRRIHIAVLVDKEHQ
KPIVIGRGGEKLKKISTEARLDMEKLFDGKVFLQVWVKVKSGWADDVRFLREFGLD

Sequences:

>Translated_296_residues
MTDTPFHCGFVAIVGRPNVGKSTLMNHLIGQKISITSKKSQTTRHRVTGIHTEDAAQFVFVDTPGFQTYHKGALNEALNK
SVKDSLGSVDCVLFLLEAMRFTAADREVMALLPKKTPVILVVNKLDKAKDKLTLQAFIDEVTAEFEFAGVEVVSAKHGQR
LAELLDQVRPHLPESMPLYPEDMITDKNERFLAAEIVREKLFRYLGEELPYEMNVEVEMFEMDGALRRIHIAVLVDKEHQ
KPIVIGRGGEKLKKISTEARLDMEKLFDGKVFLQVWVKVKSGWADDVRFLREFGLD
>Mature_295_residues
TDTPFHCGFVAIVGRPNVGKSTLMNHLIGQKISITSKKSQTTRHRVTGIHTEDAAQFVFVDTPGFQTYHKGALNEALNKS
VKDSLGSVDCVLFLLEAMRFTAADREVMALLPKKTPVILVVNKLDKAKDKLTLQAFIDEVTAEFEFAGVEVVSAKHGQRL
AELLDQVRPHLPESMPLYPEDMITDKNERFLAAEIVREKLFRYLGEELPYEMNVEVEMFEMDGALRRIHIAVLVDKEHQK
PIVIGRGGEKLKKISTEARLDMEKLFDGKVFLQVWVKVKSGWADDVRFLREFGLD

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain

Homologues:

Organism=Homo sapiens, GI24307899, Length=324, Percent_Identity=25.3086419753086, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI1788919, Length=290, Percent_Identity=49.6551724137931, Blast_Score=288, Evalue=2e-79,
Organism=Escherichia coli, GI87082120, Length=168, Percent_Identity=30.952380952381, Blast_Score=68, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24646434, Length=305, Percent_Identity=27.2131147540984, Blast_Score=107, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ERA_CHRVO (Q7NWC3)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_901737.1
- HSSP:   Q9X1F8
- ProteinModelPortal:   Q7NWC3
- SMR:   Q7NWC3
- GeneID:   2547004
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_2067
- NMPDR:   fig|243365.1.peg.2067
- HOGENOM:   HBG561652
- OMA:   QNATRRK
- PhylomeDB:   Q7NWC3
- ProtClustDB:   PRK00089
- BioCyc:   CVIO243365:CV_2067-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00367
- InterPro:   IPR005662
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- TIGRFAMs:   TIGR00436
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1; SSF54814 KH_prok

EC number: NA

Molecular weight: Translated: 33498; Mature: 33367

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTPFHCGFVAIVGRPNVGKSTLMNHLIGQKISITSKKSQTTRHRVTGIHTEDAAQFVF
CCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEECCCHHHHHHHHHCCCCCCCCCEEEE
VDTPGFQTYHKGALNEALNKSVKDSLGSVDCVLFLLEAMRFTAADREVMALLPKKTPVIL
EECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEE
VVNKLDKAKDKLTLQAFIDEVTAEFEFAGVEVVSAKHGQRLAELLDQVRPHLPESMPLYP
EEECCHHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHCCCCCCCCCC
EDMITDKNERFLAAEIVREKLFRYLGEELPYEMNVEVEMFEMDGALRRIHIAVLVDKEHQ
HHHHCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCEEEEEECCCCEEEEEEEEEEECCCC
KPIVIGRGGEKLKKISTEARLDMEKLFDGKVFLQVWVKVKSGWADDVRFLREFGLD
CCEEEECCCHHHHHHHHHHHHCHHHHHCCCEEEHHHHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TDTPFHCGFVAIVGRPNVGKSTLMNHLIGQKISITSKKSQTTRHRVTGIHTEDAAQFVF
CCCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEECCCHHHHHHHHHCCCCCCCCCEEEE
VDTPGFQTYHKGALNEALNKSVKDSLGSVDCVLFLLEAMRFTAADREVMALLPKKTPVIL
EECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEE
VVNKLDKAKDKLTLQAFIDEVTAEFEFAGVEVVSAKHGQRLAELLDQVRPHLPESMPLYP
EEECCHHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHCCCCCCCCCC
EDMITDKNERFLAAEIVREKLFRYLGEELPYEMNVEVEMFEMDGALRRIHIAVLVDKEHQ
HHHHCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCEEEEEECCCCEEEEEEEEEEECCCC
KPIVIGRGGEKLKKISTEARLDMEKLFDGKVFLQVWVKVKSGWADDVRFLREFGLD
CCEEEECCCHHHHHHHHHHHHCHHHHHCCCEEEHHHHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14500782