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The map label for this gene is rnc

Identifier: 34497521

GI number: 34497521

Start: 2253781

End: 2254491

Strand: Direct

Name: rnc

Synonym: CV_2066

Alternate gene names: 34497521

Gene position: 2253781-2254491 (Clockwise)

Preceding gene: 34497520

Following gene: 34497522

Centisome position: 47.44

GC content: 64.28

Gene sequence:

>711_bases
GTGACCCAGATAGACAATCGATTCCGGCGCCTGTCCCAGGCGCTGGATTATGCTTTTCAAAAGCCGGAACTGCTGCGCCA
GGCGCTGACGCACCGCAGTTACAGCAGCGCCAACAACGAGCGCTTCGAATTCGTCGGCGACAGCATCCTCAATTACACCG
TGGCCCGCATGCTGTACGACCAGTTCCCGCAGCTGACCGAGGGCGAGCTGTCCCGGCTGCGCGCCAACCTGGTCAACCAG
AACACGCTGGCGGAAATCGCCCATGAGCTGAAGCTGGGCGACTACCTGTATCTGGGCGAGGGCGAGCTCAAGAGCGGCGG
CTTCAACCGGCCGTCCATCCTGGCCGATGCGCTGGAGGCCACCTTCGCCGCCGTCAGCTTCGACGCCGATTTCGCCGCCG
CCGAACAGGTGGTGCGCCGCCTGTACAATCAGCGCGTCGCCACCATAGACACCACGCGCCAGGCCAAGGATGCCAAAACC
CGCTTGCAGGAAGCGCTGCAGGCGCGCAAGCTGGCGCTGCCGAAGTACCGCATCCTGTCGCAGAGCGGCGAGGCGCACGA
ACAATGGTTCAAGGTGGAGTGTGACCTGGGCGAAATGGCCCTGATCTCCACCGGCGACGGCGGCAGCCGCCGCGCCGCCG
AACAGCAGGCCGCCGAAGCGGCGCTGACCCTGCTGGAACAGAAACTCGCAGCAAGCAAGAAAAGATCATGA

Upstream 100 bases:

>100_bases
CGCGCGAAGTACCAGCGCGAGGTGCCGCTGTTCGCCAACGTCAGCCTGCTTTTCCATTTCGATACCCAGGCGGGACAACC
GCCTGCGCAATAACCATACC

Downstream 100 bases:

>100_bases
CCGATACCCCATTCCACTGCGGCTTCGTCGCCATCGTCGGCCGTCCCAACGTGGGCAAGTCCACGCTGATGAACCACCTG
ATCGGCCAGAAGATCAGCAT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MTQIDNRFRRLSQALDYAFQKPELLRQALTHRSYSSANNERFEFVGDSILNYTVARMLYDQFPQLTEGELSRLRANLVNQ
NTLAEIAHELKLGDYLYLGEGELKSGGFNRPSILADALEATFAAVSFDADFAAAEQVVRRLYNQRVATIDTTRQAKDAKT
RLQEALQARKLALPKYRILSQSGEAHEQWFKVECDLGEMALISTGDGGSRRAAEQQAAEAALTLLEQKLAASKKRS

Sequences:

>Translated_236_residues
MTQIDNRFRRLSQALDYAFQKPELLRQALTHRSYSSANNERFEFVGDSILNYTVARMLYDQFPQLTEGELSRLRANLVNQ
NTLAEIAHELKLGDYLYLGEGELKSGGFNRPSILADALEATFAAVSFDADFAAAEQVVRRLYNQRVATIDTTRQAKDAKT
RLQEALQARKLALPKYRILSQSGEAHEQWFKVECDLGEMALISTGDGGSRRAAEQQAAEAALTLLEQKLAASKKRS
>Mature_235_residues
TQIDNRFRRLSQALDYAFQKPELLRQALTHRSYSSANNERFEFVGDSILNYTVARMLYDQFPQLTEGELSRLRANLVNQN
TLAEIAHELKLGDYLYLGEGELKSGGFNRPSILADALEATFAAVSFDADFAAAEQVVRRLYNQRVATIDTTRQAKDAKTR
LQEALQARKLALPKYRILSQSGEAHEQWFKVECDLGEMALISTGDGGSRRAAEQQAAEAALTLLEQKLAASKKRS

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=240, Percent_Identity=28.3333333333333, Blast_Score=84, Evalue=8e-17,
Organism=Homo sapiens, GI155030236, Length=240, Percent_Identity=28.3333333333333, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1788920, Length=217, Percent_Identity=52.073732718894, Blast_Score=207, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI193202651, Length=234, Percent_Identity=26.9230769230769, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17506883, Length=234, Percent_Identity=26.9230769230769, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323895, Length=204, Percent_Identity=28.921568627451, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17137682, Length=224, Percent_Identity=27.6785714285714, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_CHRVO (Q7NWC4)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_901736.1
- ProteinModelPortal:   Q7NWC4
- SMR:   Q7NWC4
- GeneID:   2547190
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_2066
- NMPDR:   fig|243365.1.peg.2066
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- PhylomeDB:   Q7NWC4
- ProtClustDB:   PRK00102
- BioCyc:   CVIO243365:CV_2066-MONOMER
- BRENDA:   3.1.26.3
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 26494; Mature: 26363

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQIDNRFRRLSQALDYAFQKPELLRQALTHRSYSSANNERFEFVGDSILNYTVARMLYD
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
QFPQLTEGELSRLRANLVNQNTLAEIAHELKLGDYLYLGEGELKSGGFNRPSILADALEA
HCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHH
TFAAVSFDADFAAAEQVVRRLYNQRVATIDTTRQAKDAKTRLQEALQARKLALPKYRILS
HHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
QSGEAHEQWFKVECDLGEMALISTGDGGSRRAAEQQAAEAALTLLEQKLAASKKRS
CCCHHHHHHEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TQIDNRFRRLSQALDYAFQKPELLRQALTHRSYSSANNERFEFVGDSILNYTVARMLYD
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
QFPQLTEGELSRLRANLVNQNTLAEIAHELKLGDYLYLGEGELKSGGFNRPSILADALEA
HCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHH
TFAAVSFDADFAAAEQVVRRLYNQRVATIDTTRQAKDAKTRLQEALQARKLALPKYRILS
HHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
QSGEAHEQWFKVECDLGEMALISTGDGGSRRAAEQQAAEAALTLLEQKLAASKKRS
CCCHHHHHHEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782