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The map label for this gene is grxC [C]

Identifier: 34497491

GI number: 34497491

Start: 2218924

End: 2219655

Strand: Direct

Name: grxC [C]

Synonym: CV_2036

Alternate gene names: 34497491

Gene position: 2218924-2219655 (Clockwise)

Preceding gene: 34497485

Following gene: 34497492

Centisome position: 46.7

GC content: 62.16

Gene sequence:

>732_bases
ATGCTGCAAAATCGTGAAGGCCAACGCGTACCGAACGTCACTTTCCGCATCCGTGAAAACAACGAGTGGAAGAATGTTAC
CACCGCCGAGCTGTTCGACGGCAAAACCGTCGCCCTGTTCTCGCTGCCGGGCGCGTTCACTCCGACCTGCTCCTCCACCC
ACCTGCCGCGCTTCAACGAGCTGGCGCCGGCCTTCTTCGCCAACGGCGTGGACGCCATCCTGTGCGTATCGGTCAACGAC
ACCTTCGTGATGAATGAATGGGCCAAGGACCAGGAAGCGCAGAACATCGTGATGATCCCGGATGGCAACGGCGACTTCAC
CGAAGGCATGGGCATGCTGGTGGACAAGCAGGACCTGGGCTTCGGCAAGCGCAGCTGGCGCTACTCGATGCTGGTCAAGG
ACGGCGTGGTGGACAAGATGTTCGTCGAGCCGCAGGAGCCGGGCGATCCGTTCAAGGTGTCCGACGCCGACACCCTGCTG
AACTACATCAACCCGAGCGCCAAGAAGCCTGACCAAGTGGTCGTCTTCACCAAGGTGGGCTGCCCGCACTGCGCGCGCGC
CAAGGCCGTGCTGGCCGAAAACGGCTACGACTTCGTCGAAGTGCCGCTGGACAACAAGATCCGCGGCAAGGTGCTGGGCG
CGGTGTCCGGCGCGATGACCGCCCCGCAGGTGTTCATCAACGGCGAGCTGATCGGTTCCGCCGACGAAGTGGAAAAGCGC
TTCGCCAAGTAA

Upstream 100 bases:

>100_bases
TCAAAAGTCTTGTGACAATCAATTAGACGAATTTTGTCATGGCTATCAGAATGCACTCATCGATAGCTAACAACCGCAGT
CAACCCTCAAGGAGATAGCC

Downstream 100 bases:

>100_bases
GACGTTCGTCGCCGATGGTTTCGGGCCCTGACGCCATCGGCAATCTTTGGGCCGGTACTCCTGCCGGCCGTTTTTTCCAG
CCGGGATGCGGGACGGCATG

Product: peroxiredoxin/glutaredoxin family protein

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MLQNREGQRVPNVTFRIRENNEWKNVTTAELFDGKTVALFSLPGAFTPTCSSTHLPRFNELAPAFFANGVDAILCVSVND
TFVMNEWAKDQEAQNIVMIPDGNGDFTEGMGMLVDKQDLGFGKRSWRYSMLVKDGVVDKMFVEPQEPGDPFKVSDADTLL
NYINPSAKKPDQVVVFTKVGCPHCARAKAVLAENGYDFVEVPLDNKIRGKVLGAVSGAMTAPQVFINGELIGSADEVEKR
FAK

Sequences:

>Translated_243_residues
MLQNREGQRVPNVTFRIRENNEWKNVTTAELFDGKTVALFSLPGAFTPTCSSTHLPRFNELAPAFFANGVDAILCVSVND
TFVMNEWAKDQEAQNIVMIPDGNGDFTEGMGMLVDKQDLGFGKRSWRYSMLVKDGVVDKMFVEPQEPGDPFKVSDADTLL
NYINPSAKKPDQVVVFTKVGCPHCARAKAVLAENGYDFVEVPLDNKIRGKVLGAVSGAMTAPQVFINGELIGSADEVEKR
FAK
>Mature_243_residues
MLQNREGQRVPNVTFRIRENNEWKNVTTAELFDGKTVALFSLPGAFTPTCSSTHLPRFNELAPAFFANGVDAILCVSVND
TFVMNEWAKDQEAQNIVMIPDGNGDFTEGMGMLVDKQDLGFGKRSWRYSMLVKDGVVDKMFVEPQEPGDPFKVSDADTLL
NYINPSAKKPDQVVVFTKVGCPHCARAKAVLAENGYDFVEVPLDNKIRGKVLGAVSGAMTAPQVFINGELIGSADEVEKR
FAK

Specific function: The Disulfide Bond Functions As An Electron Carrier In The Glutathione-Dependent Synthesis Of Deoxyribonucleotides By The Enzyme Ribonucleotide Reductase. In Addition, It Is Also Involved In Reducing Some Disulfides In A Coupled System With Glutathione R

COG id: COG0678

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI6912238, Length=145, Percent_Identity=42.7586206896552, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI78706776, Length=146, Percent_Identity=41.0958904109589, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI78709078, Length=146, Percent_Identity=41.0958904109589, Blast_Score=104, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011767
- InterPro:   IPR002109
- InterPro:   IPR011906
- InterPro:   IPR014025
- InterPro:   IPR013740
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin; PF08534 Redoxin [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 26757; Mature: 26757

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00195 GLUTAREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQNREGQRVPNVTFRIRENNEWKNVTTAELFDGKTVALFSLPGAFTPTCSSTHLPRFNE
CCCCCCCCCCCCEEEEEECCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCCHHH
LAPAFFANGVDAILCVSVNDTFVMNEWAKDQEAQNIVMIPDGNGDFTEGMGMLVDKQDLG
HCHHHHHCCCCEEEEEECCCEEEECCCCCCCCCCEEEEEECCCCCCCCCCCEEEECCCCC
FGKRSWRYSMLVKDGVVDKMFVEPQEPGDPFKVSDADTLLNYINPSAKKPDQVVVFTKVG
CCCCCEEEEEEEECCCCCEEEECCCCCCCCEEECCHHHHHHHCCCCCCCCCEEEEEEECC
CPHCARAKAVLAENGYDFVEVPLDNKIRGKVLGAVSGAMTAPQVFINGELIGSADEVEKR
CCCHHHHHEEEECCCCCEEEECCCCCCCCEEEEHHHCCCCCCEEEECCEEECCHHHHHHH
FAK
HCC
>Mature Secondary Structure
MLQNREGQRVPNVTFRIRENNEWKNVTTAELFDGKTVALFSLPGAFTPTCSSTHLPRFNE
CCCCCCCCCCCCEEEEEECCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCCHHH
LAPAFFANGVDAILCVSVNDTFVMNEWAKDQEAQNIVMIPDGNGDFTEGMGMLVDKQDLG
HCHHHHHCCCCEEEEEECCCEEEECCCCCCCCCCEEEEEECCCCCCCCCCCEEEECCCCC
FGKRSWRYSMLVKDGVVDKMFVEPQEPGDPFKVSDADTLLNYINPSAKKPDQVVVFTKVG
CCCCCEEEEEEEECCCCCEEEECCCCCCCCEEECCHHHHHHHCCCCCCCCCEEEEEEECC
CPHCARAKAVLAENGYDFVEVPLDNKIRGKVLGAVSGAMTAPQVFINGELIGSADEVEKR
CCCHHHHHEEEECCCCCEEEECCCCCCCCEEEEHHHCCCCCCEEEECCEEECCHHHHHHH
FAK
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]