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The map label for this gene is tlpA [H]

Identifier: 34497305

GI number: 34497305

Start: 2003369

End: 2005003

Strand: Reverse

Name: tlpA [H]

Synonym: CV_1850

Alternate gene names: 34497305

Gene position: 2005003-2003369 (Counterclockwise)

Preceding gene: 34497306

Following gene: 34497301

Centisome position: 42.2

GC content: 68.01

Gene sequence:

>1635_bases
ATGAGCTTGTTGCAATCGATCAAAGTCGGCCCGCGCCTGAGCGCATCCTTCGCGGCGCTGCTGGCCATCCTGCTCGCCAT
CTCGGCCAGCGTCTGGAGCGGCCTCTCCCATATCGAGCAGTCGGCCCAGGCCATCGTCAACGACGATGCCAGCAAACAGC
AGGCGGCGGCCGAATTGGATAGGCACTCGCAAAACGCTGCCTTGCTGCTGCTGCAAATCATCGCCACGCCGGAGCGGAAA
CAACGCGAACCCCTGTACGCGTCGATGGACGACGCCAACCGCCGCGCCGGCGACGTCATGCAGCGCCTGAAGGCCCTGCC
CTGGAACGCCGGGCAGGCCGGCTCGCTGCAAAGACTGGCCGAACTGCGCGCCGCCTACGCCAAGGCCTTCTCCGACACCG
TGGACCTGGTGGAGGCCAATGACCCGGAGGCGCTGGCCAAACAGTACGGCGGACAGACCCGCCCGGCGCTGCAGGCGCTG
CTGGCGGCCACCGCCGAACTGTCGGCCGCCCAACAGCAGCACATGAATGCGGAAATGGGCAGCGTGCTGGCGCTGATGAG
CGCCACCCGCAGCCTGCTGCTTGCCTGCAGCGCCGCCGCGGTATTGATCGGCCTGCTGCTGGCATGGCGCGTCACCCGCA
GCATCACCCGGCCGCTGGAGCACAGCGTGGCGGTGCTGGACGCGATGGCCCAGGGCGATCTGCGCAGCCGGGTCCAGGCC
GACGGCAAGGACGAGACTGCGCAGATGCTGCGGAGAATGAACGCGATGCAAGCCGAACTGGCCGCCTTGGTGCGCGAAAT
GCGCGCCAGCGGCGACATGGTGGCCTCCGCCGCCGCCTCCACCGACGGCAGCGCGTCGGAAGTGGCGGGCAGCGTGGAAA
AGCAGCAGACGGAAATCCACCAGATCAACGGGCTTGTGGGCGCCTTCTCGGCCAAGCTGGATCGCGCGGCCGCCACCGCC
AGCCAGGCTCAGCGCCAGGCCAGGAATGCAGCGGAGCTGGCCGACAACGGCCAGCAGCTGATCGAGACCGCCTCGCGCGA
GATCGGCCTGATCGCCGGCCAGATCCGCGGCAGCGCCGAATCGGTGGACGCGCTGCGCCAACGCGCCAATTCGATGCACG
GCATGATAGAGGCCGTCACCGACATTGCCGAGCAGACCAATATGCTGGCGCTGAACGCGGCGATTGAAGCCGCCCGCGCC
GGCGAGATGGGCCGCGGCTTCGCCGTGGTGGCCGACGAAGTGCGCAATCTTGCCGCCCGCACCGCCCGGGCGACCCGGGA
AATCAACGACGTGATCAGCGCCATGGATGCGCAGACCTCGGACGCGATGGGGCGCATCGAGCAGGGCCAGCGCGAAATGG
CCCGCGGCGTGGCGCTGATAGGCGAAATCGTGGAGCCCTTGACCGAATTGAAACGCGGCGCCACCGCCACGGTGGGCGAA
TTGGACCGGCTGGCGACCGACATCGCCGAACAGGTGAGGGAAAGCCAGTCCATCGCCGACAGCGTATCAGCCATCGCCGA
GTCCGCGGATGAAAGCCTCAAGGCCAGCCAGGACGCCAGCCGCAACAGCGGCAAGCTGCGGGAGGTGAGCGCCGCATTGC
AGGCGCAGATGCGGCGTTTCGCGGTGGACAATTAA

Upstream 100 bases:

>100_bases
AGCGCGGCGGGCCATCCGCACGCGCCAGGCTCGCCGGCTATGATGACATATCGCCCACGCAGCTCCGACCAACGGTTTTC
CGCATCGAGAGGCGCACCTG

Downstream 100 bases:

>100_bases
ATCTGGCCGGCGCTCTGGACATATCAGCCGCCGCCGCGGAAACGAAACAGGGCGGCAACCATCAGCTTACCGCCCTGTTG
CGTTGCGGTTCAGGCTCGCT

Product: methyl-accepting chemotaxis transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MSLLQSIKVGPRLSASFAALLAILLAISASVWSGLSHIEQSAQAIVNDDASKQQAAAELDRHSQNAALLLLQIIATPERK
QREPLYASMDDANRRAGDVMQRLKALPWNAGQAGSLQRLAELRAAYAKAFSDTVDLVEANDPEALAKQYGGQTRPALQAL
LAATAELSAAQQQHMNAEMGSVLALMSATRSLLLACSAAAVLIGLLLAWRVTRSITRPLEHSVAVLDAMAQGDLRSRVQA
DGKDETAQMLRRMNAMQAELAALVREMRASGDMVASAAASTDGSASEVAGSVEKQQTEIHQINGLVGAFSAKLDRAAATA
SQAQRQARNAAELADNGQQLIETASREIGLIAGQIRGSAESVDALRQRANSMHGMIEAVTDIAEQTNMLALNAAIEAARA
GEMGRGFAVVADEVRNLAARTARATREINDVISAMDAQTSDAMGRIEQGQREMARGVALIGEIVEPLTELKRGATATVGE
LDRLATDIAEQVRESQSIADSVSAIAESADESLKASQDASRNSGKLREVSAALQAQMRRFAVDN

Sequences:

>Translated_544_residues
MSLLQSIKVGPRLSASFAALLAILLAISASVWSGLSHIEQSAQAIVNDDASKQQAAAELDRHSQNAALLLLQIIATPERK
QREPLYASMDDANRRAGDVMQRLKALPWNAGQAGSLQRLAELRAAYAKAFSDTVDLVEANDPEALAKQYGGQTRPALQAL
LAATAELSAAQQQHMNAEMGSVLALMSATRSLLLACSAAAVLIGLLLAWRVTRSITRPLEHSVAVLDAMAQGDLRSRVQA
DGKDETAQMLRRMNAMQAELAALVREMRASGDMVASAAASTDGSASEVAGSVEKQQTEIHQINGLVGAFSAKLDRAAATA
SQAQRQARNAAELADNGQQLIETASREIGLIAGQIRGSAESVDALRQRANSMHGMIEAVTDIAEQTNMLALNAAIEAARA
GEMGRGFAVVADEVRNLAARTARATREINDVISAMDAQTSDAMGRIEQGQREMARGVALIGEIVEPLTELKRGATATVGE
LDRLATDIAEQVRESQSIADSVSAIAESADESLKASQDASRNSGKLREVSAALQAQMRRFAVDN
>Mature_543_residues
SLLQSIKVGPRLSASFAALLAILLAISASVWSGLSHIEQSAQAIVNDDASKQQAAAELDRHSQNAALLLLQIIATPERKQ
REPLYASMDDANRRAGDVMQRLKALPWNAGQAGSLQRLAELRAAYAKAFSDTVDLVEANDPEALAKQYGGQTRPALQALL
AATAELSAAQQQHMNAEMGSVLALMSATRSLLLACSAAAVLIGLLLAWRVTRSITRPLEHSVAVLDAMAQGDLRSRVQAD
GKDETAQMLRRMNAMQAELAALVREMRASGDMVASAAASTDGSASEVAGSVEKQQTEIHQINGLVGAFSAKLDRAAATAS
QAQRQARNAAELADNGQQLIETASREIGLIAGQIRGSAESVDALRQRANSMHGMIEAVTDIAEQTNMLALNAAIEAARAG
EMGRGFAVVADEVRNLAARTARATREINDVISAMDAQTSDAMGRIEQGQREMARGVALIGEIVEPLTELKRGATATVGEL
DRLATDIAEQVRESQSIADSVSAIAESADESLKASQDASRNSGKLREVSAALQAQMRRFAVDN

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI2367378, Length=297, Percent_Identity=28.2828282828283, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1787690, Length=321, Percent_Identity=27.1028037383178, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788194, Length=305, Percent_Identity=30.1639344262295, Blast_Score=105, Evalue=9e-24,
Organism=Escherichia coli, GI1788195, Length=293, Percent_Identity=28.6689419795222, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1789453, Length=337, Percent_Identity=27.299703264095, Blast_Score=87, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 57575; Mature: 57444

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLQSIKVGPRLSASFAALLAILLAISASVWSGLSHIEQSAQAIVNDDASKQQAAAELD
CCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
RHSQNAALLLLQIIATPERKQREPLYASMDDANRRAGDVMQRLKALPWNAGQAGSLQRLA
HCCCHHHHHHHHHHHCCCHHHCCCCEECCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
ELRAAYAKAFSDTVDLVEANDPEALAKQYGGQTRPALQALLAATAELSAAQQQHMNAEMG
HHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SVLALMSATRSLLLACSAAAVLIGLLLAWRVTRSITRPLEHSVAVLDAMAQGDLRSRVQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DGKDETAQMLRRMNAMQAELAALVREMRASGDMVASAAASTDGSASEVAGSVEKQQTEIH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHH
QINGLVGAFSAKLDRAAATASQAQRQARNAAELADNGQQLIETASREIGLIAGQIRGSAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCHH
SVDALRQRANSMHGMIEAVTDIAEQTNMLALNAAIEAARAGEMGRGFAVVADEVRNLAAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
TARATREINDVISAMDAQTSDAMGRIEQGQREMARGVALIGEIVEPLTELKRGATATVGE
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
LDRLATDIAEQVRESQSIADSVSAIAESADESLKASQDASRNSGKLREVSAALQAQMRRF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
AVDN
HCCC
>Mature Secondary Structure 
SLLQSIKVGPRLSASFAALLAILLAISASVWSGLSHIEQSAQAIVNDDASKQQAAAELD
CHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
RHSQNAALLLLQIIATPERKQREPLYASMDDANRRAGDVMQRLKALPWNAGQAGSLQRLA
HCCCHHHHHHHHHHHCCCHHHCCCCEECCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
ELRAAYAKAFSDTVDLVEANDPEALAKQYGGQTRPALQALLAATAELSAAQQQHMNAEMG
HHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SVLALMSATRSLLLACSAAAVLIGLLLAWRVTRSITRPLEHSVAVLDAMAQGDLRSRVQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DGKDETAQMLRRMNAMQAELAALVREMRASGDMVASAAASTDGSASEVAGSVEKQQTEIH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHH
QINGLVGAFSAKLDRAAATASQAQRQARNAAELADNGQQLIETASREIGLIAGQIRGSAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCHH
SVDALRQRANSMHGMIEAVTDIAEQTNMLALNAAIEAARAGEMGRGFAVVADEVRNLAAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
TARATREINDVISAMDAQTSDAMGRIEQGQREMARGVALIGEIVEPLTELKRGATATVGE
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
LDRLATDIAEQVRESQSIADSVSAIAESADESLKASQDASRNSGKLREVSAALQAQMRRF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
AVDN
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]