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The map label for this gene is hmuU [H]

Identifier: 34497249

GI number: 34497249

Start: 1950058

End: 1951023

Strand: Reverse

Name: hmuU [H]

Synonym: CV_1794

Alternate gene names: 34497249

Gene position: 1951023-1950058 (Counterclockwise)

Preceding gene: 34497250

Following gene: 34497248

Centisome position: 41.06

GC content: 71.12

Gene sequence:

>966_bases
ATGCGCGTTCGCTCCCTCATCCTCGTCCTGCTTCCGCTGCTGGGCCTCACCGCCCTCGCCTCCCTGCTCCATCACAGCCA
GCTGCAAGCCCTCAGCCTGCTGAAGCTGGATCCGCAACCGCCGCTGGAATGGCAGCTGCTGCTGGAGTTGCGCCTGCCGC
GACTGTTCGCCGCCGCCTCCGCCGGCGCGCTGCTCGCCAGCGCCGGCTGCGCGGTGCAGGCGCGCTTCCGCAACCCGCTG
GCCGAGCCGGGCCTGATCGGCATCAACAGCGGCGCGGCGCTGGCCGCGGCGCTGGCGCTGAGCCTGGGCGCCGGCCTTTA
TGGCGTGGCGGCGGCCGGCTTCGCCGGCGGCCTGGGCGCGCTGCTGCTGGTGAGAGTGCTGGGAAGCGACCACGACGGCA
ACCGGCTGATATTGAGCGGACTGGCGGTCAGCACCCTGCTCGGCAGCCTGTTGACCCTGCTGATCACCATGCTGCCCGAC
GGATCGCTGCGCGTAGTCACCTTCTGGCTGATGGGCAGCTTCGCCGGCGCAGAATGGCCGCAGGCGCTGACGCTGACCGT
GGCCGCGCCGCTGATCTGGCTGGCGCTCTTCGGCCACTGGCGCTTCCTGAACGCCTTGCAGCTGGGCGAGAGTGCCGCCT
TCCACCTGGGCTTTTCCGTGCGCGGCCAGGAATGGCGCATCGTATTGCTGGCGGCGCTGGCCGCCGGCTTGGTGGTGTCC
GGGTGCGGCATGATAGGTTTCGTCGGACTGATGGCCCCGCACCTGGCGCGCCAGCTGGTCGGCAGCGACTCGCGCCGCCT
GCTCGCCGCTTCTCCGCTGCTGGGGGCCTGGCTGACCGTCAGTTCAGACTGGCTGGCCCGCGGGCTGTTGGCGCCGGCGG
AATTGCCGGTCGGCGTGATCACCAGCCTGCTGGGCGCGCCCTTCTTCCTGTGGCTGCTGCGCCGCCAGGAGGCCCGACAT
GCTTGA

Upstream 100 bases:

>100_bases
GCTGGCTGTCCGACAAGCGAAACGGCCTGTTCGACATGCAGGACGTGCTGGGCCTGCGCTGACGCCCGCGGAGGGGCGCC
CGCCCCTCCCTTTCCATCCC

Downstream 100 bases:

>100_bases
AGCCCGCGGCCTGTCGCTGCGCAAAGGCGGCCGAGCCCTGCTGACCGATGCCGGCCTGTCCCTGAAGCCCGGCGAATTGC
TGACCGTGCTGGGGCCGAAC

Product: hemin transport system permease

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MRVRSLILVLLPLLGLTALASLLHHSQLQALSLLKLDPQPPLEWQLLLELRLPRLFAAASAGALLASAGCAVQARFRNPL
AEPGLIGINSGAALAAALALSLGAGLYGVAAAGFAGGLGALLLVRVLGSDHDGNRLILSGLAVSTLLGSLLTLLITMLPD
GSLRVVTFWLMGSFAGAEWPQALTLTVAAPLIWLALFGHWRFLNALQLGESAAFHLGFSVRGQEWRIVLLAALAAGLVVS
GCGMIGFVGLMAPHLARQLVGSDSRRLLAASPLLGAWLTVSSDWLARGLLAPAELPVGVITSLLGAPFFLWLLRRQEARH
A

Sequences:

>Translated_321_residues
MRVRSLILVLLPLLGLTALASLLHHSQLQALSLLKLDPQPPLEWQLLLELRLPRLFAAASAGALLASAGCAVQARFRNPL
AEPGLIGINSGAALAAALALSLGAGLYGVAAAGFAGGLGALLLVRVLGSDHDGNRLILSGLAVSTLLGSLLTLLITMLPD
GSLRVVTFWLMGSFAGAEWPQALTLTVAAPLIWLALFGHWRFLNALQLGESAAFHLGFSVRGQEWRIVLLAALAAGLVVS
GCGMIGFVGLMAPHLARQLVGSDSRRLLAASPLLGAWLTVSSDWLARGLLAPAELPVGVITSLLGAPFFLWLLRRQEARH
A
>Mature_321_residues
MRVRSLILVLLPLLGLTALASLLHHSQLQALSLLKLDPQPPLEWQLLLELRLPRLFAAASAGALLASAGCAVQARFRNPL
AEPGLIGINSGAALAAALALSLGAGLYGVAAAGFAGGLGALLLVRVLGSDHDGNRLILSGLAVSTLLGSLLTLLITMLPD
GSLRVVTFWLMGSFAGAEWPQALTLTVAAPLIWLALFGHWRFLNALQLGESAAFHLGFSVRGQEWRIVLLAALAAGLVVS
GCGMIGFVGLMAPHLARQLVGSDSRRLLAASPLLGAWLTVSSDWLARGLLAPAELPVGVITSLLGAPFFLWLLRRQEARH
A

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790740, Length=280, Percent_Identity=40, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1790741, Length=287, Percent_Identity=38.3275261324042, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1788004, Length=274, Percent_Identity=39.7810218978102, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1786347, Length=283, Percent_Identity=33.5689045936396, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1786805, Length=292, Percent_Identity=35.958904109589, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1786804, Length=278, Percent_Identity=33.4532374100719, Blast_Score=88, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 33594; Mature: 33594

Theoretical pI: Translated: 11.36; Mature: 11.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVRSLILVLLPLLGLTALASLLHHSQLQALSLLKLDPQPPLEWQLLLELRLPRLFAAAS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
AGALLASAGCAVQARFRNPLAEPGLIGINSGAALAAALALSLGAGLYGVAAAGFAGGLGA
CCHHHHHCCCEEEEHHCCCCCCCCEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LLLVRVLGSDHDGNRLILSGLAVSTLLGSLLTLLITMLPDGSLRVVTFWLMGSFAGAEWP
HHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCC
QALTLTVAAPLIWLALFGHWRFLNALQLGESAAFHLGFSVRGQEWRIVLLAALAAGLVVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEEECCCCHHHHHHHHHHHHHHHH
GCGMIGFVGLMAPHLARQLVGSDSRRLLAASPLLGAWLTVSSDWLARGLLAPAELPVGVI
HHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHCCHHHHHHHCCCCCCCCHHHH
TSLLGAPFFLWLLRRQEARHA
HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRVRSLILVLLPLLGLTALASLLHHSQLQALSLLKLDPQPPLEWQLLLELRLPRLFAAAS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
AGALLASAGCAVQARFRNPLAEPGLIGINSGAALAAALALSLGAGLYGVAAAGFAGGLGA
CCHHHHHCCCEEEEHHCCCCCCCCEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LLLVRVLGSDHDGNRLILSGLAVSTLLGSLLTLLITMLPDGSLRVVTFWLMGSFAGAEWP
HHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCC
QALTLTVAAPLIWLALFGHWRFLNALQLGESAAFHLGFSVRGQEWRIVLLAALAAGLVVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEEECCCCHHHHHHHHHHHHHHHH
GCGMIGFVGLMAPHLARQLVGSDSRRLLAASPLLGAWLTVSSDWLARGLLAPAELPVGVI
HHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHCCHHHHHHHCCCCCCCCHHHH
TSLLGAPFFLWLLRRQEARHA
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]