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The map label for this gene is yngE [H]

Identifier: 34497219

GI number: 34497219

Start: 1919266

End: 1920864

Strand: Reverse

Name: yngE [H]

Synonym: CV_1764

Alternate gene names: 34497219

Gene position: 1920864-1919266 (Counterclockwise)

Preceding gene: 34497220

Following gene: 34497218

Centisome position: 40.43

GC content: 66.67

Gene sequence:

>1599_bases
ATGCCCATCCTCGAATCCAAGCTGTCGCCGCGCGCCGCGAACTTCGTCGCCAACGCCGACAAGATGCGCGCGCTGGTCGA
CGATCTGAAAGACAAGGTCGCCCAGGCCGCGCTGGGCGGCGGCGAGAAAGCCCGCGCCAAGCACACCGCGCGCGGCAAGC
TGCTGCCGCGCGAGCGCATCGACCTATTGCTCGACCCCGGCGCGCCGTTCCTCGAGCTGTCCCAGCTGGCCGCCTACGGC
ATGTATGGCGGCGACGCGCCCGGCGCCGGCATGATAGCCGGCATCGGCCGCATCAGCGGCGTCGACTGCCTGATCATCGC
CAACGACGCCACCGTCAAGGGCGGCACCTATTACCCGATGACGGTGAAAAAGCATTTGCGCGCGCAGGAGATCGCCCGCG
ACAACCGCTTGCCCTGCGTCTACCTGGTGGACTCCGGCGGCGCCTTCCTGCCGCTGCAGGACGAGGTGTTCCCGGACAAG
GAGCACTTCGGCCGCATCTTCTACAACCAGGCCAATCTGTCCGCCGCCGGCATTCCGCAGATCGCGGTGGTGATGGGCAG
CTGCACCGCCGGCGGCGCCTACGTGCCGGCGATGAGCGACGAGACCGTCATCGTCAAGGAACAGGGCACCATCTTCCTCG
GCGGCCCGCCGCTGGTGAAGGCCGCCACCGGCGAAGTAGTCAGCGCCGAGGAACTGGGCGGCGGCGATGTGCACACAAAA
ATCTCCGGCGTGGCCGACCACCTGGCCCAAACGGACGCCCACGCGCTGGCCATCGCCCGCCGCATCGTGTCGGACCTGAA
CTGGAAGAAACAGGGCGAGCTGGACCGCGCCGAGCCCAAGCCGCCGCGCTACGCCGCGGAGGAAATCTACGGCGTGATCC
CGGCCGATCCGAAAAAACCGTTCGACGTGCGCGAAATCATCGCCCGGCTGGTGGACGATTCGGACTTTGACGAATTCAAG
CAAAACTACGGGACCACACTGGTAACCGGCTTCGCCCGTTTGAACGGCTACCGCGTCGGCATCCTGGCCAATAACGGCAT
CCTGTTCAGCGAATCGGCGCTGAAGGGCGCGCACTTCGTCGAACTGTGCTGCCAGCGCGGCATTCCGCTGATCTTCCTGC
AGAACATCACCGGCTTCATGGTGGGCAAGAAGTATGAGAACGGCGGCATCGCCAAGGACGGCGCCAAGCTGGTGACGGCG
GTGGCCTGCGCCAAGGTGCCCAAGTTCACCGTGCTGATAGGCGGCAGCTTCGGCGCCGGCAACTACGGCATGTGCGGCCG
CGCCTACTCGCCGCGTTTCCTGTGGATGTGGCCGAACAGCCGCATCTCGGTGATGGGCGGCGAACAGGCCGCCGGCGTGC
TGGCCCAGGTGAAAAAGGAACAGCTGGGCGACGCCTTCACGCCAGAGCAGGAAGAAGCGCTGAAAGCCCCGGTGCGCCAG
CAATACGAAGAGCAGGGCCACCCCTACTACGCCAGCGCCCGTTTGTGGGACGACGGCGTGATCGACCCGGCCCAGACCCG
CGACGTGTTGGCGCTGGCGCTGGAGGCCGCGCTGTCCGCCCCGGTTGAAGCCACGCGCTTCGGCGTGTTCCGGATGTGA

Upstream 100 bases:

>100_bases
GGCGAAAGCCGTTTTCGCGCCGTCGCCATCTACGACATCAACGCCGACGGCCTGATCGCCGCCGTCTGGTTCGTCGACGC
CGAATGACAAGGTAAACCAC

Downstream 100 bases:

>100_bases
GGAGCGGATGATGAGCTACACCACGCTGCAAATCGAGCAAACCGGCAAGGTGGCCACCGTCTGGCTGAACCGGCCGGAGC
TGCACAACGCGCTGAACGAG

Product: propionyl-CoA carboxylase subunit beta

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 532; Mature: 531

Protein sequence:

>532_residues
MPILESKLSPRAANFVANADKMRALVDDLKDKVAQAALGGGEKARAKHTARGKLLPRERIDLLLDPGAPFLELSQLAAYG
MYGGDAPGAGMIAGIGRISGVDCLIIANDATVKGGTYYPMTVKKHLRAQEIARDNRLPCVYLVDSGGAFLPLQDEVFPDK
EHFGRIFYNQANLSAAGIPQIAVVMGSCTAGGAYVPAMSDETVIVKEQGTIFLGGPPLVKAATGEVVSAEELGGGDVHTK
ISGVADHLAQTDAHALAIARRIVSDLNWKKQGELDRAEPKPPRYAAEEIYGVIPADPKKPFDVREIIARLVDDSDFDEFK
QNYGTTLVTGFARLNGYRVGILANNGILFSESALKGAHFVELCCQRGIPLIFLQNITGFMVGKKYENGGIAKDGAKLVTA
VACAKVPKFTVLIGGSFGAGNYGMCGRAYSPRFLWMWPNSRISVMGGEQAAGVLAQVKKEQLGDAFTPEQEEALKAPVRQ
QYEEQGHPYYASARLWDDGVIDPAQTRDVLALALEAALSAPVEATRFGVFRM

Sequences:

>Translated_532_residues
MPILESKLSPRAANFVANADKMRALVDDLKDKVAQAALGGGEKARAKHTARGKLLPRERIDLLLDPGAPFLELSQLAAYG
MYGGDAPGAGMIAGIGRISGVDCLIIANDATVKGGTYYPMTVKKHLRAQEIARDNRLPCVYLVDSGGAFLPLQDEVFPDK
EHFGRIFYNQANLSAAGIPQIAVVMGSCTAGGAYVPAMSDETVIVKEQGTIFLGGPPLVKAATGEVVSAEELGGGDVHTK
ISGVADHLAQTDAHALAIARRIVSDLNWKKQGELDRAEPKPPRYAAEEIYGVIPADPKKPFDVREIIARLVDDSDFDEFK
QNYGTTLVTGFARLNGYRVGILANNGILFSESALKGAHFVELCCQRGIPLIFLQNITGFMVGKKYENGGIAKDGAKLVTA
VACAKVPKFTVLIGGSFGAGNYGMCGRAYSPRFLWMWPNSRISVMGGEQAAGVLAQVKKEQLGDAFTPEQEEALKAPVRQ
QYEEQGHPYYASARLWDDGVIDPAQTRDVLALALEAALSAPVEATRFGVFRM
>Mature_531_residues
PILESKLSPRAANFVANADKMRALVDDLKDKVAQAALGGGEKARAKHTARGKLLPRERIDLLLDPGAPFLELSQLAAYGM
YGGDAPGAGMIAGIGRISGVDCLIIANDATVKGGTYYPMTVKKHLRAQEIARDNRLPCVYLVDSGGAFLPLQDEVFPDKE
HFGRIFYNQANLSAAGIPQIAVVMGSCTAGGAYVPAMSDETVIVKEQGTIFLGGPPLVKAATGEVVSAEELGGGDVHTKI
SGVADHLAQTDAHALAIARRIVSDLNWKKQGELDRAEPKPPRYAAEEIYGVIPADPKKPFDVREIIARLVDDSDFDEFKQ
NYGTTLVTGFARLNGYRVGILANNGILFSESALKGAHFVELCCQRGIPLIFLQNITGFMVGKKYENGGIAKDGAKLVTAV
ACAKVPKFTVLIGGSFGAGNYGMCGRAYSPRFLWMWPNSRISVMGGEQAAGVLAQVKKEQLGDAFTPEQEEALKAPVRQQ
YEEQGHPYYASARLWDDGVIDPAQTRDVLALALEAALSAPVEATRFGVFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=525, Percent_Identity=65.9047619047619, Blast_Score=713, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=515, Percent_Identity=33.2038834951456, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI295821216, Length=535, Percent_Identity=32.3364485981308, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI310133460, Length=135, Percent_Identity=65.1851851851852, Blast_Score=167, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17552936, Length=533, Percent_Identity=63.0393996247655, Blast_Score=706, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=524, Percent_Identity=34.5419847328244, Blast_Score=263, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI25147362, Length=520, Percent_Identity=34.4230769230769, Blast_Score=260, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24586065, Length=550, Percent_Identity=63.6363636363636, Blast_Score=727, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 57057; Mature: 56926

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPILESKLSPRAANFVANADKMRALVDDLKDKVAQAALGGGEKARAKHTARGKLLPRERI
CCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHC
DLLLDPGAPFLELSQLAAYGMYGGDAPGAGMIAGIGRISGVDCLIIANDATVKGGTYYPM
CEEECCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCEEEEEECCCEECCCEECCH
TVKKHLRAQEIARDNRLPCVYLVDSGGAFLPLQDEVFPDKEHFGRIFYNQANLSAAGIPQ
HHHHHHHHHHHHHCCCCCEEEEECCCCEEECCCCCCCCCHHHCCEEEEECCCCCCCCCCE
IAVVMGSCTAGGAYVPAMSDETVIVKEQGTIFLGGPPLVKAATGEVVSAEELGGGDVHTK
EEEEEECCCCCCEEECCCCCCEEEEEECCEEEECCCCEEEECCCCEEEHHHCCCCCHHHH
ISGVADHLAQTDAHALAIARRIVSDLNWKKQGELDRAEPKPPRYAAEEIYGVIPADPKKP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHEECCCCCCCCC
FDVREIIARLVDDSDFDEFKQNYGTTLVTGFARLNGYRVGILANNGILFSESALKGAHFV
CCHHHHHHHHHCCCCHHHHHHHCCCEEEEHHHHHCCEEEEEEECCCEEEECHHHCCHHHH
ELCCQRGIPLIFLQNITGFMVGKKYENGGIAKDGAKLVTAVACAKVPKFTVLIGGSFGAG
HHHHHCCCCEEEECCCCEEEEECEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCC
NYGMCGRAYSPRFLWMWPNSRISVMGGEQAAGVLAQVKKEQLGDAFTPEQEEALKAPVRQ
CCCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
QYEEQGHPYYASARLWDDGVIDPAQTRDVLALALEAALSAPVEATRFGVFRM
HHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCEECC
>Mature Secondary Structure 
PILESKLSPRAANFVANADKMRALVDDLKDKVAQAALGGGEKARAKHTARGKLLPRERI
CCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHC
DLLLDPGAPFLELSQLAAYGMYGGDAPGAGMIAGIGRISGVDCLIIANDATVKGGTYYPM
CEEECCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCEEEEEECCCEECCCEECCH
TVKKHLRAQEIARDNRLPCVYLVDSGGAFLPLQDEVFPDKEHFGRIFYNQANLSAAGIPQ
HHHHHHHHHHHHHCCCCCEEEEECCCCEEECCCCCCCCCHHHCCEEEEECCCCCCCCCCE
IAVVMGSCTAGGAYVPAMSDETVIVKEQGTIFLGGPPLVKAATGEVVSAEELGGGDVHTK
EEEEEECCCCCCEEECCCCCCEEEEEECCEEEECCCCEEEECCCCEEEHHHCCCCCHHHH
ISGVADHLAQTDAHALAIARRIVSDLNWKKQGELDRAEPKPPRYAAEEIYGVIPADPKKP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHEECCCCCCCCC
FDVREIIARLVDDSDFDEFKQNYGTTLVTGFARLNGYRVGILANNGILFSESALKGAHFV
CCHHHHHHHHHCCCCHHHHHHHCCCEEEEHHHHHCCEEEEEEECCCEEEECHHHCCHHHH
ELCCQRGIPLIFLQNITGFMVGKKYENGGIAKDGAKLVTAVACAKVPKFTVLIGGSFGAG
HHHHHCCCCEEEECCCCEEEEECEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCC
NYGMCGRAYSPRFLWMWPNSRISVMGGEQAAGVLAQVKKEQLGDAFTPEQEEALKAPVRQ
CCCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
QYEEQGHPYYASARLWDDGVIDPAQTRDVLALALEAALSAPVEATRFGVFRM
HHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]