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The map label for this gene is nadR [C]

Identifier: 34497145

GI number: 34497145

Start: 1830450

End: 1831007

Strand: Direct

Name: nadR [C]

Synonym: CV_1690

Alternate gene names: 34497145

Gene position: 1830450-1831007 (Clockwise)

Preceding gene: 34497144

Following gene: 34497146

Centisome position: 38.53

GC content: 71.51

Gene sequence:

>558_bases
ATGATGGAGCGAAGACAGGCCGGCGGGCCGATCCGGGTGGCGATAGTCGGCCCGGAGTCCAGCGGCAAGAGCACGCTGGC
TGAGGGTTGGGCGGCGCGCCTGCGGGAGCTGGGCTGGAACGCGGCGTGGGTGGAGGAGTATTCGCGCGCCTATTACGCCG
ATCGGCCCTACGTTTCCGCGATGTCCGACATCGAGGCGATCGCCGCCGGCCAGCTGGCGTTGGAAATGCGCGCGGAAGAG
GCCGGGGCGGAAATCCTGTTGTGCGACACCACGGCGCTGACCTGCAAGATCTGGGCCGAAGTGGCGCACGGGCGGGCGTC
GGCCGCGCTGCTGGACCTGTACCGGCCGCGCGATTACGCGCTGACGGTGCTGGCCTGCCCGGACATCCCCTGGGAGCCGG
ACCCGCTGCGCAGCCATCCGACCCAGCGCGGCTGGCTGCTGGATCTGCACCGGCAGGAACTGGCGCGGCAGGGCATCGCG
GCGGTGGAGCTGAGCGGCGCGCGCGACGCGCGGCTGGCGCGGGCGATGGCGGCGCTGTCGCCCTTGTTGATTGCCTAA

Upstream 100 bases:

>100_bases
CCATTGAAAATCCGGGAAAGCACGATCTGTCGCGGTATAATAGCGGGCTTGGCCTGAACGATGGCCGGCGGGTCGCCGGC
CGAGCCGGGGAAGATGGGCG

Downstream 100 bases:

>100_bases
AAAATAATCAGCTGGCGAAAGATTTGAAAAATCATGGTTTTGGGGCGCTTGTCCACAGCGGCTCCACAACATTGTTCTCC
GGGCGCGTGGATAGCCCGGC

Product: nicotinamide mononucleotide-binding domain

Products: NAD; pyrophosphate [C]

Alternate protein names: ATPase/Kinase Involved In NAD Metabolism-Like Protein; Nicotinamide-Nucleotide Adenylyltransferase; Transcriptional Regulatory Protein NADR; Transcriptional Regulatory Protein; ATPase/Kinase NadR; NAD Metabolism ATPase/Kinase-Like Protein; NAD Metabolism Atpase/Kinase-Like Protein; Transcriptional Regulatory Protein NADr; NADR-Like Transcriptional Regulator

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MMERRQAGGPIRVAIVGPESSGKSTLAEGWAARLRELGWNAAWVEEYSRAYYADRPYVSAMSDIEAIAAGQLALEMRAEE
AGAEILLCDTTALTCKIWAEVAHGRASAALLDLYRPRDYALTVLACPDIPWEPDPLRSHPTQRGWLLDLHRQELARQGIA
AVELSGARDARLARAMAALSPLLIA

Sequences:

>Translated_185_residues
MMERRQAGGPIRVAIVGPESSGKSTLAEGWAARLRELGWNAAWVEEYSRAYYADRPYVSAMSDIEAIAAGQLALEMRAEE
AGAEILLCDTTALTCKIWAEVAHGRASAALLDLYRPRDYALTVLACPDIPWEPDPLRSHPTQRGWLLDLHRQELARQGIA
AVELSGARDARLARAMAALSPLLIA
>Mature_185_residues
MMERRQAGGPIRVAIVGPESSGKSTLAEGWAARLRELGWNAAWVEEYSRAYYADRPYVSAMSDIEAIAAGQLALEMRAEE
AGAEILLCDTTALTCKIWAEVAHGRASAALLDLYRPRDYALTVLACPDIPWEPDPLRSHPTQRGWLLDLHRQELARQGIA
AVELSGARDARLARAMAALSPLLIA

Specific function: NADr Is Bifunctional; It Interacts With Pnuc At Low Internal NAD Levels, Permitting Transport Of Nmn Intact Into The Cell. As NAD Levels Increase Within The Cell, The Affinity Of NADr For The Operator Regions Of NADa, NADb, And Pncb Increases, Repressing

COG id: COG3172

COG function: function code H; Predicted ATPase/kinase involved in NAD metabolism

Gene ontology:

Cell location: May Loosely Associate With The Membrane Through Its Interaction With The Membrane-Bound Pnuc [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 20222; Mature: 20222

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMERRQAGGPIRVAIVGPESSGKSTLAEGWAARLRELGWNAAWVEEYSRAYYADRPYVSA
CCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHH
MSDIEAIAAGQLALEMRAEEAGAEILLCDTTALTCKIWAEVAHGRASAALLDLYRPRDYA
HHHHHHHHHHHHHEEEHHHHCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHHCCCCCEE
LTVLACPDIPWEPDPLRSHPTQRGWLLDLHRQELARQGIAAVELSGARDARLARAMAALS
EEEEECCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHH
PLLIA
HHHCC
>Mature Secondary Structure
MMERRQAGGPIRVAIVGPESSGKSTLAEGWAARLRELGWNAAWVEEYSRAYYADRPYVSA
CCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHH
MSDIEAIAAGQLALEMRAEEAGAEILLCDTTALTCKIWAEVAHGRASAALLDLYRPRDYA
HHHHHHHHHHHHHEEEHHHHCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHHCCCCCEE
LTVLACPDIPWEPDPLRSHPTQRGWLLDLHRQELARQGIAAVELSGARDARLARAMAALS
EEEEECCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHH
PLLIA
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: nicotinamide nucleotide; ATP [C]

Specific reaction: nicotinamide nucleotide + ATP = NAD + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA