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The map label for this gene is norM

Identifier: 34497048

GI number: 34497048

Start: 1716449

End: 1717846

Strand: Reverse

Name: norM

Synonym: CV_1593

Alternate gene names: 34497048

Gene position: 1717846-1716449 (Counterclockwise)

Preceding gene: 34497049

Following gene: 34497047

Centisome position: 36.16

GC content: 68.67

Gene sequence:

>1398_bases
ATGCTGTTTGAACTCAATCGCGCCTCGCGCGCCGAAATCCTGGCCGAGGCGCGCCAGATCGCCGGCCTGGCGCTGCCCAT
GATGGTCGCCCAGATCGCCCAGGTGGCCACCAGCTTCGTCGACACCGTGATGGCCGGCCGCGTCGGCACCGACGACCTCG
CCGCGGTGTCGCTCGGCGCCAGCGTGTTCATCACCGTTTACGTGACGCTGATGGGCGTGGTCGCCGCGCTCAACCCCATC
CTGTCCCACCACCTGGGCTCGCGCGACCGTCGCGCCTTCAGCCGCGACGCGGCCCAGGGCCTGTGGTTCGGCCTGATGCT
CGGCGCGCTGGGCGCCGGCTTGATGCTGCTGCTGGAGGCGCCGCTGCGCCATTGGCTGCACCTGCCGCCCGACGTCACCG
ACAAGGTGATGCTGTTCATCACCGGCGCGGCCATCGGCATGCCGGCGGCGATGGCGCATCGCGCGCTGCACGCCTACGCG
TCCAGCCTGGGCCATCCCAAGGCCATCATGGTGGTCAGCCTGCTGGCGCTGGCGCTGAACATCCCGCTCAACTACATCCT
GATCCACGGCCTGTTCGGCATGCCCAGAATGGGCGGCGCCGGCTGCGGCTGGGCCACCGGCATCGTGTTCTGGTTCAACT
GCCTGGCGCTGCTAACCTATGTCAGCTGGCATCGCCATTTCCGCGACAGCCGCATCCTGGCGGGGCTGGCCGCGCCCGAC
TGGCGCCGTTTCCTCGCCTTCCTGAAGCTGGGCGTGCCCATCGGCCTGTCCTTCTTCGTCGAAGTCAGCCTGTTCTCCTT
CATCGCGCTGCTGATCGCCGAGCTGGGCACGGTGGTCGTGGCCACGCACCAGTCGGTGCTGAATTTCTCCAGCCTGATCT
ACATGCTGCCGCAAAGCGTGGCCACCGCGCTGTCGGTGCGCGTCGGCCACCATGCCGGCGCCGGCGACTACCGGGCCGCC
CGCTTCATCTCGGGCGTCGGCATGCTGATGGGCCTGGCGATGGCCGGCGGCGCGATGGCGCTGGTGCTGCTGCTGCGCGA
ACCCATCATGTGGATGTACAGCGCCGATCCCCGGGTGATCGCGATGGGCACCACGCTGCTGCTGTTCGCCGCCGTCTACC
AGCTGACCGACGCCGCCCAGACCATCGCCTCCGGCGCGCTGCGCGGCTACAAGCTGACCGCCGTGCCGATGCTGATCCAC
ATCACCTCGTTCTGGGTGGCGGGGCTGGGGCTGGGCATGCTGCTGGGGCTGACCGACTGGATCGTGCCCCGGATGGGCAT
CTACGGCTTCTGGACCGCGCTGGTGATCAGCCTGACCGTGGCCGGCCTGCTTCTGACTTACTATCTGGCCCGCGCCAGCC
GCAAGCGGCTGCACCGCGACCAAGGAATCCTGCTATGA

Upstream 100 bases:

>100_bases
AATGAGAATCCGACGGCGAAAGCTGGCCGGTCCACATGCAGACAGTATTCCGGCCGGACCGCTATAATGGACAGTTTCTG
CCCCGAATCCGCAGGACCGC

Downstream 100 bases:

>100_bases
CCCTGCAGTTTCGCGCGGACGTCGATCTGCGCCCCTACAACACCTTCGGCATGGCCGTGCGCGCCGCGCATTTCTGCCAG
CTGGACGATGCCGCCGACCT

Product: multidrug efflux protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MLFELNRASRAEILAEARQIAGLALPMMVAQIAQVATSFVDTVMAGRVGTDDLAAVSLGASVFITVYVTLMGVVAALNPI
LSHHLGSRDRRAFSRDAAQGLWFGLMLGALGAGLMLLLEAPLRHWLHLPPDVTDKVMLFITGAAIGMPAAMAHRALHAYA
SSLGHPKAIMVVSLLALALNIPLNYILIHGLFGMPRMGGAGCGWATGIVFWFNCLALLTYVSWHRHFRDSRILAGLAAPD
WRRFLAFLKLGVPIGLSFFVEVSLFSFIALLIAELGTVVVATHQSVLNFSSLIYMLPQSVATALSVRVGHHAGAGDYRAA
RFISGVGMLMGLAMAGGAMALVLLLREPIMWMYSADPRVIAMGTTLLLFAAVYQLTDAAQTIASGALRGYKLTAVPMLIH
ITSFWVAGLGLGMLLGLTDWIVPRMGIYGFWTALVISLTVAGLLLTYYLARASRKRLHRDQGILL

Sequences:

>Translated_465_residues
MLFELNRASRAEILAEARQIAGLALPMMVAQIAQVATSFVDTVMAGRVGTDDLAAVSLGASVFITVYVTLMGVVAALNPI
LSHHLGSRDRRAFSRDAAQGLWFGLMLGALGAGLMLLLEAPLRHWLHLPPDVTDKVMLFITGAAIGMPAAMAHRALHAYA
SSLGHPKAIMVVSLLALALNIPLNYILIHGLFGMPRMGGAGCGWATGIVFWFNCLALLTYVSWHRHFRDSRILAGLAAPD
WRRFLAFLKLGVPIGLSFFVEVSLFSFIALLIAELGTVVVATHQSVLNFSSLIYMLPQSVATALSVRVGHHAGAGDYRAA
RFISGVGMLMGLAMAGGAMALVLLLREPIMWMYSADPRVIAMGTTLLLFAAVYQLTDAAQTIASGALRGYKLTAVPMLIH
ITSFWVAGLGLGMLLGLTDWIVPRMGIYGFWTALVISLTVAGLLLTYYLARASRKRLHRDQGILL
>Mature_465_residues
MLFELNRASRAEILAEARQIAGLALPMMVAQIAQVATSFVDTVMAGRVGTDDLAAVSLGASVFITVYVTLMGVVAALNPI
LSHHLGSRDRRAFSRDAAQGLWFGLMLGALGAGLMLLLEAPLRHWLHLPPDVTDKVMLFITGAAIGMPAAMAHRALHAYA
SSLGHPKAIMVVSLLALALNIPLNYILIHGLFGMPRMGGAGCGWATGIVFWFNCLALLTYVSWHRHFRDSRILAGLAAPD
WRRFLAFLKLGVPIGLSFFVEVSLFSFIALLIAELGTVVVATHQSVLNFSSLIYMLPQSVATALSVRVGHHAGAGDYRAA
RFISGVGMLMGLAMAGGAMALVLLLREPIMWMYSADPRVIAMGTTLLLFAAVYQLTDAAQTIASGALRGYKLTAVPMLIH
ITSFWVAGLGLGMLLGLTDWIVPRMGIYGFWTALVISLTVAGLLLTYYLARASRKRLHRDQGILL

Specific function: Multidrug efflux pump

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family

Homologues:

Organism=Homo sapiens, GI22907060, Length=459, Percent_Identity=22.8758169934641, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI153792564, Length=443, Percent_Identity=24.3792325056433, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI38261960, Length=476, Percent_Identity=23.3193277310924, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI48994890, Length=437, Percent_Identity=38.9016018306636, Blast_Score=288, Evalue=5e-79,
Organism=Saccharomyces cerevisiae, GI6320545, Length=440, Percent_Identity=22.0454545454545, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321821, Length=395, Percent_Identity=22.7848101265823, Blast_Score=71, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NORM_CHRVO (Q7NXN3)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_901263.1
- GeneID:   2546996
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_1593
- NMPDR:   fig|243365.1.peg.1593
- HOGENOM:   HBG479615
- OMA:   SHRRIAN
- PhylomeDB:   Q7NXN3
- ProtClustDB:   PRK01766
- BioCyc:   CVIO243365:CV_1593-MONOMER
- InterPro:   IPR002528
- PANTHER:   PTHR11206
- TIGRFAMs:   TIGR00797

Pfam domain/function: PF01554 MatE

EC number: NA

Molecular weight: Translated: 50021; Mature: 50021

Theoretical pI: Translated: 10.23; Mature: 10.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xf90fd40)-; HASH(0xf354f5c)-; HASH(0xd316468)-; HASH(0xf5ca620)-; HASH(0xd4ee794)-; HASH(0xf89a178)-; HASH(0xe781918)-; HASH(0xf84d08c)-; HASH(0xea6e25c)-; HASH(0xb0724c4)-; HASH(0xf5a5f28)-; HASH(0xc2ed678)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFELNRASRAEILAEARQIAGLALPMMVAQIAQVATSFVDTVMAGRVGTDDLAAVSLGA
CEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
SVFITVYVTLMGVVAALNPILSHHLGSRDRRAFSRDAAQGLWFGLMLGALGAGLMLLLEA
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLRHWLHLPPDVTDKVMLFITGAAIGMPAAMAHRALHAYASSLGHPKAIMVVSLLALALN
HHHHHCCCCCCCCHHHHHHEECHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
IPLNYILIHGLFGMPRMGGAGCGWATGIVFWFNCLALLTYVSWHRHFRDSRILAGLAAPD
CCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCH
WRRFLAFLKLGVPIGLSFFVEVSLFSFIALLIAELGTVVVATHQSVLNFSSLIYMLPQSV
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATALSVRVGHHAGAGDYRAARFISGVGMLMGLAMAGGAMALVLLLREPIMWMYSADPRVI
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCEE
AMGTTLLLFAAVYQLTDAAQTIASGALRGYKLTAVPMLIHITSFWVAGLGLGMLLGLTDW
EHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVPRMGIYGFWTALVISLTVAGLLLTYYLARASRKRLHRDQGILL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
>Mature Secondary Structure
MLFELNRASRAEILAEARQIAGLALPMMVAQIAQVATSFVDTVMAGRVGTDDLAAVSLGA
CEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
SVFITVYVTLMGVVAALNPILSHHLGSRDRRAFSRDAAQGLWFGLMLGALGAGLMLLLEA
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLRHWLHLPPDVTDKVMLFITGAAIGMPAAMAHRALHAYASSLGHPKAIMVVSLLALALN
HHHHHCCCCCCCCHHHHHHEECHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
IPLNYILIHGLFGMPRMGGAGCGWATGIVFWFNCLALLTYVSWHRHFRDSRILAGLAAPD
CCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCH
WRRFLAFLKLGVPIGLSFFVEVSLFSFIALLIAELGTVVVATHQSVLNFSSLIYMLPQSV
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATALSVRVGHHAGAGDYRAARFISGVGMLMGLAMAGGAMALVLLLREPIMWMYSADPRVI
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCEE
AMGTTLLLFAAVYQLTDAAQTIASGALRGYKLTAVPMLIHITSFWVAGLGLGMLLGLTDW
EHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVPRMGIYGFWTALVISLTVAGLLLTYYLARASRKRLHRDQGILL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 14500782