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The map label for this gene is murB

Identifier: 34497047

GI number: 34497047

Start: 1715427

End: 1716452

Strand: Reverse

Name: murB

Synonym: CV_1592

Alternate gene names: 34497047

Gene position: 1716452-1715427 (Counterclockwise)

Preceding gene: 34497048

Following gene: 34497046

Centisome position: 36.13

GC content: 69.79

Gene sequence:

>1026_bases
ATGACCCTGCAGTTTCGCGCGGACGTCGATCTGCGCCCCTACAACACCTTCGGCATGGCCGTGCGCGCCGCGCATTTCTG
CCAGCTGGACGATGCCGCCGACCTGCCGGCCCTGCTCGCGCATCCGCTGTATCGGCAAGGCCCGGTGCTGTGGCTGGGCG
GCGGCAGCAACCTGCTGCTGACCCGCGATTACCCCGGCCTGGTGGTCAAGGTGGCGCTGGCCGGCATCCGCCTGCTGCGC
GAGGACGGCGACGACATGATCGTCGAGGCCGCGGCCGGCGAAAACTGGCACGGTTTCGTCCAGCACGCGCTGGCCCAGGG
TTGGTACGGCCTGGAAAACCTCAGCCTGATCCCCGGCACTGTCGGGGCGAGCCCGGTGCAGAACATCGGCGCCTACGGCG
TCGAGGTCAAGGACCGCCTGCTGGAGGTGGTGTGCGCGCAGCTGGACCGGAACGGCGAGGCCGCGACGCTGTCGAACGCC
GAGTGCCGCTTCGGCTACCGCGACAGCGTGTTCAAGCACGAGGCGGCCGGCCGTCTGCTGGTGACAGCGGTCCGCTTTCG
GCTGTCGCGCCGCGCGGAGCTTCGCACCGGCTACGGCGACATCCAGCAGCAGCTGCAAGCCGACGGCGTGGATCGGCCGA
CGCCGCTGGACGTGAGCCGCGCCGTGGTCGCCATCCGCCAGAGCAAGCTGCCCGATCCCGCCGTGCTGGGCAACGCCGGC
AGCTTCTTCAAGAATCCGGTCGTCCCCGCGGAACAGGCCGCCGCGCTGCTGGAACGCCATCCGCAGCTGCCGCGCTACCC
CGCCGCCGACGGCAAGGTCAAGCTGGCCGCCGGCTGGCTGATAGACCAATGCGGACTCAAGGGTTACCGCGACGGCGACG
CCGGCGTGCACGACAGACAGGCGCTGGTGCTGGTCAACCACGGCCGCGCCACCGGCGAACAGATGCGCGCGCTGGCGCGC
AAGGTGCAGCAGACCGTGAAAGAGAAATTCGGCGTGGAGCTGGAACCGGAACCGCTGATCCTGTAA

Upstream 100 bases:

>100_bases
CCGCGCTGGTGATCAGCCTGACCGTGGCCGGCCTGCTTCTGACTTACTATCTGGCCCGCGCCAGCCGCAAGCGGCTGCAC
CGCGACCAAGGAATCCTGCT

Downstream 100 bases:

>100_bases
GCGCCCCAGCCCGCCCCCGCAACGCAATGTCTTTGGAGAGCAAATGAGCAAGAAACCGGAAGTCCTGGTATTCGATCTGG
GCGGCGTATTGGTGGACTGG

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MTLQFRADVDLRPYNTFGMAVRAAHFCQLDDAADLPALLAHPLYRQGPVLWLGGGSNLLLTRDYPGLVVKVALAGIRLLR
EDGDDMIVEAAAGENWHGFVQHALAQGWYGLENLSLIPGTVGASPVQNIGAYGVEVKDRLLEVVCAQLDRNGEAATLSNA
ECRFGYRDSVFKHEAAGRLLVTAVRFRLSRRAELRTGYGDIQQQLQADGVDRPTPLDVSRAVVAIRQSKLPDPAVLGNAG
SFFKNPVVPAEQAAALLERHPQLPRYPAADGKVKLAAGWLIDQCGLKGYRDGDAGVHDRQALVLVNHGRATGEQMRALAR
KVQQTVKEKFGVELEPEPLIL

Sequences:

>Translated_341_residues
MTLQFRADVDLRPYNTFGMAVRAAHFCQLDDAADLPALLAHPLYRQGPVLWLGGGSNLLLTRDYPGLVVKVALAGIRLLR
EDGDDMIVEAAAGENWHGFVQHALAQGWYGLENLSLIPGTVGASPVQNIGAYGVEVKDRLLEVVCAQLDRNGEAATLSNA
ECRFGYRDSVFKHEAAGRLLVTAVRFRLSRRAELRTGYGDIQQQLQADGVDRPTPLDVSRAVVAIRQSKLPDPAVLGNAG
SFFKNPVVPAEQAAALLERHPQLPRYPAADGKVKLAAGWLIDQCGLKGYRDGDAGVHDRQALVLVNHGRATGEQMRALAR
KVQQTVKEKFGVELEPEPLIL
>Mature_340_residues
TLQFRADVDLRPYNTFGMAVRAAHFCQLDDAADLPALLAHPLYRQGPVLWLGGGSNLLLTRDYPGLVVKVALAGIRLLRE
DGDDMIVEAAAGENWHGFVQHALAQGWYGLENLSLIPGTVGASPVQNIGAYGVEVKDRLLEVVCAQLDRNGEAATLSNAE
CRFGYRDSVFKHEAAGRLLVTAVRFRLSRRAELRTGYGDIQQQLQADGVDRPTPLDVSRAVVAIRQSKLPDPAVLGNAGS
FFKNPVVPAEQAAALLERHPQLPRYPAADGKVKLAAGWLIDQCGLKGYRDGDAGVHDRQALVLVNHGRATGEQMRALARK
VQQTVKEKFGVELEPEPLIL

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

Organism=Escherichia coli, GI1790407, Length=332, Percent_Identity=49.3975903614458, Blast_Score=290, Evalue=1e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_CHRVO (Q7NXN4)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_901262.1
- ProteinModelPortal:   Q7NXN4
- SMR:   Q7NXN4
- GeneID:   2549932
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_1592
- NMPDR:   fig|243365.1.peg.1592
- HOGENOM:   HBG686573
- OMA:   GAAPMQN
- PhylomeDB:   Q7NXN4
- ProtClustDB:   PRK00046
- BioCyc:   CVIO243365:CV_1592-MONOMER
- BRENDA:   1.1.1.158
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 37107; Mature: 36976

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 167-167 ACT_SITE 241-241 ACT_SITE 337-337

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLQFRADVDLRPYNTFGMAVRAAHFCQLDDAADLPALLAHPLYRQGPVLWLGGGSNLLL
CEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHCHHHHCCCEEEEECCCCEEE
TRDYPGLVVKVALAGIRLLREDGDDMIVEAAAGENWHGFVQHALAQGWYGLENLSLIPGT
ECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCEECCCC
VGASPVQNIGAYGVEVKDRLLEVVCAQLDRNGEAATLSNAECRFGYRDSVFKHEAAGRLL
CCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHCCHHH
VTAVRFRLSRRAELRTGYGDIQQQLQADGVDRPTPLDVSRAVVAIRQSKLPDPAVLGNAG
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEECCCC
SFFKNPVVPAEQAAALLERHPQLPRYPAADGKVKLAAGWLIDQCGLKGYRDGDAGVHDRQ
HHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECHHHHHHCCCCCCCCCCCCCCCE
ALVLVNHGRATGEQMRALARKVQQTVKEKFGVELEPEPLIL
EEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TLQFRADVDLRPYNTFGMAVRAAHFCQLDDAADLPALLAHPLYRQGPVLWLGGGSNLLL
EEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHCHHHHCCCEEEEECCCCEEE
TRDYPGLVVKVALAGIRLLREDGDDMIVEAAAGENWHGFVQHALAQGWYGLENLSLIPGT
ECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCEECCCC
VGASPVQNIGAYGVEVKDRLLEVVCAQLDRNGEAATLSNAECRFGYRDSVFKHEAAGRLL
CCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHCCHHH
VTAVRFRLSRRAELRTGYGDIQQQLQADGVDRPTPLDVSRAVVAIRQSKLPDPAVLGNAG
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEECCCC
SFFKNPVVPAEQAAALLERHPQLPRYPAADGKVKLAAGWLIDQCGLKGYRDGDAGVHDRQ
HHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECHHHHHHCCCCCCCCCCCCCCCE
ALVLVNHGRATGEQMRALARKVQQTVKEKFGVELEPEPLIL
EEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782