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The map label for this gene is livM [H]

Identifier: 34496959

GI number: 34496959

Start: 1607571

End: 1608662

Strand: Direct

Name: livM [H]

Synonym: CV_1504

Alternate gene names: 34496959

Gene position: 1607571-1608662 (Clockwise)

Preceding gene: 34496958

Following gene: 34496960

Centisome position: 33.84

GC content: 64.84

Gene sequence:

>1092_bases
ATGGATCTGAATCATCTGAGCACCGGCAAGAAAATGGCGGTCTTCGCCGCCTGCGCGGTCCTTCTGGCCGTGCTGCCCTT
CCTGGTCGGCGGCGCGCTGGGCAATTCCTGGGTGCGCATCATCGACTTCGCGCTGCTGTACGTGATGCTGGCGCTGGGCC
TGAACATCGTGGTGGGCTTCGCCGGCCTGCTGGACCTGGGCTTCATCGCCTTCTACGCGATCGGCGCCTATACCTACGCG
CTGCTGAGCTCGCCGCACTTCGACATCCACTGGCTATTCTTCCTCACCATTCCGCTGGGCGCGGCCTTCGCCTCGCTGGG
CGGGGTGCTGCTGGGCACGCCGGTGCTGAAGCTGAAGGGCGACTACCTGGCCATCGTGACCCTGGGTTTCGGCGAGATCG
TGCGCATCTTCATGAACAACCTGAACCAGCCGGTCAACATCACCAACGGTCCCCAGGGCATCAACCTGATCGACCCGATC
CACATCGGCGGCGCGTCGCTGGGCCAGACCATCGAGCTGTTCGGGCTGAGCTTCCACAACGTCTACCTGTACTACTACCT
GTTCCTGGCGCTGACCGTGCTGGTGGTGATCATGGCCTGGCGTCTGCAGCACTCCCGCATCGGCCGCGCCTGGGTGGCGC
TGCGCGAGGACGACATCGCCGCCGCGGCGATGGGCATCAACATCCGCAACATCAAGCTCTTGGCCTTCGGCCTGGGCGCC
TTGTCCGGCGGCGTGGCCGGCGGCCTGTTCGCCTCGTTCCAGGGCTTCGTGTCGCCGGAATCGTTCAGCCTGCTGGAGTC
CATCATGATCCTGGCCATGATCGTGCTGGGCGGCATGGGCCACATCCCGGGCGTGATCCTGGGCGCCGTGGTGCTGACCA
TCGCGCCGGAAATCCTGCGCGACGTGATCGGCCCGCTGCAGATGAAGACCGTCGGCCGCATGCTGATCGACCCGGAAAAC
GCCCGCATGCTGCTGTTCGGCCTGGCGATGGTGGTGATGATGCTGGTCCGTCCGGAAGGGATGTGGCCGTCCAAGCGGCG
CAAGGCTGAGTTCCAGCACGCCAAAGAAGACGCCGCGGTGCAGAAAGGTTAA

Upstream 100 bases:

>100_bases
ATCATCGCCTTCATGGTGCTGATCCTGGTGCTGATCTTCCGTCCGTCCGGCCTGCTGGGCGAAAAAATGGCCGACCGCGC
CTGATCCGGAGGAGAGAGAC

Downstream 100 bases:

>100_bases
TCATGGCTGAAGTTTTGCTGAAAATCGAAGGCATCCATAAACGTTTCGGCGGCCTGCACGCGCTCAACGATGTCTCCCTG
ACCATCAACAAGGGCGAGAT

Product: leucine/isoleucine/valine transport system permease

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MDLNHLSTGKKMAVFAACAVLLAVLPFLVGGALGNSWVRIIDFALLYVMLALGLNIVVGFAGLLDLGFIAFYAIGAYTYA
LLSSPHFDIHWLFFLTIPLGAAFASLGGVLLGTPVLKLKGDYLAIVTLGFGEIVRIFMNNLNQPVNITNGPQGINLIDPI
HIGGASLGQTIELFGLSFHNVYLYYYLFLALTVLVVIMAWRLQHSRIGRAWVALREDDIAAAAMGINIRNIKLLAFGLGA
LSGGVAGGLFASFQGFVSPESFSLLESIMILAMIVLGGMGHIPGVILGAVVLTIAPEILRDVIGPLQMKTVGRMLIDPEN
ARMLLFGLAMVVMMLVRPEGMWPSKRRKAEFQHAKEDAAVQKG

Sequences:

>Translated_363_residues
MDLNHLSTGKKMAVFAACAVLLAVLPFLVGGALGNSWVRIIDFALLYVMLALGLNIVVGFAGLLDLGFIAFYAIGAYTYA
LLSSPHFDIHWLFFLTIPLGAAFASLGGVLLGTPVLKLKGDYLAIVTLGFGEIVRIFMNNLNQPVNITNGPQGINLIDPI
HIGGASLGQTIELFGLSFHNVYLYYYLFLALTVLVVIMAWRLQHSRIGRAWVALREDDIAAAAMGINIRNIKLLAFGLGA
LSGGVAGGLFASFQGFVSPESFSLLESIMILAMIVLGGMGHIPGVILGAVVLTIAPEILRDVIGPLQMKTVGRMLIDPEN
ARMLLFGLAMVVMMLVRPEGMWPSKRRKAEFQHAKEDAAVQKG
>Mature_363_residues
MDLNHLSTGKKMAVFAACAVLLAVLPFLVGGALGNSWVRIIDFALLYVMLALGLNIVVGFAGLLDLGFIAFYAIGAYTYA
LLSSPHFDIHWLFFLTIPLGAAFASLGGVLLGTPVLKLKGDYLAIVTLGFGEIVRIFMNNLNQPVNITNGPQGINLIDPI
HIGGASLGQTIELFGLSFHNVYLYYYLFLALTVLVVIMAWRLQHSRIGRAWVALREDDIAAAAMGINIRNIKLLAFGLGA
LSGGVAGGLFASFQGFVSPESFSLLESIMILAMIVLGGMGHIPGVILGAVVLTIAPEILRDVIGPLQMKTVGRMLIDPEN
ARMLLFGLAMVVMMLVRPEGMWPSKRRKAEFQHAKEDAAVQKG

Specific function: Component of the high affinity leucine, isoleucine, valine, transport system (LIV-I), which is operative without Na(+) and is specific for alanine and threonine, in addition to branched-chain amino acids [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=351, Percent_Identity=41.8803418803419, Blast_Score=210, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 39053; Mature: 39053

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLNHLSTGKKMAVFAACAVLLAVLPFLVGGALGNSWVRIIDFALLYVMLALGLNIVVGF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AGLLDLGFIAFYAIGAYTYALLSSPHFDIHWLFFLTIPLGAAFASLGGVLLGTPVLKLKG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCEEECC
DYLAIVTLGFGEIVRIFMNNLNQPVNITNGPQGINLIDPIHIGGASLGQTIELFGLSFHN
CEEEEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHH
VYLYYYLFLALTVLVVIMAWRLQHSRIGRAWVALREDDIAAAAMGINIRNIKLLAFGLGA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCCHHHHHHCCCEEEEEEEEEHHHH
LSGGVAGGLFASFQGFVSPESFSLLESIMILAMIVLGGMGHIPGVILGAVVLTIAPEILR
HCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
DVIGPLQMKTVGRMLIDPENARMLLFGLAMVVMMLVRPEGMWPSKRRKAEFQHAKEDAAV
HHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHC
QKG
CCC
>Mature Secondary Structure
MDLNHLSTGKKMAVFAACAVLLAVLPFLVGGALGNSWVRIIDFALLYVMLALGLNIVVGF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AGLLDLGFIAFYAIGAYTYALLSSPHFDIHWLFFLTIPLGAAFASLGGVLLGTPVLKLKG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCEEECC
DYLAIVTLGFGEIVRIFMNNLNQPVNITNGPQGINLIDPIHIGGASLGQTIELFGLSFHN
CEEEEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHH
VYLYYYLFLALTVLVVIMAWRLQHSRIGRAWVALREDDIAAAAMGINIRNIKLLAFGLGA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCCHHHHHHCCCEEEEEEEEEHHHH
LSGGVAGGLFASFQGFVSPESFSLLESIMILAMIVLGGMGHIPGVILGAVVLTIAPEILR
HCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
DVIGPLQMKTVGRMLIDPENARMLLFGLAMVVMMLVRPEGMWPSKRRKAEFQHAKEDAAV
HHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHC
QKG
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2120183; 10984043 [H]