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The map label for this gene is livH [H]

Identifier: 34496958

GI number: 34496958

Start: 1606625

End: 1607554

Strand: Direct

Name: livH [H]

Synonym: CV_1503

Alternate gene names: 34496958

Gene position: 1606625-1607554 (Clockwise)

Preceding gene: 34496956

Following gene: 34496959

Centisome position: 33.82

GC content: 63.87

Gene sequence:

>930_bases
GTGGACATTTTTCTGCAGCAAATCCTGAACGGTCTCGTTCTGGGTAGCATCTACGCGCTGATCGCGCTGGGCTACACCAT
GGTGTACGGGATCATGGGCCTGATCAACTTCGCCCACGGCGAAGTGGTGATGTTCGGCGCCATGGTCACCATCACCGTCA
TCACCACCCTGATGGGGATGGGCATCAACCTGCCGGGGCCGGCGCTGGTGCTGATCGGCCTTCTGGTGGCCATTCCCGCC
TGCATGCTGCTCGGCTTCACCATCGAGCGCGTCGCCTACCGCCCGTTGCGGGGCAAGCAGCGCCTGGCGCCGCTGATCAC
CGCGATCGGCGTGTCCATCGTGCTGCAACAGGTCGCCATCCTGATCTGGGGCCGCAACTACATCCCCTTCCCGCAGATTC
TGGACCATGATGTGGTGAGCATTTTCGGCGCCAGCATCACCAAGCTGCAGATCGTGATCATCGCGCTGTGCCTGGCCATC
ATGGCCGGCCTGCTGCTGATGGTGGAAAAGACCAAGCTCGGCCGCGCCATGCGCGCCACCAGCCAGAACCCGGCCGTGGC
CGGCCTGATGGGCGTCAACGTCAACACCATCATCTCCGCCACCTTCGTCATCGGTTCCGGCCTGGGCGCTATCGCCGGCG
TGATGGTGGCCACCAACTACGAACAGGCCCACTACTACATGGGCTTCATGATCGGTCTGAAGGCCTTCACCGCCGCGGTG
CTGGGCGGCATCGGCAACCTGGGCGGCGCGGTGGCCGGCGGCATTCTGCTGGGCATCATCGAAAGCCTGGGCGCCGGCTA
CATCGGCTCGCTGACCGGCGGCTTCCTGGGGTCCAACTACCAGGACATCATCGCCTTCATGGTGCTGATCCTGGTGCTGA
TCTTCCGTCCGTCCGGCCTGCTGGGCGAAAAAATGGCCGACCGCGCCTGA

Upstream 100 bases:

>100_bases
AGCGAAATGGCCTGTCCCGGGAGGATAAAACAGGCAGCAGTCAATAAGAGGAAACATCCCGCAAAGCTGCCGGGTAGACA
ATCAGAGGAGATCTCCAAAC

Downstream 100 bases:

>100_bases
TCCGGAGGAGAGAGACATGGATCTGAATCATCTGAGCACCGGCAAGAAAATGGCGGTCTTCGCCGCCTGCGCGGTCCTTC
TGGCCGTGCTGCCCTTCCTG

Product: leucine/isoleucine/valine transport system permease

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MDIFLQQILNGLVLGSIYALIALGYTMVYGIMGLINFAHGEVVMFGAMVTITVITTLMGMGINLPGPALVLIGLLVAIPA
CMLLGFTIERVAYRPLRGKQRLAPLITAIGVSIVLQQVAILIWGRNYIPFPQILDHDVVSIFGASITKLQIVIIALCLAI
MAGLLLMVEKTKLGRAMRATSQNPAVAGLMGVNVNTIISATFVIGSGLGAIAGVMVATNYEQAHYYMGFMIGLKAFTAAV
LGGIGNLGGAVAGGILLGIIESLGAGYIGSLTGGFLGSNYQDIIAFMVLILVLIFRPSGLLGEKMADRA

Sequences:

>Translated_309_residues
MDIFLQQILNGLVLGSIYALIALGYTMVYGIMGLINFAHGEVVMFGAMVTITVITTLMGMGINLPGPALVLIGLLVAIPA
CMLLGFTIERVAYRPLRGKQRLAPLITAIGVSIVLQQVAILIWGRNYIPFPQILDHDVVSIFGASITKLQIVIIALCLAI
MAGLLLMVEKTKLGRAMRATSQNPAVAGLMGVNVNTIISATFVIGSGLGAIAGVMVATNYEQAHYYMGFMIGLKAFTAAV
LGGIGNLGGAVAGGILLGIIESLGAGYIGSLTGGFLGSNYQDIIAFMVLILVLIFRPSGLLGEKMADRA
>Mature_309_residues
MDIFLQQILNGLVLGSIYALIALGYTMVYGIMGLINFAHGEVVMFGAMVTITVITTLMGMGINLPGPALVLIGLLVAIPA
CMLLGFTIERVAYRPLRGKQRLAPLITAIGVSIVLQQVAILIWGRNYIPFPQILDHDVVSIFGASITKLQIVIIALCLAI
MAGLLLMVEKTKLGRAMRATSQNPAVAGLMGVNVNTIISATFVIGSGLGAIAGVMVATNYEQAHYYMGFMIGLKAFTAAV
LGGIGNLGGAVAGGILLGIIESLGAGYIGSLTGGFLGSNYQDIIAFMVLILVLIFRPSGLLGEKMADRA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=309, Percent_Identity=45.6310679611651, Blast_Score=235, Evalue=3e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 32345; Mature: 32345

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIFLQQILNGLVLGSIYALIALGYTMVYGIMGLINFAHGEVVMFGAMVTITVITTLMGM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHC
GINLPGPALVLIGLLVAIPACMLLGFTIERVAYRPLRGKQRLAPLITAIGVSIVLQQVAI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
LIWGRNYIPFPQILDHDVVSIFGASITKLQIVIIALCLAIMAGLLLMVEKTKLGRAMRAT
HHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SQNPAVAGLMGVNVNTIISATFVIGSGLGAIAGVMVATNYEQAHYYMGFMIGLKAFTAAV
CCCCCEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LGGIGNLGGAVAGGILLGIIESLGAGYIGSLTGGFLGSNYQDIIAFMVLILVLIFRPSGL
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCC
LGEKMADRA
HHHHHHCCC
>Mature Secondary Structure
MDIFLQQILNGLVLGSIYALIALGYTMVYGIMGLINFAHGEVVMFGAMVTITVITTLMGM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHC
GINLPGPALVLIGLLVAIPACMLLGFTIERVAYRPLRGKQRLAPLITAIGVSIVLQQVAI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
LIWGRNYIPFPQILDHDVVSIFGASITKLQIVIIALCLAIMAGLLLMVEKTKLGRAMRAT
HHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SQNPAVAGLMGVNVNTIISATFVIGSGLGAIAGVMVATNYEQAHYYMGFMIGLKAFTAAV
CCCCCEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LGGIGNLGGAVAGGILLGIIESLGAGYIGSLTGGFLGSNYQDIIAFMVLILVLIFRPSGL
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCC
LGEKMADRA
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]