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The map label for this gene is uvrC

Identifier: 34496760

GI number: 34496760

Start: 1374848

End: 1376653

Strand: Direct

Name: uvrC

Synonym: CV_1305

Alternate gene names: 34496760

Gene position: 1374848-1376653 (Clockwise)

Preceding gene: 34496759

Following gene: 34496761

Centisome position: 28.94

GC content: 64.95

Gene sequence:

>1806_bases
GTGTCCAAGCCCGCATTCGATTACCGGAACGTATTGCAGAACCTGCCCACGCTGCCCGGCGTCTACCGCATGCTCGACGC
GGCGGGCAAGGTGCTCTACGTCGGCAAGGCGATAGACCTGAAGCGCCGCGTCAGCTCCTATTTCCAGAAAAACGATCTCA
GTCCGCGCATCCAGCTGATGGTCAGGCAGATCGCCAGCATCGAGACCACGGTCACCCGCTCCGAAGCCGAGGCGCTGATC
CTGGAGAACAACCTGATCAAGGCGCTGGCGCCGCGCTACAACATCCTGTTCCGCGACGACAAGTCCTATCCCTACCTGAT
GTTCAGCGGCCACGCGTTTCCGCAGATGGCCTATTACCGCGGCGAGCCGAAGAAGCCCAACCAGTACTTCGGCCCTTATC
CCAACGGCTACGCGGTGCGGGAAAGCATCCAGATCCTGCAGAAAGTGTTCCGGCTGCGCACCTGCGAGGACGCGGTGTTT
GCCAACCGCTCCCGTCCCTGCCTGCTGTACCAGATCAAGCGTTGCTCCGGCCCCTGCGTCGATCATATTTCCAAGGAAGA
GTACGCGGCCGATGTCGCCAGCGCGGTGGCCTTTCTCAATGGCCGCCAGAGCGAGCTGATCAACGAGCTGACCCGGCGGA
TGACGGCGGCGGCCGAGGCGATGGCGTTCGAGCAGGCTGCCGAGCTGCGCGACCAGATCCAGGCGCTGGCGCGGGTGCAG
GAAAAACAGTTCGTCGCCAGCAACCAAAGCCAGCAGGACTGCGACGTGGTGGCGGCGCGGGTGCGCGACGGCGTGCCCTG
CGTGAACCTGGTGATGATACGCGGCGGCCGGCACCTGGGCGACAAGAGCCATTTCCCGATCGGCGGCGAGGCCGATACCG
AGCAGGAAATCCTGGAAGCCTTCATCGGCCAGCATTATCAGCATGCCGGCGTGCCGGCGGCGCTGGTTGTGAATGGCGTG
GTGGACGATGCGCTGCAGCAGTTCTTGCAAGAGAGGGCCGGCCGCAAGGTTTACATCGTCGGCAATCCGATAGGCGAGCG
CCGGGTCTGGCTGGAAATGGCGGAGAAGAACGCCGAACTGGCCATCCTGCAGCGTCTGGGCAGCAAGGCGACGCAGGCGC
AGCGGCTGGCGCAGCTGAACGAGGTGCTGGAATTGGAAGACGCCGGCCGTTTCGAGTGCTTCGACATCAGCCACACCATG
GGCGAGGCCACGGTGGCGTCCTGCGTGGTGTACGACAAGGGCGCGATGCAGCCGACCGAGTACCGCCGTTTCAACATCAC
CACCGCCGCGCCGGGGGACGATTACGCGGCGATGCGCGAAGTCCTGTCACGCCGCTACGGCAAACTGGCGGAAGGCGAGG
GCAGGCTGCCGGACGCGGTGTTCATCGACGGCGGCAAGGGCCAGGTGGGCGTGGCGCTGGAGGTGCTGGGCGAGCTGGGG
CTGAATCTGCCCATCGTCGGCATCGCCAAGGGCGAGGAGCGCAAACCCGGTCTGGAAACGCTGATCCTGCCTTATTTGGA
AAAGACGCTACAATTGCGCCAGGACCATCCGGCGCTGCACCTGATCCAGACCGTGCGCGACGAGGCCCACCGCTTCGCCA
TCACCGGCCACCGCGCGCGGCGGGCCAAGGCGCGCACCTCGTCGACGCTGGAAGATATTCCAGGCATCGGCGCCAAGCGC
CGCCAGCAGCTCTTGACCCGCTTCGGCGGCTTGCGCGGCGTGGCGACGGCCAGCGTCGACGATCTGGCGCAGGTGGAGGG
CATCAGCCGTACCTTGGCGGAAAAGATTTACAATGCGCTGCATTGA

Upstream 100 bases:

>100_bases
GCATCCGCATGCCGGGCTCCACCGCGCTGGCGACCGACGCGCAGCGCAACGAATTGATCCGCCAGGCTCAGAAAGACGTC
CAGACCTGGTGCAGCAAATA

Downstream 100 bases:

>100_bases
TCGTTGCATTGATACATGAAAGCGGCGGGTGCCCCTGATCCAGGCTCGGGGCGCCGGCCGGCGTTGTTGACGAGCCTGAA
GCGACAAGACCAAGACCAAT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 601; Mature: 600

Protein sequence:

>601_residues
MSKPAFDYRNVLQNLPTLPGVYRMLDAAGKVLYVGKAIDLKRRVSSYFQKNDLSPRIQLMVRQIASIETTVTRSEAEALI
LENNLIKALAPRYNILFRDDKSYPYLMFSGHAFPQMAYYRGEPKKPNQYFGPYPNGYAVRESIQILQKVFRLRTCEDAVF
ANRSRPCLLYQIKRCSGPCVDHISKEEYAADVASAVAFLNGRQSELINELTRRMTAAAEAMAFEQAAELRDQIQALARVQ
EKQFVASNQSQQDCDVVAARVRDGVPCVNLVMIRGGRHLGDKSHFPIGGEADTEQEILEAFIGQHYQHAGVPAALVVNGV
VDDALQQFLQERAGRKVYIVGNPIGERRVWLEMAEKNAELAILQRLGSKATQAQRLAQLNEVLELEDAGRFECFDISHTM
GEATVASCVVYDKGAMQPTEYRRFNITTAAPGDDYAAMREVLSRRYGKLAEGEGRLPDAVFIDGGKGQVGVALEVLGELG
LNLPIVGIAKGEERKPGLETLILPYLEKTLQLRQDHPALHLIQTVRDEAHRFAITGHRARRAKARTSSTLEDIPGIGAKR
RQQLLTRFGGLRGVATASVDDLAQVEGISRTLAEKIYNALH

Sequences:

>Translated_601_residues
MSKPAFDYRNVLQNLPTLPGVYRMLDAAGKVLYVGKAIDLKRRVSSYFQKNDLSPRIQLMVRQIASIETTVTRSEAEALI
LENNLIKALAPRYNILFRDDKSYPYLMFSGHAFPQMAYYRGEPKKPNQYFGPYPNGYAVRESIQILQKVFRLRTCEDAVF
ANRSRPCLLYQIKRCSGPCVDHISKEEYAADVASAVAFLNGRQSELINELTRRMTAAAEAMAFEQAAELRDQIQALARVQ
EKQFVASNQSQQDCDVVAARVRDGVPCVNLVMIRGGRHLGDKSHFPIGGEADTEQEILEAFIGQHYQHAGVPAALVVNGV
VDDALQQFLQERAGRKVYIVGNPIGERRVWLEMAEKNAELAILQRLGSKATQAQRLAQLNEVLELEDAGRFECFDISHTM
GEATVASCVVYDKGAMQPTEYRRFNITTAAPGDDYAAMREVLSRRYGKLAEGEGRLPDAVFIDGGKGQVGVALEVLGELG
LNLPIVGIAKGEERKPGLETLILPYLEKTLQLRQDHPALHLIQTVRDEAHRFAITGHRARRAKARTSSTLEDIPGIGAKR
RQQLLTRFGGLRGVATASVDDLAQVEGISRTLAEKIYNALH
>Mature_600_residues
SKPAFDYRNVLQNLPTLPGVYRMLDAAGKVLYVGKAIDLKRRVSSYFQKNDLSPRIQLMVRQIASIETTVTRSEAEALIL
ENNLIKALAPRYNILFRDDKSYPYLMFSGHAFPQMAYYRGEPKKPNQYFGPYPNGYAVRESIQILQKVFRLRTCEDAVFA
NRSRPCLLYQIKRCSGPCVDHISKEEYAADVASAVAFLNGRQSELINELTRRMTAAAEAMAFEQAAELRDQIQALARVQE
KQFVASNQSQQDCDVVAARVRDGVPCVNLVMIRGGRHLGDKSHFPIGGEADTEQEILEAFIGQHYQHAGVPAALVVNGVV
DDALQQFLQERAGRKVYIVGNPIGERRVWLEMAEKNAELAILQRLGSKATQAQRLAQLNEVLELEDAGRFECFDISHTMG
EATVASCVVYDKGAMQPTEYRRFNITTAAPGDDYAAMREVLSRRYGKLAEGEGRLPDAVFIDGGKGQVGVALEVLGELGL
NLPIVGIAKGEERKPGLETLILPYLEKTLQLRQDHPALHLIQTVRDEAHRFAITGHRARRAKARTSSTLEDIPGIGAKRR
QQLLTRFGGLRGVATASVDDLAQVEGISRTLAEKIYNALH

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=607, Percent_Identity=48.4349258649094, Blast_Score=571, Evalue=1e-164,
Organism=Escherichia coli, GI1788037, Length=185, Percent_Identity=28.6486486486486, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_CHRVO (Q7NYG9)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_900975.1
- ProteinModelPortal:   Q7NYG9
- GeneID:   2551234
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_1305
- NMPDR:   fig|243365.1.peg.1305
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q7NYG9
- ProtClustDB:   PRK00558
- BioCyc:   CVIO243365:CV_1305-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 66870; Mature: 66739

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPAFDYRNVLQNLPTLPGVYRMLDAAGKVLYVGKAIDLKRRVSSYFQKNDLSPRIQLM
CCCCCHHHHHHHHHCCCCHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHCCCCHHHHHH
VRQIASIETTVTRSEAEALILENNLIKALAPRYNILFRDDKSYPYLMFSGHAFPQMAYYR
HHHHHHHHHHHHHHHHCEEEHHCHHHHHHCCCCEEEEECCCCCCEEEECCCCCCHHHHHC
GEPKKPNQYFGPYPNGYAVRESIQILQKVFRLRTCEDAVFANRSRPCLLYQIKRCSGPCV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHCCCCHH
DHISKEEYAADVASAVAFLNGRQSELINELTRRMTAAAEAMAFEQAAELRDQIQALARVQ
HHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKQFVASNQSQQDCDVVAARVRDGVPCVNLVMIRGGRHLGDKSHFPIGGEADTEQEILEA
HHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHH
FIGQHYQHAGVPAALVVNGVVDDALQQFLQERAGRKVYIVGNPIGERRVWLEMAEKNAEL
HHHCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCHH
AILQRLGSKATQAQRLAQLNEVLELEDAGRFECFDISHTMGEATVASCVVYDKGAMQPTE
HHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHCHHHHHHHHEECCCCCCCCC
YRRFNITTAAPGDDYAAMREVLSRRYGKLAEGEGRLPDAVFIDGGKGQVGVALEVLGELG
CEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCC
LNLPIVGIAKGEERKPGLETLILPYLEKTLQLRQDHPALHLIQTVRDEAHRFAITGHRAR
CCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEECCHHH
RAKARTSSTLEDIPGIGAKRRQQLLTRFGGLRGVATASVDDLAQVEGISRTLAEKIYNAL
HHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHC
H
C
>Mature Secondary Structure 
SKPAFDYRNVLQNLPTLPGVYRMLDAAGKVLYVGKAIDLKRRVSSYFQKNDLSPRIQLM
CCCCHHHHHHHHHCCCCHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHCCCCHHHHHH
VRQIASIETTVTRSEAEALILENNLIKALAPRYNILFRDDKSYPYLMFSGHAFPQMAYYR
HHHHHHHHHHHHHHHHCEEEHHCHHHHHHCCCCEEEEECCCCCCEEEECCCCCCHHHHHC
GEPKKPNQYFGPYPNGYAVRESIQILQKVFRLRTCEDAVFANRSRPCLLYQIKRCSGPCV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHCCCCHH
DHISKEEYAADVASAVAFLNGRQSELINELTRRMTAAAEAMAFEQAAELRDQIQALARVQ
HHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKQFVASNQSQQDCDVVAARVRDGVPCVNLVMIRGGRHLGDKSHFPIGGEADTEQEILEA
HHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHH
FIGQHYQHAGVPAALVVNGVVDDALQQFLQERAGRKVYIVGNPIGERRVWLEMAEKNAEL
HHHCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCHH
AILQRLGSKATQAQRLAQLNEVLELEDAGRFECFDISHTMGEATVASCVVYDKGAMQPTE
HHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHCHHHHHHHHEECCCCCCCCC
YRRFNITTAAPGDDYAAMREVLSRRYGKLAEGEGRLPDAVFIDGGKGQVGVALEVLGELG
CEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCC
LNLPIVGIAKGEERKPGLETLILPYLEKTLQLRQDHPALHLIQTVRDEAHRFAITGHRAR
CCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEECCHHH
RAKARTSSTLEDIPGIGAKRRQQLLTRFGGLRGVATASVDDLAQVEGISRTLAEKIYNAL
HHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHC
H
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782