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The map label for this gene is yuxL [H]

Identifier: 34496725

GI number: 34496725

Start: 1334639

End: 1336543

Strand: Direct

Name: yuxL [H]

Synonym: CV_1270

Alternate gene names: 34496725

Gene position: 1334639-1336543 (Clockwise)

Preceding gene: 34496721

Following gene: 34496727

Centisome position: 28.09

GC content: 62.41

Gene sequence:

>1905_bases
ATGGCCGGATTCCACGTCCTCACCAAGAAAGAAACCGCGTTGAAAACGAAAACCCTGACTGTGCTGCTGGCGTCGTTGTT
GTCCGGTTCCGCGCTGGCGGCGGACATCCCGCTGCGCGACTTTTTCCGCAATCCCGAGCAAAGCAACTTCACGGTGTCGC
CGGACGGCAGGAGCGTGGCCTTCCTGTCGCCGTGGGAGTCGAGGCGCAACATCGTGGTGCGCCGCCCCGGCCAGCCCGAC
AAGCGCGTCACCGCCATCAAGGACCGCGACCTGTCCGGTTATTTCTGGAAGGGCAACGACCGGCTGGTCTACGTCAAGGA
CAATGCCGGCGACGAGAACTTCCACCTGTACAGCGTGGATCTGAAAAGCGGCAAGACCCGCGACCTGACGCCATTCCCCG
GCGTGCGCGCCGAGATCGTCGACGGCCTGATCGACAACGACAGGCAGCTGTTGATCAGCCTGAACAAGCGCAAGCCGGAG
ATCTTCGACGTCTACCGCATCGACCTGCAAACCGGCCAACTGACGCTGGAAGCGGAAAACCCGGGCAAGGTGGCCAGCTG
GATCACCGATCACAAGGGCAATATCCGCATCGCGATCGAGACCGACGGCGTCAACAACACCGTGTTGTACCGCGACCAGC
CCGGCGGCAAGTTCCGCAAGCTGATGACCACCAATTTCCGCGAGAATTTCACGCCGCTGTTCTTCACCTTCGACAACCAG
CGTTTCTACGCCGCCAGCAGCCTGGGGCGCGACAAGGCCGCCATCGTCGAATACGACCCCAAGACCGGCAAGGAGGCGAA
GGAGATCTACGCGCGCCAGGATGTCGATGTCTCCAGCCTGGACTATTCGCACAAGCGCAAGGTGATCACTTGCGCCGGCT
TCGAAACCGACAAGCCGGGGCGCGAGTGCTTCGATCCGCAAGCGCGCGAACTGTACGCCAGGCTGCAGGCGCATTTCCCG
GGCTACCAGGTGGACATCACCTCCGGCAGCCGCAACGAGGACCGCTTCGTGGTGGCGGCCTGGAGCGACAAGACCCAGGG
CAAGCGCTATCTGTATGACAAGAAGCGCGACAAGCTGACGCTGCTGGCCGAGATCACGCCCTGGCTGCCGGAAGACAAGA
TGGCCAGCATGAAGCCGATCCAGTACCGCAGCCGCGACGGCCTGACCATCAACGGCTACCTGACGCTGCCGCGCGGCAAG
GAGGACGCCAAGGATCTGCCGGTGATCGTCAACCCGCACGGCGGACCGTGGTATCGCGACAGCTGGCGCTTCAATCCGGA
AGTGCAGTTCTTCGCCAGCCGCGGCTGGGCGGTGCTGCAGATGAATTTCCGCGGCTCCACCGGCTATGGCCGCCAGTTCT
GGGAAGCCTCGTTCAAGGAGTGGGGCGGCAAGATGCAGGACGACGTCACCGACGGCGTGGACTGGCTGGTCAAGCAGGGC
GTGGCCGATCCCAAGAAAGTGTGCATCTACGGCGGCAGCTACGGCGGCTACGCGACGCTGTCCGGCATCACCAAGACCCC
GGAGCTGTACCGCTGCGCGGTGGATTACGTCGGGGTGTCCAATCTGTTCACCTTCATGAAGACCATTCCGCCGTACTGGA
AGCCGTTCCTGGATTCGATGTACGAGATGGTGGGTCATCCTGAAAAGGACAAGGAACTGCTGCGCGAGCGCTCGCCGGTG
TTCCATGTCGACCGCATCCAGTCGCCGCTGTTGGTGCTGCAGGGCGCCAAGGATCCGCGCGTCAACATCAACGAGTCCAA
CCAGATCGTCGAGGCGCTGAAGAAGCGCGGCGTGGATGTCGAGTACATCGTCAAGGATAACGAGGGCCACGGCTTCCACA
ACGAGGAAAACCGCTTCGCCGCCTACGGCGCGATGGAGCGGTTCTTCAAGAAATACCTGGACTGA

Upstream 100 bases:

>100_bases
TTTAATCAGTAAAAATTCCATTCGCATGTTGATGATGGATTGCCCTGGCGGTAACATGATTTTTCCGCGCGCATGCCGCG
CTTGGCGCCGGGCCGCAGCG

Downstream 100 bases:

>100_bases
TCGTCCGCTGCGTCAGCCATCTCAGCCCGCCGCCCGGCGGGCTGTTTCGTTTACCGCGTCAGCCAACCCGCCGCCGCGCA
CAGGCCCACCACCAGCCAGG

Product: dipeptidyl anminopeptidase

Products: Hydrolyzed protein [C]

Alternate protein names: NA

Number of amino acids: Translated: 634; Mature: 633

Protein sequence:

>634_residues
MAGFHVLTKKETALKTKTLTVLLASLLSGSALAADIPLRDFFRNPEQSNFTVSPDGRSVAFLSPWESRRNIVVRRPGQPD
KRVTAIKDRDLSGYFWKGNDRLVYVKDNAGDENFHLYSVDLKSGKTRDLTPFPGVRAEIVDGLIDNDRQLLISLNKRKPE
IFDVYRIDLQTGQLTLEAENPGKVASWITDHKGNIRIAIETDGVNNTVLYRDQPGGKFRKLMTTNFRENFTPLFFTFDNQ
RFYAASSLGRDKAAIVEYDPKTGKEAKEIYARQDVDVSSLDYSHKRKVITCAGFETDKPGRECFDPQARELYARLQAHFP
GYQVDITSGSRNEDRFVVAAWSDKTQGKRYLYDKKRDKLTLLAEITPWLPEDKMASMKPIQYRSRDGLTINGYLTLPRGK
EDAKDLPVIVNPHGGPWYRDSWRFNPEVQFFASRGWAVLQMNFRGSTGYGRQFWEASFKEWGGKMQDDVTDGVDWLVKQG
VADPKKVCIYGGSYGGYATLSGITKTPELYRCAVDYVGVSNLFTFMKTIPPYWKPFLDSMYEMVGHPEKDKELLRERSPV
FHVDRIQSPLLVLQGAKDPRVNINESNQIVEALKKRGVDVEYIVKDNEGHGFHNEENRFAAYGAMERFFKKYLD

Sequences:

>Translated_634_residues
MAGFHVLTKKETALKTKTLTVLLASLLSGSALAADIPLRDFFRNPEQSNFTVSPDGRSVAFLSPWESRRNIVVRRPGQPD
KRVTAIKDRDLSGYFWKGNDRLVYVKDNAGDENFHLYSVDLKSGKTRDLTPFPGVRAEIVDGLIDNDRQLLISLNKRKPE
IFDVYRIDLQTGQLTLEAENPGKVASWITDHKGNIRIAIETDGVNNTVLYRDQPGGKFRKLMTTNFRENFTPLFFTFDNQ
RFYAASSLGRDKAAIVEYDPKTGKEAKEIYARQDVDVSSLDYSHKRKVITCAGFETDKPGRECFDPQARELYARLQAHFP
GYQVDITSGSRNEDRFVVAAWSDKTQGKRYLYDKKRDKLTLLAEITPWLPEDKMASMKPIQYRSRDGLTINGYLTLPRGK
EDAKDLPVIVNPHGGPWYRDSWRFNPEVQFFASRGWAVLQMNFRGSTGYGRQFWEASFKEWGGKMQDDVTDGVDWLVKQG
VADPKKVCIYGGSYGGYATLSGITKTPELYRCAVDYVGVSNLFTFMKTIPPYWKPFLDSMYEMVGHPEKDKELLRERSPV
FHVDRIQSPLLVLQGAKDPRVNINESNQIVEALKKRGVDVEYIVKDNEGHGFHNEENRFAAYGAMERFFKKYLD
>Mature_633_residues
AGFHVLTKKETALKTKTLTVLLASLLSGSALAADIPLRDFFRNPEQSNFTVSPDGRSVAFLSPWESRRNIVVRRPGQPDK
RVTAIKDRDLSGYFWKGNDRLVYVKDNAGDENFHLYSVDLKSGKTRDLTPFPGVRAEIVDGLIDNDRQLLISLNKRKPEI
FDVYRIDLQTGQLTLEAENPGKVASWITDHKGNIRIAIETDGVNNTVLYRDQPGGKFRKLMTTNFRENFTPLFFTFDNQR
FYAASSLGRDKAAIVEYDPKTGKEAKEIYARQDVDVSSLDYSHKRKVITCAGFETDKPGRECFDPQARELYARLQAHFPG
YQVDITSGSRNEDRFVVAAWSDKTQGKRYLYDKKRDKLTLLAEITPWLPEDKMASMKPIQYRSRDGLTINGYLTLPRGKE
DAKDLPVIVNPHGGPWYRDSWRFNPEVQFFASRGWAVLQMNFRGSTGYGRQFWEASFKEWGGKMQDDVTDGVDWLVKQGV
ADPKKVCIYGGSYGGYATLSGITKTPELYRCAVDYVGVSNLFTFMKTIPPYWKPFLDSMYEMVGHPEKDKELLRERSPVF
HVDRIQSPLLVLQGAKDPRVNINESNQIVEALKKRGVDVEYIVKDNEGHGFHNEENRFAAYGAMERFFKKYLD

Specific function: Cleaves Peptide Bonds On The C-Terminal Side Of Lysyl And Argininyl Residues. [C]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI23510451, Length=243, Percent_Identity=27.9835390946502, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI194394146, Length=332, Percent_Identity=24.3975903614458, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI18765694, Length=242, Percent_Identity=23.1404958677686, Blast_Score=70, Evalue=8e-12,
Organism=Homo sapiens, GI16933540, Length=259, Percent_Identity=24.3243243243243, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI18450280, Length=248, Percent_Identity=25.4032258064516, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI37577089, Length=248, Percent_Identity=25.4032258064516, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI25144537, Length=641, Percent_Identity=29.3291731669267, Blast_Score=281, Evalue=7e-76,
Organism=Caenorhabditis elegans, GI25144540, Length=428, Percent_Identity=32.4766355140187, Blast_Score=233, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI25144543, Length=550, Percent_Identity=28, Blast_Score=213, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17552908, Length=208, Percent_Identity=34.1346153846154, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI25149159, Length=262, Percent_Identity=33.206106870229, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17564634, Length=250, Percent_Identity=23.6, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17564632, Length=250, Percent_Identity=23.6, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17550672, Length=411, Percent_Identity=23.8442822384428, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17508019, Length=307, Percent_Identity=24.7557003257329, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17508017, Length=307, Percent_Identity=24.7557003257329, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011042
- InterPro:   IPR011659
- InterPro:   IPR001375 [H]

Pfam domain/function: PF07676 PD40; PF00326 Peptidase_S9 [H]

EC number: 3.4.21.83 [C]

Molecular weight: Translated: 72443; Mature: 72312

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGFHVLTKKETALKTKTLTVLLASLLSGSALAADIPLRDFFRNPEQSNFTVSPDGRSVA
CCCCEEEECCCHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHCCCCCCCEEECCCCCEEE
FLSPWESRRNIVVRRPGQPDKRVTAIKDRDLSGYFWKGNDRLVYVKDNAGDENFHLYSVD
EECCCCCCCCEEEECCCCCCCCEEEEECCCCCCEEECCCCEEEEEECCCCCCCEEEEEEE
LKSGKTRDLTPFPGVRAEIVDGLIDNDRQLLISLNKRKPEIFDVYRIDLQTGQLTLEAEN
ECCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEEEEEECEEEEEECC
PGKVASWITDHKGNIRIAIETDGVNNTVLYRDQPGGKFRKLMTTNFRENFTPLFFTFDNQ
CCCHHHHHCCCCCCEEEEEEECCCCCEEEEECCCCCHHHHHHHCCCCCCCCEEEEEECCC
RFYAASSLGRDKAAIVEYDPKTGKEAKEIYARQDVDVSSLDYSHKRKVITCAGFETDKPG
EEEEECCCCCCCEEEEEECCCCCCHHHHHHHHCCCCHHHCCCCCCCCEEEEECCCCCCCC
RECFDPQARELYARLQAHFPGYQVDITSGSRNEDRFVVAAWSDKTQGKRYLYDKKRDKLT
HHHCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEECCCCCCCCEECCCCCCCEE
LLAEITPWLPEDKMASMKPIQYRSRDGLTINGYLTLPRGKEDAKDLPVIVNPHGGPWYRD
EEEECCCCCCCCCCCCCCCCEECCCCCEEEEEEEECCCCCCCCCCCCEEECCCCCCCCCC
SWRFNPEVQFFASRGWAVLQMNFRGSTGYGRQFWEASFKEWGGKMQDDVTDGVDWLVKQG
CCEECCCEEEEECCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
VADPKKVCIYGGSYGGYATLSGITKTPELYRCAVDYVGVSNLFTFMKTIPPYWKPFLDSM
CCCCCEEEEECCCCCCEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHH
YEMVGHPEKDKELLRERSPVFHVDRIQSPLLVLQGAKDPRVNINESNQIVEALKKRGVDV
HHHHCCCCHHHHHHHHCCCEEEEHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCE
EYIVKDNEGHGFHNEENRFAAYGAMERFFKKYLD
EEEEECCCCCCCCCCCCCEEHHHHHHHHHHHHCC
>Mature Secondary Structure 
AGFHVLTKKETALKTKTLTVLLASLLSGSALAADIPLRDFFRNPEQSNFTVSPDGRSVA
CCCEEEECCCHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHCCCCCCCEEECCCCCEEE
FLSPWESRRNIVVRRPGQPDKRVTAIKDRDLSGYFWKGNDRLVYVKDNAGDENFHLYSVD
EECCCCCCCCEEEECCCCCCCCEEEEECCCCCCEEECCCCEEEEEECCCCCCCEEEEEEE
LKSGKTRDLTPFPGVRAEIVDGLIDNDRQLLISLNKRKPEIFDVYRIDLQTGQLTLEAEN
ECCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEEEEEECEEEEEECC
PGKVASWITDHKGNIRIAIETDGVNNTVLYRDQPGGKFRKLMTTNFRENFTPLFFTFDNQ
CCCHHHHHCCCCCCEEEEEEECCCCCEEEEECCCCCHHHHHHHCCCCCCCCEEEEEECCC
RFYAASSLGRDKAAIVEYDPKTGKEAKEIYARQDVDVSSLDYSHKRKVITCAGFETDKPG
EEEEECCCCCCCEEEEEECCCCCCHHHHHHHHCCCCHHHCCCCCCCCEEEEECCCCCCCC
RECFDPQARELYARLQAHFPGYQVDITSGSRNEDRFVVAAWSDKTQGKRYLYDKKRDKLT
HHHCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEECCCCCCCCEECCCCCCCEE
LLAEITPWLPEDKMASMKPIQYRSRDGLTINGYLTLPRGKEDAKDLPVIVNPHGGPWYRD
EEEECCCCCCCCCCCCCCCCEECCCCCEEEEEEEECCCCCCCCCCCCEEECCCCCCCCCC
SWRFNPEVQFFASRGWAVLQMNFRGSTGYGRQFWEASFKEWGGKMQDDVTDGVDWLVKQG
CCEECCCEEEEECCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
VADPKKVCIYGGSYGGYATLSGITKTPELYRCAVDYVGVSNLFTFMKTIPPYWKPFLDSM
CCCCCEEEEECCCCCCEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHH
YEMVGHPEKDKELLRERSPVFHVDRIQSPLLVLQGAKDPRVNINESNQIVEALKKRGVDV
HHHHCCCCHHHHHHHHCCCEEEEHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCE
EYIVKDNEGHGFHNEENRFAAYGAMERFFKKYLD
EEEEECCCCCCCCCCCCCEEHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Ca2+ [C]

Kcat value (1/min): 11820 [C]

Specific activity: NA

Km value (mM): 0.92 {benzoyl-Lys} 0.6 {N-benzoyl-Arg} 0.23 {tosyl-Arg} 0.5 {benzoyl-Arg} 0.48 {benzoyl-Arg} 0.25 {benzoyl-Arg} 0.33 {N-benzyloxycarbonyl-Lys} 0.31 {N-benzyloxycarbonyl-Lys} 80 {acetyl-tyrosine} 0.47 {tosyl-Lys-methyl} [C]

Substrates: Protein; H2O [C]

Specific reaction: Protein + H2O = hydrolyzed protein [C]

General reaction: Peptide bond hydrolysis [C]

Inhibitor: Antipain; Aromaticamidines; Benzamidine; Co2+; DFP; Fe2+; Hg2+; L-Arginine; Leupeptin sulfhydryl agents, trypsin inhibitors, 1, 10-phenanthroline; p-Aminobenzamidine; Tosyl -Leuchloromethyl ketone; Zn2+ [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 3098560 [H]