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The map label for this gene is ppx [H]

Identifier: 34496717

GI number: 34496717

Start: 1325869

End: 1327362

Strand: Direct

Name: ppx [H]

Synonym: CV_1262

Alternate gene names: 34496717

Gene position: 1325869-1327362 (Clockwise)

Preceding gene: 34496716

Following gene: 34496718

Centisome position: 27.91

GC content: 67.54

Gene sequence:

>1494_bases
TTGACACACGCCACGCCCCCGCACACCGTGCTGGCCACTATAGACCTGGGTTCCAACAGCTTCCGGCTGCAAGTGTCCCG
CGTGGTGGATGACCAGCTGTACGCCCTGGACGTGATGAAGGAGACCGTGCGCCTGGGCGCCGGCCTCACCGCCGACAAAC
ACCTGGATGACGACACCCAAGCGCGCGCGCTGGCCTGCCTGGCCCGCTTCGGCGAGCGGCTGCGCGGCTTCGTGCCGGCC
CAGGTGCGGGTGGTCGGCACCAATACCCTGCGCGTGGCGAAGAACGCGCCGGCCTTCATCGCCGAGGCCGAGGAGAGGCT
GGGCTTCCCGATCGAGGTGATCGCCGGCCGCGAAGAGGCGCGGCTGATCTACCTGGGCGCCGCCCACTCGCTGCCGGACA
CCAAGGAGCGCCGGATGGTGGTGGATATCGGCGGCGGCTCCACCGAATTCATCATCGGCAGCCATTACAAGGCGCTGGTC
ACCGAGAGCCTGCCGCTCGGCTGCGTCAGCTACACGCTGCGCTTCTTCCCGGAGGGCAAGCTGACCCGCGGCAACTTCCG
CGACGCCACCATGGCGGCCCGCAACGAGATCCAGCGCATCCGCCACGAGTACCGTCCCAGCGAGTGGCAGCTCGCCGTCG
GCACTTCCGGCACCGCGCGCTCGCTGCGCGACGTGCTGGAGATCAACGACTGGAGCCGGGCGGACATCACGCTGGCGGGC
ATGGAGCAGCTGCGCGAAGTGCTGATCAAGCAAGGCAATATCGACTCGATCAAGGTCAACGGCCTCAAGGCCGACCGCGC
GCCGGTGCTGGCCGGCGGCCTCGCCATCATGATCGCGGTGTTCGAAGAGCTGGAAATCGAGAAGATGATCGTCACCGAGG
GCGCGCTGCGCGACGGCGTGCTCTACGACCTGCTGGGCCGCCAGCGCGAGAAGGACATGCGCGACAGCACGGTGGCGCTG
TTCAAGCGCCGCTACCACGCCGATACCCAGCAGGCCGAGCGCGTCAACCTGCTGGCCGAACGCCTGTACCGGATGCTGGC
CGGCGAAGACGTCGACCAGGACATGCTGAAGCGCCTGTCCTGGGCGGCCAAGCTGCACGAGATCGGCCTGACCATCGCCC
ACACCGCCTATCACAAGCATTCCGCCTACATCCTGCAGAACGCCGACATGCCCGGCTTCTCCAAGCGCGAGCAAGCCACG
CTGTCCGCCATCGTGCTGGGCCACCGCGGCGACATGGGCAAGATGGCGCAGTACATCAGCCAGCCGGCGCTGTGGCAGGC
GGTGGTGGCGCTGCGGCTGGCCGTGCTGTTCTACCGCAGCCGGATCAACGTCGTCCTGCCGGACGAACTGGACCTGCGGC
AGCACGCCCGCGGCTTCACGCTGTCGCTGAGCGGCGACTGGCTGGAGGCCAATCCGCTGTCCGCCAGCAGCTTCCGCCAG
GAAGTGAACCAGTGGAAGAATGTCGGCTTCCAGCTCGACATCGTGCAGAAATAG

Upstream 100 bases:

>100_bases
AACATCTCGCGGTTACCGCCATTTTGCTTGCCGGGCGCGCCGGGCGATGTTCGCCCCGAGGCGGCCCCGCGGGCGCAACC
GAACAAGAAAAGGGGTGTCC

Downstream 100 bases:

>100_bases
GCTGCCGATGCGCCATCCGGAATTGAAGGAAAGGCTGCCGACGCTGGGGGAGCAGGCGGGAACGCTGCTGTCGGTGGGCG
ATGCCAAGCACGCCGGCACC

Product: exopolyphosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MTHATPPHTVLATIDLGSNSFRLQVSRVVDDQLYALDVMKETVRLGAGLTADKHLDDDTQARALACLARFGERLRGFVPA
QVRVVGTNTLRVAKNAPAFIAEAEERLGFPIEVIAGREEARLIYLGAAHSLPDTKERRMVVDIGGGSTEFIIGSHYKALV
TESLPLGCVSYTLRFFPEGKLTRGNFRDATMAARNEIQRIRHEYRPSEWQLAVGTSGTARSLRDVLEINDWSRADITLAG
MEQLREVLIKQGNIDSIKVNGLKADRAPVLAGGLAIMIAVFEELEIEKMIVTEGALRDGVLYDLLGRQREKDMRDSTVAL
FKRRYHADTQQAERVNLLAERLYRMLAGEDVDQDMLKRLSWAAKLHEIGLTIAHTAYHKHSAYILQNADMPGFSKREQAT
LSAIVLGHRGDMGKMAQYISQPALWQAVVALRLAVLFYRSRINVVLPDELDLRQHARGFTLSLSGDWLEANPLSASSFRQ
EVNQWKNVGFQLDIVQK

Sequences:

>Translated_497_residues
MTHATPPHTVLATIDLGSNSFRLQVSRVVDDQLYALDVMKETVRLGAGLTADKHLDDDTQARALACLARFGERLRGFVPA
QVRVVGTNTLRVAKNAPAFIAEAEERLGFPIEVIAGREEARLIYLGAAHSLPDTKERRMVVDIGGGSTEFIIGSHYKALV
TESLPLGCVSYTLRFFPEGKLTRGNFRDATMAARNEIQRIRHEYRPSEWQLAVGTSGTARSLRDVLEINDWSRADITLAG
MEQLREVLIKQGNIDSIKVNGLKADRAPVLAGGLAIMIAVFEELEIEKMIVTEGALRDGVLYDLLGRQREKDMRDSTVAL
FKRRYHADTQQAERVNLLAERLYRMLAGEDVDQDMLKRLSWAAKLHEIGLTIAHTAYHKHSAYILQNADMPGFSKREQAT
LSAIVLGHRGDMGKMAQYISQPALWQAVVALRLAVLFYRSRINVVLPDELDLRQHARGFTLSLSGDWLEANPLSASSFRQ
EVNQWKNVGFQLDIVQK
>Mature_496_residues
THATPPHTVLATIDLGSNSFRLQVSRVVDDQLYALDVMKETVRLGAGLTADKHLDDDTQARALACLARFGERLRGFVPAQ
VRVVGTNTLRVAKNAPAFIAEAEERLGFPIEVIAGREEARLIYLGAAHSLPDTKERRMVVDIGGGSTEFIIGSHYKALVT
ESLPLGCVSYTLRFFPEGKLTRGNFRDATMAARNEIQRIRHEYRPSEWQLAVGTSGTARSLRDVLEINDWSRADITLAGM
EQLREVLIKQGNIDSIKVNGLKADRAPVLAGGLAIMIAVFEELEIEKMIVTEGALRDGVLYDLLGRQREKDMRDSTVALF
KRRYHADTQQAERVNLLAERLYRMLAGEDVDQDMLKRLSWAAKLHEIGLTIAHTAYHKHSAYILQNADMPGFSKREQATL
SAIVLGHRGDMGKMAQYISQPALWQAVVALRLAVLFYRSRINVVLPDELDLRQHARGFTLSLSGDWLEANPLSASSFRQE
VNQWKNVGFQLDIVQK

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=499, Percent_Identity=37.6753507014028, Blast_Score=332, Evalue=2e-92,
Organism=Escherichia coli, GI48994966, Length=487, Percent_Identity=37.1663244353183, Blast_Score=306, Evalue=3e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 55539; Mature: 55407

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHATPPHTVLATIDLGSNSFRLQVSRVVDDQLYALDVMKETVRLGAGLTADKHLDDDTQ
CCCCCCCCEEEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
ARALACLARFGERLRGFVPAQVRVVGTNTLRVAKNAPAFIAEAEERLGFPIEVIAGREEA
HHHHHHHHHHHHHHCCCCCCEEEEEECCEEEEECCCCHHHHHHHHHCCCCEEEEECCCCC
RLIYLGAAHSLPDTKERRMVVDIGGGSTEFIIGSHYKALVTESLPLGCVSYTLRFFPEGK
EEEEEECCCCCCCCCCCEEEEEECCCCEEEEEECCHHHHHHCCCCCHHHHHHHHHCCCCC
LTRGNFRDATMAARNEIQRIRHEYRPSEWQLAVGTSGTARSLRDVLEINDWSRADITLAG
CCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCEEHHH
MEQLREVLIKQGNIDSIKVNGLKADRAPVLAGGLAIMIAVFEELEIEKMIVTEGALRDGV
HHHHHHHHHHCCCCCEEEECCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCH
LYDLLGRQREKDMRDSTVALFKRRYHADTQQAERVNLLAERLYRMLAGEDVDQDMLKRLS
HHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
WAAKLHEIGLTIAHTAYHKHSAYILQNADMPGFSKREQATLSAIVLGHRGDMGKMAQYIS
HHHHHHHCCEEEEEHHHHCCCEEEEECCCCCCCCCHHHHHEEEEEEECCCCHHHHHHHHC
QPALWQAVVALRLAVLFYRSRINVVLPDELDLRQHARGFTLSLSGDWLEANPLSASSFRQ
CCHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHCCCEEEEECCCEEECCCCCHHHHHH
EVNQWKNVGFQLDIVQK
HHHHHHCCCEEEEEECC
>Mature Secondary Structure 
THATPPHTVLATIDLGSNSFRLQVSRVVDDQLYALDVMKETVRLGAGLTADKHLDDDTQ
CCCCCCCEEEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
ARALACLARFGERLRGFVPAQVRVVGTNTLRVAKNAPAFIAEAEERLGFPIEVIAGREEA
HHHHHHHHHHHHHHCCCCCCEEEEEECCEEEEECCCCHHHHHHHHHCCCCEEEEECCCCC
RLIYLGAAHSLPDTKERRMVVDIGGGSTEFIIGSHYKALVTESLPLGCVSYTLRFFPEGK
EEEEEECCCCCCCCCCCEEEEEECCCCEEEEEECCHHHHHHCCCCCHHHHHHHHHCCCCC
LTRGNFRDATMAARNEIQRIRHEYRPSEWQLAVGTSGTARSLRDVLEINDWSRADITLAG
CCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCEEHHH
MEQLREVLIKQGNIDSIKVNGLKADRAPVLAGGLAIMIAVFEELEIEKMIVTEGALRDGV
HHHHHHHHHHCCCCCEEEECCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCH
LYDLLGRQREKDMRDSTVALFKRRYHADTQQAERVNLLAERLYRMLAGEDVDQDMLKRLS
HHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
WAAKLHEIGLTIAHTAYHKHSAYILQNADMPGFSKREQATLSAIVLGHRGDMGKMAQYIS
HHHHHHHCCEEEEEHHHHCCCEEEEECCCCCCCCCHHHHHEEEEEEECCCCHHHHHHHHC
QPALWQAVVALRLAVLFYRSRINVVLPDELDLRQHARGFTLSLSGDWLEANPLSASSFRQ
CCHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHCCCEEEEECCCEEECCCCCHHHHHH
EVNQWKNVGFQLDIVQK
HHHHHHCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]