Click here to switch to the map view.

The map label for this gene is rpiA

Identifier: 34496715

GI number: 34496715

Start: 1324247

End: 1324906

Strand: Direct

Name: rpiA

Synonym: CV_1260

Alternate gene names: 34496715

Gene position: 1324247-1324906 (Clockwise)

Preceding gene: 34496714

Following gene: 34496716

Centisome position: 27.87

GC content: 64.85

Gene sequence:

>660_bases
ATGCTGACCCAGGATCAACTGAAACTCGCCGTCGCCAAGAAGGCGCTGGAATTCGTGCCGGAAGACGCCATCATCGGCGT
GGGCACCGGCAGCACCGTCAACCTGTTCATCGAGGAACTGGCCGGCATCAAGGGTCGCATCAAGGGCGCTGTGTCCAGCT
CGGAGGCTTCCACCGCCCGCCTGAAGGCCCATCATATCCAGGTGTTCGATCTGAACGAAGTGGAGAAACTGTCGGTCTAC
ATCGACGGCGCCGACGAGATCAACCACCACCTGCACATGATCAAGGGCGGCGGCGCGGCGCTGACGCGCGAGAAGATCGT
CGCCGGCGTCGCCGACGAGTTCATCTGCATCGCCGACGAGAAGAAGTACGTGACCATGCTGGGCGCCTTCCCGCTGCCGA
TCGAGGTGATCCCGATGGCGCGCAGCTACGTCGCGCGCGAGCTGGTGAAGCTGGGCGGCCACCCGGAGCTGCGCCAGGGC
GTGACCACCGACAACGGCAACGTGATTCTGGACGTGCACGGCCTGCAGATCATGAAGCCGGTGGAGCTGGAGGAAACCAT
CAACCACATCGCCGGCGTCGTCACCTGCGGCCTGTTCGCCCGCCGCCGCGCCGACGTGCTGCTGCTGGGCAAGCAGGACG
GCGTGGAAGTGCTGCGCTGA

Upstream 100 bases:

>100_bases
GCGGCCAGGCATCATGCCGGCCAAGTCCGCTTGTGGGATAATCGCGCATCCTCGCTCATGCCGGGCATGGGCGGCACAAC
ACCAACCAGGAGGCCTCATC

Downstream 100 bases:

>100_bases
GCGGATGAAACCGATCCGGCCGCCGGGTGGCGGCCGGCTGCCGAAGATGGCATGTCACGGAGCTGTCATCTGACTGTCTT
ACAATTCCCCCTTTCCTGCT

Product: ribose-5-phosphate isomerase A

Products: NA

Alternate protein names: Phosphoriboisomerase A; PRI

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MLTQDQLKLAVAKKALEFVPEDAIIGVGTGSTVNLFIEELAGIKGRIKGAVSSSEASTARLKAHHIQVFDLNEVEKLSVY
IDGADEINHHLHMIKGGGAALTREKIVAGVADEFICIADEKKYVTMLGAFPLPIEVIPMARSYVARELVKLGGHPELRQG
VTTDNGNVILDVHGLQIMKPVELEETINHIAGVVTCGLFARRRADVLLLGKQDGVEVLR

Sequences:

>Translated_219_residues
MLTQDQLKLAVAKKALEFVPEDAIIGVGTGSTVNLFIEELAGIKGRIKGAVSSSEASTARLKAHHIQVFDLNEVEKLSVY
IDGADEINHHLHMIKGGGAALTREKIVAGVADEFICIADEKKYVTMLGAFPLPIEVIPMARSYVARELVKLGGHPELRQG
VTTDNGNVILDVHGLQIMKPVELEETINHIAGVVTCGLFARRRADVLLLGKQDGVEVLR
>Mature_219_residues
MLTQDQLKLAVAKKALEFVPEDAIIGVGTGSTVNLFIEELAGIKGRIKGAVSSSEASTARLKAHHIQVFDLNEVEKLSVY
IDGADEINHHLHMIKGGGAALTREKIVAGVADEFICIADEKKYVTMLGAFPLPIEVIPMARSYVARELVKLGGHPELRQG
VTTDNGNVILDVHGLQIMKPVELEETINHIAGVVTCGLFARRRADVLLLGKQDGVEVLR

Specific function: Nonoxidative branch of the pentose phosphate pathway. [C]

COG id: COG0120

COG function: function code G; Ribose 5-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose 5-phosphate isomerase family

Homologues:

Organism=Homo sapiens, GI94536842, Length=236, Percent_Identity=36.4406779661017, Blast_Score=111, Evalue=5e-25,
Organism=Escherichia coli, GI1789280, Length=217, Percent_Identity=65.4377880184332, Blast_Score=290, Evalue=4e-80,
Organism=Caenorhabditis elegans, GI17551758, Length=202, Percent_Identity=36.6336633663366, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324669, Length=216, Percent_Identity=32.4074074074074, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281364072, Length=203, Percent_Identity=34.9753694581281, Blast_Score=93, Evalue=2e-19,

Paralogues:

None

Copy number: 740 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): RPIA_CHRVO (Q7NYL4)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_900930.1
- ProteinModelPortal:   Q7NYL4
- SMR:   Q7NYL4
- GeneID:   2550751
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_1260
- NMPDR:   fig|243365.1.peg.1260
- HOGENOM:   HBG515603
- OMA:   VFDLNSV
- PhylomeDB:   Q7NYL4
- ProtClustDB:   PRK00702
- BioCyc:   CVIO243365:CV_1260-MONOMER
- BRENDA:   5.3.1.6
- HAMAP:   MF_00170
- InterPro:   IPR004788
- InterPro:   IPR020672
- PANTHER:   PTHR11934
- TIGRFAMs:   TIGR00021

Pfam domain/function: PF06026 Rib_5-P_isom_A

EC number: =5.3.1.6

Molecular weight: Translated: 23677; Mature: 23677

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTQDQLKLAVAKKALEFVPEDAIIGVGTGSTVNLFIEELAGIKGRIKGAVSSSEASTAR
CCCHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHCCCCCEEECCCCCCCCHHHE
LKAHHIQVFDLNEVEKLSVYIDGADEINHHLHMIKGGGAALTREKIVAGVADEFICIADE
EEEEEEEEEECCCCEEEEEEECCHHHCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEECC
KKYVTMLGAFPLPIEVIPMARSYVARELVKLGGHPELRQGVTTDNGNVILDVHGLQIMKP
CEEEEEECCCCCCEEEEHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEEECCCEEECC
VELEETINHIAGVVTCGLFARRRADVLLLGKQDGVEVLR
CCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHCC
>Mature Secondary Structure
MLTQDQLKLAVAKKALEFVPEDAIIGVGTGSTVNLFIEELAGIKGRIKGAVSSSEASTAR
CCCHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHCCCCCEEECCCCCCCCHHHE
LKAHHIQVFDLNEVEKLSVYIDGADEINHHLHMIKGGGAALTREKIVAGVADEFICIADE
EEEEEEEEEECCCCEEEEEEECCHHHCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEECC
KKYVTMLGAFPLPIEVIPMARSYVARELVKLGGHPELRQGVTTDNGNVILDVHGLQIMKP
CEEEEEECCCCCCEEEEHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEEECCCEEECC
VELEETINHIAGVVTCGLFARRRADVLLLGKQDGVEVLR
CCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782