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The map label for this gene is dtd

Identifier: 34496706

GI number: 34496706

Start: 1316511

End: 1316963

Strand: Direct

Name: dtd

Synonym: CV_1251

Alternate gene names: 34496706

Gene position: 1316511-1316963 (Clockwise)

Preceding gene: 34496702

Following gene: 34496707

Centisome position: 27.71

GC content: 67.55

Gene sequence:

>453_bases
ATGCGGGTGTTGGTGCAGAGAGTGAGCCAGGCGGCGGTGACGGTGGATGGACAAACCAGCGGAGAGATCGGCGCGGGCGC
GCTGCTGCTGGTGGGGATCGAGGAGTCGGACGGCCCGGACGACATCGGCTGGCTGGTGCGCAAGATCAGCCAGCTGCGCA
TCTTCAACGACGAGGCCGGGGTGATGAACCGCAGCCTGATCGATTGCGGCGGCGAGGCGCTGGCGGTCAGCCAGTTCACG
CTGCACGCCAGCGTGAAGAAGGGCAACCGCCCATCGTATTCGCGCGCCGCGCGCGGCGAAATCTCGAGGCCTTTGTTCGA
CCGCTTCGTCGCGGAGCTGTCCGCCGCGCTGGGCAAGACCGTCCCAACCGGGGTGTTCGGCGCGGACATGCGGGTCAGCC
TGGTCAATGACGGGCCGGTCACCATCTGGCTGGACAGCCGGAATCCGGAGTAG

Upstream 100 bases:

>100_bases
CTTTTCTTGAACTGGCGCTATTGTACCCGCGCGCGGCGGCTCGCGTCCGTCGCGAAGGAATGGGTAGAATGAAACCAGTA
TCGCGAAGAGGAATGCAGGC

Downstream 100 bases:

>100_bases
GGCGATGGGCGGGAGGTGGCAGCATCCGTGGCGGGTTCTGGTGGTGCCCTATTATTTGAACCGCTACGCGCGCCAGGTGC
ACGTGCTGAGAGTGGCGTTG

Product: D-tyrosyl-tRNA(Tyr) deacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 150; Mature: 150

Protein sequence:

>150_residues
MRVLVQRVSQAAVTVDGQTSGEIGAGALLLVGIEESDGPDDIGWLVRKISQLRIFNDEAGVMNRSLIDCGGEALAVSQFT
LHASVKKGNRPSYSRAARGEISRPLFDRFVAELSAALGKTVPTGVFGADMRVSLVNDGPVTIWLDSRNPE

Sequences:

>Translated_150_residues
MRVLVQRVSQAAVTVDGQTSGEIGAGALLLVGIEESDGPDDIGWLVRKISQLRIFNDEAGVMNRSLIDCGGEALAVSQFT
LHASVKKGNRPSYSRAARGEISRPLFDRFVAELSAALGKTVPTGVFGADMRVSLVNDGPVTIWLDSRNPE
>Mature_150_residues
MRVLVQRVSQAAVTVDGQTSGEIGAGALLLVGIEESDGPDDIGWLVRKISQLRIFNDEAGVMNRSLIDCGGEALAVSQFT
LHASVKKGNRPSYSRAARGEISRPLFDRFVAELSAALGKTVPTGVFGADMRVSLVNDGPVTIWLDSRNPE

Specific function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine

COG id: COG1490

COG function: function code J; D-Tyr-tRNAtyr deacylase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DTD family

Homologues:

Organism=Homo sapiens, GI30795227, Length=151, Percent_Identity=41.0596026490066, Blast_Score=106, Evalue=9e-24,
Organism=Escherichia coli, GI1790320, Length=144, Percent_Identity=47.2222222222222, Blast_Score=129, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI115533292, Length=150, Percent_Identity=37.3333333333333, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6319982, Length=148, Percent_Identity=43.9189189189189, Blast_Score=122, Evalue=2e-29,
Organism=Drosophila melanogaster, GI281361569, Length=151, Percent_Identity=43.7086092715232, Blast_Score=115, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTD_CHRVO (Q7NYM3)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_900921.1
- ProteinModelPortal:   Q7NYM3
- SMR:   Q7NYM3
- GeneID:   2550689
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_1251
- NMPDR:   fig|243365.1.peg.1251
- HOGENOM:   HBG286048
- OMA:   MKAVIQR
- PhylomeDB:   Q7NYM3
- ProtClustDB:   PRK05273
- BioCyc:   CVIO243365:CV_1251-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00518
- InterPro:   IPR003732
- Gene3D:   G3DSA:3.50.80.10
- PANTHER:   PTHR10472
- TIGRFAMs:   TIGR00256

Pfam domain/function: PF02580 Tyr_Deacylase; SSF69500 DTyrtRNA_deacyls

EC number: NA

Molecular weight: Translated: 16010; Mature: 16010

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: ACT_SITE 80-80

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLVQRVSQAAVTVDGQTSGEIGAGALLLVGIEESDGPDDIGWLVRKISQLRIFNDEAG
CHHHHHHHHHHEEEECCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHEEECCCCC
VMNRSLIDCGGEALAVSQFTLHASVKKGNRPSYSRAARGEISRPLFDRFVAELSAALGKT
CCCCHHHHCCCCEEEEEEEEEEEEECCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCCC
VPTGVFGADMRVSLVNDGPVTIWLDSRNPE
CCCCCCCCCEEEEEECCCCEEEEECCCCCC
>Mature Secondary Structure
MRVLVQRVSQAAVTVDGQTSGEIGAGALLLVGIEESDGPDDIGWLVRKISQLRIFNDEAG
CHHHHHHHHHHEEEECCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHEEECCCCC
VMNRSLIDCGGEALAVSQFTLHASVKKGNRPSYSRAARGEISRPLFDRFVAELSAALGKT
CCCCHHHHCCCCEEEEEEEEEEEEECCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCCC
VPTGVFGADMRVSLVNDGPVTIWLDSRNPE
CCCCCCCCCEEEEEECCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782