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The map label for this gene is fumC

Identifier: 34496575

GI number: 34496575

Start: 1171180

End: 1172565

Strand: Reverse

Name: fumC

Synonym: CV_1120

Alternate gene names: 34496575

Gene position: 1172565-1171180 (Counterclockwise)

Preceding gene: 34496585

Following gene: 34496570

Centisome position: 24.68

GC content: 69.84

Gene sequence:

>1386_bases
ATGACGAAAACCGTACGCAGCGAAACCGACACCTTCGGTCCGATCGACGTCCCCGCCGCTGCGCTGTGGGGGGCGCAGAC
CCAGCGCTCGCTGGCGCATTTCCGCATTTCCAGCGAGAAGATGCCGCCGGAGCTGATCCTGGCGCTGGCTCGGGTCAAGC
GCGCCTGCGCCGAGGCCAACCGCGGGCTGGGCAAGCTGGACGACGCCAAGGCCGCCGCCATCGCCGGCGCGGCCGACGAG
GTGCTGGCGGGCCGACACGACGGCGAGTTTCCGCTGTCGGTGTGGCAGACCGGCTCCGGCACCCAGAGCAATATGAATAT
GAACGAGGTGCTGGCCAACCGCGCGTCGGAGCTGCTGGGCGGCCGGCGCGGGCCGGGCCGGCTGGTCCATCCCAACGACG
ACGTCAATCTCGGCCAGTCGTCCAACGACATCTTCCCCACCGCGATGCACGTCGCCGCCGCCACGCAGGTCAAGGAACGG
CTGCTGCCGTCGCTGGATCTGCTGCGCCACGCGCTCGAATCCAAAGCCGAAGCCTTCGCCGACGTCGTCAAGATAGGCCG
CACCCATCTGCAGGACGCCACGCCGCTGACGCTGGGCCAGGAGATCTCCGGCTGGGCGGCGCAACTGGCGCTGTCCGAAC
AGGCGGTGCGCGCGGCGCTGCCCATGCTGTGCCAGCTGGCGGTCGGCGGCACCGCGGTGGGCACCGGCCTCAACACCGAT
CCAAGCTTCGGCGCCGCGGTGGCGGCGCGCCTGGCCGAGCAAAGCGGCCTGCCATTCGAAAGCGCCGGCAACAAATTCGC
CGCGCTGGCCGGCCACGAGCCGCTCGTGTTCGCCCACGGCGCGCTGAAAACGCTGGCCGCCGCGCTGATGAAGATCGCCA
ACGACATCCGCTGGCTGGCTTCCGGCCCGCGCAGCGGCCTGGGCGAGCTGTCGCTGCCGGAGAACGAGCCGGGCAGCTCC
ATCATGCCGGGCAAGGTCAACCCCACCCAGTGCGAAGCGATGACCATGCTGTGCTGCCAGGTGCTGGGCAACGACGCGGC
GCTGGCCATCGGCGCCGCGTCCGGCAATTTCGAACTGAACGTGTTCAAGCCGCTGATCGCGCACAACTTCCTGCAAAGCG
CGCGGCTGCTGGCAGACGGCATGGACAGCCTGCGCGAGCACTGCGTGGACGGCATGGAAGCCAACCGCGCGCGCATCGCC
GAACTGATGGCGCGCTCGCTGATGCTGGTCACCGCGCTGAACCCGCACATCGGCTACGACAAGGCGGCCGCCATCGCCAA
ACACGCCCATCGCCACGGCACCACGCTGCGCGAGGCGGCGCTGGCGCTGGGCCACCTGAGCGCCGAGCAGTTCGACGCCT
GGGTGCGGCCGGAAGACATGGTGTGA

Upstream 100 bases:

>100_bases
GCGGATGGGAAGGCGTCCGCCGCCAGAATCTGACATCCTGCGTCAGGATAGATTAGGACCGGCCCCGCCGGCGCAAGTTC
GACCCGAAAAGGATGATGGC

Downstream 100 bases:

>100_bases
GCGGCGGGCCCTGCCGGACGGGAAGACGGGAGCCGATGGCCCTGCCGGGCCGGTCTCCCGTCGGGCAGCCCAGGCGAGTC
AAGCCGTCATCCGCGCGGCG

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MTKTVRSETDTFGPIDVPAAALWGAQTQRSLAHFRISSEKMPPELILALARVKRACAEANRGLGKLDDAKAAAIAGAADE
VLAGRHDGEFPLSVWQTGSGTQSNMNMNEVLANRASELLGGRRGPGRLVHPNDDVNLGQSSNDIFPTAMHVAAATQVKER
LLPSLDLLRHALESKAEAFADVVKIGRTHLQDATPLTLGQEISGWAAQLALSEQAVRAALPMLCQLAVGGTAVGTGLNTD
PSFGAAVAARLAEQSGLPFESAGNKFAALAGHEPLVFAHGALKTLAAALMKIANDIRWLASGPRSGLGELSLPENEPGSS
IMPGKVNPTQCEAMTMLCCQVLGNDAALAIGAASGNFELNVFKPLIAHNFLQSARLLADGMDSLREHCVDGMEANRARIA
ELMARSLMLVTALNPHIGYDKAAAIAKHAHRHGTTLREAALALGHLSAEQFDAWVRPEDMV

Sequences:

>Translated_461_residues
MTKTVRSETDTFGPIDVPAAALWGAQTQRSLAHFRISSEKMPPELILALARVKRACAEANRGLGKLDDAKAAAIAGAADE
VLAGRHDGEFPLSVWQTGSGTQSNMNMNEVLANRASELLGGRRGPGRLVHPNDDVNLGQSSNDIFPTAMHVAAATQVKER
LLPSLDLLRHALESKAEAFADVVKIGRTHLQDATPLTLGQEISGWAAQLALSEQAVRAALPMLCQLAVGGTAVGTGLNTD
PSFGAAVAARLAEQSGLPFESAGNKFAALAGHEPLVFAHGALKTLAAALMKIANDIRWLASGPRSGLGELSLPENEPGSS
IMPGKVNPTQCEAMTMLCCQVLGNDAALAIGAASGNFELNVFKPLIAHNFLQSARLLADGMDSLREHCVDGMEANRARIA
ELMARSLMLVTALNPHIGYDKAAAIAKHAHRHGTTLREAALALGHLSAEQFDAWVRPEDMV
>Mature_460_residues
TKTVRSETDTFGPIDVPAAALWGAQTQRSLAHFRISSEKMPPELILALARVKRACAEANRGLGKLDDAKAAAIAGAADEV
LAGRHDGEFPLSVWQTGSGTQSNMNMNEVLANRASELLGGRRGPGRLVHPNDDVNLGQSSNDIFPTAMHVAAATQVKERL
LPSLDLLRHALESKAEAFADVVKIGRTHLQDATPLTLGQEISGWAAQLALSEQAVRAALPMLCQLAVGGTAVGTGLNTDP
SFGAAVAARLAEQSGLPFESAGNKFAALAGHEPLVFAHGALKTLAAALMKIANDIRWLASGPRSGLGELSLPENEPGSSI
MPGKVNPTQCEAMTMLCCQVLGNDAALAIGAASGNFELNVFKPLIAHNFLQSARLLADGMDSLREHCVDGMEANRARIAE
LMARSLMLVTALNPHIGYDKAAAIAKHAHRHGTTLREAALALGHLSAEQFDAWVRPEDMV

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily

Homologues:

Organism=Homo sapiens, GI19743875, Length=460, Percent_Identity=60, Blast_Score=545, Evalue=1e-155,
Organism=Homo sapiens, GI266458395, Length=66, Percent_Identity=48.4848484848485, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1787896, Length=458, Percent_Identity=69.2139737991266, Blast_Score=634, Evalue=0.0,
Organism=Escherichia coli, GI87082375, Length=464, Percent_Identity=38.1465517241379, Blast_Score=328, Evalue=6e-91,
Organism=Caenorhabditis elegans, GI17553882, Length=459, Percent_Identity=60.7843137254902, Blast_Score=561, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI32565146, Length=325, Percent_Identity=63.6923076923077, Blast_Score=427, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6324993, Length=463, Percent_Identity=56.3714902807775, Blast_Score=531, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24640179, Length=463, Percent_Identity=57.8833693304536, Blast_Score=557, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24640177, Length=463, Percent_Identity=57.8833693304536, Blast_Score=556, Evalue=1e-158,
Organism=Drosophila melanogaster, GI78710009, Length=460, Percent_Identity=56.9565217391304, Blast_Score=539, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24662684, Length=466, Percent_Identity=57.5107296137339, Blast_Score=531, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24583245, Length=460, Percent_Identity=50, Blast_Score=452, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FUMC_CHRVO (Q7NZ02)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_900790.1
- ProteinModelPortal:   Q7NZ02
- SMR:   Q7NZ02
- GeneID:   2550480
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_1120
- NMPDR:   fig|243365.1.peg.1120
- HOGENOM:   HBG284369
- OMA:   AGHEPLT
- PhylomeDB:   Q7NZ02
- ProtClustDB:   PRK00485
- BioCyc:   CVIO243365:CV_1120-MONOMER
- BRENDA:   4.2.1.2
- HAMAP:   MF_00743
- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00979

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.2.1.2

Molecular weight: Translated: 48610; Mature: 48479

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: BINDING 101-101

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTVRSETDTFGPIDVPAAALWGAQTQRSLAHFRISSEKMPPELILALARVKRACAEAN
CCCCCCCCCCCCCCCCCCHHHHHCHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHH
RGLGKLDDAKAAAIAGAADEVLAGRHDGEFPLSVWQTGSGTQSNMNMNEVLANRASELLG
CCCCCCCHHHHHHHHCCHHHHHHCCCCCCCCHHEEECCCCCCCCCCHHHHHHHHHHHHHC
GRRGPGRLVHPNDDVNLGQSSNDIFPTAMHVAAATQVKERLLPSLDLLRHALESKAEAFA
CCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
DVVKIGRTHLQDATPLTLGQEISGWAAQLALSEQAVRAALPMLCQLAVGGTAVGTGLNTD
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCC
PSFGAAVAARLAEQSGLPFESAGNKFAALAGHEPLVFAHGALKTLAAALMKIANDIRWLA
CCHHHHHHHHHHHHCCCCHHHCCCCEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
SGPRSGLGELSLPENEPGSSIMPGKVNPTQCEAMTMLCCQVLGNDAALAIGAASGNFELN
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEE
VFKPLIAHNFLQSARLLADGMDSLREHCVDGMEANRARIAELMARSLMLVTALNPHIGYD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCH
KAAAIAKHAHRHGTTLREAALALGHLSAEQFDAWVRPEDMV
HHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHCCCCCCCCC
>Mature Secondary Structure 
TKTVRSETDTFGPIDVPAAALWGAQTQRSLAHFRISSEKMPPELILALARVKRACAEAN
CCCCCCCCCCCCCCCCCHHHHHCHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHH
RGLGKLDDAKAAAIAGAADEVLAGRHDGEFPLSVWQTGSGTQSNMNMNEVLANRASELLG
CCCCCCCHHHHHHHHCCHHHHHHCCCCCCCCHHEEECCCCCCCCCCHHHHHHHHHHHHHC
GRRGPGRLVHPNDDVNLGQSSNDIFPTAMHVAAATQVKERLLPSLDLLRHALESKAEAFA
CCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
DVVKIGRTHLQDATPLTLGQEISGWAAQLALSEQAVRAALPMLCQLAVGGTAVGTGLNTD
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCC
PSFGAAVAARLAEQSGLPFESAGNKFAALAGHEPLVFAHGALKTLAAALMKIANDIRWLA
CCHHHHHHHHHHHHCCCCHHHCCCCEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
SGPRSGLGELSLPENEPGSSIMPGKVNPTQCEAMTMLCCQVLGNDAALAIGAASGNFELN
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEE
VFKPLIAHNFLQSARLLADGMDSLREHCVDGMEANRARIAELMARSLMLVTALNPHIGYD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCH
KAAAIAKHAHRHGTTLREAALALGHLSAEQFDAWVRPEDMV
HHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782