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The map label for this gene is fruB(HI) [H]

Identifier: 34496435

GI number: 34496435

Start: 1014979

End: 1017492

Strand: Reverse

Name: fruB(HI) [H]

Synonym: CV_0980

Alternate gene names: 34496435

Gene position: 1017492-1014979 (Counterclockwise)

Preceding gene: 34496436

Following gene: 34496434

Centisome position: 21.42

GC content: 69.45

Gene sequence:

>2514_bases
ATGGGCACCATCGCACCAAGACTAGACGTTCTGGCCCCCCTATCCGGGTGGCTGGTCCCCTTGGACAGCGTTCCGGACCC
GGTGTTCGCCGGCAAGATGGTTGGCGACGGCATCTCGCTCGACCCCACTTCGGGCAGCCTGCTGGCTCCGGTCAGCGGCG
TGGTCAGCAACCTGCACTCCGCCCACCACGCGCTGACCATCACCACCTCGGAAGGCGTGGAAGTGATGGTGCACATCGGC
ATCGACACCGTGATGCTGAAGGGCGAGGGCTTTTTCCCGCTGGTCGAGCAAGGCCAGCAGGTCAGCGCCGGCCAGCCGGT
CATCGACTTCGACCTCGACCTGGTGGGCCGCAAGGCGGCCAGCCTGCTGACCCAGATCATCGTCACCAACGGCGATGAAA
CCGTGAGCAAGATGAAACTGTCGGACGGTTTGGTAGCTGCCGGCAAGGACATCGTGCTGTCGCTGCAATTGGCCAACGGC
AAGGCGGTGCTGCAAGTCGAGGCCAGCGAACCCCAATTGTCCGCCGACATCGTCATCGGCAACCCGGCCGGCCTGCACGC
CCGTCCCGCCGCCGTGTTCGCCAGCAAGGCCAAGTCCTTCGCCTCCGACATCCAGCTGATCCTGGGCGACAAAGAAGCCA
ACGCCAAATCCGTAGTGGCCATCATGGGCCTGGCCACCAAGCTGGGCGACGCGGTGCGCGTGCGCGCCGCCGGCGCCGAC
GCCGCGGCCGCCATCGCCGAACTGACCCAGCTACTGAACGACCGTTGCGGCGAGAAAGCCGACGAGGCGCCGATCGCTCC
GGCGGCGCCCGTCTTCGCGCAGCAGCAGGACAGCGACACCCAGCTGGCCGGCGTGGGCGCCTCGCCGGGCATCGCCATCG
GCCGCATCGTCCACCATAGGCTGCAAGAATTCGACGTGCCCGAACAGGGCAAGGGCGCCAATGTGGAACAGCAGGCCTTC
GCCCGCGCCACCGAGGAAGCCTCGGCCCAGCTGGACCTGGTCAAGGCGCAGCTGACCGACCCGGCCAAGCAGGCCATCCT
GTCCATGCACCAGGAGCTGCTGCAAGACCCGGACCTGCTGGCGCAAACCTATACCGGCCTGGCCGACGGCAAGTCCGCCG
CCTGGTCCTGGCGCGCCGCCTTCAGCGCCTATTCCGCCCGCCTGGAGGCGCAGGACAACGCCCTGCTGCGCGAACGCGCC
AACGACATCCGCGACGTCGGCCGCCGCGTGCTGGCCCTGCTGGCCGGCGTGAAGCAGGCCGCGCTGGAGCTGCCGGCCGG
CTCCATCCTGATCGCCGAGGACCTGGCCCCGTCCGACACCGCCTCGCTGGATCCGTCCAAAGTGATGGGCTTCTGTACCC
GCACCGGCGGCGCCACCAGCCACGTGGCCATCCTGGCGCGCTCGCTGGGCATCCCGGCCATCTGCGGCATCTCGCAGTCC
GCGCTGAAGCTGCCGGAAGGCCTGCAGGTGATCCTGAACGGCAACGAGGGCACGCTGGCCATCGCCCCGACGACTGAAGA
TCTGGCCGCCGCCGAGCAGGAAATCGCCCGCCTGGCCGAACGCCGCGCCGCCGAAGCCAAGAGCTCGATGCAGCCGGCCG
CCACCAGCGACGGCGCGCGCATCGACGTGGTGGCCAATATCCGCAACGCCGCCGACGCGCGCGAAGCGGTGGCCAAGGGC
GCGGAAGGCGTGGGCCTGCTGCGCTCGGAATTCCTGTTCGACAACCGCGACACCGCGCCGACCGAAGCAGAACAGGCGGC
CGAGTACTGCGCGGTAGCCGAGGCGCTGGGCAAGGACCGCCCGCTGGTGGTGCGCACGCTGGACGTGGGCGGCGACAAGC
CGCTGTCCTATCTGCCGCTGCCCAAGGAAGACAACCCCTTCCTCGGCCTGCGCGGCATCCGCGTCAGCCTGGACCGCCCG
GACCTGCTGCGCACCCAGTTGCGCGCCATCCTGCGCGCCGCGCCGCTGACCCAGCTGCACATCATGTTCCCGATGGTCGC
CTCGCTGGAAGAGCTGCGCGCCGCCAAGGCCGTGCTGGCCGAAGAGCAGGCCGCCGCCGGTGCGTCCAACGTCAAGGTGG
GCATCATGGTGGAAGTGCCGTCCGCCGCGGTGCTGGCCGCGCGCTTCGCGCCGGAGGTGGACTTCTTCTCCATCGGCACC
AACGACCTGACCCAGTACGTGCTGGCGATGGACCGCGGCCACCCGCAGTTGGCCAAGCAGGCCGACGCGCTGCATCCGGG
CGTGCTGGCGATGATCGCGCTGACTTGCGAAGGCGCGCGCGCCCACGGCAAATGGGTGGGCGTCTGCGGCGGCCTGGCCT
CCGACGAGCGTGCGGCGCCGCTGCTGGTCGGCATGGGCGTGACCGAACTGTCGGTCAGCACGCCGGCCGTCGCCTCGGTG
AAGGCCACCCTGGCGCGCTGGAGCATGGACGAGTGCCGCCAGTTGGCGAAGGACGTGCTGGCGCTGTCGACGGTGACCGA
CGTCCGCCACCATCTGAATCAACACGCTCGTTAA

Upstream 100 bases:

>100_bases
AAGCATGCCCAGGCGCCGCCGCCGCAAGGCCCCGAGCGACCGGCTTGATTGACGCTCGTAATAAAACGACTGGAATTATC
CACGAATTGAGGAGTTTTTC

Downstream 100 bases:

>100_bases
AAGCATAAGCCTCGGCGCCGGCGGGATCCGCGGCGCCGGATGGGGAGACCTTCGGGGCCACCCGATGCCATCCGGCGCCG
CCCAAGCGGACCTGGCGGGC

Product: phosphoenolpyruvate-protein phosphotransferase

Products: NA

Alternate protein names: MTP; Phosphoenolpyruvate-protein phosphotransferase; Phosphotransferase system enzyme I; Phosphocarrier protein HPr; Protein H; Fructose-specific phosphotransferase enzyme IIA component; EIII-Fru; PTS system fructose-specific EIIA component [H]

Number of amino acids: Translated: 837; Mature: 836

Protein sequence:

>837_residues
MGTIAPRLDVLAPLSGWLVPLDSVPDPVFAGKMVGDGISLDPTSGSLLAPVSGVVSNLHSAHHALTITTSEGVEVMVHIG
IDTVMLKGEGFFPLVEQGQQVSAGQPVIDFDLDLVGRKAASLLTQIIVTNGDETVSKMKLSDGLVAAGKDIVLSLQLANG
KAVLQVEASEPQLSADIVIGNPAGLHARPAAVFASKAKSFASDIQLILGDKEANAKSVVAIMGLATKLGDAVRVRAAGAD
AAAAIAELTQLLNDRCGEKADEAPIAPAAPVFAQQQDSDTQLAGVGASPGIAIGRIVHHRLQEFDVPEQGKGANVEQQAF
ARATEEASAQLDLVKAQLTDPAKQAILSMHQELLQDPDLLAQTYTGLADGKSAAWSWRAAFSAYSARLEAQDNALLRERA
NDIRDVGRRVLALLAGVKQAALELPAGSILIAEDLAPSDTASLDPSKVMGFCTRTGGATSHVAILARSLGIPAICGISQS
ALKLPEGLQVILNGNEGTLAIAPTTEDLAAAEQEIARLAERRAAEAKSSMQPAATSDGARIDVVANIRNAADAREAVAKG
AEGVGLLRSEFLFDNRDTAPTEAEQAAEYCAVAEALGKDRPLVVRTLDVGGDKPLSYLPLPKEDNPFLGLRGIRVSLDRP
DLLRTQLRAILRAAPLTQLHIMFPMVASLEELRAAKAVLAEEQAAAGASNVKVGIMVEVPSAAVLAARFAPEVDFFSIGT
NDLTQYVLAMDRGHPQLAKQADALHPGVLAMIALTCEGARAHGKWVGVCGGLASDERAAPLLVGMGVTELSVSTPAVASV
KATLARWSMDECRQLAKDVLALSTVTDVRHHLNQHAR

Sequences:

>Translated_837_residues
MGTIAPRLDVLAPLSGWLVPLDSVPDPVFAGKMVGDGISLDPTSGSLLAPVSGVVSNLHSAHHALTITTSEGVEVMVHIG
IDTVMLKGEGFFPLVEQGQQVSAGQPVIDFDLDLVGRKAASLLTQIIVTNGDETVSKMKLSDGLVAAGKDIVLSLQLANG
KAVLQVEASEPQLSADIVIGNPAGLHARPAAVFASKAKSFASDIQLILGDKEANAKSVVAIMGLATKLGDAVRVRAAGAD
AAAAIAELTQLLNDRCGEKADEAPIAPAAPVFAQQQDSDTQLAGVGASPGIAIGRIVHHRLQEFDVPEQGKGANVEQQAF
ARATEEASAQLDLVKAQLTDPAKQAILSMHQELLQDPDLLAQTYTGLADGKSAAWSWRAAFSAYSARLEAQDNALLRERA
NDIRDVGRRVLALLAGVKQAALELPAGSILIAEDLAPSDTASLDPSKVMGFCTRTGGATSHVAILARSLGIPAICGISQS
ALKLPEGLQVILNGNEGTLAIAPTTEDLAAAEQEIARLAERRAAEAKSSMQPAATSDGARIDVVANIRNAADAREAVAKG
AEGVGLLRSEFLFDNRDTAPTEAEQAAEYCAVAEALGKDRPLVVRTLDVGGDKPLSYLPLPKEDNPFLGLRGIRVSLDRP
DLLRTQLRAILRAAPLTQLHIMFPMVASLEELRAAKAVLAEEQAAAGASNVKVGIMVEVPSAAVLAARFAPEVDFFSIGT
NDLTQYVLAMDRGHPQLAKQADALHPGVLAMIALTCEGARAHGKWVGVCGGLASDERAAPLLVGMGVTELSVSTPAVASV
KATLARWSMDECRQLAKDVLALSTVTDVRHHLNQHAR
>Mature_836_residues
GTIAPRLDVLAPLSGWLVPLDSVPDPVFAGKMVGDGISLDPTSGSLLAPVSGVVSNLHSAHHALTITTSEGVEVMVHIGI
DTVMLKGEGFFPLVEQGQQVSAGQPVIDFDLDLVGRKAASLLTQIIVTNGDETVSKMKLSDGLVAAGKDIVLSLQLANGK
AVLQVEASEPQLSADIVIGNPAGLHARPAAVFASKAKSFASDIQLILGDKEANAKSVVAIMGLATKLGDAVRVRAAGADA
AAAIAELTQLLNDRCGEKADEAPIAPAAPVFAQQQDSDTQLAGVGASPGIAIGRIVHHRLQEFDVPEQGKGANVEQQAFA
RATEEASAQLDLVKAQLTDPAKQAILSMHQELLQDPDLLAQTYTGLADGKSAAWSWRAAFSAYSARLEAQDNALLRERAN
DIRDVGRRVLALLAGVKQAALELPAGSILIAEDLAPSDTASLDPSKVMGFCTRTGGATSHVAILARSLGIPAICGISQSA
LKLPEGLQVILNGNEGTLAIAPTTEDLAAAEQEIARLAERRAAEAKSSMQPAATSDGARIDVVANIRNAADAREAVAKGA
EGVGLLRSEFLFDNRDTAPTEAEQAAEYCAVAEALGKDRPLVVRTLDVGGDKPLSYLPLPKEDNPFLGLRGIRVSLDRPD
LLRTQLRAILRAAPLTQLHIMFPMVASLEELRAAKAVLAEEQAAAGASNVKVGIMVEVPSAAVLAARFAPEVDFFSIGTN
DLTQYVLAMDRGHPQLAKQADALHPGVLAMIALTCEGARAHGKWVGVCGGLASDERAAPLLVGMGVTELSVSTPAVASVK
ATLARWSMDECRQLAKDVLALSTVTDVRHHLNQHAR

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1080

COG function: function code G; Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIA type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788756, Length=569, Percent_Identity=40.597539543058, Blast_Score=381, Evalue=1e-107,
Organism=Escherichia coli, GI48994992, Length=681, Percent_Identity=34.0675477239354, Blast_Score=350, Evalue=2e-97,
Organism=Escherichia coli, GI1788726, Length=662, Percent_Identity=35.3474320241692, Blast_Score=335, Evalue=7e-93,
Organism=Escherichia coli, GI1789193, Length=582, Percent_Identity=33.3333333333333, Blast_Score=291, Evalue=8e-80,
Organism=Escherichia coli, GI1788757, Length=149, Percent_Identity=46.3087248322148, Blast_Score=136, Evalue=5e-33,
Organism=Escherichia coli, GI1787994, Length=404, Percent_Identity=28.7128712871287, Blast_Score=125, Evalue=8e-30,
Organism=Escherichia coli, GI1786894, Length=141, Percent_Identity=39.7163120567376, Blast_Score=121, Evalue=2e-28,
Organism=Escherichia coli, GI226510935, Length=302, Percent_Identity=29.8013245033113, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1790159, Length=143, Percent_Identity=32.1678321678322, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2659 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 4,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008279
- InterPro:   IPR006318
- InterPro:   IPR018274
- InterPro:   IPR023151
- InterPro:   IPR000121
- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR001020
- InterPro:   IPR005698
- InterPro:   IPR000032
- InterPro:   IPR002114
- InterPro:   IPR008731
- InterPro:   IPR015813 [H]

Pfam domain/function: PF05524 PEP-utilisers_N; PF00391 PEP-utilizers; PF02896 PEP-utilizers_C; PF00381 PTS-HPr; PF00359 PTS_EIIA_2 [H]

EC number: =2.7.3.9 [H]

Molecular weight: Translated: 87392; Mature: 87261

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00369 PTS_HPR_HIS ; PS00589 PTS_HPR_SER ; PS00371 PTS_EIIA_TYPE_1_HIS ; PS51093 PTS_EIIA_TYPE_1 ; PS00742 PEP_ENZYMES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTIAPRLDVLAPLSGWLVPLDSVPDPVFAGKMVGDGISLDPTSGSLLAPVSGVVSNLHS
CCCCCCCHHHHCCCCCCEEECCCCCCCHHCCHHCCCCCEECCCCCCHHHHHHHHHHHHHH
AHHALTITTSEGVEVMVHIGIDTVMLKGEGFFPLVEQGQQVSAGQPVIDFDLDLVGRKAA
HHEEEEEEECCCCEEEEEECCEEEEEECCCCCHHHHCCCCCCCCCCEEEECHHHHHHHHH
SLLTQIIVTNGDETVSKMKLSDGLVAAGKDIVLSLQLANGKAVLQVEASEPQLSADIVIG
HHHHHHHHCCCCHHHHHHHHCCCCEECCCEEEEEEEEECCEEEEEEECCCCCCEEEEEEC
NPAGLHARPAAVFASKAKSFASDIQLILGDKEANAKSVVAIMGLATKLGDAVRVRAAGAD
CCCCCCCCHHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHCCEEEEEECCCH
AAAAIAELTQLLNDRCGEKADEAPIAPAAPVFAQQQDSDTQLAGVGASPGIAIGRIVHHR
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHCCCCCCCCEEEECCCCCCHHHHHHHHHH
LQEFDVPEQGKGANVEQQAFARATEEASAQLDLVKAQLTDPAKQAILSMHQELLQDPDLL
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHH
AQTYTGLADGKSAAWSWRAAFSAYSARLEAQDNALLRERANDIRDVGRRVLALLAGVKQA
HHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALELPAGSILIAEDLAPSDTASLDPSKVMGFCTRTGGATSHVAILARSLGIPAICGISQS
HHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEECCCHH
ALKLPEGLQVILNGNEGTLAIAPTTEDLAAAEQEIARLAERRAAEAKSSMQPAATSDGAR
HHCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCE
IDVVANIRNAADAREAVAKGAEGVGLLRSEFLFDNRDTAPTEAEQAAEYCAVAEALGKDR
EEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCC
PLVVRTLDVGGDKPLSYLPLPKEDNPFLGLRGIRVSLDRPDLLRTQLRAILRAAPLTQLH
CEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHCCCHHHH
IMFPMVASLEELRAAKAVLAEEQAAAGASNVKVGIMVEVPSAAVLAARFAPEVDFFSIGT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHCCCCCEEECCC
NDLTQYVLAMDRGHPQLAKQADALHPGVLAMIALTCEGARAHGKWVGVCGGLASDERAAP
HHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCC
LLVGMGVTELSVSTPAVASVKATLARWSMDECRQLAKDVLALSTVTDVRHHLNQHAR
EEEECCCCEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GTIAPRLDVLAPLSGWLVPLDSVPDPVFAGKMVGDGISLDPTSGSLLAPVSGVVSNLHS
CCCCCCHHHHCCCCCCEEECCCCCCCHHCCHHCCCCCEECCCCCCHHHHHHHHHHHHHH
AHHALTITTSEGVEVMVHIGIDTVMLKGEGFFPLVEQGQQVSAGQPVIDFDLDLVGRKAA
HHEEEEEEECCCCEEEEEECCEEEEEECCCCCHHHHCCCCCCCCCCEEEECHHHHHHHHH
SLLTQIIVTNGDETVSKMKLSDGLVAAGKDIVLSLQLANGKAVLQVEASEPQLSADIVIG
HHHHHHHHCCCCHHHHHHHHCCCCEECCCEEEEEEEEECCEEEEEEECCCCCCEEEEEEC
NPAGLHARPAAVFASKAKSFASDIQLILGDKEANAKSVVAIMGLATKLGDAVRVRAAGAD
CCCCCCCCHHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHCCEEEEEECCCH
AAAAIAELTQLLNDRCGEKADEAPIAPAAPVFAQQQDSDTQLAGVGASPGIAIGRIVHHR
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHCCCCCCCCEEEECCCCCCHHHHHHHHHH
LQEFDVPEQGKGANVEQQAFARATEEASAQLDLVKAQLTDPAKQAILSMHQELLQDPDLL
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHH
AQTYTGLADGKSAAWSWRAAFSAYSARLEAQDNALLRERANDIRDVGRRVLALLAGVKQA
HHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALELPAGSILIAEDLAPSDTASLDPSKVMGFCTRTGGATSHVAILARSLGIPAICGISQS
HHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEECCCHH
ALKLPEGLQVILNGNEGTLAIAPTTEDLAAAEQEIARLAERRAAEAKSSMQPAATSDGAR
HHCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCE
IDVVANIRNAADAREAVAKGAEGVGLLRSEFLFDNRDTAPTEAEQAAEYCAVAEALGKDR
EEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCC
PLVVRTLDVGGDKPLSYLPLPKEDNPFLGLRGIRVSLDRPDLLRTQLRAILRAAPLTQLH
CEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHCCCHHHH
IMFPMVASLEELRAAKAVLAEEQAAAGASNVKVGIMVEVPSAAVLAARFAPEVDFFSIGT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHCCCCCEEECCC
NDLTQYVLAMDRGHPQLAKQADALHPGVLAMIALTCEGARAHGKWVGVCGGLASDERAAP
HHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCC
LLVGMGVTELSVSTPAVASVKATLARWSMDECRQLAKDVLALSTVTDVRHHLNQHAR
EEEECCCCEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2193161 [H]