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The map label for this gene is mdtP [H]

Identifier: 34496223

GI number: 34496223

Start: 789557

End: 790987

Strand: Reverse

Name: mdtP [H]

Synonym: CV_0768

Alternate gene names: 34496223

Gene position: 790987-789557 (Counterclockwise)

Preceding gene: 34496224

Following gene: 34496222

Centisome position: 16.65

GC content: 68.2

Gene sequence:

>1431_bases
ATGGAGACCGACAAGGTGAACAAGAAATCCTGGCCACAAACCGCCGGGGTGTTGCTGATCAGCGCCGTGCTGAGCGGCTG
CGCCAGCTTCGGCCCAGACGCCGCCCCCGACCAAATGGTAGGAGCCGACCAGCTCAAGCTGGCCGTCGCCGGCCAACAGA
ATGTCCGCGCCGACTGGTGGCGCCAATTGAACGATCCCGAGCTTGACCGCCTGGTCGAAGCCACGCTGAAAGACGCGCCG
TCGCTGAAGCTGGCCGCCGCGCGGCTGCGCCAGGCGCGCGCCGCGGTCGGCATCGTGGAAAGCAAGGACGGCCCGCAGCT
GGACGCCATGGCCAACGCCGTGCAAATCCACGCCGATCCGCTGAAGGCGCTCCCGCACAACGACAAGGATTACATCAACG
CCTACACCGCGGCGCTGGTCGGCAGTTGGGAATTCGATTTCTGGGGCAAGAACCACGCCGCCGTCAGCGCCGCCCTCGGC
CAGCAGCAGGCCGTCGCCTACGAAGGCCAGCAAACCCGCCTGCTGCTGACCCAGGCCGTGGTCGCCCAATACACCCAGCT
GCAGCGCAGCCTGGCCCAGTCCAGGCTGCTGTCCCAGCGCCTGGCCATCGCCCAGAGCCGCCAGAAGCTGACCCAGGCCC
GCGTCAACGCCGGTCTGCTGCCCGGCGACAACCAACGCGGCAACGAAGTGTCGATCGAGCGGCTGCAGCAGCAGCAAAGC
GCGCTGGACAACGACATCGCCCGCAGCCGCCACGCGCTGGCCGCGCTGACCGGACAAGGCCCGCAGCAGCAGGACAGCCT
GAATCCCGGCAAACTGGACGCCGCGCCGCAACCGGCGCTGGACAAGCTGGACGCCAACCTGCTGGGCCGCCGTCCGGACA
TCGCCGCCCAGCGCGCCCGCGTCGAATCGATGACGGCCTCGGTCAAGGAGGCGCGCGCCGAGTTCTACCCCAACGTCAAG
CTGACCGTGTTCGCCGGCCAGAGCTCGCTGAAAATGGACCAGCTGTGGAAGAGCGAATCGTCGTTGTGGGGCTTCATGCC
GGCCATCAGCCTGCCGATCTTCCACTCCGGCCAGCTGCAGTCCAACCTGTCCAAGCAACAGGCCGGCTACGACATGGCGG
TGCAGCAATACAACCAGACCGTGCTGGACGCGCTGCGCGACGCCGCCGACGCGGTCAGCGGCTGGCAGAACAGCCAGCGC
CAGCTGCAACAGTCCGAGCGCGCGCTGCAGAGCAGCCGCAAGGCCAATGACTCGATGGCCGCCCGCCTGCGCGCCGGCCT
GGTCAACAAGCTGTCGCTGCTCGACTCCCAGGACGCGCTGCTGAGCCAGCAATCCGCCAACATCGACGCCCAGGCCGCCA
ACCGCCTGGCCTGGGCCTCCCTGAACACCGCATTGGGCGGCGGCTTCGACAACCAGGCCGCCAGCCGCTAA

Upstream 100 bases:

>100_bases
CCTGAGCAAGCTCGGCGGCTGAGCCCGCGCTTTTTCACTCGAATAATAACCCGGGTGATTATCACCAGATTAATCACGTC
CGGACCGACATGCATCATTG

Downstream 100 bases:

>100_bases
GGACGCACGAAAATGGATCAGAAACTGGAAACCGCGAAGACTCGCAAACGCAACCTGCTGGTGGCCACCACCCTGTTCGC
CGCCATCGCCATCGGCTACG

Product: outer membrane multidrug resistance lipoprotein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
METDKVNKKSWPQTAGVLLISAVLSGCASFGPDAAPDQMVGADQLKLAVAGQQNVRADWWRQLNDPELDRLVEATLKDAP
SLKLAAARLRQARAAVGIVESKDGPQLDAMANAVQIHADPLKALPHNDKDYINAYTAALVGSWEFDFWGKNHAAVSAALG
QQQAVAYEGQQTRLLLTQAVVAQYTQLQRSLAQSRLLSQRLAIAQSRQKLTQARVNAGLLPGDNQRGNEVSIERLQQQQS
ALDNDIARSRHALAALTGQGPQQQDSLNPGKLDAAPQPALDKLDANLLGRRPDIAAQRARVESMTASVKEARAEFYPNVK
LTVFAGQSSLKMDQLWKSESSLWGFMPAISLPIFHSGQLQSNLSKQQAGYDMAVQQYNQTVLDALRDAADAVSGWQNSQR
QLQQSERALQSSRKANDSMAARLRAGLVNKLSLLDSQDALLSQQSANIDAQAANRLAWASLNTALGGGFDNQAASR

Sequences:

>Translated_476_residues
METDKVNKKSWPQTAGVLLISAVLSGCASFGPDAAPDQMVGADQLKLAVAGQQNVRADWWRQLNDPELDRLVEATLKDAP
SLKLAAARLRQARAAVGIVESKDGPQLDAMANAVQIHADPLKALPHNDKDYINAYTAALVGSWEFDFWGKNHAAVSAALG
QQQAVAYEGQQTRLLLTQAVVAQYTQLQRSLAQSRLLSQRLAIAQSRQKLTQARVNAGLLPGDNQRGNEVSIERLQQQQS
ALDNDIARSRHALAALTGQGPQQQDSLNPGKLDAAPQPALDKLDANLLGRRPDIAAQRARVESMTASVKEARAEFYPNVK
LTVFAGQSSLKMDQLWKSESSLWGFMPAISLPIFHSGQLQSNLSKQQAGYDMAVQQYNQTVLDALRDAADAVSGWQNSQR
QLQQSERALQSSRKANDSMAARLRAGLVNKLSLLDSQDALLSQQSANIDAQAANRLAWASLNTALGGGFDNQAASR
>Mature_476_residues
METDKVNKKSWPQTAGVLLISAVLSGCASFGPDAAPDQMVGADQLKLAVAGQQNVRADWWRQLNDPELDRLVEATLKDAP
SLKLAAARLRQARAAVGIVESKDGPQLDAMANAVQIHADPLKALPHNDKDYINAYTAALVGSWEFDFWGKNHAAVSAALG
QQQAVAYEGQQTRLLLTQAVVAQYTQLQRSLAQSRLLSQRLAIAQSRQKLTQARVNAGLLPGDNQRGNEVSIERLQQQQS
ALDNDIARSRHALAALTGQGPQQQDSLNPGKLDAAPQPALDKLDANLLGRRPDIAAQRARVESMTASVKEARAEFYPNVK
LTVFAGQSSLKMDQLWKSESSLWGFMPAISLPIFHSGQLQSNLSKQQAGYDMAVQQYNQTVLDALRDAADAVSGWQNSQR
QLQQSERALQSSRKANDSMAARLRAGLVNKLSLLDSQDALLSQQSANIDAQAANRLAWASLNTALGGGFDNQAASR

Specific function: Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI2367348, Length=473, Percent_Identity=29.3868921775898, Blast_Score=172, Evalue=6e-44,
Organism=Escherichia coli, GI1786785, Length=463, Percent_Identity=25.9179265658747, Blast_Score=122, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 51553; Mature: 51553

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METDKVNKKSWPQTAGVLLISAVLSGCASFGPDAAPDQMVGADQLKLAVAGQQNVRADWW
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHEEEEECCCCCCCHHHH
RQLNDPELDRLVEATLKDAPSLKLAAARLRQARAAVGIVESKDGPQLDAMANAVQIHADP
HCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCEEECCCCCCHHHHHHHHHEECCH
LKALPHNDKDYINAYTAALVGSWEFDFWGKNHAAVSAALGQQQAVAYEGQQTRLLLTQAV
HHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCHHHHHHCCCCCHHHHHHHHH
VAQYTQLQRSLAQSRLLSQRLAIAQSRQKLTQARVNAGLLPGDNQRGNEVSIERLQQQQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
ALDNDIARSRHALAALTGQGPQQQDSLNPGKLDAAPQPALDKLDANLLGRRPDIAAQRAR
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHH
VESMTASVKEARAEFYPNVKLTVFAGQSSLKMDQLWKSESSLWGFMPAISLPIFHSGQLQ
HHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEECCHHH
SNLSKQQAGYDMAVQQYNQTVLDALRDAADAVSGWQNSQRQLQQSERALQSSRKANDSMA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
ARLRAGLVNKLSLLDSQDALLSQQSANIDAQAANRLAWASLNTALGGGFDNQAASR
HHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
METDKVNKKSWPQTAGVLLISAVLSGCASFGPDAAPDQMVGADQLKLAVAGQQNVRADWW
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHEEEEECCCCCCCHHHH
RQLNDPELDRLVEATLKDAPSLKLAAARLRQARAAVGIVESKDGPQLDAMANAVQIHADP
HCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCEEECCCCCCHHHHHHHHHEECCH
LKALPHNDKDYINAYTAALVGSWEFDFWGKNHAAVSAALGQQQAVAYEGQQTRLLLTQAV
HHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCHHHHHHCCCCCHHHHHHHHH
VAQYTQLQRSLAQSRLLSQRLAIAQSRQKLTQARVNAGLLPGDNQRGNEVSIERLQQQQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
ALDNDIARSRHALAALTGQGPQQQDSLNPGKLDAAPQPALDKLDANLLGRRPDIAAQRAR
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHH
VESMTASVKEARAEFYPNVKLTVFAGQSSLKMDQLWKSESSLWGFMPAISLPIFHSGQLQ
HHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEECCHHH
SNLSKQQAGYDMAVQQYNQTVLDALRDAADAVSGWQNSQRQLQQSERALQSSRKANDSMA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
ARLRAGLVNKLSLLDSQDALLSQQSANIDAQAANRLAWASLNTALGGGFDNQAASR
HHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]