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The map label for this gene is gcvT [H]

Identifier: 33864479

GI number: 33864479

Start: 2341674

End: 2342798

Strand: Direct

Name: gcvT [H]

Synonym: PMT2215

Alternate gene names: 33864479

Gene position: 2341674-2342798 (Clockwise)

Preceding gene: 33864478

Following gene: 33864480

Centisome position: 97.13

GC content: 55.82

Gene sequence:

>1125_bases
GTGAATCTGCAACACACACCCCTCCATGACCTCTGCCGAGATGCAGGCGGCCGGATGGTGCCCTTTGCCGGCTGGGACAT
GCCAGTGCAGTTCTCTGGCCTACTCCAAGAACATCAGGCAGTGCGTCAGCAGGTGGGAATGTTCGATATCTCTCATATGG
GAGTGCTGCGTCTCGAAGGAACCAACCCCAAAGACCACTTGCAAGCACTAGTGCCAACCGACCTCAATCGCATCGGTCCA
GGTGAGGCTTGCTACACGGTGCTGCTCAACGAAACAGGCGGAATTCTCGATGACCTAGTCATTTATGACCTTGGCACCAA
TAAGCAAGACAGCCAAAGCCTGCTGATTGTGATTAATGCAGCCTGCAGCAAAACCGACACCATCTGGTTAAAGCAACATT
TGCAGCCCGCAGGCATCGCACTCTCGGATGCCAAGAACAATGGCGTCTTACTGGCACTACAAGGACCCCAAGCGACCAAG
GTGTTGGAACGCTTAAGTGGCGAATCACTAGCGAGCCTTCCCCGCTTCGGCCATCGCCAAGTCCAGTTTTACGGCCTGGG
AGCGAAAGATCCCTCTTCAGTCTTCGTTGCACGAACTGGCTACACCGGCGAAGACGGATTTGAACTGCTCCTGAAGGCAG
AAGCCGGCCGAGCCCTCTGGCTCAAATTGCTCGCAGAAGGAGTCATCCCATGCGGACTCGGTTCCCGTGACACCCTGCGT
CTAGAGGCAGCAATGCACCTCTATGGACAGGACATGGACATCAATACAACACCCTTCGAGGCTGGTCTCGGCTGGTTGGT
ACACCTGGAAATGCCTGCTCCATTCATGGGTCGAACTGCCTTAGAGCAACAAGCAGAGCAAGGCCCCATTCGCCGCTTGG
TCGGTCTAAAGCTGTCTGGACGAGCCATAGCCCGTCATGGATACCCACTGCTTCACAACAACAACAAAGTGGGAGAAATC
ACAAGCGGCACCTGGTCACCCAGTCTGGAAGAAGCGATAGCCCTGGGCTATCTACCCACAGCTCTAGCCCGCATCGGTAA
CGAAGTGGAGGTAGAGATCCGCGGCAAGCACCACCGGGCAACGGTGGTGAAGCGCCCCTTTTATCGCCGTCCTTCCCTTA
GCTGA

Upstream 100 bases:

>100_bases
CGGATTGGACGACTGAAATCGTCAAATCTGCGACTTTCCTTCCGCTTCTGCAAACCCAATAGCACCCTCCATAGGATTTC
GGCACTGCAACGTCCAGCCC

Downstream 100 bases:

>100_bases
AGGCCATCGCCAAAACCGGTCGTTCTAATAAGCGGCAACAAGCCCCTGTGGGAAACTCGCTTTTCATCCTGAAGCCTTCC
CCATGCGCAGCAACGGTTGC

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MNLQHTPLHDLCRDAGGRMVPFAGWDMPVQFSGLLQEHQAVRQQVGMFDISHMGVLRLEGTNPKDHLQALVPTDLNRIGP
GEACYTVLLNETGGILDDLVIYDLGTNKQDSQSLLIVINAACSKTDTIWLKQHLQPAGIALSDAKNNGVLLALQGPQATK
VLERLSGESLASLPRFGHRQVQFYGLGAKDPSSVFVARTGYTGEDGFELLLKAEAGRALWLKLLAEGVIPCGLGSRDTLR
LEAAMHLYGQDMDINTTPFEAGLGWLVHLEMPAPFMGRTALEQQAEQGPIRRLVGLKLSGRAIARHGYPLLHNNNKVGEI
TSGTWSPSLEEAIALGYLPTALARIGNEVEVEIRGKHHRATVVKRPFYRRPSLS

Sequences:

>Translated_374_residues
MNLQHTPLHDLCRDAGGRMVPFAGWDMPVQFSGLLQEHQAVRQQVGMFDISHMGVLRLEGTNPKDHLQALVPTDLNRIGP
GEACYTVLLNETGGILDDLVIYDLGTNKQDSQSLLIVINAACSKTDTIWLKQHLQPAGIALSDAKNNGVLLALQGPQATK
VLERLSGESLASLPRFGHRQVQFYGLGAKDPSSVFVARTGYTGEDGFELLLKAEAGRALWLKLLAEGVIPCGLGSRDTLR
LEAAMHLYGQDMDINTTPFEAGLGWLVHLEMPAPFMGRTALEQQAEQGPIRRLVGLKLSGRAIARHGYPLLHNNNKVGEI
TSGTWSPSLEEAIALGYLPTALARIGNEVEVEIRGKHHRATVVKRPFYRRPSLS
>Mature_374_residues
MNLQHTPLHDLCRDAGGRMVPFAGWDMPVQFSGLLQEHQAVRQQVGMFDISHMGVLRLEGTNPKDHLQALVPTDLNRIGP
GEACYTVLLNETGGILDDLVIYDLGTNKQDSQSLLIVINAACSKTDTIWLKQHLQPAGIALSDAKNNGVLLALQGPQATK
VLERLSGESLASLPRFGHRQVQFYGLGAKDPSSVFVARTGYTGEDGFELLLKAEAGRALWLKLLAEGVIPCGLGSRDTLR
LEAAMHLYGQDMDINTTPFEAGLGWLVHLEMPAPFMGRTALEQQAEQGPIRRLVGLKLSGRAIARHGYPLLHNNNKVGEI
TSGTWSPSLEEAIALGYLPTALARIGNEVEVEIRGKHHRATVVKRPFYRRPSLS

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=372, Percent_Identity=35.4838709677419, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI257796258, Length=358, Percent_Identity=34.9162011173184, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI257796254, Length=369, Percent_Identity=32.2493224932249, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI257796256, Length=317, Percent_Identity=34.0694006309148, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI24797151, Length=346, Percent_Identity=28.6127167630058, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI197927446, Length=328, Percent_Identity=25, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI21361378, Length=328, Percent_Identity=25, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI194306651, Length=336, Percent_Identity=27.0833333333333, Blast_Score=96, Evalue=7e-20,
Organism=Escherichia coli, GI1789272, Length=378, Percent_Identity=38.3597883597884, Blast_Score=243, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17560118, Length=381, Percent_Identity=32.5459317585302, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI32563613, Length=399, Percent_Identity=23.3082706766917, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71994045, Length=371, Percent_Identity=23.1805929919137, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71994052, Length=371, Percent_Identity=23.1805929919137, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320222, Length=386, Percent_Identity=36.2694300518135, Blast_Score=200, Evalue=4e-52,
Organism=Drosophila melanogaster, GI20129441, Length=394, Percent_Identity=36.2944162436548, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI28571104, Length=328, Percent_Identity=25.3048780487805, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI20130091, Length=435, Percent_Identity=23.9080459770115, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 40867; Mature: 40867

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLQHTPLHDLCRDAGGRMVPFAGWDMPVQFSGLLQEHQAVRQQVGMFDISHMGVLRLEG
CCCCCCCHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCEEECCCEEEEEEC
TNPKDHLQALVPTDLNRIGPGEACYTVLLNETGGILDDLVIYDLGTNKQDSQSLLIVINA
CCHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCHHCEEEEECCCCCCCCCEEEEEEEC
ACSKTDTIWLKQHLQPAGIALSDAKNNGVLLALQGPQATKVLERLSGESLASLPRFGHRQ
CCCCCCCHHHHHCCCCCCEEEECCCCCCEEEEECCCHHHHHHHHHCCCHHHHCCCCCCCE
VQFYGLGAKDPSSVFVARTGYTGEDGFELLLKAEAGRALWLKLLAEGVIPCGLGSRDTLR
EEEEECCCCCCCCEEEEECCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCEEE
LEAAMHLYGQDMDINTTPFEAGLGWLVHLEMPAPFMGRTALEQQAEQGPIRRLVGLKLSG
EEEEHHHCCCCCCCCCCCHHCCCEEEEEEECCCCCCCHHHHHHHHHHCHHHHHHCCEECC
RAIARHGYPLLHNNNKVGEITSGTWSPSLEEAIALGYLPTALARIGNEVEVEIRGKHHRA
CEEHHCCCEEEECCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEE
TVVKRPFYRRPSLS
EEECCCCCCCCCCC
>Mature Secondary Structure
MNLQHTPLHDLCRDAGGRMVPFAGWDMPVQFSGLLQEHQAVRQQVGMFDISHMGVLRLEG
CCCCCCCHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCEEECCCEEEEEEC
TNPKDHLQALVPTDLNRIGPGEACYTVLLNETGGILDDLVIYDLGTNKQDSQSLLIVINA
CCHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCHHCEEEEECCCCCCCCCEEEEEEEC
ACSKTDTIWLKQHLQPAGIALSDAKNNGVLLALQGPQATKVLERLSGESLASLPRFGHRQ
CCCCCCCHHHHHCCCCCCEEEECCCCCCEEEEECCCHHHHHHHHHCCCHHHHCCCCCCCE
VQFYGLGAKDPSSVFVARTGYTGEDGFELLLKAEAGRALWLKLLAEGVIPCGLGSRDTLR
EEEEECCCCCCCCEEEEECCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCEEE
LEAAMHLYGQDMDINTTPFEAGLGWLVHLEMPAPFMGRTALEQQAEQGPIRRLVGLKLSG
EEEEHHHCCCCCCCCCCCHHCCCEEEEEEECCCCCCCHHHHHHHHHHCHHHHHHCCEECC
RAIARHGYPLLHNNNKVGEITSGTWSPSLEEAIALGYLPTALARIGNEVEVEIRGKHHRA
CEEHHCCCEEEECCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEE
TVVKRPFYRRPSLS
EEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA