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The map label for this gene is pyrD

Identifier: 33864358

GI number: 33864358

Start: 2206690

End: 2207868

Strand: Direct

Name: pyrD

Synonym: PMT2094

Alternate gene names: 33864358

Gene position: 2206690-2207868 (Clockwise)

Preceding gene: 33864357

Following gene: 33864359

Centisome position: 91.53

GC content: 58.18

Gene sequence:

>1179_bases
ATGGCTGAGCCATCACCTGCAAAGGTGTACTCCACCGGTGGGTTGTATCGCCGTTGGCTGGGAGCAATACTCGCGAATGA
TCAGGGCTTAGATCCGGAACAGTTGACTCAAGCAGCATTGAGTGCCCTTAGCCAGACGTCCCTACGTAGAGATTGGCCAG
GCGTATCAGCTGTCCTGGCAGCTATAGCGTTGGATTTGCAACGCCATGATCTGCGGCTTGAGCAAGTGTTGTTCGGCTGC
CGATTTCTTAATCCTGTTGGACTGGCGGCTGGCTTTGACAAAAACGGAGTGGCGGCCAGTATCTGGGATCGCTTTGGATT
TGGATTCGCCGAACTCGGCACTGTGACTTGGCATGGGCAGACCGGTAACCCTCGGCCCCGACTCTTTCGCCTTGCTGCTG
AGCAGGCCGCTTTGAACCGGATGGGTTTCAACAACAACGGTGCTGAGGTAATGCGTCGCACTTTGGAGAAACAGGCTTTG
CCTTCACCTGGCCAGCGTCCAGCTGTGCTGGGTCTCAACTTGGGCAAATCCAGGATCACGCCATTGGAGCAGGCCCCAGA
CGACTACGCCTTATCGCTTGAGTTGCTAGCACCATTGGCGGATTACGCCGTGATCAATGTCAGCTCTCCTAATACACCAG
GCTTGCGTGATCTCCAGGATGCCAGCCAGTTAAGGCGTCTGGTGGAACGATTGCGCCGATTGCCAGGATGCCCGCCACTA
CTGGTGAAGATCGCTCCGGATCTCGAGGATGATGCCATTGATGGCCTGGCTCGCTTGGCTTATGAGGAGGGTTTGGCAGG
TGTCATTGCTGTGAATACAAGCCTCGACAGATTCGGCCTCGACGGGCGGGTCCTTCCCAAAACGGGCCGCACCCTCGCGG
AGGAGGCTGGTGGGCTCAGTGGAGCGCCTCTGCGTCAACGGGCCTTGGAGGTGCTGCGTCGGCTGCGGGCCACGGCAGGT
CCAGCGTTGCCCTTGATCGGCGTGGGAGGCATCGACTCGCCAGAGGCTGCATGGGAGCGAATCAGTGCCGGAGCTTCACT
TGTGCAGCTTTACACCGGTTGGATCTTTAAGGGTCCAGATTTGGTACCAAATATTTTGGATGGGCTGATCGGCCAGCTTG
ACCGCCATGGCTTCCGGCATGTGTCGGAGGCTGTCGGGAGCGGCGTGCCCTGGCAGTAG

Upstream 100 bases:

>100_bases
CCTGGCGTTGGCGCGATTGGCTATTGGAGCCTGTGGGGGAAAACCGCTGGCGATTGCACCGCTGCGCGGCAGGATCGGAT
CAGATCTGAGGAGGCCCAGG

Downstream 100 bases:

>100_bases
CCGATACCCTTCATCCAGAGCGGGGTTGCCTTTCCTTGGTGTTGGCTGGTCTACGCGAACGTTTTCCGCAGCTGGAACAG
TTGCAGGCCATGGCGGAGCG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MAEPSPAKVYSTGGLYRRWLGAILANDQGLDPEQLTQAALSALSQTSLRRDWPGVSAVLAAIALDLQRHDLRLEQVLFGC
RFLNPVGLAAGFDKNGVAASIWDRFGFGFAELGTVTWHGQTGNPRPRLFRLAAEQAALNRMGFNNNGAEVMRRTLEKQAL
PSPGQRPAVLGLNLGKSRITPLEQAPDDYALSLELLAPLADYAVINVSSPNTPGLRDLQDASQLRRLVERLRRLPGCPPL
LVKIAPDLEDDAIDGLARLAYEEGLAGVIAVNTSLDRFGLDGRVLPKTGRTLAEEAGGLSGAPLRQRALEVLRRLRATAG
PALPLIGVGGIDSPEAAWERISAGASLVQLYTGWIFKGPDLVPNILDGLIGQLDRHGFRHVSEAVGSGVPWQ

Sequences:

>Translated_392_residues
MAEPSPAKVYSTGGLYRRWLGAILANDQGLDPEQLTQAALSALSQTSLRRDWPGVSAVLAAIALDLQRHDLRLEQVLFGC
RFLNPVGLAAGFDKNGVAASIWDRFGFGFAELGTVTWHGQTGNPRPRLFRLAAEQAALNRMGFNNNGAEVMRRTLEKQAL
PSPGQRPAVLGLNLGKSRITPLEQAPDDYALSLELLAPLADYAVINVSSPNTPGLRDLQDASQLRRLVERLRRLPGCPPL
LVKIAPDLEDDAIDGLARLAYEEGLAGVIAVNTSLDRFGLDGRVLPKTGRTLAEEAGGLSGAPLRQRALEVLRRLRATAG
PALPLIGVGGIDSPEAAWERISAGASLVQLYTGWIFKGPDLVPNILDGLIGQLDRHGFRHVSEAVGSGVPWQ
>Mature_391_residues
AEPSPAKVYSTGGLYRRWLGAILANDQGLDPEQLTQAALSALSQTSLRRDWPGVSAVLAAIALDLQRHDLRLEQVLFGCR
FLNPVGLAAGFDKNGVAASIWDRFGFGFAELGTVTWHGQTGNPRPRLFRLAAEQAALNRMGFNNNGAEVMRRTLEKQALP
SPGQRPAVLGLNLGKSRITPLEQAPDDYALSLELLAPLADYAVINVSSPNTPGLRDLQDASQLRRLVERLRRLPGCPPLL
VKIAPDLEDDAIDGLARLAYEEGLAGVIAVNTSLDRFGLDGRVLPKTGRTLAEEAGGLSGAPLRQRALEVLRRLRATAGP
ALPLIGVGGIDSPEAAWERISAGASLVQLYTGWIFKGPDLVPNILDGLIGQLDRHGFRHVSEAVGSGVPWQ

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=327, Percent_Identity=44.954128440367, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI119943098, Length=320, Percent_Identity=26.25, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1787177, Length=297, Percent_Identity=43.4343434343434, Blast_Score=226, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17509475, Length=329, Percent_Identity=40.1215805471125, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI281361352, Length=334, Percent_Identity=39.2215568862275, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI17137316, Length=334, Percent_Identity=39.2215568862275, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24640763, Length=365, Percent_Identity=26.027397260274, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI18858217, Length=365, Percent_Identity=26.027397260274, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_PROMM (Q7V473)

Other databases:

- EMBL:   BX548175
- RefSeq:   NP_895918.1
- ProteinModelPortal:   Q7V473
- SMR:   Q7V473
- STRING:   Q7V473
- GeneID:   1727733
- GenomeReviews:   BX548175_GR
- KEGG:   pmt:PMT2094
- NMPDR:   fig|74547.1.peg.2085
- eggNOG:   COG0167
- HOGENOM:   HBG351027
- OMA:   AALNRMG
- ProtClustDB:   PRK05286
- BioCyc:   PMAR74547:PMT2094-MONOMER
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 42093; Mature: 41961

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 209-209

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEPSPAKVYSTGGLYRRWLGAILANDQGLDPEQLTQAALSALSQTSLRRDWPGVSAVLA
CCCCCCCEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
AIALDLQRHDLRLEQVLFGCRFLNPVGLAAGFDKNGVAASIWDRFGFGFAELGTVTWHGQ
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHCCCHHHHCEEEEECC
TGNPRPRLFRLAAEQAALNRMGFNNNGAEVMRRTLEKQALPSPGQRPAVLGLNLGKSRIT
CCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHCC
PLEQAPDDYALSLELLAPLADYAVINVSSPNTPGLRDLQDASQLRRLVERLRRLPGCPPL
CHHHCCCCCEEHHHHHHHHHCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCE
LVKIAPDLEDDAIDGLARLAYEEGLAGVIAVNTSLDRFGLDGRVLPKTGRTLAEEAGGLS
EEEECCCCCHHHHHHHHHHHHHHCCCEEEEEECCHHHHCCCCEECCCCCHHHHHHCCCCC
GAPLRQRALEVLRRLRATAGPALPLIGVGGIDSPEAAWERISAGASLVQLYTGWIFKGPD
CCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCC
LVPNILDGLIGQLDRHGFRHVSEAVGSGVPWQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AEPSPAKVYSTGGLYRRWLGAILANDQGLDPEQLTQAALSALSQTSLRRDWPGVSAVLA
CCCCCCEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
AIALDLQRHDLRLEQVLFGCRFLNPVGLAAGFDKNGVAASIWDRFGFGFAELGTVTWHGQ
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHCCCHHHHCEEEEECC
TGNPRPRLFRLAAEQAALNRMGFNNNGAEVMRRTLEKQALPSPGQRPAVLGLNLGKSRIT
CCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHCC
PLEQAPDDYALSLELLAPLADYAVINVSSPNTPGLRDLQDASQLRRLVERLRRLPGCPPL
CHHHCCCCCEEHHHHHHHHHCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCE
LVKIAPDLEDDAIDGLARLAYEEGLAGVIAVNTSLDRFGLDGRVLPKTGRTLAEEAGGLS
EEEECCCCCHHHHHHHHHHHHHHCCCEEEEEECCHHHHCCCCEECCCCCHHHHHHCCCCC
GAPLRQRALEVLRRLRATAGPALPLIGVGGIDSPEAAWERISAGASLVQLYTGWIFKGPD
CCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCC
LVPNILDGLIGQLDRHGFRHVSEAVGSGVPWQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12917642