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The map label for this gene is pabA [H]

Identifier: 33864332

GI number: 33864332

Start: 2174276

End: 2174884

Strand: Direct

Name: pabA [H]

Synonym: PMT2067

Alternate gene names: 33864332

Gene position: 2174276-2174884 (Clockwise)

Preceding gene: 33864331

Following gene: 33864333

Centisome position: 90.19

GC content: 55.99

Gene sequence:

>609_bases
ATGCTCCTAATTATCGACAACTACGACAGCTTCACCTTCAACCTGGTGCAGTATTTAGGGGAACTGGCCGCAAAGCATCC
TGTCGCTGCTGATCTACGGGTTGAGCGCAACGATGCTCTCTGCCTCAGCCAAATCAGGGAGCTACACCCCGCCGCCATCC
TGCTCTCACCTGGTCCGGGCAATCCTGATCAATCCGGAGTTTGCCTGGAGGTGCTGACCGAGCTGGCTCCCACAATCCCC
ACCCTCGGGGTGTGCTTGGGGCATCAAGCCCTAGCTCAAGCCTACGGAGGCAAGGTGGTGCAAGCTGATGAACTGATGCA
TGGCAAAACCTCGCCTGTGCTGCACAACGGCGAAGGGCTGTTTAAAGGCTTACCCCTACCACTCACTGCTACCAGATATC
ACAGCCTGATTGCCGAGCGAGAGAGCCTGCCGGACTGCCTAGAAGTCACCGCATGGCTAGAGGACGGCACAATCATGGGC
CTACGTCATCGAACACACCCCCATCTACAAGGAGTGCAGTTCCATCCCGAAAGTGTGCTCACAGAAGCAGGCCATCAACT
GCTTACCAACTTTTTGCGTCTGACTGAAGCCAGCGAAAAGCACTGCTAA

Upstream 100 bases:

>100_bases
CTGCTGTGATGGTTGCCGCCATTAGCTCTCTACTGATTGCCCTGCTGCTGCTGCTCCCTCCTCTACTGATCCGCCTTGGG
CTCTGACGCCCTGCAGCCCC

Downstream 100 bases:

>100_bases
CTTCCAAAACACTCCCGCTTCCACTCATGCCTTCCCTCTTCAAGGTTCTGAGCACCCGTAGCCTTTCTGCAGCTTCAGCT
GTGGGTTTAGTACTGTCCTC

Product: para-aminobenzoate synthase component II

Products: NA

Alternate protein names: ADC synthase [H]

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MLLIIDNYDSFTFNLVQYLGELAAKHPVAADLRVERNDALCLSQIRELHPAAILLSPGPGNPDQSGVCLEVLTELAPTIP
TLGVCLGHQALAQAYGGKVVQADELMHGKTSPVLHNGEGLFKGLPLPLTATRYHSLIAERESLPDCLEVTAWLEDGTIMG
LRHRTHPHLQGVQFHPESVLTEAGHQLLTNFLRLTEASEKHC

Sequences:

>Translated_202_residues
MLLIIDNYDSFTFNLVQYLGELAAKHPVAADLRVERNDALCLSQIRELHPAAILLSPGPGNPDQSGVCLEVLTELAPTIP
TLGVCLGHQALAQAYGGKVVQADELMHGKTSPVLHNGEGLFKGLPLPLTATRYHSLIAERESLPDCLEVTAWLEDGTIMG
LRHRTHPHLQGVQFHPESVLTEAGHQLLTNFLRLTEASEKHC
>Mature_202_residues
MLLIIDNYDSFTFNLVQYLGELAAKHPVAADLRVERNDALCLSQIRELHPAAILLSPGPGNPDQSGVCLEVLTELAPTIP
TLGVCLGHQALAQAYGGKVVQADELMHGKTSPVLHNGEGLFKGLPLPLTATRYHSLIAERESLPDCLEVTAWLEDGTIMG
LRHRTHPHLQGVQFHPESVLTEAGHQLLTNFLRLTEASEKHC

Specific function: Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine [H]

COG id: COG0512

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1789760, Length=192, Percent_Identity=60.9375, Blast_Score=241, Evalue=2e-65,
Organism=Escherichia coli, GI1787517, Length=196, Percent_Identity=39.2857142857143, Blast_Score=136, Evalue=8e-34,
Organism=Escherichia coli, GI1786215, Length=179, Percent_Identity=30.7262569832402, Blast_Score=65, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322638, Length=195, Percent_Identity=45.1282051282051, Blast_Score=187, Evalue=9e-49,
Organism=Saccharomyces cerevisiae, GI6324361, Length=212, Percent_Identity=33.0188679245283, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45555749, Length=132, Percent_Identity=34.0909090909091, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24642586, Length=132, Percent_Identity=34.0909090909091, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR006221 [H]

Pfam domain/function: PF00117 GATase [H]

EC number: =2.6.1.85 [H]

Molecular weight: Translated: 22045; Mature: 22045

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLIIDNYDSFTFNLVQYLGELAAKHPVAADLRVERNDALCLSQIRELHPAAILLSPGPG
CEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHCCCEEEEECCCCC
NPDQSGVCLEVLTELAPTIPTLGVCLGHQALAQAYGGKVVQADELMHGKTSPVLHNGEGL
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEHHHHHCCCCCCCEECCCCH
FKGLPLPLTATRYHSLIAERESLPDCLEVTAWLEDGTIMGLRHRTHPHLQGVQFHPESVL
HCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCEECHHHHH
TEAGHQLLTNFLRLTEASEKHC
HHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLLIIDNYDSFTFNLVQYLGELAAKHPVAADLRVERNDALCLSQIRELHPAAILLSPGPG
CEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHCCCEEEEECCCCC
NPDQSGVCLEVLTELAPTIPTLGVCLGHQALAQAYGGKVVQADELMHGKTSPVLHNGEGL
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEHHHHHCCCCCCCEECCCCH
FKGLPLPLTATRYHSLIAERESLPDCLEVTAWLEDGTIMGLRHRTHPHLQGVQFHPESVL
HCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCEECHHHHH
TEAGHQLLTNFLRLTEASEKHC
HHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350604; 2403545; 9278503; 2546924; 8096767 [H]