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The map label for this gene is menA [H]

Identifier: 33864324

GI number: 33864324

Start: 2168169

End: 2169143

Strand: Reverse

Name: menA [H]

Synonym: PMT2059

Alternate gene names: 33864324

Gene position: 2169143-2168169 (Counterclockwise)

Preceding gene: 33864326

Following gene: 33864323

Centisome position: 89.97

GC content: 57.64

Gene sequence:

>975_bases
ATGCCAGACCAGCAGGATGTTGCATCCCTTTACGCCAAGGCCTCTACAAGGCGAGCTCTTTGGAAAGCCGCGATCAAGTG
GCCGATGTACTCCGTGGCAGTGATGCCGGCGTTGCTGGCGGCTGGTTGGCGGGTGGGGGCCGGCGAAGCAGTGCGTCTTG
ATCAACTGCTTGGCTTTTTGGTTGCTGCTGTGCTGCTTTTGCTTTGGGAAAACCTCAGCAACGACCTCTTTGATGCAGAT
ACCGGCGTGGACAGCTTCACCAAGTTGCATTCGGTGGTTGCGCTGCTGGGTCAGCGGAGACCTGTGCGCCGCTTTGCTCA
CTTAGCGCTCGTGCTGGGCTTGTTGTTGATGTTGCTGTTGGCTTTGCGCAGTAGTGCTGCTGTGCTCTTTTTGGTGCTGG
TGAGTTGTGGTTTGGGATATCTCTACCAGGGGCCGCCCTTTCGCTGGGGCTACATAGGCCTCGGTGAGCCGCTGTGTTGG
TTGGCTTTTGGCCCTTTCGCTACTGCCGCTGCCTTGTTGGCGTTAGCACCGCTCAACGGTGATGGATCAGTGATTCCATG
GGCAACGGCGTTCACCCTGGGGAGTGGTCCGGCCTTAGCGACAACCTTGGTGCTCTTTTGCTCTCATTTTCATCAAGTCG
CTGAGGATGCGGCTTTTGGCAAACGATCGCCTGTGGTGCGCTTGGGCACAGCTCGTGCGGCGGCTTTGGTGCCCTGGATT
CTTTCGCTTGTGTTTGCTCTGGAGTGGATCCCTGTGCTGCAGGGAGATTGGCCGCTGACAGCTCTGCTTGGTGGTTTGGG
ATTGCCTGCAGGAGCAGCGCTGGTCCGTTTGCTTCGCCATCACCATGATCAGCCAGAGAAGATTCGTGGCAGCAAGTTTT
TGGCATTGCGCTTTCAGGCGCTCAATGGCTTGGGGTTGAGCTTGGGCCTAGCGCTAGCGCCTTGCTTGGGCTTTGCGCTA
TCTAGCGCAGGTTGA

Upstream 100 bases:

>100_bases
AGGTTGCTGAAACTACGGTCAGCTTTCATCCGGGATCGGAGTTGAGCGCGGGTCCTGCTCAAATGTATGGGCCTTTCCCT
GGTTTCCAGGCTTCTTTCCC

Downstream 100 bases:

>100_bases
GTTGATGGCTCTCAAGTTTCAGTGCAAACCGTTTTCATTTCGTTTGAGTCGGGTGTTGCAGACGGCTCAGGGGGTTGTTG
AAGAACGTCAGGGTTGGTTG

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MPDQQDVASLYAKASTRRALWKAAIKWPMYSVAVMPALLAAGWRVGAGEAVRLDQLLGFLVAAVLLLLWENLSNDLFDAD
TGVDSFTKLHSVVALLGQRRPVRRFAHLALVLGLLLMLLLALRSSAAVLFLVLVSCGLGYLYQGPPFRWGYIGLGEPLCW
LAFGPFATAAALLALAPLNGDGSVIPWATAFTLGSGPALATTLVLFCSHFHQVAEDAAFGKRSPVVRLGTARAAALVPWI
LSLVFALEWIPVLQGDWPLTALLGGLGLPAGAALVRLLRHHHDQPEKIRGSKFLALRFQALNGLGLSLGLALAPCLGFAL
SSAG

Sequences:

>Translated_324_residues
MPDQQDVASLYAKASTRRALWKAAIKWPMYSVAVMPALLAAGWRVGAGEAVRLDQLLGFLVAAVLLLLWENLSNDLFDAD
TGVDSFTKLHSVVALLGQRRPVRRFAHLALVLGLLLMLLLALRSSAAVLFLVLVSCGLGYLYQGPPFRWGYIGLGEPLCW
LAFGPFATAAALLALAPLNGDGSVIPWATAFTLGSGPALATTLVLFCSHFHQVAEDAAFGKRSPVVRLGTARAAALVPWI
LSLVFALEWIPVLQGDWPLTALLGGLGLPAGAALVRLLRHHHDQPEKIRGSKFLALRFQALNGLGLSLGLALAPCLGFAL
SSAG
>Mature_323_residues
PDQQDVASLYAKASTRRALWKAAIKWPMYSVAVMPALLAAGWRVGAGEAVRLDQLLGFLVAAVLLLLWENLSNDLFDADT
GVDSFTKLHSVVALLGQRRPVRRFAHLALVLGLLLMLLLALRSSAAVLFLVLVSCGLGYLYQGPPFRWGYIGLGEPLCWL
AFGPFATAAALLALAPLNGDGSVIPWATAFTLGSGPALATTLVLFCSHFHQVAEDAAFGKRSPVVRLGTARAAALVPWIL
SLVFALEWIPVLQGDWPLTALLGGLGLPAGAALVRLLRHHHDQPEKIRGSKFLALRFQALNGLGLSLGLALAPCLGFALS
SAG

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011937
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 34440; Mature: 34309

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDQQDVASLYAKASTRRALWKAAIKWPMYSVAVMPALLAAGWRVGAGEAVRLDQLLGFL
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
VAAVLLLLWENLSNDLFDADTGVDSFTKLHSVVALLGQRRPVRRFAHLALVLGLLLMLLL
HHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
ALRSSAAVLFLVLVSCGLGYLYQGPPFRWGYIGLGEPLCWLAFGPFATAAALLALAPLNG
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
DGSVIPWATAFTLGSGPALATTLVLFCSHFHQVAEDAAFGKRSPVVRLGTARAAALVPWI
CCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHH
LSLVFALEWIPVLQGDWPLTALLGGLGLPAGAALVRLLRHHHDQPEKIRGSKFLALRFQA
HHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHH
LNGLGLSLGLALAPCLGFALSSAG
HCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PDQQDVASLYAKASTRRALWKAAIKWPMYSVAVMPALLAAGWRVGAGEAVRLDQLLGFL
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
VAAVLLLLWENLSNDLFDADTGVDSFTKLHSVVALLGQRRPVRRFAHLALVLGLLLMLLL
HHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
ALRSSAAVLFLVLVSCGLGYLYQGPPFRWGYIGLGEPLCWLAFGPFATAAALLALAPLNG
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
DGSVIPWATAFTLGSGPALATTLVLFCSHFHQVAEDAAFGKRSPVVRLGTARAAALVPWI
CCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHH
LSLVFALEWIPVLQGDWPLTALLGGLGLPAGAALVRLLRHHHDQPEKIRGSKFLALRFQA
HHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHH
LNGLGLSLGLALAPCLGFALSSAG
HCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]