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The map label for this gene is iscS [H]

Identifier: 33864310

GI number: 33864310

Start: 2157192

End: 2158370

Strand: Direct

Name: iscS [H]

Synonym: PMT2045

Alternate gene names: 33864310

Gene position: 2157192-2158370 (Clockwise)

Preceding gene: 33864305

Following gene: 33864311

Centisome position: 89.48

GC content: 57.34

Gene sequence:

>1179_bases
ATGCTGCCAAGCCTTTCCAGTGGATCCCTAAAACAATCCCCCCTTTGCTTGGATTATCAGGCAACCACACCCTGTGCTGC
CGAGGTTGTCAAGGCCATGGCCGCCTACTGGAGCGAGGACTGGGGAAATGCCTCAAGCCGCCAACATCGCTCTGGATTGA
AGGCCGCAGCCGCAGTGAGCCTCGCTCGAGAGCAACTGGCCTGCCATCTGCGCGTCACACCGCAACGCGTGATCTTTACG
AGCGGTGCCACAGAAGCTAATAACCTGGCGCTAGTGGGCCATGCCAGGGCAAGAGCAGAACAACGCGGAGCACCAGGCCA
CCTGATCACGCTGGTTACTGAACACCATGCCGTACTCGATCCGCTGCGCCAATTGCAAAAGGAAGGTTTCCGACTAACCG
AACTACAACCACGGGCTGATGGTCTACTGCGACCGGAGCAACTGGCTGAGGCATTTGAAAACGACACGCTGCTCGTGAGC
GTGATGGTCGCCAACAATGAAACGGGTGTCATCCAACCCCTAGCAGAGCTGTCAGAGCTTTGCCGTAAGCGTGATGTGGT
TCTGCATAGCGATGCCGCACAAGCCTTTGGTCACGTCCATCTCGATGCAGATGCTCTCGGGCTCGATCTGGTCAGCATCA
GCGGCCACAAGCTTTACGGCCCTAAAGGGATCGGCGCACTCGTCGTACGTCCTGAAGTACCAATCAAACCCTTGCAGTGG
GGTGGGGGCCAAGAGCAGGGCCTAAGGCCTGGGACACTACCCGTGCCATTAATTGTGGGCCTCGCTAAAGCCGTAGAACT
AGCCATGGAGGACATCACGAGCCGCCAAGACAAGCTCTGCACGCTGCGTAATCAACTCTGGGATGGTTTACGAGAACGCC
TCCCCGATCTCATCCTCAATGGATCGCTAGAGCACAGGCTGCCTCACAATCTCAACATCACAATTCCAGGCGTGCGCGGC
AGCAACCTGCATCAACAATTGCGACCGCTCATTGCTTGCAGCAGCGGCTCTGCCTGCAGCCAAGGAGCCCCATCCCATGT
GCTGATGGCCTTAGGACGCACATCAGCTGAGGCGGAAGCCTCGATTCGACTGAGCTTGGGTCGCAACACCTCAAGCGAAG
AGATCACCCAGGCTGTGGAGTCGATTAGCAATGTCGTGACCGACCTGAGAGCTAGATAG

Upstream 100 bases:

>100_bases
CTCTGAAGGGCGGAGGCATAACAAAAACAAGGCCGTGAGGCTCAGACCAACGATCCTGAAAGAACGACGCATGCGCGACA
GAGCAACGGAACTTTCCACC

Downstream 100 bases:

>100_bases
CAACAACTGCCTCACAATCGATGTCGCAGTTTCAAAAAATCCTGAGCAAAACTTTTACTGCAGCTAGTTTTTAACAACAT
CTGTGTATTAGACGGTGGCA

Product: NifS-like aminotransferase class-V

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MLPSLSSGSLKQSPLCLDYQATTPCAAEVVKAMAAYWSEDWGNASSRQHRSGLKAAAAVSLAREQLACHLRVTPQRVIFT
SGATEANNLALVGHARARAEQRGAPGHLITLVTEHHAVLDPLRQLQKEGFRLTELQPRADGLLRPEQLAEAFENDTLLVS
VMVANNETGVIQPLAELSELCRKRDVVLHSDAAQAFGHVHLDADALGLDLVSISGHKLYGPKGIGALVVRPEVPIKPLQW
GGGQEQGLRPGTLPVPLIVGLAKAVELAMEDITSRQDKLCTLRNQLWDGLRERLPDLILNGSLEHRLPHNLNITIPGVRG
SNLHQQLRPLIACSSGSACSQGAPSHVLMALGRTSAEAEASIRLSLGRNTSSEEITQAVESISNVVTDLRAR

Sequences:

>Translated_392_residues
MLPSLSSGSLKQSPLCLDYQATTPCAAEVVKAMAAYWSEDWGNASSRQHRSGLKAAAAVSLAREQLACHLRVTPQRVIFT
SGATEANNLALVGHARARAEQRGAPGHLITLVTEHHAVLDPLRQLQKEGFRLTELQPRADGLLRPEQLAEAFENDTLLVS
VMVANNETGVIQPLAELSELCRKRDVVLHSDAAQAFGHVHLDADALGLDLVSISGHKLYGPKGIGALVVRPEVPIKPLQW
GGGQEQGLRPGTLPVPLIVGLAKAVELAMEDITSRQDKLCTLRNQLWDGLRERLPDLILNGSLEHRLPHNLNITIPGVRG
SNLHQQLRPLIACSSGSACSQGAPSHVLMALGRTSAEAEASIRLSLGRNTSSEEITQAVESISNVVTDLRAR
>Mature_392_residues
MLPSLSSGSLKQSPLCLDYQATTPCAAEVVKAMAAYWSEDWGNASSRQHRSGLKAAAAVSLAREQLACHLRVTPQRVIFT
SGATEANNLALVGHARARAEQRGAPGHLITLVTEHHAVLDPLRQLQKEGFRLTELQPRADGLLRPEQLAEAFENDTLLVS
VMVANNETGVIQPLAELSELCRKRDVVLHSDAAQAFGHVHLDADALGLDLVSISGHKLYGPKGIGALVVRPEVPIKPLQW
GGGQEQGLRPGTLPVPLIVGLAKAVELAMEDITSRQDKLCTLRNQLWDGLRERLPDLILNGSLEHRLPHNLNITIPGVRG
SNLHQQLRPLIACSSGSACSQGAPSHVLMALGRTSAEAEASIRLSLGRNTSSEEITQAVESISNVVTDLRAR

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=381, Percent_Identity=43.8320209973753, Blast_Score=311, Evalue=7e-85,
Organism=Homo sapiens, GI156713448, Length=413, Percent_Identity=35.1089588377724, Blast_Score=211, Evalue=7e-55,
Organism=Escherichia coli, GI48994898, Length=383, Percent_Identity=45.1697127937337, Blast_Score=322, Evalue=3e-89,
Organism=Escherichia coli, GI1789175, Length=305, Percent_Identity=29.1803278688525, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787970, Length=309, Percent_Identity=27.5080906148867, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI25143064, Length=371, Percent_Identity=44.2048517520216, Blast_Score=303, Evalue=8e-83,
Organism=Caenorhabditis elegans, GI17533177, Length=324, Percent_Identity=33.9506172839506, Blast_Score=163, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6319831, Length=381, Percent_Identity=43.3070866141732, Blast_Score=302, Evalue=8e-83,
Organism=Drosophila melanogaster, GI20129463, Length=381, Percent_Identity=45.4068241469816, Blast_Score=309, Evalue=2e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 42145; Mature: 42145

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPSLSSGSLKQSPLCLDYQATTPCAAEVVKAMAAYWSEDWGNASSRQHRSGLKAAAAVS
CCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LAREQLACHLRVTPQRVIFTSGATEANNLALVGHARARAEQRGAPGHLITLVTEHHAVLD
HHHHHHHEEEEECCCEEEEECCCCCCCCEEEEECHHHHHHHCCCCCEEEEEEEHHHHHHH
PLRQLQKEGFRLTELQPRADGLLRPEQLAEAFENDTLLVSVMVANNETGVIQPLAELSEL
HHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHH
CRKRDVVLHSDAAQAFGHVHLDADALGLDLVSISGHKLYGPKGIGALVVRPEVPIKPLQW
HHHCCCEEECCHHHHHCEEEECCHHHCEEEEEECCCEEECCCCCCEEEECCCCCCCCCCC
GGGQEQGLRPGTLPVPLIVGLAKAVELAMEDITSRQDKLCTLRNQLWDGLRERLPDLILN
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCC
GSLEHRLPHNLNITIPGVRGSNLHQQLRPLIACSSGSACSQGAPSHVLMALGRTSAEAEA
CCHHHCCCCCCEEEECCCCCCCHHHHHHHHEEECCCCCCCCCCCHHHHHHHCCCCCCCCE
SIRLSLGRNTSSEEITQAVESISNVVTDLRAR
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLPSLSSGSLKQSPLCLDYQATTPCAAEVVKAMAAYWSEDWGNASSRQHRSGLKAAAAVS
CCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LAREQLACHLRVTPQRVIFTSGATEANNLALVGHARARAEQRGAPGHLITLVTEHHAVLD
HHHHHHHEEEEECCCEEEEECCCCCCCCEEEEECHHHHHHHCCCCCEEEEEEEHHHHHHH
PLRQLQKEGFRLTELQPRADGLLRPEQLAEAFENDTLLVSVMVANNETGVIQPLAELSEL
HHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHH
CRKRDVVLHSDAAQAFGHVHLDADALGLDLVSISGHKLYGPKGIGALVVRPEVPIKPLQW
HHHCCCEEECCHHHHHCEEEECCHHHCEEEEEECCCEEECCCCCCEEEECCCCCCCCCCC
GGGQEQGLRPGTLPVPLIVGLAKAVELAMEDITSRQDKLCTLRNQLWDGLRERLPDLILN
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCC
GSLEHRLPHNLNITIPGVRGSNLHQQLRPLIACSSGSACSQGAPSHVLMALGRTSAEAEA
CCHHHCCCCCCEEEECCCCCCCHHHHHHHHEEECCCCCCCCCCCHHHHHHHCCCCCCCCE
SIRLSLGRNTSSEEITQAVESISNVVTDLRAR
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA