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The map label for this gene is hemD [H]

Identifier: 33864231

GI number: 33864231

Start: 2076990

End: 2077823

Strand: Direct

Name: hemD [H]

Synonym: PMT1966

Alternate gene names: 33864231

Gene position: 2076990-2077823 (Clockwise)

Preceding gene: 33864230

Following gene: 33864234

Centisome position: 86.15

GC content: 54.44

Gene sequence:

>834_bases
ATGAGCAGCAAACCCATAGCTCCCCTTCATGGCCGCACAATCATCATGACCCGTGCCCAGGAGCAACAGAGTGAGGCTCG
GAGTCAGCTTCATGCCCTTGGATCAAACGTTCTGGATCTGCCCGCTCTTGTAATTGGCCCACCCGACGATTGGCAACCCC
TCGATGATGCCTTAGCCGACATCAAGACATTCCACTGGTTGGTGTTCTCCAGTGCCAATGGAGTACGGGCCGTTGAAGAA
CGGCTGCAGCGGATCGGCCAATCTCTTGCCAATCGTCCCAAGGGACTAAAACTTGCAGCAGTAGGCCGCAAAACAGCCCA
ATATCTTGAACACCTAGGAGCTGCTGTTGATTTTGTTCCACCCAACTTTGTGGCTGACAGCCTGATCAATCATTTCCCAG
TGTCAGGCTTTGGACTGAAAATGCTGCTGCCAAGAGTGCAGAGCGGTGGCCGCACCATTCTGGGAGAAGCCTTCCGGGAA
AGCGGAGCACACGTGATTGAAGTGGCAGCTTATGAATCCCGTTGCCCAGAAGCAATCCCGGATGACACGGCCACAGCCCT
CGCAAACAGCAATGTGGATGCAATTGCTTTCAGCAGCGGCAAGACCGCTGCACACACAGCAAGTTTGCTCAGCCATCGTT
TTGGCAGCGACTGGCTACAGCAACTTGAAACAGTCAAAGTCATCTCCATCGGCCCCCAGACAAGCCTCAGCTGTGAGCAG
CATTTTGGAAGGGTCGATCAAGAAGCCGATCCCCACAACCTTGAGGGGCTTATCAGTGCTTGTGTTAAAGCATGCAGGTC
GGAGGCTGAGACTTGCCCCCCTGGCTCAAGGTGA

Upstream 100 bases:

>100_bases
ACAAGGCGATTACGCTGCTGCACCGTCAAGGACGAAGCAAGGAAAGCGAAGGGCTGCGCCATCAGGTAGCAGGCATTGTG
AAACTGAATGAGGAAGAGAA

Downstream 100 bases:

>100_bases
TGCACCCGCGCTGAACGTCGATCGATAGCAGCGACCAGCTTGGCGGTAACAGCTGGTCCGCCTCAACCTGACCGGGGCAA
CGACCTCCAGGCCCCACGCA

Product: uroporphyrinogen III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 277; Mature: 276

Protein sequence:

>277_residues
MSSKPIAPLHGRTIIMTRAQEQQSEARSQLHALGSNVLDLPALVIGPPDDWQPLDDALADIKTFHWLVFSSANGVRAVEE
RLQRIGQSLANRPKGLKLAAVGRKTAQYLEHLGAAVDFVPPNFVADSLINHFPVSGFGLKMLLPRVQSGGRTILGEAFRE
SGAHVIEVAAYESRCPEAIPDDTATALANSNVDAIAFSSGKTAAHTASLLSHRFGSDWLQQLETVKVISIGPQTSLSCEQ
HFGRVDQEADPHNLEGLISACVKACRSEAETCPPGSR

Sequences:

>Translated_277_residues
MSSKPIAPLHGRTIIMTRAQEQQSEARSQLHALGSNVLDLPALVIGPPDDWQPLDDALADIKTFHWLVFSSANGVRAVEE
RLQRIGQSLANRPKGLKLAAVGRKTAQYLEHLGAAVDFVPPNFVADSLINHFPVSGFGLKMLLPRVQSGGRTILGEAFRE
SGAHVIEVAAYESRCPEAIPDDTATALANSNVDAIAFSSGKTAAHTASLLSHRFGSDWLQQLETVKVISIGPQTSLSCEQ
HFGRVDQEADPHNLEGLISACVKACRSEAETCPPGSR
>Mature_276_residues
SSKPIAPLHGRTIIMTRAQEQQSEARSQLHALGSNVLDLPALVIGPPDDWQPLDDALADIKTFHWLVFSSANGVRAVEER
LQRIGQSLANRPKGLKLAAVGRKTAQYLEHLGAAVDFVPPNFVADSLINHFPVSGFGLKMLLPRVQSGGRTILGEAFRES
GAHVIEVAAYESRCPEAIPDDTATALANSNVDAIAFSSGKTAAHTASLLSHRFGSDWLQQLETVKVISIGPQTSLSCEQH
FGRVDQEADPHNLEGLISACVKACRSEAETCPPGSR

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 29757; Mature: 29626

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKPIAPLHGRTIIMTRAQEQQSEARSQLHALGSNVLDLPALVIGPPDDWQPLDDALAD
CCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCHHHCCEEEECCCCCCCHHHHHHHH
IKTFHWLVFSSANGVRAVEERLQRIGQSLANRPKGLKLAAVGRKTAQYLEHLGAAVDFVP
HHHHHHHEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHCCHHCCCC
PNFVADSLINHFPVSGFGLKMLLPRVQSGGRTILGEAFRESGAHVIEVAAYESRCPEAIP
CHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEHHHHCCCCCC
DDTATALANSNVDAIAFSSGKTAAHTASLLSHRFGSDWLQQLETVKVISIGPQTSLSCEQ
CCHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHEEEEEECCCCCCCHHH
HFGRVDQEADPHNLEGLISACVKACRSEAETCPPGSR
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SSKPIAPLHGRTIIMTRAQEQQSEARSQLHALGSNVLDLPALVIGPPDDWQPLDDALAD
CCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCHHHCCEEEECCCCCCCHHHHHHHH
IKTFHWLVFSSANGVRAVEERLQRIGQSLANRPKGLKLAAVGRKTAQYLEHLGAAVDFVP
HHHHHHHEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHCCHHCCCC
PNFVADSLINHFPVSGFGLKMLLPRVQSGGRTILGEAFRESGAHVIEVAAYESRCPEAIP
CHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEHHHHCCCCCC
DDTATALANSNVDAIAFSSGKTAAHTASLLSHRFGSDWLQQLETVKVISIGPQTSLSCEQ
CCHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHEEEEEECCCCCCCHHH
HFGRVDQEADPHNLEGLISACVKACRSEAETCPPGSR
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8123787 [H]