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The map label for this gene is galE [H]

Identifier: 33864173

GI number: 33864173

Start: 2011096

End: 2012142

Strand: Direct

Name: galE [H]

Synonym: PMT1907

Alternate gene names: 33864173

Gene position: 2011096-2012142 (Clockwise)

Preceding gene: 33864168

Following gene: 33864174

Centisome position: 83.42

GC content: 55.11

Gene sequence:

>1047_bases
ATGGCCGAGTTGTTGATCACGGGTGGTGCCGGGTTCATTGGCAGTCACACCTGCCTGGTGCTTTTGGAAGCCGGCCACAG
GCTGGTGATACTCGACAACTTTTCCAATAGCTCAGCTATTGCCTCAAAAAGGGTAGCCGAACTTGCTGGAGTGGCCGCTC
AAGAGCGAATGCTCGTATTGGAGGGCGATATCCGCAATAGCAACGATCTAGATCGCGCTTTCAACTCAATGGAAAACGGC
ATTGCAGCTGTGGTGCACTTCGCGGGGCTCAAGGCAGTTCATGAATCAGTTCAGTTGCCACTGAAATACTGGGATGTGAA
TGTGGCTGGCAGCCGCTGCCTACTGGAAGCCATGCAACGACATAACTGCCGCACGATTGTTTTCAGCAGTAGTGCAACGC
TCTATGGCTATCCCGAGCAAATCCCAATCCCTGAAACGACTAGGGTGCAACCGATCAATCCATATGGTCAAAGCAAGGCA
GCGGTGGAGCAGTTACTAGATGACCTGGCCTGCAGCGAACCTGGTTGGCGCATTGCCCGATTGCGCTATTTCAATCCAGT
TGGAGCCCACTCCAGCGGCTGCATCGGCGAAGATCCCAAGGGAATACCCAACAACCTTTTCCCTTTTGTGAGCCAAGTAG
CAGTAGGCCGGCGAGCAGAACTCCAAGTATTTGGAGCCGATTGGCCTACACCCGATGGGAGTGGTGTGCGCGACTACATC
CATGTGATGGACTTAGCTGAGGGACACCGAGCTGCACTGGAGGTCCTGCAACGAGAGGAACCGCAACTCCTCACTCTTAA
TCTCGGCAGTGGCAAAGGCCACTCGGTGTTGGAAGTCGTGCAGGCCTTTGAAAAGGCAAGCGGCCAACCCGTTCCATACA
GCATTAACCAGCGCCGCGCTGGAGATGCCGCATGTAGCGTCGCAGATCCAAGACTGGCCGCCGAGCGGTTGGGATGGTAC
ACGCAGCGCAGCCTGTCAGACATGTGCCGCGACAGTTGGAATTGGCAGAAGGCCAATCCACAGGGCTACAGCCAGAAACA
ACAATGA

Upstream 100 bases:

>100_bases
ACTCTGCAATGGCTCATCTGATCAACTGATCATTTCAAGAGTCTTATGAAATGGAACAGTTACAGCTCCTAGCCTGACTG
CCTAAGTCATTTAATTTGCG

Downstream 100 bases:

>100_bases
AACCATTGTTATTCACCAAGACCAACACATAGCCAGGCCAGACCTAGGGTCACCAAGTCGCTGTGATGCCCTTGTCCTGG
CGCAATCCTCGCCGCAACTT

Product: UDP-glucose-4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MAELLITGGAGFIGSHTCLVLLEAGHRLVILDNFSNSSAIASKRVAELAGVAAQERMLVLEGDIRNSNDLDRAFNSMENG
IAAVVHFAGLKAVHESVQLPLKYWDVNVAGSRCLLEAMQRHNCRTIVFSSSATLYGYPEQIPIPETTRVQPINPYGQSKA
AVEQLLDDLACSEPGWRIARLRYFNPVGAHSSGCIGEDPKGIPNNLFPFVSQVAVGRRAELQVFGADWPTPDGSGVRDYI
HVMDLAEGHRAALEVLQREEPQLLTLNLGSGKGHSVLEVVQAFEKASGQPVPYSINQRRAGDAACSVADPRLAAERLGWY
TQRSLSDMCRDSWNWQKANPQGYSQKQQ

Sequences:

>Translated_348_residues
MAELLITGGAGFIGSHTCLVLLEAGHRLVILDNFSNSSAIASKRVAELAGVAAQERMLVLEGDIRNSNDLDRAFNSMENG
IAAVVHFAGLKAVHESVQLPLKYWDVNVAGSRCLLEAMQRHNCRTIVFSSSATLYGYPEQIPIPETTRVQPINPYGQSKA
AVEQLLDDLACSEPGWRIARLRYFNPVGAHSSGCIGEDPKGIPNNLFPFVSQVAVGRRAELQVFGADWPTPDGSGVRDYI
HVMDLAEGHRAALEVLQREEPQLLTLNLGSGKGHSVLEVVQAFEKASGQPVPYSINQRRAGDAACSVADPRLAAERLGWY
TQRSLSDMCRDSWNWQKANPQGYSQKQQ
>Mature_347_residues
AELLITGGAGFIGSHTCLVLLEAGHRLVILDNFSNSSAIASKRVAELAGVAAQERMLVLEGDIRNSNDLDRAFNSMENGI
AAVVHFAGLKAVHESVQLPLKYWDVNVAGSRCLLEAMQRHNCRTIVFSSSATLYGYPEQIPIPETTRVQPINPYGQSKAA
VEQLLDDLACSEPGWRIARLRYFNPVGAHSSGCIGEDPKGIPNNLFPFVSQVAVGRRAELQVFGADWPTPDGSGVRDYIH
VMDLAEGHRAALEVLQREEPQLLTLNLGSGKGHSVLEVVQAFEKASGQPVPYSINQRRAGDAACSVADPRLAAERLGWYT
QRSLSDMCRDSWNWQKANPQGYSQKQQ

Specific function: Galactose metabolism; third step. [C]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=354, Percent_Identity=51.9774011299435, Blast_Score=349, Evalue=2e-96,
Organism=Homo sapiens, GI56118217, Length=354, Percent_Identity=51.9774011299435, Blast_Score=349, Evalue=2e-96,
Organism=Homo sapiens, GI189083684, Length=354, Percent_Identity=51.9774011299435, Blast_Score=349, Evalue=2e-96,
Organism=Homo sapiens, GI7657641, Length=359, Percent_Identity=23.9554317548747, Blast_Score=85, Evalue=8e-17,
Organism=Escherichia coli, GI1786974, Length=341, Percent_Identity=51.3196480938416, Blast_Score=342, Evalue=2e-95,
Organism=Escherichia coli, GI48994969, Length=372, Percent_Identity=25.5376344086022, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788353, Length=367, Percent_Identity=25.0681198910082, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71982035, Length=350, Percent_Identity=46.5714285714286, Blast_Score=317, Evalue=4e-87,
Organism=Caenorhabditis elegans, GI71982038, Length=352, Percent_Identity=46.3068181818182, Blast_Score=317, Evalue=5e-87,
Organism=Saccharomyces cerevisiae, GI6319493, Length=348, Percent_Identity=48.8505747126437, Blast_Score=332, Evalue=4e-92,
Organism=Drosophila melanogaster, GI19923002, Length=351, Percent_Identity=47.5783475783476, Blast_Score=332, Evalue=2e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 38021; Mature: 37890

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELLITGGAGFIGSHTCLVLLEAGHRLVILDNFSNSSAIASKRVAELAGVAAQERMLVL
CCEEEEECCCCCCCCCEEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCEEEE
EGDIRNSNDLDRAFNSMENGIAAVVHFAGLKAVHESVQLPLKYWDVNVAGSRCLLEAMQR
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHH
HNCRTIVFSSSATLYGYPEQIPIPETTRVQPINPYGQSKAAVEQLLDDLACSEPGWRIAR
CCCEEEEEECCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEE
LRYFNPVGAHSSGCIGEDPKGIPNNLFPFVSQVAVGRRAELQVFGADWPTPDGSGVRDYI
EEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHH
HVMDLAEGHRAALEVLQREEPQLLTLNLGSGKGHSVLEVVQAFEKASGQPVPYSINQRRA
HHHHHCCCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
GDAACSVADPRLAAERLGWYTQRSLSDMCRDSWNWQKANPQGYSQKQQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AELLITGGAGFIGSHTCLVLLEAGHRLVILDNFSNSSAIASKRVAELAGVAAQERMLVL
CEEEEECCCCCCCCCEEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCEEEE
EGDIRNSNDLDRAFNSMENGIAAVVHFAGLKAVHESVQLPLKYWDVNVAGSRCLLEAMQR
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHH
HNCRTIVFSSSATLYGYPEQIPIPETTRVQPINPYGQSKAAVEQLLDDLACSEPGWRIAR
CCCEEEEEECCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEE
LRYFNPVGAHSSGCIGEDPKGIPNNLFPFVSQVAVGRRAELQVFGADWPTPDGSGVRDYI
EEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHH
HVMDLAEGHRAALEVLQREEPQLLTLNLGSGKGHSVLEVVQAFEKASGQPVPYSINQRRA
HHHHHCCCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
GDAACSVADPRLAAERLGWYTQRSLSDMCRDSWNWQKANPQGYSQKQQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8978088; 8969509; 9384377 [H]