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The map label for this gene is pyrE [H]

Identifier: 33864135

GI number: 33864135

Start: 1974775

End: 1975365

Strand: Direct

Name: pyrE [H]

Synonym: PMT1868

Alternate gene names: 33864135

Gene position: 1974775-1975365 (Clockwise)

Preceding gene: 33864130

Following gene: 33864136

Centisome position: 81.91

GC content: 58.54

Gene sequence:

>591_bases
ATGAGCCCTCTTCCCCCATCGGCGGAGGCCTGCCGCAATGAGCTGCTCAACCGGCTAGCGCGAGAGGCCTACCGCCATGG
AGACTTCACCCTGGCCTCTGGTCGCCAAAGCAACCACTACGTGAACTGCAAGCCAGTCAGCCTCAGTGGATCTGGCCTGG
CGTTGCTCGGCCTGGCCTTACTCAAATATGTAGAGCCCGATGCTGTTTGTGTCGCTGGCCTCACCCTCGGCGCCGATCCC
TTGGTGAGTGCAGTAGCGATGGCAGCAGCACAAGCGGAACGCACTCTCAATGCGCTAATCGTGAGAAAGCAAGCCAAAGG
CCATGGCACCGCTGCTTGGCTTGAAGGTCCACTACCTCCCAGCGGTGCACGCATCACCGTTTTGGAAGACGTTGTCACCA
CAGGCGGATCGTCACTCAAAGCCGTGCAACAGCTGCGTGAGACGGGCTATCTGGTGACACGCGTCGTCACGATCGTCGAT
CGACAAGAAGGTGGTGAAGAAGCCTTGAATGCTGCTGAGTTAGAGCTTGTCAGTTTGTACCAGCTCAATCAGGTCGCTGA
GCGGGCCAGACAGCTGGAGACAGAGACATGA

Upstream 100 bases:

>100_bases
AAACCAAGCATCCTTAGCTTATGGAAGGACACCCAAGCCATAACTGCAAAAAACACGGCTACGCGCAAACTAGGCAATGA
ATCCTTAACGCACCAGCCCA

Downstream 100 bases:

>100_bases
GCAGCTCGAGCAAGCAACGATGGGACGCCCTTAAACCCCTATTGAGGCTGGAGGGTTCTGGTAGTCGAGACTTTCTTCAC
GGCCAGACCAGTGCCGATCT

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MSPLPPSAEACRNELLNRLAREAYRHGDFTLASGRQSNHYVNCKPVSLSGSGLALLGLALLKYVEPDAVCVAGLTLGADP
LVSAVAMAAAQAERTLNALIVRKQAKGHGTAAWLEGPLPPSGARITVLEDVVTTGGSSLKAVQQLRETGYLVTRVVTIVD
RQEGGEEALNAAELELVSLYQLNQVAERARQLETET

Sequences:

>Translated_196_residues
MSPLPPSAEACRNELLNRLAREAYRHGDFTLASGRQSNHYVNCKPVSLSGSGLALLGLALLKYVEPDAVCVAGLTLGADP
LVSAVAMAAAQAERTLNALIVRKQAKGHGTAAWLEGPLPPSGARITVLEDVVTTGGSSLKAVQQLRETGYLVTRVVTIVD
RQEGGEEALNAAELELVSLYQLNQVAERARQLETET
>Mature_195_residues
SPLPPSAEACRNELLNRLAREAYRHGDFTLASGRQSNHYVNCKPVSLSGSGLALLGLALLKYVEPDAVCVAGLTLGADPL
VSAVAMAAAQAERTLNALIVRKQAKGHGTAAWLEGPLPPSGARITVLEDVVTTGGSSLKAVQQLRETGYLVTRVVTIVDR
QEGGEEALNAAELELVSLYQLNQVAERARQLETET

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=183, Percent_Identity=31.1475409836066, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17554964, Length=174, Percent_Identity=35.632183908046, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17508631, Length=176, Percent_Identity=27.8409090909091, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 20785; Mature: 20654

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPLPPSAEACRNELLNRLAREAYRHGDFTLASGRQSNHYVNCKPVSLSGSGLALLGLAL
CCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEEEECCCCHHHHHHHH
LKYVEPDAVCVAGLTLGADPLVSAVAMAAAQAERTLNALIVRKQAKGHGTAAWLEGPLPP
HHHCCCCHHEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCC
SGARITVLEDVVTTGGSSLKAVQQLRETGYLVTRVVTIVDRQEGGEEALNAAELELVSLY
CCCEEEEHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
QLNQVAERARQLETET
HHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SPLPPSAEACRNELLNRLAREAYRHGDFTLASGRQSNHYVNCKPVSLSGSGLALLGLAL
CCCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEEEECCCCHHHHHHHH
LKYVEPDAVCVAGLTLGADPLVSAVAMAAAQAERTLNALIVRKQAKGHGTAAWLEGPLPP
HHHCCCCHHEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCC
SGARITVLEDVVTTGGSSLKAVQQLRETGYLVTRVVTIVDRQEGGEEALNAAELELVSLY
CCCEEEEHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
QLNQVAERARQLETET
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA