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The map label for this gene is csd [H]

Identifier: 33863870

GI number: 33863870

Start: 1702465

End: 1703769

Strand: Reverse

Name: csd [H]

Synonym: PMT1603

Alternate gene names: 33863870

Gene position: 1703769-1702465 (Counterclockwise)

Preceding gene: 33863871

Following gene: 33863868

Centisome position: 70.67

GC content: 53.79

Gene sequence:

>1305_bases
ATGACCTCTTCCGTTAGTTCAGAGCAGAGCATGCCGTTGGAAATGGCAGCTGTAGAAACTTCAGCGAACCTGGCAGAGCT
CACGCGAGCGGATTTCCCGCTACTAGGCCAGACCGCCTGCTTAGGTCAGCCCTTGATTTACATGGACCATGCGGCGACAA
GTCAGAAGCCACGGCAGGTGCTGGATGCATTACAGCATTACTACGACCATGACAACGCCAATGTGCACCGTGGTGCCCAT
CAGTTGAGTGTTCGGGCTACTGAGGATTTTGAACGAGCACGTCAGAAGGTGGCTGATTTCATCGCTGCCTCAAGCGCGCG
GGAAATCGTTTTCACAAGGAATGCGAGTGAGGCGATCAACCTGGTGGCTCGCACTTGGGGAGATGCCAACCTGCATGAAG
GTGACGAGGTGCTGCTCACCTTGATGGAGCATCACAGCAACATTGTTCCTTGGCAGATGCTTGCAAAGCGAACAGGTTGC
GTACTGCGCTTTGTCGACCTCACCGATTGCGGGGAGCTTGATTTAAACGATCTTCGGCACAAGCTCTCCGAGCGGACTCG
TTTGATCAGCCTGGCTCATTTGAGCAATGTGCTGGGCTGTTTTAACCCGATCTCTGAGGTCACTGCAGAGGCTCATCGCT
TTGGTGCTCTTGTGTTGCTGGATGCTTGCCAGAGCTTGCCACATATGCCTGTTGATGTTTCTCGGCTTGGATGTGACTTT
CTCGTGGGTTCTTCCCACAAATTATGCGGTCCTACCGGGATGGGTTTTCTTTGGGCTCGAGAGGAGTTACTTGATGCCAT
GCCGCCTTTCCTCGGAGGTGGCGAAATGATTCAGGACGTTTATCTCGACCACAGCAGCTGGGCTGATCTGCCCTACAAGT
TTGAAGCAGGTACCCCTGCTATTGGGGAAGCGATTGGTATGGGCGTTGCTCTCGACTACCTGAACCAGGTTGGCTTAGAT
CGTATTCACGCTTGGGAGCAGCAGCTCACGCTGCAATTGTTTGATCGCCTCCAAGCCATTGATGGGTTGACGATTCTGGG
CCCAACTCCTCAGCAGGAGCCTGATCGGGCGGTCTTGGCGGCTTTCACGGTGGATGGCTTGCATCCCAATGATGTTGGTG
CCCTGCTTGATTCAGCAGGGATCTGTATTCGTAGTGGCCACCACTGCACCCAGCCTTTGCATCGTCACTATGGGATCCCT
GGATCAGCTCGTGCCAGCTTGAGCTTCACCAACACACCAGAAGAAGTCGATCGTTTTGCTGAGGAATTGGTTGCGACGAT
TGGCTTCTTAAGAGAGCACAGCTAG

Upstream 100 bases:

>100_bases
TTACTGCGTGCGTTTTGTGATGAGGTGATTTGCATGCTCCCATCTACTGCAAAGGCCTGGCGGCCTTTGGCTCGATTGTT
GGATGGGGTTTGAGTCGATC

Downstream 100 bases:

>100_bases
AGCTTTAGGTGGCGGCGGAAGAATTGCTCAGTTGCTTCTAAGACTTTGATCTTGACAGCACTGTCGCGAAAGCCGTGGCC
TTCCTGCTCAAAAATGTGCA

Product: cysteine desulfurase or selenocysteine lyase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MTSSVSSEQSMPLEMAAVETSANLAELTRADFPLLGQTACLGQPLIYMDHAATSQKPRQVLDALQHYYDHDNANVHRGAH
QLSVRATEDFERARQKVADFIAASSAREIVFTRNASEAINLVARTWGDANLHEGDEVLLTLMEHHSNIVPWQMLAKRTGC
VLRFVDLTDCGELDLNDLRHKLSERTRLISLAHLSNVLGCFNPISEVTAEAHRFGALVLLDACQSLPHMPVDVSRLGCDF
LVGSSHKLCGPTGMGFLWAREELLDAMPPFLGGGEMIQDVYLDHSSWADLPYKFEAGTPAIGEAIGMGVALDYLNQVGLD
RIHAWEQQLTLQLFDRLQAIDGLTILGPTPQQEPDRAVLAAFTVDGLHPNDVGALLDSAGICIRSGHHCTQPLHRHYGIP
GSARASLSFTNTPEEVDRFAEELVATIGFLREHS

Sequences:

>Translated_434_residues
MTSSVSSEQSMPLEMAAVETSANLAELTRADFPLLGQTACLGQPLIYMDHAATSQKPRQVLDALQHYYDHDNANVHRGAH
QLSVRATEDFERARQKVADFIAASSAREIVFTRNASEAINLVARTWGDANLHEGDEVLLTLMEHHSNIVPWQMLAKRTGC
VLRFVDLTDCGELDLNDLRHKLSERTRLISLAHLSNVLGCFNPISEVTAEAHRFGALVLLDACQSLPHMPVDVSRLGCDF
LVGSSHKLCGPTGMGFLWAREELLDAMPPFLGGGEMIQDVYLDHSSWADLPYKFEAGTPAIGEAIGMGVALDYLNQVGLD
RIHAWEQQLTLQLFDRLQAIDGLTILGPTPQQEPDRAVLAAFTVDGLHPNDVGALLDSAGICIRSGHHCTQPLHRHYGIP
GSARASLSFTNTPEEVDRFAEELVATIGFLREHS
>Mature_433_residues
TSSVSSEQSMPLEMAAVETSANLAELTRADFPLLGQTACLGQPLIYMDHAATSQKPRQVLDALQHYYDHDNANVHRGAHQ
LSVRATEDFERARQKVADFIAASSAREIVFTRNASEAINLVARTWGDANLHEGDEVLLTLMEHHSNIVPWQMLAKRTGCV
LRFVDLTDCGELDLNDLRHKLSERTRLISLAHLSNVLGCFNPISEVTAEAHRFGALVLLDACQSLPHMPVDVSRLGCDFL
VGSSHKLCGPTGMGFLWAREELLDAMPPFLGGGEMIQDVYLDHSSWADLPYKFEAGTPAIGEAIGMGVALDYLNQVGLDR
IHAWEQQLTLQLFDRLQAIDGLTILGPTPQQEPDRAVLAAFTVDGLHPNDVGALLDSAGICIRSGHHCTQPLHRHYGIPG
SARASLSFTNTPEEVDRFAEELVATIGFLREHS

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=405, Percent_Identity=24.9382716049383, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI156713448, Length=448, Percent_Identity=24.3303571428571, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1787970, Length=397, Percent_Identity=47.3551637279597, Blast_Score=377, Evalue=1e-106,
Organism=Escherichia coli, GI1789175, Length=389, Percent_Identity=36.5038560411311, Blast_Score=264, Evalue=1e-71,
Organism=Escherichia coli, GI48994898, Length=407, Percent_Identity=26.044226044226, Blast_Score=108, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI25143064, Length=218, Percent_Identity=29.3577981651376, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI193211090, Length=373, Percent_Identity=24.3967828418231, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319831, Length=405, Percent_Identity=25.9259259259259, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI20129463, Length=409, Percent_Identity=26.161369193154, Blast_Score=105, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 47624; Mature: 47493

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSVSSEQSMPLEMAAVETSANLAELTRADFPLLGQTACLGQPLIYMDHAATSQKPRQV
CCCCCCCCCCCCEEHHHHHCCCHHHHHHHCCCCCCCCHHHCCCCEEEEECCCCCCCHHHH
LDALQHYYDHDNANVHRGAHQLSVRATEDFERARQKVADFIAASSAREIVFTRNASEAIN
HHHHHHHHCCCCCCHHCCHHHEEEECHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHH
LVARTWGDANLHEGDEVLLTLMEHHSNIVPWQMLAKRTGCVLRFVDLTDCGELDLNDLRH
HHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEECCCCCCCCHHHHHH
KLSERTRLISLAHLSNVLGCFNPISEVTAEAHRFGALVLLDACQSLPHMPVDVSRLGCDF
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCHH
LVGSSHKLCGPTGMGFLWAREELLDAMPPFLGGGEMIQDVYLDHSSWADLPYKFEAGTPA
EECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCCH
IGEAIGMGVALDYLNQVGLDRIHAWEQQLTLQLFDRLQAIDGLTILGPTPQQEPDRAVLA
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCEEE
AFTVDGLHPNDVGALLDSAGICIRSGHHCTQPLHRHYGIPGSARASLSFTNTPEEVDRFA
EEEECCCCCHHHHHHHHCCCCEEECCCHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHH
EELVATIGFLREHS
HHHHHHHHHHHCCC
>Mature Secondary Structure 
TSSVSSEQSMPLEMAAVETSANLAELTRADFPLLGQTACLGQPLIYMDHAATSQKPRQV
CCCCCCCCCCCEEHHHHHCCCHHHHHHHCCCCCCCCHHHCCCCEEEEECCCCCCCHHHH
LDALQHYYDHDNANVHRGAHQLSVRATEDFERARQKVADFIAASSAREIVFTRNASEAIN
HHHHHHHHCCCCCCHHCCHHHEEEECHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHH
LVARTWGDANLHEGDEVLLTLMEHHSNIVPWQMLAKRTGCVLRFVDLTDCGELDLNDLRH
HHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEECCCCCCCCHHHHHH
KLSERTRLISLAHLSNVLGCFNPISEVTAEAHRFGALVLLDACQSLPHMPVDVSRLGCDF
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCHH
LVGSSHKLCGPTGMGFLWAREELLDAMPPFLGGGEMIQDVYLDHSSWADLPYKFEAGTPA
EECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCCH
IGEAIGMGVALDYLNQVGLDRIHAWEQQLTLQLFDRLQAIDGLTILGPTPQQEPDRAVLA
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCEEE
AFTVDGLHPNDVGALLDSAGICIRSGHHCTQPLHRHYGIPGSARASLSFTNTPEEVDRFA
EEEECCCCCHHHHHHHHCCCCEEECCCHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHH
EELVATIGFLREHS
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]