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The map label for this gene is thyX [H]

Identifier: 33863817

GI number: 33863817

Start: 1642692

End: 1643324

Strand: Direct

Name: thyX [H]

Synonym: PMT1550

Alternate gene names: 33863817

Gene position: 1642692-1643324 (Clockwise)

Preceding gene: 33863816

Following gene: 33863819

Centisome position: 68.14

GC content: 45.02

Gene sequence:

>633_bases
ATGAATAGCGTATCCTTAATCTCCGTAACGCCCAAGGCAGAAGAAATCATTGCTTACTGTGCGAGAGTCTCAAATCCTCA
AAATCAAGACAATCCTGATAGCGAAAGGCTTATCCGCTATCTGATTAAACATCGTCACTGGAGTCCCTTCGAGATGGCCC
ATATAGTTATGGAAATAGGAACGACCCGAGCAATAGCAGCGCAAATCCTCAGACATCGAAGCTTCTCTTTTCAAGAATTT
AGTCAGCGCTATGCTGATGTCTCAACAATGGCCTTTGCTAAGCCGCCTTCACTACGCAGGCAAGACATAAAAAACAGGCA
AAGTAGCATCGACGATCTTGATCAAGAGACAGTATCAAAACTGAGTTCAAAAGCGAACTTATTGTTTGAACAAAGTCGCG
ACCTATACCAAGAGATGCTTGCAGCTGGTGTCGCGAAAGAATGCGCAAGAGAAGTTCTCCCACTAGCAACTCCCACGAAA
ATCTATATGGCAGGGAGCGTTAGATCTTGGCTTCATTATATCGATCTGCGCTCCGCACATGGCACCCAAAAAGAACACCA
AGACGTTGCTATCAAGTGCCGAGAAATACTCACAAAAGAGATGCCTTGCGTATGCAATGCAATGTGGCCTTGA

Upstream 100 bases:

>100_bases
TTTCGCTCTCAGTCGGAAGATAAGGCTCAACAATAAACATCATCCCAAAAAAACAGCCGATCACAAACCCAAACCATTCA
ATCTCCCAATCATCAGATTC

Downstream 100 bases:

>100_bases
AAAGAAAATATTAAAGCCAGGATTGATATTACCAGAATTGCCAGGGTTCAAGTTTAATCTTTAGCTAGCATGTAAATCAA
TTAAATTAATCGCCTTAAAG

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MNSVSLISVTPKAEEIIAYCARVSNPQNQDNPDSERLIRYLIKHRHWSPFEMAHIVMEIGTTRAIAAQILRHRSFSFQEF
SQRYADVSTMAFAKPPSLRRQDIKNRQSSIDDLDQETVSKLSSKANLLFEQSRDLYQEMLAAGVAKECAREVLPLATPTK
IYMAGSVRSWLHYIDLRSAHGTQKEHQDVAIKCREILTKEMPCVCNAMWP

Sequences:

>Translated_210_residues
MNSVSLISVTPKAEEIIAYCARVSNPQNQDNPDSERLIRYLIKHRHWSPFEMAHIVMEIGTTRAIAAQILRHRSFSFQEF
SQRYADVSTMAFAKPPSLRRQDIKNRQSSIDDLDQETVSKLSSKANLLFEQSRDLYQEMLAAGVAKECAREVLPLATPTK
IYMAGSVRSWLHYIDLRSAHGTQKEHQDVAIKCREILTKEMPCVCNAMWP
>Mature_210_residues
MNSVSLISVTPKAEEIIAYCARVSNPQNQDNPDSERLIRYLIKHRHWSPFEMAHIVMEIGTTRAIAAQILRHRSFSFQEF
SQRYADVSTMAFAKPPSLRRQDIKNRQSSIDDLDQETVSKLSSKANLLFEQSRDLYQEMLAAGVAKECAREVLPLATPTK
IYMAGSVRSWLHYIDLRSAHGTQKEHQDVAIKCREILTKEMPCVCNAMWP

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 24039; Mature: 24039

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSVSLISVTPKAEEIIAYCARVSNPQNQDNPDSERLIRYLIKHRHWSPFEMAHIVMEIG
CCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHC
TTRAIAAQILRHRSFSFQEFSQRYADVSTMAFAKPPSLRRQDIKNRQSSIDDLDQETVSK
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LSSKANLLFEQSRDLYQEMLAAGVAKECAREVLPLATPTKIYMAGSVRSWLHYIDLRSAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEHHHHHHHHHHHHHHHCC
GTQKEHQDVAIKCREILTKEMPCVCNAMWP
CCCHHHHHHHHHHHHHHHHCCCHHHCCCCC
>Mature Secondary Structure
MNSVSLISVTPKAEEIIAYCARVSNPQNQDNPDSERLIRYLIKHRHWSPFEMAHIVMEIG
CCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHC
TTRAIAAQILRHRSFSFQEFSQRYADVSTMAFAKPPSLRRQDIKNRQSSIDDLDQETVSK
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LSSKANLLFEQSRDLYQEMLAAGVAKECAREVLPLATPTKIYMAGSVRSWLHYIDLRSAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEHHHHHHHHHHHHHHHCC
GTQKEHQDVAIKCREILTKEMPCVCNAMWP
CCCHHHHHHHHHHHHHHHHCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]