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The map label for this gene is BioA [H]

Identifier: 33863760

GI number: 33863760

Start: 1577775

End: 1579103

Strand: Direct

Name: BioA [H]

Synonym: PMT1493

Alternate gene names: 33863760

Gene position: 1577775-1579103 (Clockwise)

Preceding gene: 33863758

Following gene: 33863763

Centisome position: 65.44

GC content: 56.66

Gene sequence:

>1329_bases
ATGGCAACACAATCCCATCGGATCATGGATTGCTTCGATCCACTCGCCGCCCCAAACGCCAACAACTGGCATCCCCATCT
CTGGCCTCCCTTCACTCAGATCGCATCGGCCTCACCGCCGCAACGTGTCATCGCGGCGGATGGAGCTCTATTGATGCTGG
ATGGTGCACCTCCCCTGATTGATGCAATCAGCAGCTGGTGGGTCACCCTGCATGGCCATGCCAATCCCAGCATCGCCGCT
GCCATCGCAACCCAAGCACAGCAACTGGAGCAGGTGATCTTTGCTGACTTCATTCATCCCCAAGCAGAACAACTGGCAGA
GCGCCTCAGTGCCGTAACAGGCCTTCAACGCCTGTTTTTCTCCGACAACGGCTCTACCGCCGTGGAGGTTGCGCTCAAGA
TCGCTTGTCAGTGCTGGCACAACCGCGGCGAGCCTCGGCAACAACTCATCGCTTTCAACGGGGCCTACCACGGCGACACG
TTCGGGGCGATGGCAGTGGGGGAGCGCAACCTATTCAGTGCCCCCTTTGAGGAGATGTTGTTTCCAGTAGCACGGGTGCC
CTGGCCCGCTACTTGGTGGGGCGATGAAGAGGTTGAAACACGTGAACGGATTGCTCTAACTGAACTGGAACGCTGCCTTC
AAACCCCAACAGCAGCAGTCATCTTGGAGCCATTAGTCCAAGGAGCAGGCGGCATGGCCATGGTGCGAGCGGAATTCCTA
CAAGGAGTCGAACAACGCGTACGTGCTGCGGGAGCCTTGCTGATTGCTGATGAGGTTCTGACTGGTTTCGGACGCTGTGG
AGCCCTATTCGCCTTCAAGCGTGCAGGGCTTGCTCCCGATTTGATCGCCTTATCTAAAGGACTCACCGGGGGATTTTTGC
CCATGGGCGTCACCATGGCCCGTGAAGAGGTGTTTGAGGCCTTCTTAGGAGATGATCCATCTCTCACCCTCTGGCACGGT
CATAGCTTCACTGCTAATCCCCTAGGTTGCGCAGCCGCAAACGCAAGCCTCGATCTACTGGAGGCCAACCCAGAAAGCTA
CGAAAACTTTGAGGCTAGGCATCGACCTCATCTCGAAGCCCTAGCTGAACATCCAAAGGTGCAGCAACCAAGACTGACCG
GCACCATCGCCGCCTTCGACCTCGCTATAGACGGAACCCATGGCTACCTCAATCCAGCAGGACGAATCGTCAAACAACAA
GCCATCAACAATGGTGTCTTCCTGCGGCCTCTTGGTCAGGTCGTTTATCTGCTGCCTCCGCTCTGCCTCAATGACGCTCA
ACTTGAGCAATGCTATGCAGCCATCAATTTAGGCTTGGAAGCCCTCTGA

Upstream 100 bases:

>100_bases
GTTGGTTTAACAGTTGGTTTTAGAGCCTGCTTTGTTATCTGCTTGAAAGGATTGCAAAGAGCCATCTTGATCGGTTCAGG
CCGCAACATCACGATCCAAG

Downstream 100 bases:

>100_bases
GTTCAAGCGCTCAACAGAAGCAACACCATCGTTCTTAAGGGCCTTCTGAAAGAGCAGCCTCCACATCGGAGCGGGGCAGA
CCATAAGGGAAACAGCACTG

Product: diaminopelargonic acid synthase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MATQSHRIMDCFDPLAAPNANNWHPHLWPPFTQIASASPPQRVIAADGALLMLDGAPPLIDAISSWWVTLHGHANPSIAA
AIATQAQQLEQVIFADFIHPQAEQLAERLSAVTGLQRLFFSDNGSTAVEVALKIACQCWHNRGEPRQQLIAFNGAYHGDT
FGAMAVGERNLFSAPFEEMLFPVARVPWPATWWGDEEVETRERIALTELERCLQTPTAAVILEPLVQGAGGMAMVRAEFL
QGVEQRVRAAGALLIADEVLTGFGRCGALFAFKRAGLAPDLIALSKGLTGGFLPMGVTMAREEVFEAFLGDDPSLTLWHG
HSFTANPLGCAAANASLDLLEANPESYENFEARHRPHLEALAEHPKVQQPRLTGTIAAFDLAIDGTHGYLNPAGRIVKQQ
AINNGVFLRPLGQVVYLLPPLCLNDAQLEQCYAAINLGLEAL

Sequences:

>Translated_442_residues
MATQSHRIMDCFDPLAAPNANNWHPHLWPPFTQIASASPPQRVIAADGALLMLDGAPPLIDAISSWWVTLHGHANPSIAA
AIATQAQQLEQVIFADFIHPQAEQLAERLSAVTGLQRLFFSDNGSTAVEVALKIACQCWHNRGEPRQQLIAFNGAYHGDT
FGAMAVGERNLFSAPFEEMLFPVARVPWPATWWGDEEVETRERIALTELERCLQTPTAAVILEPLVQGAGGMAMVRAEFL
QGVEQRVRAAGALLIADEVLTGFGRCGALFAFKRAGLAPDLIALSKGLTGGFLPMGVTMAREEVFEAFLGDDPSLTLWHG
HSFTANPLGCAAANASLDLLEANPESYENFEARHRPHLEALAEHPKVQQPRLTGTIAAFDLAIDGTHGYLNPAGRIVKQQ
AINNGVFLRPLGQVVYLLPPLCLNDAQLEQCYAAINLGLEAL
>Mature_441_residues
ATQSHRIMDCFDPLAAPNANNWHPHLWPPFTQIASASPPQRVIAADGALLMLDGAPPLIDAISSWWVTLHGHANPSIAAA
IATQAQQLEQVIFADFIHPQAEQLAERLSAVTGLQRLFFSDNGSTAVEVALKIACQCWHNRGEPRQQLIAFNGAYHGDTF
GAMAVGERNLFSAPFEEMLFPVARVPWPATWWGDEEVETRERIALTELERCLQTPTAAVILEPLVQGAGGMAMVRAEFLQ
GVEQRVRAAGALLIADEVLTGFGRCGALFAFKRAGLAPDLIALSKGLTGGFLPMGVTMAREEVFEAFLGDDPSLTLWHGH
SFTANPLGCAAANASLDLLEANPESYENFEARHRPHLEALAEHPKVQQPRLTGTIAAFDLAIDGTHGYLNPAGRIVKQQA
INNGVFLRPLGQVVYLLPPLCLNDAQLEQCYAAINLGLEAL

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=420, Percent_Identity=26.4285714285714, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI13994255, Length=308, Percent_Identity=28.8961038961039, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI226442709, Length=378, Percent_Identity=27.2486772486773, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI226442705, Length=421, Percent_Identity=25.8907363420428, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI4557809, Length=394, Percent_Identity=24.3654822335025, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI24119277, Length=419, Percent_Identity=25.0596658711217, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI284507298, Length=246, Percent_Identity=28.4552845528455, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1786991, Length=427, Percent_Identity=36.768149882904, Blast_Score=248, Evalue=6e-67,
Organism=Escherichia coli, GI145693181, Length=391, Percent_Identity=34.7826086956522, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI1789016, Length=377, Percent_Identity=31.8302387267904, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1789759, Length=303, Percent_Identity=30.6930693069307, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1788044, Length=420, Percent_Identity=27.8571428571429, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1787560, Length=386, Percent_Identity=29.7927461139896, Blast_Score=111, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI71992977, Length=437, Percent_Identity=24.4851258581236, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25144271, Length=375, Percent_Identity=23.2, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI32564660, Length=412, Percent_Identity=24.2718446601942, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25144274, Length=216, Percent_Identity=29.1666666666667, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324386, Length=451, Percent_Identity=29.490022172949, Blast_Score=196, Evalue=8e-51,
Organism=Saccharomyces cerevisiae, GI6324432, Length=426, Percent_Identity=26.2910798122066, Blast_Score=120, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6323470, Length=333, Percent_Identity=27.027027027027, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI21356575, Length=323, Percent_Identity=27.8637770897833, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI161085790, Length=409, Percent_Identity=25.6723716381418, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI28574759, Length=296, Percent_Identity=26.6891891891892, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21357415, Length=422, Percent_Identity=23.696682464455, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 47880; Mature: 47749

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATQSHRIMDCFDPLAAPNANNWHPHLWPPFTQIASASPPQRVIAADGALLMLDGAPPLI
CCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCEEEECCCCEEEECCCCHHH
DAISSWWVTLHGHANPSIAAAIATQAQQLEQVIFADFIHPQAEQLAERLSAVTGLQRLFF
HHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHC
SDNGSTAVEVALKIACQCWHNRGEPRQQLIAFNGAYHGDTFGAMAVGERNLFSAPFEEML
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHEEECCCCCCCCCCCCCCCCCCCCCCCHHHHH
FPVARVPWPATWWGDEEVETRERIALTELERCLQTPTAAVILEPLVQGAGGMAMVRAEFL
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHH
QGVEQRVRAAGALLIADEVLTGFGRCGALFAFKRAGLAPDLIALSKGLTGGFLPMGVTMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHH
REEVFEAFLGDDPSLTLWHGHSFTANPLGCAAANASLDLLEANPESYENFEARHRPHLEA
HHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCCCHHHCCHHHCCCHHHH
LAEHPKVQQPRLTGTIAAFDLAIDGTHGYLNPAGRIVKQQAINNGVFLRPLGQVVYLLPP
HHCCCCCCCCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCEEECHHHHHHHHCCC
LCLNDAQLEQCYAAINLGLEAL
CCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
ATQSHRIMDCFDPLAAPNANNWHPHLWPPFTQIASASPPQRVIAADGALLMLDGAPPLI
CCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCEEEECCCCEEEECCCCHHH
DAISSWWVTLHGHANPSIAAAIATQAQQLEQVIFADFIHPQAEQLAERLSAVTGLQRLFF
HHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHC
SDNGSTAVEVALKIACQCWHNRGEPRQQLIAFNGAYHGDTFGAMAVGERNLFSAPFEEML
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHEEECCCCCCCCCCCCCCCCCCCCCCCHHHHH
FPVARVPWPATWWGDEEVETRERIALTELERCLQTPTAAVILEPLVQGAGGMAMVRAEFL
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHH
QGVEQRVRAAGALLIADEVLTGFGRCGALFAFKRAGLAPDLIALSKGLTGGFLPMGVTMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHH
REEVFEAFLGDDPSLTLWHGHSFTANPLGCAAANASLDLLEANPESYENFEARHRPHLEA
HHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCCCHHHCCHHHCCCHHHH
LAEHPKVQQPRLTGTIAAFDLAIDGTHGYLNPAGRIVKQQAINNGVFLRPLGQVVYLLPP
HHCCCCCCCCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCEEECHHHHHHHHCCC
LCLNDAQLEQCYAAINLGLEAL
CCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]