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The map label for this gene is pepP [H]

Identifier: 33863723

GI number: 33863723

Start: 1543001

End: 1544278

Strand: Reverse

Name: pepP [H]

Synonym: PMT1456

Alternate gene names: 33863723

Gene position: 1544278-1543001 (Counterclockwise)

Preceding gene: 33863730

Following gene: 33863721

Centisome position: 64.05

GC content: 55.63

Gene sequence:

>1278_bases
ATGGCGCAATTGGGGGGAGTGGCAGCGGTAATTCCAGCGGCTTCGTTCGTGACGCATCACGCCGATTGCGAGTATCCGTT
TCGTCAAAACAGTGACTTCTGGTATCTCACGGGTCTGGATGAGCCTGATGCGGTGGCTTTGCTTTTGCCCTATCGGCCCG
AAGGTGAGCGTTTTGTGCTGTTTGTGCAACCCAAAGAGCCAACTACTGAAGTATGGAATGGCTTCCGTTGGGGTGTCGAG
GGAGCAGTGGCGCAGTTTGGCGCTGATCGTGCTCATCCAATAGCTGAATTGCCTCAGCTGTTGGGCGATTACCTCAAAGG
CGCCGAAGCGATTGGCTTCAGGGTGGGTAAGCACCCAAATGTGGAGCCACTGGTTCTGCAGGCCTGGGCTAAGCAACTCG
ATCAGGCCCCACGCAGCGGCGTATCAGCGCTTGGTCTTGTGGCCCCTTGCCCTTTCATCCATCAGTTGAGATTGCGCAAG
GGAGCAGAGGAAATCGAGCGCATGCGTGAGACGGCTCGGATTTCTGCGCAAGCTCATCAGCTGGTTCGGAATACGGCGCG
TCCGGGCATGAATGAGCGACAGCTGCAGGCTGTAATCGAGCAGCATTTTCTTGAGCAAGGCGCGCGCGGCCCTGCCTATG
GATCGATCGTGGCCGGCGGCGATAACGCCTGCGTGTTGCATTACACCGCTAACAATGCTCCGCTTGTTGATGGCGAGCTG
GTGCTGATCGATGCAGGCTGTTCGCTCGTTGATTACTACAACGGAGATATCACTCGTACATTCCCTGTTAACGGACGCTT
TAGCGCAGAGCAACGCGCTCTGTATGAGCTGGTTTTAGCAGCGCAGCAGGCAGCGATCGCTGAGGTAAGACCGGGTGGCA
CTGCTGATCGCGTGCATGATCTTGCGGTGCGGGTGCTTGTCGAAGGGCTTGTGGAATTGGGTTTATTGCTTGGCAGTGTT
GATGGACTGATTGAACAAGGGGCCTACCGACACCTTTATATGCATCGCACTGGCCATTGGCTGGGCCTTGATGTTCATGA
TGTAGGCGCCTATCGCCTTGGTGAGCATCCGGTGGATCTTGAGCCCGGCATGGTGTTAACAGTGGAACCGGGTTTGTATG
TCAGTGACCGTTTGCCAGTGCCGGATGGGCAGCCTGCGATTGCTGATCGTTGGAAGGGGGTCGGCATTCGTATTGAAGAT
GATGTGTTGGTAAGTGAGCAGGGGAATGAGGTGCTCACATCGTTAGCGGAGAAAAGTGTTGAAGCAATGCAGCGATAA

Upstream 100 bases:

>100_bases
CCCCCTGCATGGTGTTCTGCTGCCATCCTGACGTCCAAATGCTGTTGTGTCTCTTGCCGTGACCGATCTGTGTATCTTCC
ATCAGCGTCGCACTTGCTTG

Downstream 100 bases:

>100_bases
GGGAGTCACTGTTGCTCTGGCGAGATCCATTGCTGCAGTTGTTTTTTAGTGCCGGTCAACGGAGTATCTTCAGCGAAGAT
GCAGAACTATTAATTACCAG

Product: aminopeptidase P

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MAQLGGVAAVIPAASFVTHHADCEYPFRQNSDFWYLTGLDEPDAVALLLPYRPEGERFVLFVQPKEPTTEVWNGFRWGVE
GAVAQFGADRAHPIAELPQLLGDYLKGAEAIGFRVGKHPNVEPLVLQAWAKQLDQAPRSGVSALGLVAPCPFIHQLRLRK
GAEEIERMRETARISAQAHQLVRNTARPGMNERQLQAVIEQHFLEQGARGPAYGSIVAGGDNACVLHYTANNAPLVDGEL
VLIDAGCSLVDYYNGDITRTFPVNGRFSAEQRALYELVLAAQQAAIAEVRPGGTADRVHDLAVRVLVEGLVELGLLLGSV
DGLIEQGAYRHLYMHRTGHWLGLDVHDVGAYRLGEHPVDLEPGMVLTVEPGLYVSDRLPVPDGQPAIADRWKGVGIRIED
DVLVSEQGNEVLTSLAEKSVEAMQR

Sequences:

>Translated_425_residues
MAQLGGVAAVIPAASFVTHHADCEYPFRQNSDFWYLTGLDEPDAVALLLPYRPEGERFVLFVQPKEPTTEVWNGFRWGVE
GAVAQFGADRAHPIAELPQLLGDYLKGAEAIGFRVGKHPNVEPLVLQAWAKQLDQAPRSGVSALGLVAPCPFIHQLRLRK
GAEEIERMRETARISAQAHQLVRNTARPGMNERQLQAVIEQHFLEQGARGPAYGSIVAGGDNACVLHYTANNAPLVDGEL
VLIDAGCSLVDYYNGDITRTFPVNGRFSAEQRALYELVLAAQQAAIAEVRPGGTADRVHDLAVRVLVEGLVELGLLLGSV
DGLIEQGAYRHLYMHRTGHWLGLDVHDVGAYRLGEHPVDLEPGMVLTVEPGLYVSDRLPVPDGQPAIADRWKGVGIRIED
DVLVSEQGNEVLTSLAEKSVEAMQR
>Mature_424_residues
AQLGGVAAVIPAASFVTHHADCEYPFRQNSDFWYLTGLDEPDAVALLLPYRPEGERFVLFVQPKEPTTEVWNGFRWGVEG
AVAQFGADRAHPIAELPQLLGDYLKGAEAIGFRVGKHPNVEPLVLQAWAKQLDQAPRSGVSALGLVAPCPFIHQLRLRKG
AEEIERMRETARISAQAHQLVRNTARPGMNERQLQAVIEQHFLEQGARGPAYGSIVAGGDNACVLHYTANNAPLVDGELV
LIDAGCSLVDYYNGDITRTFPVNGRFSAEQRALYELVLAAQQAAIAEVRPGGTADRVHDLAVRVLVEGLVELGLLLGSVD
GLIEQGAYRHLYMHRTGHWLGLDVHDVGAYRLGEHPVDLEPGMVLTVEPGLYVSDRLPVPDGQPAIADRWKGVGIRIEDD
VLVSEQGNEVLTSLAEKSVEAMQR

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=416, Percent_Identity=32.9326923076923, Blast_Score=215, Evalue=7e-56,
Organism=Homo sapiens, GI149589008, Length=434, Percent_Identity=31.5668202764977, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI260593665, Length=303, Percent_Identity=36.6336633663366, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI260593663, Length=246, Percent_Identity=37.8048780487805, Blast_Score=143, Evalue=3e-34,
Organism=Escherichia coli, GI1789275, Length=420, Percent_Identity=44.047619047619, Blast_Score=339, Evalue=2e-94,
Organism=Escherichia coli, GI1788728, Length=274, Percent_Identity=35.7664233576642, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1790282, Length=357, Percent_Identity=27.7310924369748, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17508215, Length=437, Percent_Identity=30.4347826086957, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI71989583, Length=282, Percent_Identity=32.6241134751773, Blast_Score=128, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6320922, Length=411, Percent_Identity=32.360097323601, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6321118, Length=425, Percent_Identity=30.5882352941176, Blast_Score=173, Evalue=4e-44,
Organism=Drosophila melanogaster, GI19920384, Length=428, Percent_Identity=37.3831775700935, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI21357079, Length=444, Percent_Identity=31.7567567567568, Blast_Score=176, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 46397; Mature: 46266

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQLGGVAAVIPAASFVTHHADCEYPFRQNSDFWYLTGLDEPDAVALLLPYRPEGERFVL
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCEEEEEECCCCCCEEEE
FVQPKEPTTEVWNGFRWGVEGAVAQFGADRAHPIAELPQLLGDYLKGAEAIGFRVGKHPN
EEECCCCHHHHHCCEECCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHEECCCCCC
VEPLVLQAWAKQLDQAPRSGVSALGLVAPCPFIHQLRLRKGAEEIERMRETARISAQAHQ
CCHHHHHHHHHHHHHCHHCCCHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LVRNTARPGMNERQLQAVIEQHFLEQGARGPAYGSIVAGGDNACVLHYTANNAPLVDGEL
HHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEEECCCCCEECCEE
VLIDAGCSLVDYYNGDITRTFPVNGRFSAEQRALYELVLAAQQAAIAEVRPGGTADRVHD
EEEECCCCEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LAVRVLVEGLVELGLLLGSVDGLIEQGAYRHLYMHRTGHWLGLDVHDVGAYRLGEHPVDL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEHHHCCCEECCCCCCCC
EPGMVLTVEPGLYVSDRLPVPDGQPAIADRWKGVGIRIEDDVLVSEQGNEVLTSLAEKSV
CCCEEEEECCCEEEECCCCCCCCCCHHHHHCCCCCEEEECCEEECCCCHHHHHHHHHHHH
EAMQR
HHHCC
>Mature Secondary Structure 
AQLGGVAAVIPAASFVTHHADCEYPFRQNSDFWYLTGLDEPDAVALLLPYRPEGERFVL
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCEEEEEECCCCCCEEEE
FVQPKEPTTEVWNGFRWGVEGAVAQFGADRAHPIAELPQLLGDYLKGAEAIGFRVGKHPN
EEECCCCHHHHHCCEECCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHEECCCCCC
VEPLVLQAWAKQLDQAPRSGVSALGLVAPCPFIHQLRLRKGAEEIERMRETARISAQAHQ
CCHHHHHHHHHHHHHCHHCCCHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LVRNTARPGMNERQLQAVIEQHFLEQGARGPAYGSIVAGGDNACVLHYTANNAPLVDGEL
HHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEEECCCCCEECCEE
VLIDAGCSLVDYYNGDITRTFPVNGRFSAEQRALYELVLAAQQAAIAEVRPGGTADRVHD
EEEECCCCEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LAVRVLVEGLVELGLLLGSVDGLIEQGAYRHLYMHRTGHWLGLDVHDVGAYRLGEHPVDL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEHHHCCCEECCCCCCCC
EPGMVLTVEPGLYVSDRLPVPDGQPAIADRWKGVGIRIEDDVLVSEQGNEVLTSLAEKSV
CCCEEEEECCCEEEECCCCCCCCCCHHHHHCCCCCEEEECCEEECCCCHHHHHHHHHHHH
EAMQR
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]