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The map label for this gene is serA [H]

Identifier: 33863698

GI number: 33863698

Start: 1519033

End: 1520631

Strand: Reverse

Name: serA [H]

Synonym: PMT1431

Alternate gene names: 33863698

Gene position: 1520631-1519033 (Counterclockwise)

Preceding gene: 33863702

Following gene: 33863697

Centisome position: 63.07

GC content: 56.91

Gene sequence:

>1599_bases
TTGCGCCGGTTGATGACGAAAGTTCTGGTTTCAGACCCTATCGACCAAGCGGGAATTGACATCCTCGCTCAGGTTGCACA
GGTGGATCAGCGTGTGGGCCTGTCAGAGGATGACCTCAAGGCGATGATCGGCGACTACGACGCGCTGATGATTCGTTCTG
GCACGCAGGTCACGGCGGATGTGATCAAAGCCGGCGCACGTTTGCGCATCATTGGTCGGGCGGGTGTTGGCGTCGATAAT
GTTGATGTGCCGACGGCCACCCAACAGGGTGTTTTGGTGGTGAATTCGCCGGAAGGCAACACGATTGCTGCTGCCGAACA
AGCGTTGGCTTTAATGCTTTCGCTCTCTCGGCATGTGCCTCAGGCCCATGCCAGCACGATGGCTGGGGGTTGGGATCGCA
AGAAATATGTAGGGAACGAGCTCTATAAGAAAGTTCTTGGCGTGGTTGGGCTCGGCAAGATTGGCTCCCATGTGGCCCGA
GTCTGCAATGCCATGGGTATGGAGGTCATCGCTTACGACCCCTTCATCTCTGCGGACCGTGCTCAACAGATGCAGGTGCG
ACTCTCAAGCTTGGAGAATCTTTTTGAGCAGGCCGACTACATCACCTTGCATCTCCCTCGTACTCCCGATACCGAGAATT
TGGTCAATGCGGAATTGCTGGGCAAGATGAAGTCCACAGCAAGGCTCGTGAACTGTGCTCGCGGTGGCATCATCGATGAG
TCAGCCCTTGCTGATGCCTTGACGGCTGGAGTGATTGGTGGGGCTGCCTTGGATGTTTATGCCCAGGAGCCATTGGCTAC
CGATTCGCCGCTGCGCTCTGTACAGGAGCGCTTGATCCTTACGCCCCACCTTGGAGCTTCGACGACTGAGGCGCAGGAGA
ACGTGGCTGTGGATGTGGCGGAACAGATCCGAGACGTCCTGCTTGGCCTTCCTGCCCGCAGTGCTGTGAACATCCCTGGC
CTCAGTGCAGAGATCATGGAGCGGCTCAAGCCTCATTTGCAATTAGCCGAGACCCTGGGGCTGTTGGTGAGCCAGCTCTC
CGGAGGACAGTTGCAGGAGCTTGAAGTTCGTCTTCAGGGGGAGTTCGCTCAGCATCCCTCTCAGCCTCTGGTGATTGCTG
CTCTCAAGGGGGTGCTGAGCAGTGCCCTTGGCGATCGGATCAATTACGTGAATGCGTCCTTAGAAGCCAAGGGCCGTGGC
ATTCGTGTCTTGGAGGTCAAGGACGAGACAAGTAAGGATTTTGCCGGAGGGTCCTTGCAACTGACGACTCGTGGTGACCA
GGGCGGTCACAGCGTGACGGGTGCGGTGTTTGCCAATGGCGATCTGCGCATCACCACCATTGATGAATTCCCGGTCAACG
TGTCGCCTAGTCGACACATGCTGTTGACCAGGCACCGCGATATGCCTGGGATCATCGGTCAGTTGGGCTCCGTGCTTGGT
GAACACAACGTCAACATTGCATCGATGCAGGTGGGGCGTCGCATTGTGCGCGGTGATGCGGTGATGGTTTTGAGCATTGA
TGATCCAATTCCGCCCAGCTTGCTGGTCACCATCCATGCGATCAATGGCATTAAGGAAGCCCATCCGGTCACCCTCTGA

Upstream 100 bases:

>100_bases
AATAGCCATACAACACACCTCAATCGTTTGAATTCTGAACCCTGTTTTGTGATCTGCAGGGCTTGGAGCATGTAGATCTC
TACAGTGCCCTGCTGCAGTC

Downstream 100 bases:

>100_bases
TCAGGGCTGATGAGATGAACTTTGCTGCTGCTCTTCGCTGGTGGCGTCTTTCTCTGCCTATTGCAGATGAGCTGGAAGAG
TCGCTCATTTGGAAGCTGAC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 532; Mature: 532

Protein sequence:

>532_residues
MRRLMTKVLVSDPIDQAGIDILAQVAQVDQRVGLSEDDLKAMIGDYDALMIRSGTQVTADVIKAGARLRIIGRAGVGVDN
VDVPTATQQGVLVVNSPEGNTIAAAEQALALMLSLSRHVPQAHASTMAGGWDRKKYVGNELYKKVLGVVGLGKIGSHVAR
VCNAMGMEVIAYDPFISADRAQQMQVRLSSLENLFEQADYITLHLPRTPDTENLVNAELLGKMKSTARLVNCARGGIIDE
SALADALTAGVIGGAALDVYAQEPLATDSPLRSVQERLILTPHLGASTTEAQENVAVDVAEQIRDVLLGLPARSAVNIPG
LSAEIMERLKPHLQLAETLGLLVSQLSGGQLQELEVRLQGEFAQHPSQPLVIAALKGVLSSALGDRINYVNASLEAKGRG
IRVLEVKDETSKDFAGGSLQLTTRGDQGGHSVTGAVFANGDLRITTIDEFPVNVSPSRHMLLTRHRDMPGIIGQLGSVLG
EHNVNIASMQVGRRIVRGDAVMVLSIDDPIPPSLLVTIHAINGIKEAHPVTL

Sequences:

>Translated_532_residues
MRRLMTKVLVSDPIDQAGIDILAQVAQVDQRVGLSEDDLKAMIGDYDALMIRSGTQVTADVIKAGARLRIIGRAGVGVDN
VDVPTATQQGVLVVNSPEGNTIAAAEQALALMLSLSRHVPQAHASTMAGGWDRKKYVGNELYKKVLGVVGLGKIGSHVAR
VCNAMGMEVIAYDPFISADRAQQMQVRLSSLENLFEQADYITLHLPRTPDTENLVNAELLGKMKSTARLVNCARGGIIDE
SALADALTAGVIGGAALDVYAQEPLATDSPLRSVQERLILTPHLGASTTEAQENVAVDVAEQIRDVLLGLPARSAVNIPG
LSAEIMERLKPHLQLAETLGLLVSQLSGGQLQELEVRLQGEFAQHPSQPLVIAALKGVLSSALGDRINYVNASLEAKGRG
IRVLEVKDETSKDFAGGSLQLTTRGDQGGHSVTGAVFANGDLRITTIDEFPVNVSPSRHMLLTRHRDMPGIIGQLGSVLG
EHNVNIASMQVGRRIVRGDAVMVLSIDDPIPPSLLVTIHAINGIKEAHPVTL
>Mature_532_residues
MRRLMTKVLVSDPIDQAGIDILAQVAQVDQRVGLSEDDLKAMIGDYDALMIRSGTQVTADVIKAGARLRIIGRAGVGVDN
VDVPTATQQGVLVVNSPEGNTIAAAEQALALMLSLSRHVPQAHASTMAGGWDRKKYVGNELYKKVLGVVGLGKIGSHVAR
VCNAMGMEVIAYDPFISADRAQQMQVRLSSLENLFEQADYITLHLPRTPDTENLVNAELLGKMKSTARLVNCARGGIIDE
SALADALTAGVIGGAALDVYAQEPLATDSPLRSVQERLILTPHLGASTTEAQENVAVDVAEQIRDVLLGLPARSAVNIPG
LSAEIMERLKPHLQLAETLGLLVSQLSGGQLQELEVRLQGEFAQHPSQPLVIAALKGVLSSALGDRINYVNASLEAKGRG
IRVLEVKDETSKDFAGGSLQLTTRGDQGGHSVTGAVFANGDLRITTIDEFPVNVSPSRHMLLTRHRDMPGIIGQLGSVLG
EHNVNIASMQVGRRIVRGDAVMVLSIDDPIPPSLLVTIHAINGIKEAHPVTL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=401, Percent_Identity=41.1471321695761, Blast_Score=289, Evalue=4e-78,
Organism=Homo sapiens, GI61743967, Length=272, Percent_Identity=35.2941176470588, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI4557497, Length=272, Percent_Identity=35.2941176470588, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI6912396, Length=328, Percent_Identity=30.4878048780488, Blast_Score=139, Evalue=9e-33,
Organism=Homo sapiens, GI145580578, Length=310, Percent_Identity=32.5806451612903, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI4557499, Length=310, Percent_Identity=32.5806451612903, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI145580575, Length=299, Percent_Identity=32.4414715719064, Blast_Score=124, Evalue=3e-28,
Organism=Escherichia coli, GI1789279, Length=327, Percent_Identity=33.0275229357798, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI87082289, Length=272, Percent_Identity=32.7205882352941, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1787645, Length=196, Percent_Identity=34.6938775510204, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788660, Length=265, Percent_Identity=30.188679245283, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87081824, Length=159, Percent_Identity=32.0754716981132, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=324, Percent_Identity=45.3703703703704, Blast_Score=275, Evalue=4e-74,
Organism=Caenorhabditis elegans, GI25147481, Length=274, Percent_Identity=31.3868613138686, Blast_Score=117, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320925, Length=326, Percent_Identity=34.0490797546012, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6322116, Length=328, Percent_Identity=32.9268292682927, Blast_Score=172, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6324055, Length=243, Percent_Identity=27.5720164609054, Blast_Score=107, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6324964, Length=261, Percent_Identity=27.9693486590038, Blast_Score=106, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6321253, Length=156, Percent_Identity=34.6153846153846, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324980, Length=185, Percent_Identity=27.5675675675676, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6325144, Length=172, Percent_Identity=30.2325581395349, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19921140, Length=301, Percent_Identity=46.5116279069767, Blast_Score=259, Evalue=4e-69,
Organism=Drosophila melanogaster, GI24646446, Length=273, Percent_Identity=34.7985347985348, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24646448, Length=273, Percent_Identity=34.7985347985348, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24646452, Length=273, Percent_Identity=34.7985347985348, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24646450, Length=273, Percent_Identity=34.7985347985348, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI62472511, Length=316, Percent_Identity=33.8607594936709, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24585516, Length=313, Percent_Identity=27.4760383386581, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28574284, Length=318, Percent_Identity=27.3584905660377, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI45551003, Length=318, Percent_Identity=27.3584905660377, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24585514, Length=318, Percent_Identity=27.3584905660377, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI28574282, Length=318, Percent_Identity=27.3584905660377, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI45552429, Length=318, Percent_Identity=27.3584905660377, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI28571528, Length=320, Percent_Identity=29.6875, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28574286, Length=253, Percent_Identity=29.2490118577075, Blast_Score=115, Evalue=9e-26,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 56593; Mature: 56593

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRLMTKVLVSDPIDQAGIDILAQVAQVDQRVGLSEDDLKAMIGDYDALMIRSGTQVTAD
CHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCHHHHH
VIKAGARLRIIGRAGVGVDNVDVPTATQQGVLVVNSPEGNTIAAAEQALALMLSLSRHVP
HHHCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHCC
QAHASTMAGGWDRKKYVGNELYKKVLGVVGLGKIGSHVARVCNAMGMEVIAYDPFISADR
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEECCCCCCHH
AQQMQVRLSSLENLFEQADYITLHLPRTPDTENLVNAELLGKMKSTARLVNCARGGIIDE
HHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
SALADALTAGVIGGAALDVYAQEPLATDSPLRSVQERLILTPHLGASTTEAQENVAVDVA
HHHHHHHHHHHHCCHHEEEEECCCCCCCHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHH
EQIRDVLLGLPARSAVNIPGLSAEIMERLKPHLQLAETLGLLVSQLSGGQLQELEVRLQG
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHEEEEC
EFAQHPSQPLVIAALKGVLSSALGDRINYVNASLEAKGRGIRVLEVKDETSKDFAGGSLQ
HHHCCCCCCHHHHHHHHHHHHHHCCHHHEECCEEECCCCCEEEEEECCCCCCCCCCCEEE
LTTRGDQGGHSVTGAVFANGDLRITTIDEFPVNVSPSRHMLLTRHRDMPGIIGQLGSVLG
EEECCCCCCCEEEEEEEECCCEEEEEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHC
EHNVNIASMQVGRRIVRGDAVMVLSIDDPIPPSLLVTIHAINGIKEAHPVTL
CCCCEEEHHHHHHHHCCCCEEEEEECCCCCCCHHEEEEEHHCCCCCCCCCCC
>Mature Secondary Structure
MRRLMTKVLVSDPIDQAGIDILAQVAQVDQRVGLSEDDLKAMIGDYDALMIRSGTQVTAD
CHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCHHHHH
VIKAGARLRIIGRAGVGVDNVDVPTATQQGVLVVNSPEGNTIAAAEQALALMLSLSRHVP
HHHCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHCC
QAHASTMAGGWDRKKYVGNELYKKVLGVVGLGKIGSHVARVCNAMGMEVIAYDPFISADR
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEECCCCCCHH
AQQMQVRLSSLENLFEQADYITLHLPRTPDTENLVNAELLGKMKSTARLVNCARGGIIDE
HHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
SALADALTAGVIGGAALDVYAQEPLATDSPLRSVQERLILTPHLGASTTEAQENVAVDVA
HHHHHHHHHHHHCCHHEEEEECCCCCCCHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHH
EQIRDVLLGLPARSAVNIPGLSAEIMERLKPHLQLAETLGLLVSQLSGGQLQELEVRLQG
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHEEEEC
EFAQHPSQPLVIAALKGVLSSALGDRINYVNASLEAKGRGIRVLEVKDETSKDFAGGSLQ
HHHCCCCCCHHHHHHHHHHHHHHCCHHHEECCEEECCCCCEEEEEECCCCCCCCCCCEEE
LTTRGDQGGHSVTGAVFANGDLRITTIDEFPVNVSPSRHMLLTRHRDMPGIIGQLGSVLG
EEECCCCCCCEEEEEEEECCCEEEEEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHC
EHNVNIASMQVGRRIVRGDAVMVLSIDDPIPPSLLVTIHAINGIKEAHPVTL
CCCCEEEHHHHHHHHCCCCEEEEEECCCCCCCHHEEEEEHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]