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The map label for this gene is rnz [H]

Identifier: 33863693

GI number: 33863693

Start: 1514258

End: 1515283

Strand: Direct

Name: rnz [H]

Synonym: PMT1426

Alternate gene names: 33863693

Gene position: 1514258-1515283 (Clockwise)

Preceding gene: 33863690

Following gene: 33863694

Centisome position: 62.81

GC content: 58.77

Gene sequence:

>1026_bases
GTGCCCCGATCACAACAACCAGGCCAGGCCCCAAGCCATGGCAGCATGGTCTTTGGGGTGTGCAAGGCCTTGCAGGTCAC
CTTTCTCGGCACCAGCTCGGGCGTACCGACACGAGCCCGCAATGTTTCTGCCGTGGCTCTGCGGCTGCCCCAACGTGCTG
AGTTGTGGCTGTTTGATTGCGGAGAAGGTACTCAGCATCAATTCCTGCGCAGCGATCTGCGTCTTTCTCAACTCAGACGA
GTGTTTGTTAGCCACATGCATGGCGACCATGTGTTTGGCCTGCCGGGTCTGTTGGCCAGCCTCGGCCTATCCGGCAACAG
CAACGGAGTGGATCTCTACGGCCCCGATCCACTGGAAAGCTATCTGCAAGGCGTGCTGCGCAATAGCTCCACCAGGATCG
GATACCCCCTCAAGGTTCATCGCGTGCGAGACGCAGCAGAGCAGAACCTGATTGTTTTTGAAGACAAAGACATCCTGGTG
CGCTGCACCCCGCTCACTCATCGCGTGCCGGCCTACGCCTATCGCGTGGAGCAAAAACCCAAGCCAGGCCATTTCAACCT
TGAACGAGCCCAAAGCCTCGGCATCCCGCCAGGCCCCGTCTATGCCGCCTTAAAGCGTGGTGAACAGGTCAGCCTCGATG
ATGGTCGCGTGGTGGATGGCCGGGACTTCTGCGGACCAGATCGCCCAGGCGCCAGCATCGTGTTCTGCACCGATACGGTG
TTTTCAGAAGCTGCTGTCTCGCTAGCCGCAGGAGCAGACCTGCTGATCCACGAAGCAACCTTCGCCCATAGCGAAGCAGA
AATGGCTTATCAGAAGCAGCACTCCACCAGCACCATGGCGGCCCAAACAGCTGCCGAAGCCGGCGTCGGGAAACTCGTAT
TGACCCACCTCAGTCCCCGCTATGCGCCAGGCAATCCGGTCACCCCAAATGACCTGCTACGAGAAGCTCAAGCGATCTTT
TCGAACACCATCCTCGCCAAGGATTTCCTCAGTTTTGAAGTCGCTCCGCGCTGCAACAGTTCTTGA

Upstream 100 bases:

>100_bases
CAGCAGGGCTTACGGCCGTGAGTGTGACCCCACCGACCAATCCCATAGCCCATAGCGGCGCTGGCAAAGCCAATCAACAT
GTTCAACAAGGACATTCAGT

Downstream 100 bases:

>100_bases
TTACGGCCCTTAGAGCTCCCGCCCCGTGATACAAGGTGTTGTCGCTTCTGTCAGTAACTGGCGTATTCCATGGCCTCTCT
CTTTGCATCCCTGGGACGGT

Product: hypothetical protein

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z [H]

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MPRSQQPGQAPSHGSMVFGVCKALQVTFLGTSSGVPTRARNVSAVALRLPQRAELWLFDCGEGTQHQFLRSDLRLSQLRR
VFVSHMHGDHVFGLPGLLASLGLSGNSNGVDLYGPDPLESYLQGVLRNSSTRIGYPLKVHRVRDAAEQNLIVFEDKDILV
RCTPLTHRVPAYAYRVEQKPKPGHFNLERAQSLGIPPGPVYAALKRGEQVSLDDGRVVDGRDFCGPDRPGASIVFCTDTV
FSEAAVSLAAGADLLIHEATFAHSEAEMAYQKQHSTSTMAAQTAAEAGVGKLVLTHLSPRYAPGNPVTPNDLLREAQAIF
SNTILAKDFLSFEVAPRCNSS

Sequences:

>Translated_341_residues
MPRSQQPGQAPSHGSMVFGVCKALQVTFLGTSSGVPTRARNVSAVALRLPQRAELWLFDCGEGTQHQFLRSDLRLSQLRR
VFVSHMHGDHVFGLPGLLASLGLSGNSNGVDLYGPDPLESYLQGVLRNSSTRIGYPLKVHRVRDAAEQNLIVFEDKDILV
RCTPLTHRVPAYAYRVEQKPKPGHFNLERAQSLGIPPGPVYAALKRGEQVSLDDGRVVDGRDFCGPDRPGASIVFCTDTV
FSEAAVSLAAGADLLIHEATFAHSEAEMAYQKQHSTSTMAAQTAAEAGVGKLVLTHLSPRYAPGNPVTPNDLLREAQAIF
SNTILAKDFLSFEVAPRCNSS
>Mature_340_residues
PRSQQPGQAPSHGSMVFGVCKALQVTFLGTSSGVPTRARNVSAVALRLPQRAELWLFDCGEGTQHQFLRSDLRLSQLRRV
FVSHMHGDHVFGLPGLLASLGLSGNSNGVDLYGPDPLESYLQGVLRNSSTRIGYPLKVHRVRDAAEQNLIVFEDKDILVR
CTPLTHRVPAYAYRVEQKPKPGHFNLERAQSLGIPPGPVYAALKRGEQVSLDDGRVVDGRDFCGPDRPGASIVFCTDTVF
SEAAVSLAAGADLLIHEATFAHSEAEMAYQKQHSTSTMAAQTAAEAGVGKLVLTHLSPRYAPGNPVTPNDLLREAQAIFS
NTILAKDFLSFEVAPRCNSS

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA [H]

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family [H]

Homologues:

Organism=Homo sapiens, GI8922122, Length=360, Percent_Identity=32.5, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI260166619, Length=216, Percent_Identity=30.0925925925926, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI260166622, Length=131, Percent_Identity=37.4045801526718, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI145553959, Length=131, Percent_Identity=37.4045801526718, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI87082078, Length=313, Percent_Identity=42.1725239616613, Blast_Score=255, Evalue=4e-69,
Organism=Drosophila melanogaster, GI24652403, Length=294, Percent_Identity=28.2312925170068, Blast_Score=85, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR013471 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.26.11 [H]

Molecular weight: Translated: 36924; Mature: 36793

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRSQQPGQAPSHGSMVFGVCKALQVTFLGTSSGVPTRARNVSAVALRLPQRAELWLFDC
CCCCCCCCCCCCCCCHHHHHHHHHEEEEEECCCCCCCCCCCCEEEEEECCCCCCEEEEEC
GEGTQHQFLRSDLRLSQLRRVFVSHMHGDHVFGLPGLLASLGLSGNSNGVDLYGPDPLES
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHCCCCCCCCEECCCCCHHHH
YLQGVLRNSSTRIGYPLKVHRVRDAAEQNLIVFEDKDILVRCTPLTHRVPAYAYRVEQKP
HHHHHHHCCCCCCCCCEEEHHHHHHHHCCEEEEECCCEEEEECCCCCCCCHHEEEECCCC
KPGHFNLERAQSLGIPPGPVYAALKRGEQVSLDDGRVVDGRDFCGPDRPGASIVFCTDTV
CCCCCCHHHHHHCCCCCCHHHHHHHCCCEEECCCCEEECCCCCCCCCCCCCEEEEEEHHH
FSEAAVSLAAGADLLIHEATFAHSEAEMAYQKQHSTSTMAAQTAAEAGVGKLVLTHLSPR
HHHHHHHHHCCCCEEEEHHHHHCHHHHHHHHHHCCHHHHHHHHHHHCCCHHEEEECCCCC
YAPGNPVTPNDLLREAQAIFSNTILAKDFLSFEVAPRCNSS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCC
>Mature Secondary Structure 
PRSQQPGQAPSHGSMVFGVCKALQVTFLGTSSGVPTRARNVSAVALRLPQRAELWLFDC
CCCCCCCCCCCCCCHHHHHHHHHEEEEEECCCCCCCCCCCCEEEEEECCCCCCEEEEEC
GEGTQHQFLRSDLRLSQLRRVFVSHMHGDHVFGLPGLLASLGLSGNSNGVDLYGPDPLES
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHCCCCCCCCEECCCCCHHHH
YLQGVLRNSSTRIGYPLKVHRVRDAAEQNLIVFEDKDILVRCTPLTHRVPAYAYRVEQKP
HHHHHHHCCCCCCCCCEEEHHHHHHHHCCEEEEECCCEEEEECCCCCCCCHHEEEECCCC
KPGHFNLERAQSLGIPPGPVYAALKRGEQVSLDDGRVVDGRDFCGPDRPGASIVFCTDTV
CCCCCCHHHHHHCCCCCCHHHHHHHCCCEEECCCCEEECCCCCCCCCCCCCEEEEEEHHH
FSEAAVSLAAGADLLIHEATFAHSEAEMAYQKQHSTSTMAAQTAAEAGVGKLVLTHLSPR
HHHHHHHHHCCCCEEEEHHHHHCHHHHHHHHHHCCHHHHHHHHHHHCCCHHEEEECCCCC
YAPGNPVTPNDLLREAQAIFSNTILAKDFLSFEVAPRCNSS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA