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The map label for this gene is dapL [H]

Identifier: 33863627

GI number: 33863627

Start: 1446098

End: 1447294

Strand: Reverse

Name: dapL [H]

Synonym: PMT1360

Alternate gene names: 33863627

Gene position: 1447294-1446098 (Counterclockwise)

Preceding gene: 33863628

Following gene: 33863626

Centisome position: 60.03

GC content: 55.97

Gene sequence:

>1197_bases
ATGGCGACTTCAAGGCGTCTAGGCAGATTGGGTCGTGGCGTTTTTGACCGCAATGACCGCCGTAAGCAGGCTTATCGCTT
GGCTAACGCAGGCCCTCAAAGTTTGCCTCTGCTGGATTTGTCACTGGGGTCCACAGACTTATCACCTCCAGCGGTGGCAC
TTGAGGCTATTGAAGTTGCTCTAAGGGCACCTGAGAGCTCTTCCTATTGCTTGCATGCTTCGACGAGGCCCTTTCGGGAG
GCGGTCGCTGCGTGGAGTCAGAGGCGCTTCGGTGTCAGCGTTGATCCAGATCGGGAAGTGTTGTTGTTGGTCGGTTCACA
GGAGGGAACGGCCCACCTGCCTTTGGCAGTTTTGGATCCTGGGGATTCTGCCTTGATTCTGGATCCTGCCTATCCCTCAC
ATCGGGGTGGGTTGATTTTGGCCGATGCCCGTATTGAACGACTGCTGCTACGACCGGAGCAGGAATGGCGACCTGACTTC
AAGGCTTTAAGCAACAGTCAGTGGGACCAGTTGCGGATGATGGTTTTTGGGTTTCCTCATAACCCCACAGCCCAGGTAGG
AGAACAGAGCTGGTTGGCGGAAGCCATGGATCGGGGCATCCGTCATCAAGTGGTGGTTGCTCACGACAATCCTTATGTGG
ATTTGGCACTGGACGGTGAGGCGCCAGCTCTGTTGCGTTGTCCTGGTTGGAGGGAATGCGGGATTGAGTTTTTCTCCTTC
TCCAAGGCCTGGTGCTTGGGGGGGTTCCGATTGGCCTTTGCGATTGGTGCTGAACATTTGATTACAGCCCTACGTGAGCT
CAAGGGTGTCGTGGATTTCAACCAATCCTTGGCGTTACAGAGAGGCGCCATAGCCGCCCTTACCGATGCCCAAGATTGGC
CTCAAGAGATTCTTGGGGTTTACCGGGAGCGCAGAGACAGGACCCTGGCAGCTCTCCACGCATTGGGTTGGCATGCTCCT
TGTCCATCAATGGCGCTTTATCTTTGGTTGCCGATTCCAGCCTGGGCAAAACAGCAGAACTACAACGATGAGACTTTGGC
GGCAGATCTTTTGGATCAGACTGGAGTTGCCTTGACGCCTGGATCAGGTTTTGGCTCCGGCGGGGATGGTTGGCTTCGCC
TGGCCCTGGTCCATCCGGTGGAAGATTTGGAGGCGGCAGTTGCCCGGATGTGGCCTTGGTGGCATGCGCACATCTGA

Upstream 100 bases:

>100_bases
CATTGTGCTGCAAGATGTCTTGCCTCCTTTGCGGAGTTCTTAACGGCTGCTTATTTGATGTAGTAACCGATCACCAAAAC
ACAGTTTTAGCTTTCCGTTG

Downstream 100 bases:

>100_bases
CTCATGGACTGGTGCTGCTGCGGTTGCCCGTTTGTGGCGTAGGCAGTCTTGCGGGGCTAGGCCATGGCAGTTGCGATGGC
AGCCGGTCTGTGCGAGTACT

Product: aminotransferase class-I

Products: NA

Alternate protein names: DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MATSRRLGRLGRGVFDRNDRRKQAYRLANAGPQSLPLLDLSLGSTDLSPPAVALEAIEVALRAPESSSYCLHASTRPFRE
AVAAWSQRRFGVSVDPDREVLLLVGSQEGTAHLPLAVLDPGDSALILDPAYPSHRGGLILADARIERLLLRPEQEWRPDF
KALSNSQWDQLRMMVFGFPHNPTAQVGEQSWLAEAMDRGIRHQVVVAHDNPYVDLALDGEAPALLRCPGWRECGIEFFSF
SKAWCLGGFRLAFAIGAEHLITALRELKGVVDFNQSLALQRGAIAALTDAQDWPQEILGVYRERRDRTLAALHALGWHAP
CPSMALYLWLPIPAWAKQQNYNDETLAADLLDQTGVALTPGSGFGSGGDGWLRLALVHPVEDLEAAVARMWPWWHAHI

Sequences:

>Translated_398_residues
MATSRRLGRLGRGVFDRNDRRKQAYRLANAGPQSLPLLDLSLGSTDLSPPAVALEAIEVALRAPESSSYCLHASTRPFRE
AVAAWSQRRFGVSVDPDREVLLLVGSQEGTAHLPLAVLDPGDSALILDPAYPSHRGGLILADARIERLLLRPEQEWRPDF
KALSNSQWDQLRMMVFGFPHNPTAQVGEQSWLAEAMDRGIRHQVVVAHDNPYVDLALDGEAPALLRCPGWRECGIEFFSF
SKAWCLGGFRLAFAIGAEHLITALRELKGVVDFNQSLALQRGAIAALTDAQDWPQEILGVYRERRDRTLAALHALGWHAP
CPSMALYLWLPIPAWAKQQNYNDETLAADLLDQTGVALTPGSGFGSGGDGWLRLALVHPVEDLEAAVARMWPWWHAHI
>Mature_397_residues
ATSRRLGRLGRGVFDRNDRRKQAYRLANAGPQSLPLLDLSLGSTDLSPPAVALEAIEVALRAPESSSYCLHASTRPFREA
VAAWSQRRFGVSVDPDREVLLLVGSQEGTAHLPLAVLDPGDSALILDPAYPSHRGGLILADARIERLLLRPEQEWRPDFK
ALSNSQWDQLRMMVFGFPHNPTAQVGEQSWLAEAMDRGIRHQVVVAHDNPYVDLALDGEAPALLRCPGWRECGIEFFSFS
KAWCLGGFRLAFAIGAEHLITALRELKGVVDFNQSLALQRGAIAALTDAQDWPQEILGVYRERRDRTLAALHALGWHAPC
PSMALYLWLPIPAWAKQQNYNDETLAADLLDQTGVALTPGSGFGSGGDGWLRLALVHPVEDLEAAVARMWPWWHAHI

Specific function: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=397, Percent_Identity=20.6549118387909, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI169881279, Length=397, Percent_Identity=20.6549118387909, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI56713256, Length=309, Percent_Identity=20.3883495145631, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI56713254, Length=314, Percent_Identity=21.656050955414, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1788722, Length=384, Percent_Identity=32.2916666666667, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1786816, Length=393, Percent_Identity=22.9007633587786, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1788627, Length=418, Percent_Identity=23.2057416267943, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71994472, Length=386, Percent_Identity=23.5751295336788, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71994476, Length=386, Percent_Identity=23.5751295336788, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17567369, Length=213, Percent_Identity=23.0046948356808, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR019881
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.83 [H]

Molecular weight: Translated: 43972; Mature: 43840

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATSRRLGRLGRGVFDRNDRRKQAYRLANAGPQSLPLLDLSLGSTDLSPPAVALEAIEVA
CCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHH
LRAPESSSYCLHASTRPFREAVAAWSQRRFGVSVDPDREVLLLVGSQEGTAHLPLAVLDP
HCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCEEEECC
GDSALILDPAYPSHRGGLILADARIERLLLRPEQEWRPDFKALSNSQWDQLRMMVFGFPH
CCCEEEECCCCCCCCCCEEEEHHHHHHHHCCCCHHHCCCHHHHCCCCHHHEEEEEEECCC
NPTAQVGEQSWLAEAMDRGIRHQVVVAHDNPYVDLALDGEAPALLRCPGWRECGIEFFSF
CCHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEECCCCCEEEECCCCHHHCHHHHHC
SKAWCLGGFRLAFAIGAEHLITALRELKGVVDFNQSLALQRGAIAALTDAQDWPQEILGV
CHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEEECCCHHHHHHHHHH
YRERRDRTLAALHALGWHAPCPSMALYLWLPIPAWAKQQNYNDETLAADLLDQTGVALTP
HHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHCCCCCHHHHHHHHHHCCCCEECC
GSGFGSGGDGWLRLALVHPVEDLEAAVARMWPWWHAHI
CCCCCCCCCCEEEEEEECCHHHHHHHHHHHCCCHHCCC
>Mature Secondary Structure 
ATSRRLGRLGRGVFDRNDRRKQAYRLANAGPQSLPLLDLSLGSTDLSPPAVALEAIEVA
CCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHH
LRAPESSSYCLHASTRPFREAVAAWSQRRFGVSVDPDREVLLLVGSQEGTAHLPLAVLDP
HCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCEEEECC
GDSALILDPAYPSHRGGLILADARIERLLLRPEQEWRPDFKALSNSQWDQLRMMVFGFPH
CCCEEEECCCCCCCCCCEEEEHHHHHHHHCCCCHHHCCCHHHHCCCCHHHEEEEEEECCC
NPTAQVGEQSWLAEAMDRGIRHQVVVAHDNPYVDLALDGEAPALLRCPGWRECGIEFFSF
CCHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEECCCCCEEEECCCCHHHCHHHHHC
SKAWCLGGFRLAFAIGAEHLITALRELKGVVDFNQSLALQRGAIAALTDAQDWPQEILGV
CHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEEECCCHHHHHHHHHH
YRERRDRTLAALHALGWHAPCPSMALYLWLPIPAWAKQQNYNDETLAADLLDQTGVALTP
HHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHCCCCCHHHHHHHHHHCCCCEECC
GSGFGSGGDGWLRLALVHPVEDLEAAVARMWPWWHAHI
CCCCCCCCCCEEEEEEECCHHHHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA