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The map label for this gene is hemC [H]

Identifier: 33863541

GI number: 33863541

Start: 1361833

End: 1362786

Strand: Direct

Name: hemC [H]

Synonym: PMT1273

Alternate gene names: 33863541

Gene position: 1361833-1362786 (Clockwise)

Preceding gene: 33863540

Following gene: 33863545

Centisome position: 56.49

GC content: 56.08

Gene sequence:

>954_bases
ATGGTCCTCACCCAACTGCGCATCGCCTCACGCCGAAGCCAGCTGGCCATGGTGCAAACCAATTGGGTGCAAGCGGAACT
GGAGCAAGCACACCCTGGCCTTTCCATCTCGGTAGAAGCGATGGCAACCCAGGGAGACAAAATTCTCGATGTCGCCCTTG
CCAAGATCGGCGACAAAGGCCTGTTCACGAAAGAGCTTGAAGCTCAGATGCTGGTAGGGCGTGCTGATATAGCTGTTCAT
TCCCTCAAAGATCTACCCACCAATCTTCCCGAAGGGCTCATGCTTGGGTGCGTGACTGAGCGAGAAGACCCAGCCGACGC
TCTGGTAGTGAATCAAAAGAATGCCGAGCATCAACTCGACACCCTGCCTGAAGGGGCAATCGTTGGCACAAGCTCGCTAC
GGCGTCTCGCCCAATTACGGCATCACTACCCCCATCTGGTGTTTAAGGATGTGCGCGGCAATGTGATCACCCGCCTTGAA
AAACTGGATGCCGGCAACTATGACTGCCTGATCCTTGCAGCAGCAGGTCTGACAAGGCTTGGCTTTGGAGATCGCATTCA
TCAGTTGATTCCCAGCGAGATCTCCCTTCATGCCGTTGGCCAGGGAGCCCTAGGCATTGAATGCGTGGAGGGTCACCCCG
AAGTCCTCGAGGCCATCAAGGCACTGGAACACAAACCAACAGCGCAGCGCTGCCTTGCTGAGCGGGCCTTACTAAGAGAA
CTAGAAGGGGGCTGCCAGGTCCCCATCGGTGTCAATAGCCGCATCGAAGCCAACGAATTACTGCTCACAGGCATGGTTGC
CAGCTTGGATGGCAAACGCTTGATACGTGATCAGCAGCGCGGCCCAATTGATCGCTGTGAAGCCATCGGCAAGGAACTCG
CTGAAACGCTGAAATCTCAAGGCGCTGGAGAGATCCTTGCGGAGATCTTCGCTGCTGTCAGGCCAGAAGCCTGA

Upstream 100 bases:

>100_bases
CCGAAAAACCTCCCTTCCCTCAGAGCATTAACGGATTAGCAGCCCATCGCGAAGATCGTGGGGTCGACTGCTTAATCTGG
AGGGCTGGAGTTCTGAACAC

Downstream 100 bases:

>100_bases
CTACTCTCAATCTCTATTGAGCCAGCTAGCGAGATCAATCAAGCACTCGTCAGTCTGTTGGCTGCGCTGACAAGGATCAG
CGCAGGATTTCCACAGTTGT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MVLTQLRIASRRSQLAMVQTNWVQAELEQAHPGLSISVEAMATQGDKILDVALAKIGDKGLFTKELEAQMLVGRADIAVH
SLKDLPTNLPEGLMLGCVTEREDPADALVVNQKNAEHQLDTLPEGAIVGTSSLRRLAQLRHHYPHLVFKDVRGNVITRLE
KLDAGNYDCLILAAAGLTRLGFGDRIHQLIPSEISLHAVGQGALGIECVEGHPEVLEAIKALEHKPTAQRCLAERALLRE
LEGGCQVPIGVNSRIEANELLLTGMVASLDGKRLIRDQQRGPIDRCEAIGKELAETLKSQGAGEILAEIFAAVRPEA

Sequences:

>Translated_317_residues
MVLTQLRIASRRSQLAMVQTNWVQAELEQAHPGLSISVEAMATQGDKILDVALAKIGDKGLFTKELEAQMLVGRADIAVH
SLKDLPTNLPEGLMLGCVTEREDPADALVVNQKNAEHQLDTLPEGAIVGTSSLRRLAQLRHHYPHLVFKDVRGNVITRLE
KLDAGNYDCLILAAAGLTRLGFGDRIHQLIPSEISLHAVGQGALGIECVEGHPEVLEAIKALEHKPTAQRCLAERALLRE
LEGGCQVPIGVNSRIEANELLLTGMVASLDGKRLIRDQQRGPIDRCEAIGKELAETLKSQGAGEILAEIFAAVRPEA
>Mature_317_residues
MVLTQLRIASRRSQLAMVQTNWVQAELEQAHPGLSISVEAMATQGDKILDVALAKIGDKGLFTKELEAQMLVGRADIAVH
SLKDLPTNLPEGLMLGCVTEREDPADALVVNQKNAEHQLDTLPEGAIVGTSSLRRLAQLRHHYPHLVFKDVRGNVITRLE
KLDAGNYDCLILAAAGLTRLGFGDRIHQLIPSEISLHAVGQGALGIECVEGHPEVLEAIKALEHKPTAQRCLAERALLRE
LEGGCQVPIGVNSRIEANELLLTGMVASLDGKRLIRDQQRGPIDRCEAIGKELAETLKSQGAGEILAEIFAAVRPEA

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=331, Percent_Identity=44.7129909365559, Blast_Score=267, Evalue=7e-72,
Organism=Homo sapiens, GI66933009, Length=331, Percent_Identity=44.7129909365559, Blast_Score=267, Evalue=7e-72,
Organism=Escherichia coli, GI48994974, Length=315, Percent_Identity=51.1111111111111, Blast_Score=293, Evalue=1e-80,
Organism=Saccharomyces cerevisiae, GI6319996, Length=316, Percent_Identity=45.253164556962, Blast_Score=247, Evalue=1e-66,
Organism=Drosophila melanogaster, GI20130425, Length=284, Percent_Identity=45.4225352112676, Blast_Score=239, Evalue=2e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 34337; Mature: 34337

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLTQLRIASRRSQLAMVQTNWVQAELEQAHPGLSISVEAMATQGDKILDVALAKIGDKG
CCEEHHHHHHHHHHEEEHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHCCCC
LFTKELEAQMLVGRADIAVHSLKDLPTNLPEGLMLGCVTEREDPADALVVNQKNAEHQLD
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCEEEEECCCCHHHHH
TLPEGAIVGTSSLRRLAQLRHHYPHLVFKDVRGNVITRLEKLDAGNYDCLILAAAGLTRL
CCCCCCEECHHHHHHHHHHHHHCCCCEEHHHCCHHHHHHHHHCCCCCCEEEEEECCHHHC
GFGDRIHQLIPSEISLHAVGQGALGIECVEGHPEVLEAIKALEHKPTAQRCLAERALLRE
CCHHHHHHHCCCCCEEEEECCCCCCEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LEGGCQVPIGVNSRIEANELLLTGMVASLDGKRLIRDQQRGPIDRCEAIGKELAETLKSQ
HCCCCEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
GAGEILAEIFAAVRPEA
CHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVLTQLRIASRRSQLAMVQTNWVQAELEQAHPGLSISVEAMATQGDKILDVALAKIGDKG
CCEEHHHHHHHHHHEEEHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHCCCC
LFTKELEAQMLVGRADIAVHSLKDLPTNLPEGLMLGCVTEREDPADALVVNQKNAEHQLD
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCEEEEECCCCHHHHH
TLPEGAIVGTSSLRRLAQLRHHYPHLVFKDVRGNVITRLEKLDAGNYDCLILAAAGLTRL
CCCCCCEECHHHHHHHHHHHHHCCCCEEHHHCCHHHHHHHHHCCCCCCEEEEEECCHHHC
GFGDRIHQLIPSEISLHAVGQGALGIECVEGHPEVLEAIKALEHKPTAQRCLAERALLRE
CCHHHHHHHCCCCCEEEEECCCCCCEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LEGGCQVPIGVNSRIEANELLLTGMVASLDGKRLIRDQQRGPIDRCEAIGKELAETLKSQ
HCCCCEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
GAGEILAEIFAAVRPEA
CHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA