Click here to switch to the map view.

The map label for this gene is zwf [H]

Identifier: 33863373

GI number: 33863373

Start: 1193456

End: 1194979

Strand: Direct

Name: zwf [H]

Synonym: PMT1102

Alternate gene names: 33863373

Gene position: 1193456-1194979 (Clockwise)

Preceding gene: 33863372

Following gene: 33863374

Centisome position: 49.5

GC content: 54.0

Gene sequence:

>1524_bases
ATGAGCACCACGATCACCAACCCTTTACGGGTTGGACTACGTCAAGAGCGGGTTATCGCTCCGCAGTGCCTAGTCATCTT
TGGTGCAAGTGGCGACCTGACCCACCGAAAATTGGTTCCAGCCCTTTTCGAGCTATACAAACAACGGCGGCTACCGAGTG
AATTCGCCCTACTTGGCTGCGCGCGACGTCCTTGGAGCAACGAAATATTTCGCCAAAAAATGGCTGAAGCCCTCGGCGAG
ACTATCAACGAAAACCATCTTGCTTGGGATCAATTCGCCGCTGGTCTTTTTTACGAACCTGTCGATCTACAGAAGCCAGA
AGACCTCATCAAACTCAGCCATCGGCTGGAAGAGATTGATCGACTCCGCGCCACCCGCAGCAATCGCACCTTCTATCTTT
CGGTGTCACCAAAGTTCTACGGCAGTGGCTGCAAAGCTCTTGCTAATGCCGGTCTTCTAAGTGATCCCAAACGCAGTCGA
GTGGTTATCGAAAAACCATTCGGGCGTGATTACGCCAGTGCTCAGTCTTTAAATCAAATCGTCCAAAGCTGTGGCCAAGA
GAATCAAATCTTCCGCATCGACCACTACCTCGGCAAAGAAACAGTCCAGAACATCCTTGTGCTGCGATTCGCAAATACCA
TCTTTGAACCAATCTGGAACCGGAATTACATCTCCAGCGTTCAAATCACAGCCGCTGAAACCGTAGGGGTTGAAGAACGA
GCCAACTACTACGAATCGTCAGGGGCCCTGCGCGACATGGTGCAAAACCATCTCACCCAGATGCTGGCCATCACCACGAT
GGAACCGCCAGGGCGCTTTGACCCTGAGGCAATCCGCAATGAAAAAGCCAAGGTTTTGCTAGCGGCTCGCCTAGCGGATG
AGTTGGAACCTTGGAACTGCTGCATCCGTGGCCAGTACGCACCTGGCGGCACCAAGGAAGCTCCGATAGCAGGCTACCGA
CAGGAGCCGGGTGTCGATCCCAGCAGCACCACCGAGACCTATGTAGCGATGAAACTTTTCATCGACAACTGGCGCTGGCA
GGGAGTGCCCTTTTACGTTCGCACTGGCAAACGACTGGCAAAGCGTCTTAGTGAAGTGGTTCTCACCTTTCGAGAAGCAC
CCGTGCATCTTTTCGATGCCGCTGGGGGCAGCCCTACAGCGAACCAACTCATCCTGCGAATCCAACCGGATGAAGGAGCC
GAGTGGCGCTTTGAGGTGAAGTCACCTGGTTCAGGCATGCGCAGCCGACCAGTAGAGATGGAATTCTCCTATGACGAATC
CTTCGGTGAGCCATCCGATGAGGGATACGTCCGACTTTTAGCCGATGCCATGCTCAGTGACCCAACTTTATTCACCCGCA
GTGATGAGGTTGAAGCAGCGTGGCGCCTTTACACCCCTCTCCTGGAACTGATTGAAGACAGCCCATGGCAATTGCCCATT
CATCCCTATGAATCACGTACCTGGGGGCCCGCTGCTGCCGATACCCTGCTTGCCAATGACGGATTGCTCTGGCGCCGACC
CTGA

Upstream 100 bases:

>100_bases
CAAATTTTTTTGGGCATACGACGACAAACCATGCCGGGATGGTCTGGAGCACTTTGAATTCACAGATCCTTGGTTACCCG
TCAGAAGAGGTCTGTGTTCC

Downstream 100 bases:

>100_bases
TTCCGCCTGGCTCATCTCATCTTGATTACTCAGCTCTATCCATGTCCCCCCAGCTCACGCTTCAGAGCCCTCTGCAACTC
CCTCCTAGTGAGGTCCCTAG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MSTTITNPLRVGLRQERVIAPQCLVIFGASGDLTHRKLVPALFELYKQRRLPSEFALLGCARRPWSNEIFRQKMAEALGE
TINENHLAWDQFAAGLFYEPVDLQKPEDLIKLSHRLEEIDRLRATRSNRTFYLSVSPKFYGSGCKALANAGLLSDPKRSR
VVIEKPFGRDYASAQSLNQIVQSCGQENQIFRIDHYLGKETVQNILVLRFANTIFEPIWNRNYISSVQITAAETVGVEER
ANYYESSGALRDMVQNHLTQMLAITTMEPPGRFDPEAIRNEKAKVLLAARLADELEPWNCCIRGQYAPGGTKEAPIAGYR
QEPGVDPSSTTETYVAMKLFIDNWRWQGVPFYVRTGKRLAKRLSEVVLTFREAPVHLFDAAGGSPTANQLILRIQPDEGA
EWRFEVKSPGSGMRSRPVEMEFSYDESFGEPSDEGYVRLLADAMLSDPTLFTRSDEVEAAWRLYTPLLELIEDSPWQLPI
HPYESRTWGPAAADTLLANDGLLWRRP

Sequences:

>Translated_507_residues
MSTTITNPLRVGLRQERVIAPQCLVIFGASGDLTHRKLVPALFELYKQRRLPSEFALLGCARRPWSNEIFRQKMAEALGE
TINENHLAWDQFAAGLFYEPVDLQKPEDLIKLSHRLEEIDRLRATRSNRTFYLSVSPKFYGSGCKALANAGLLSDPKRSR
VVIEKPFGRDYASAQSLNQIVQSCGQENQIFRIDHYLGKETVQNILVLRFANTIFEPIWNRNYISSVQITAAETVGVEER
ANYYESSGALRDMVQNHLTQMLAITTMEPPGRFDPEAIRNEKAKVLLAARLADELEPWNCCIRGQYAPGGTKEAPIAGYR
QEPGVDPSSTTETYVAMKLFIDNWRWQGVPFYVRTGKRLAKRLSEVVLTFREAPVHLFDAAGGSPTANQLILRIQPDEGA
EWRFEVKSPGSGMRSRPVEMEFSYDESFGEPSDEGYVRLLADAMLSDPTLFTRSDEVEAAWRLYTPLLELIEDSPWQLPI
HPYESRTWGPAAADTLLANDGLLWRRP
>Mature_506_residues
STTITNPLRVGLRQERVIAPQCLVIFGASGDLTHRKLVPALFELYKQRRLPSEFALLGCARRPWSNEIFRQKMAEALGET
INENHLAWDQFAAGLFYEPVDLQKPEDLIKLSHRLEEIDRLRATRSNRTFYLSVSPKFYGSGCKALANAGLLSDPKRSRV
VIEKPFGRDYASAQSLNQIVQSCGQENQIFRIDHYLGKETVQNILVLRFANTIFEPIWNRNYISSVQITAAETVGVEERA
NYYESSGALRDMVQNHLTQMLAITTMEPPGRFDPEAIRNEKAKVLLAARLADELEPWNCCIRGQYAPGGTKEAPIAGYRQ
EPGVDPSSTTETYVAMKLFIDNWRWQGVPFYVRTGKRLAKRLSEVVLTFREAPVHLFDAAGGSPTANQLILRIQPDEGAE
WRFEVKSPGSGMRSRPVEMEFSYDESFGEPSDEGYVRLLADAMLSDPTLFTRSDEVEAAWRLYTPLLELIEDSPWQLPIH
PYESRTWGPAAADTLLANDGLLWRRP

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=495, Percent_Identity=35.7575757575758, Blast_Score=289, Evalue=3e-78,
Organism=Homo sapiens, GI109389365, Length=495, Percent_Identity=35.7575757575758, Blast_Score=289, Evalue=4e-78,
Organism=Homo sapiens, GI52145310, Length=488, Percent_Identity=29.5081967213115, Blast_Score=165, Evalue=1e-40,
Organism=Escherichia coli, GI1788158, Length=496, Percent_Identity=39.1129032258064, Blast_Score=348, Evalue=4e-97,
Organism=Caenorhabditis elegans, GI17538218, Length=510, Percent_Identity=33.5294117647059, Blast_Score=295, Evalue=3e-80,
Organism=Saccharomyces cerevisiae, GI6324088, Length=477, Percent_Identity=34.8008385744235, Blast_Score=268, Evalue=1e-72,
Organism=Drosophila melanogaster, GI24643350, Length=479, Percent_Identity=35.6993736951983, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24643352, Length=479, Percent_Identity=35.6993736951983, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI221513548, Length=476, Percent_Identity=28.781512605042, Blast_Score=205, Evalue=5e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 57449; Mature: 57318

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTITNPLRVGLRQERVIAPQCLVIFGASGDLTHRKLVPALFELYKQRRLPSEFALLGC
CCCCCCCHHHHCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHC
ARRPWSNEIFRQKMAEALGETINENHLAWDQFAAGLFYEPVDLQKPEDLIKLSHRLEEID
CCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHH
RLRATRSNRTFYLSVSPKFYGSGCKALANAGLLSDPKRSRVVIEKPFGRDYASAQSLNQI
HHHHHCCCCEEEEEECCCHHCCCHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHH
VQSCGQENQIFRIDHYLGKETVQNILVLRFANTIFEPIWNRNYISSVQITAAETVGVEER
HHHCCCCCCEEEEHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHCCHHHH
ANYYESSGALRDMVQNHLTQMLAITTMEPPGRFDPEAIRNEKAKVLLAARLADELEPWNC
HHHHHHCCHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHCCHHHHHHHHHHHHHCCCCCE
CIRGQYAPGGTKEAPIAGYRQEPGVDPSSTTETYVAMKLFIDNWRWQGVPFYVRTGKRLA
EEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHEEEEEEECCCCCCCCCEEECCHHHHH
KRLSEVVLTFREAPVHLFDAAGGSPTANQLILRIQPDEGAEWRFEVKSPGSGMRSRPVEM
HHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCEEE
EFSYDESFGEPSDEGYVRLLADAMLSDPTLFTRSDEVEAAWRLYTPLLELIEDSPWQLPI
EECCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCEECC
HPYESRTWGPAAADTLLANDGLLWRRP
CCCCCCCCCCHHHHHHEECCCEEECCC
>Mature Secondary Structure 
STTITNPLRVGLRQERVIAPQCLVIFGASGDLTHRKLVPALFELYKQRRLPSEFALLGC
CCCCCCHHHHCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHC
ARRPWSNEIFRQKMAEALGETINENHLAWDQFAAGLFYEPVDLQKPEDLIKLSHRLEEID
CCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHH
RLRATRSNRTFYLSVSPKFYGSGCKALANAGLLSDPKRSRVVIEKPFGRDYASAQSLNQI
HHHHHCCCCEEEEEECCCHHCCCHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHH
VQSCGQENQIFRIDHYLGKETVQNILVLRFANTIFEPIWNRNYISSVQITAAETVGVEER
HHHCCCCCCEEEEHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHCCHHHH
ANYYESSGALRDMVQNHLTQMLAITTMEPPGRFDPEAIRNEKAKVLLAARLADELEPWNC
HHHHHHCCHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHCCHHHHHHHHHHHHHCCCCCE
CIRGQYAPGGTKEAPIAGYRQEPGVDPSSTTETYVAMKLFIDNWRWQGVPFYVRTGKRLA
EEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHEEEEEEECCCCCCCCCEEECCHHHHH
KRLSEVVLTFREAPVHLFDAAGGSPTANQLILRIQPDEGAEWRFEVKSPGSGMRSRPVEM
HHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCEEE
EFSYDESFGEPSDEGYVRLLADAMLSDPTLFTRSDEVEAAWRLYTPLLELIEDSPWQLPI
EECCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCEECC
HPYESRTWGPAAADTLLANDGLLWRRP
CCCCCCCCCCHHHHHHEECCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]