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The map label for this gene is kprS

Identifier: 33863345

GI number: 33863345

Start: 1159752

End: 1160750

Strand: Direct

Name: kprS

Synonym: PMT1074

Alternate gene names: 33863345

Gene position: 1159752-1160750 (Clockwise)

Preceding gene: 33863343

Following gene: 33863346

Centisome position: 48.11

GC content: 53.15

Gene sequence:

>999_bases
GTGACGAGTTTTCTGACCGCAGCCCGTACCGAACAAGAGAGCATCAGCTATGACATGCAGCGTCTGCGCTTGTTCAGCGG
CACCTCAAATCCAGCTCTTGCAAGAGAGATTGCGGCCTACCTAGGTGTTCCCGATGGTCCAAGGATCTGCAAACGGTTCG
CAGATGGTGAGCTCTATGTACAAATCCAGGAATCGATCCGAGGTTGTGACGTCTTCCTGATTCAGCCCACCTGTGCGCCA
GTGAACGACAATTTGATGGAGCTGCTGATCATGGTTGATGCCTGTCAGCGCGCCTCTGCCAGGCAGATCACTGCGGTAGT
TCCCTACTACGGCTATGCAAGAGCCGACCGCAAAACGGCTGGTCGCGAGTCAATCACTGCCAAGCTCACCGCAAACCTAC
TGGTGAAATCTGGCGTGAACAGAGTCCTCGCCATGGATCTGCATTCCGCCCAAATCCAGGGCTACTTTGACATCCCTTGC
GATCACATCTACGGCTCACCAGTCTTGGTTGATTACCTCGCAGCACAAGAACTTAACGAAGTCGTGGTGGTATCTCCAGA
TGTTGGAGGAGTCGCACGAGCCCGAGCCTTTGCGAAACAAATGAGGGATGCGCCACTGGCAATTATTGATAAGCGCCGAT
CAGGTCACAACGTTGCCGAAAGTCTCACAGTGATCGGCGATGTGGCTGGGAAAACAGCCATCCTGATCGACGATATGATC
GACACTGGGGGAACAATTTGCTCAGGGGCTCGTCTTCTTCGACAACAAGGGGCTAAACGAGTTATTGCCTGTGCCTCCCA
TGCCGTGTTTTCGCCCCCCGCCTGCGAACGATTATCCGAAGAAGGCTTATTCGAACAAGTCTTGGTTACCAACAGCATTC
CCATCGCTGCGGAACGACACTTCCCTCAATTGCAGGTACTTTCAGTGGCCAATATGCTTGGCGAAGCGATTTGGCGCATC
CATGAGGAAAGCTCTGTGAGCTCAATGTTTAGAGGATGA

Upstream 100 bases:

>100_bases
ATGGGAGCAATCATCAGGCGACCCTACATAGAGAAGAAGTTGAGATGGGAGCCTTTGCAGCACTAGCATCGGAGTACAGC
TGATATTGCTCGCTGGCGAC

Downstream 100 bases:

>100_bases
CTCTGAGGTTAAGTCTAAAATTAGCTGCTAAGCAATAGAGATGACTCTTCTTAGAGCAGCTCATCAATATTTTAGCCACT
AAAATCGAAGCAAAATCAAT

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MTSFLTAARTEQESISYDMQRLRLFSGTSNPALAREIAAYLGVPDGPRICKRFADGELYVQIQESIRGCDVFLIQPTCAP
VNDNLMELLIMVDACQRASARQITAVVPYYGYARADRKTAGRESITAKLTANLLVKSGVNRVLAMDLHSAQIQGYFDIPC
DHIYGSPVLVDYLAAQELNEVVVVSPDVGGVARARAFAKQMRDAPLAIIDKRRSGHNVAESLTVIGDVAGKTAILIDDMI
DTGGTICSGARLLRQQGAKRVIACASHAVFSPPACERLSEEGLFEQVLVTNSIPIAAERHFPQLQVLSVANMLGEAIWRI
HEESSVSSMFRG

Sequences:

>Translated_332_residues
MTSFLTAARTEQESISYDMQRLRLFSGTSNPALAREIAAYLGVPDGPRICKRFADGELYVQIQESIRGCDVFLIQPTCAP
VNDNLMELLIMVDACQRASARQITAVVPYYGYARADRKTAGRESITAKLTANLLVKSGVNRVLAMDLHSAQIQGYFDIPC
DHIYGSPVLVDYLAAQELNEVVVVSPDVGGVARARAFAKQMRDAPLAIIDKRRSGHNVAESLTVIGDVAGKTAILIDDMI
DTGGTICSGARLLRQQGAKRVIACASHAVFSPPACERLSEEGLFEQVLVTNSIPIAAERHFPQLQVLSVANMLGEAIWRI
HEESSVSSMFRG
>Mature_331_residues
TSFLTAARTEQESISYDMQRLRLFSGTSNPALAREIAAYLGVPDGPRICKRFADGELYVQIQESIRGCDVFLIQPTCAPV
NDNLMELLIMVDACQRASARQITAVVPYYGYARADRKTAGRESITAKLTANLLVKSGVNRVLAMDLHSAQIQGYFDIPCD
HIYGSPVLVDYLAAQELNEVVVVSPDVGGVARARAFAKQMRDAPLAIIDKRRSGHNVAESLTVIGDVAGKTAILIDDMID
TGGTICSGARLLRQQGAKRVIACASHAVFSPPACERLSEEGLFEQVLVTNSIPIAAERHFPQLQVLSVANMLGEAIWRIH
EESSVSSMFRG

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family

Homologues:

Organism=Homo sapiens, GI4506127, Length=315, Percent_Identity=42.8571428571429, Blast_Score=269, Evalue=3e-72,
Organism=Homo sapiens, GI4506129, Length=315, Percent_Identity=42.5396825396825, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI28557709, Length=315, Percent_Identity=42.2222222222222, Blast_Score=264, Evalue=9e-71,
Organism=Homo sapiens, GI84875539, Length=318, Percent_Identity=42.4528301886792, Blast_Score=262, Evalue=4e-70,
Organism=Homo sapiens, GI4506133, Length=347, Percent_Identity=35.1585014409222, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI194018537, Length=346, Percent_Identity=34.1040462427746, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI310128524, Length=144, Percent_Identity=29.1666666666667, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI310115209, Length=144, Percent_Identity=29.1666666666667, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI310118259, Length=144, Percent_Identity=29.1666666666667, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI310119946, Length=144, Percent_Identity=29.1666666666667, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1787458, Length=314, Percent_Identity=50.6369426751592, Blast_Score=328, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI17554702, Length=328, Percent_Identity=41.4634146341463, Blast_Score=252, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI25149168, Length=315, Percent_Identity=42.2222222222222, Blast_Score=252, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI71989924, Length=328, Percent_Identity=41.4634146341463, Blast_Score=251, Evalue=4e-67,
Organism=Caenorhabditis elegans, GI17554704, Length=310, Percent_Identity=42.5806451612903, Blast_Score=248, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI17570245, Length=338, Percent_Identity=29.8816568047337, Blast_Score=162, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6319403, Length=316, Percent_Identity=39.873417721519, Blast_Score=239, Evalue=5e-64,
Organism=Saccharomyces cerevisiae, GI6320946, Length=312, Percent_Identity=41.3461538461538, Blast_Score=238, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6321776, Length=315, Percent_Identity=38.7301587301587, Blast_Score=225, Evalue=7e-60,
Organism=Saccharomyces cerevisiae, GI6322667, Length=199, Percent_Identity=40.2010050251256, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6324511, Length=96, Percent_Identity=39.5833333333333, Blast_Score=83, Evalue=8e-17,
Organism=Drosophila melanogaster, GI21355239, Length=315, Percent_Identity=43.1746031746032, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI45551540, Length=338, Percent_Identity=40.8284023668639, Blast_Score=253, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24651458, Length=356, Percent_Identity=30.6179775280899, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24651456, Length=356, Percent_Identity=30.6179775280899, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI281362873, Length=356, Percent_Identity=30.6179775280899, Blast_Score=181, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24651454, Length=356, Percent_Identity=30.6179775280899, Blast_Score=181, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24651462, Length=183, Percent_Identity=36.6120218579235, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24651464, Length=183, Percent_Identity=36.6120218579235, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI45552010, Length=183, Percent_Identity=36.6120218579235, Blast_Score=129, Evalue=3e-30,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): KPRS_PROMM (Q7V6S2)

Other databases:

- EMBL:   BX548175
- RefSeq:   NP_894905.1
- ProteinModelPortal:   Q7V6S2
- SMR:   Q7V6S2
- STRING:   Q7V6S2
- GeneID:   1728637
- GenomeReviews:   BX548175_GR
- KEGG:   pmt:PMT1074
- NMPDR:   fig|74547.1.peg.1072
- eggNOG:   COG0462
- HOGENOM:   HBG519284
- OMA:   CATHAVF
- ProtClustDB:   PRK02812
- BioCyc:   PMAR74547:PMT1074-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00583_B
- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01251

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.7.6.1

Molecular weight: Translated: 36113; Mature: 35982

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00114 PRPP_SYNTHASE; PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSFLTAARTEQESISYDMQRLRLFSGTSNPALAREIAAYLGVPDGPRICKRFADGELYV
CCCCHHHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCEEEE
QIQESIRGCDVFLIQPTCAPVNDNLMELLIMVDACQRASARQITAVVPYYGYARADRKTA
EEHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHCCHHHC
GRESITAKLTANLLVKSGVNRVLAMDLHSAQIQGYFDIPCDHIYGSPVLVDYLAAQELNE
CHHHHHHHHHHHHHHHHCCCCEEEEECHHHHCCEEECCCHHHHCCCHHHHHHHHHHCCCC
VVVVSPDVGGVARARAFAKQMRDAPLAIIDKRRSGHNVAESLTVIGDVAGKTAILIDDMI
EEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEHHH
DTGGTICSGARLLRQQGAKRVIACASHAVFSPPACERLSEEGLFEQVLVTNSIPIAAERH
HCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHCCCCCCCCCC
FPQLQVLSVANMLGEAIWRIHEESSVSSMFRG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSFLTAARTEQESISYDMQRLRLFSGTSNPALAREIAAYLGVPDGPRICKRFADGELYV
CCCHHHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCEEEE
QIQESIRGCDVFLIQPTCAPVNDNLMELLIMVDACQRASARQITAVVPYYGYARADRKTA
EEHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHCCHHHC
GRESITAKLTANLLVKSGVNRVLAMDLHSAQIQGYFDIPCDHIYGSPVLVDYLAAQELNE
CHHHHHHHHHHHHHHHHCCCCEEEEECHHHHCCEEECCCHHHHCCCHHHHHHHHHHCCCC
VVVVSPDVGGVARARAFAKQMRDAPLAIIDKRRSGHNVAESLTVIGDVAGKTAILIDDMI
EEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEHHH
DTGGTICSGARLLRQQGAKRVIACASHAVFSPPACERLSEEGLFEQVLVTNSIPIAAERH
HCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHCCCCCCCCCC
FPQLQVLSVANMLGEAIWRIHEESSVSSMFRG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642