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The map label for this gene is metA [H]

Identifier: 33863148

GI number: 33863148

Start: 959734

End: 960627

Strand: Direct

Name: metA [H]

Synonym: PMT0876

Alternate gene names: 33863148

Gene position: 959734-960627 (Clockwise)

Preceding gene: 33863147

Following gene: 33863150

Centisome position: 39.81

GC content: 50.67

Gene sequence:

>894_bases
ATGGCGCTGATCCTGCCACGCAGTTATCACAAGATCGCCGCGGTGGAGAAGAACCGGATCTCATGGATCGAGCCGGAACT
TGCGGAACGTCAGGACATCCGGCCATTAAGAATCGGAATCCTCAACATCATGCCCCTGGGCAAGCAGTATGAATTCAATC
TGCTGCATCCCCTAGGGCTTTCACCTCTTCAGATCGAACCGATCTGGATAAGGCTAAGTAGCCATAGCTATAAAACATGG
GACCTTGCTCATCTCGATAATCTCTATGTGAGCTGGGAGGAAGCAATGGAACCCAATCCTCTTGATGGTTTGATCATCAC
TGGAGCACCAGTTGAGCATCTTCCATTTGAGGAGGTGAACTACTGGCCAGAGCTAGTAAAAATCATCGAACAGGCACGGC
AGAACTGTGCAAACACGCTTGGCTTGTGCTGGGCTGGTTTTGCAATGGCCTATCTCGAAGGTGTCGATAAAAAATCATTT
GCCAAAAAGTTGTTCGGGGTGTTCCCAATGCGCAGCTTGGTCCCCGGCCATGCCCTGATGGGCACTCAAGACGATCGATT
TGTGTGTCCGCAGAGTCGCCATGCTGGGTTGCATGATGGCGCAATGGAAGCAGCACAACGACAGGGACGTCTACGTTTAC
TTGCCCATGGTGAGAAGGTTGGCTACACAATCTTTGAGACCACCGATCAACGCCAACTGGTTCATCTTGGCCATCCGGAG
TACAACGCGGGGCGCCTGTTAACAGAGATGGAACGTGATCAAGCGCGAGGTGATGTTCAGCCCCCTGAAAATTTTGATCC
AGACAACCCTTTAACTCTATGGCGATCACATCGCAATCTACTGTTTCAACACTGGCTCTGGTTCTGCTATCAAAGAGTAA
GCTTGCGTGACTAA

Upstream 100 bases:

>100_bases
CCACAATGGTTAGGGTATCTGTTGGCCTTGAACACATCGAAGACATCAAGGCTGATTTTGAACAGGCCCTAGCGGCCATC
AGTTGAGACTGGAGGCATCG

Downstream 100 bases:

>100_bases
AATGCTGTCATAATGACTATGTATAGCAAACAGAATAACCCAAAAAGCCAGGAAATCTCTATCAATCAACCTCGAAAGCA
CCATAGATCGAGGGGCTTTC

Product: homoserine O-succinyltransferase

Products: NA

Alternate protein names: Homoserine O-transsuccinylase; HTS [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MALILPRSYHKIAAVEKNRISWIEPELAERQDIRPLRIGILNIMPLGKQYEFNLLHPLGLSPLQIEPIWIRLSSHSYKTW
DLAHLDNLYVSWEEAMEPNPLDGLIITGAPVEHLPFEEVNYWPELVKIIEQARQNCANTLGLCWAGFAMAYLEGVDKKSF
AKKLFGVFPMRSLVPGHALMGTQDDRFVCPQSRHAGLHDGAMEAAQRQGRLRLLAHGEKVGYTIFETTDQRQLVHLGHPE
YNAGRLLTEMERDQARGDVQPPENFDPDNPLTLWRSHRNLLFQHWLWFCYQRVSLRD

Sequences:

>Translated_297_residues
MALILPRSYHKIAAVEKNRISWIEPELAERQDIRPLRIGILNIMPLGKQYEFNLLHPLGLSPLQIEPIWIRLSSHSYKTW
DLAHLDNLYVSWEEAMEPNPLDGLIITGAPVEHLPFEEVNYWPELVKIIEQARQNCANTLGLCWAGFAMAYLEGVDKKSF
AKKLFGVFPMRSLVPGHALMGTQDDRFVCPQSRHAGLHDGAMEAAQRQGRLRLLAHGEKVGYTIFETTDQRQLVHLGHPE
YNAGRLLTEMERDQARGDVQPPENFDPDNPLTLWRSHRNLLFQHWLWFCYQRVSLRD
>Mature_296_residues
ALILPRSYHKIAAVEKNRISWIEPELAERQDIRPLRIGILNIMPLGKQYEFNLLHPLGLSPLQIEPIWIRLSSHSYKTWD
LAHLDNLYVSWEEAMEPNPLDGLIITGAPVEHLPFEEVNYWPELVKIIEQARQNCANTLGLCWAGFAMAYLEGVDKKSFA
KKLFGVFPMRSLVPGHALMGTQDDRFVCPQSRHAGLHDGAMEAAQRQGRLRLLAHGEKVGYTIFETTDQRQLVHLGHPEY
NAGRLLTEMERDQARGDVQPPENFDPDNPLTLWRSHRNLLFQHWLWFCYQRVSLRD

Specific function: Methionine biosynthesis; HTS variant; first step. [C]

COG id: COG1897

COG function: function code E; Homoserine trans-succinylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HTS family [H]

Homologues:

Organism=Escherichia coli, GI1790443, Length=299, Percent_Identity=34.1137123745819, Blast_Score=160, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005697
- ProDom:   PD037892 [H]

Pfam domain/function: PF04204 HTS [H]

EC number: =2.3.1.46 [H]

Molecular weight: Translated: 34318; Mature: 34187

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALILPRSYHKIAAVEKNRISWIEPELAERQDIRPLRIGILNIMPLGKQYEFNLLHPLGL
CEEECCCCCHHHHHCCCCCCCCCCCCHHHHCCCCHHEEEEEHEECCCCCCCEEEECCCCC
SPLQIEPIWIRLSSHSYKTWDLAHLDNLYVSWEEAMEPNPLDGLIITGAPVEHLPFEEVN
CCEEEEEEEEEEECCCCCEEEHHHHHHHEEEHHHHCCCCCCCCEEECCCCCCCCCHHHHH
YWPELVKIIEQARQNCANTLGLCWAGFAMAYLEGVDKKSFAKKLFGVFPMRSLVPGHALM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHCCCCCEE
GTQDDRFVCPQSRHAGLHDGAMEAAQRQGRLRLLAHGEKVGYTIFETTDQRQLVHLGHPE
CCCCCCEECCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCEEEEECCCCCEEEEECCCC
YNAGRLLTEMERDQARGDVQPPENFDPDNPLTLWRSHRNLLFQHWLWFCYQRVSLRD
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ALILPRSYHKIAAVEKNRISWIEPELAERQDIRPLRIGILNIMPLGKQYEFNLLHPLGL
EEECCCCCHHHHHCCCCCCCCCCCCHHHHCCCCHHEEEEEHEECCCCCCCEEEECCCCC
SPLQIEPIWIRLSSHSYKTWDLAHLDNLYVSWEEAMEPNPLDGLIITGAPVEHLPFEEVN
CCEEEEEEEEEEECCCCCEEEHHHHHHHEEEHHHHCCCCCCCCEEECCCCCCCCCHHHHH
YWPELVKIIEQARQNCANTLGLCWAGFAMAYLEGVDKKSFAKKLFGVFPMRSLVPGHALM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHCCCCCEE
GTQDDRFVCPQSRHAGLHDGAMEAAQRQGRLRLLAHGEKVGYTIFETTDQRQLVHLGHPE
CCCCCCEECCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCEEEEECCCCCEEEEECCCC
YNAGRLLTEMERDQARGDVQPPENFDPDNPLTLWRSHRNLLFQHWLWFCYQRVSLRD
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]